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  1. Article: Erratum corrige: "Efficacy of tocilizumab monotherapy after response to combined tocilizumab and methotrexate in patients with rheumatoid arthritis: the randomised JUST-ACT study". J.L. Pablos et al.

    Pablos, José Luis / Navarro, Federico / Blanco, Francisco José / Román-Ivorra, José Antonio / Alonso, Alberto / Martín Mola, Emilio / Cantalejo, Miguel / Ercole, Liliana / Rivero, Natividad

    Clinical and experimental rheumatology

    2020  Volume 38, Issue 3, Page(s) 585

    Language English
    Publishing date 2020-05-27
    Publishing country Italy
    Document type Journal Article ; Published Erratum
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Efficacy of tocilizumab monotherapy after response to combined tocilizumab and methotrexate in patients with rheumatoid arthritis: the randomised JUST-ACT study.

    Pablos, José Luis / Navarro, Federico / Blanco, Francisco José / Román-Ivorra, José Antonio / Alonso, Alberto / Martín Mola, Emilio / Cantalejo, Miguel / Ercole, Liliana / Rivero, Natividad

    Clinical and experimental rheumatology

    2018  Volume 37, Issue 3, Page(s) 437–444

    Abstract: Objectives: The aim of the JUST-ACT study was to assess whether the add-on effect of tocilizumab (TCZ) to background methotrexate (MTX) observed in MTX-inadequate responders with active rheumatoid arthritis (RA), would be sustained when MTX is withdrawn. ...

    Abstract Objectives: The aim of the JUST-ACT study was to assess whether the add-on effect of tocilizumab (TCZ) to background methotrexate (MTX) observed in MTX-inadequate responders with active rheumatoid arthritis (RA), would be sustained when MTX is withdrawn.
    Methods: A double-blind, parallel-group, phase 3 study in biologic-naïve RA patients with a disease activity score 28 (DAS28)>3.2 despite MTX which were treated with TCZ+MTX for an initial 16-week period. Patients who at week 16 achieved low disease activity (LDA) (DAS28≤3.2) were randomised to continue with TCZ+MTX or switch to TCZ + placebo (PBO) for an additional 12 weeks. The primary endpoint was the change in DAS28-ESR from the randomisation at week 16 to week 28. Non-inferiority was confirmed if the upper limit of the two-sided 95%CI for the treatment difference between TCZ+MTX and TCZ monotherapy groups was lower than the selected non-inferiority margin of 0.6.
    Results: 261 patients completed the first 16 weeks of TCZ+MTX treatment and 165 were randomised (83 to TCZ+MTX and 82 to TCZ+PBO). For the primary endpoint, the adjusted treatment difference (95% CI) in mean change of DAS28-ESR was -0.06 (-0.40 to 0.27), and therefore the non-inferiority of switching to TCZ monotherapy versus continuing with TCZ+MTX was demonstrated. In both treatment groups, the percentage of patients in clinical remission from 16 to 28 weeks was similar as were the improvements in disease activity, functional disability and quality of life.
    Conclusions: In MTX non-responder patients achieving LDA with TCZ+MTX, switching to TCZ monotherapy is non-inferior to continuing the combination.
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Male ; Methotrexate/therapeutic use ; Middle Aged ; Quality of Life ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; tocilizumab (I031V2H011) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2018-09-17
    Publishing country Italy
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2002: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Points to Consider in the Foundation of Multidisciplinary Units for Psoriatic Arthritis: A Delphi Study and a Systematic Review of the Literature.

    Gratacos-Masmitja, Jordi / Luelmo-Aguilar, Jesus / Zarco-Montejo, Pedro / Botella-Estrada, Rafael / Carrizosa-Esquivel, Ana Maria / Garcia-Vivar, Maria Luz / Perez-Barrio, Silvia / Roman-Ivorra, Jose Antonio / Ruiz-Montesino, Maria Dolores / Lopez-Estebaranz, Jose Luis

    Advances in therapy

    2016  Volume 33, Issue 12, Page(s) 2150–2159

    Abstract: Introduction: In numerous clinical practice guidelines, emphasis is placed on the need for coordinated care of psoriatic arthritis (PsA) between rheumatologists and the objective was to develop experience-based points to consider facilitating the ... ...

    Abstract Introduction: In numerous clinical practice guidelines, emphasis is placed on the need for coordinated care of psoriatic arthritis (PsA) between rheumatologists and the objective was to develop experience-based points to consider facilitating the implementation of multidisciplinary units (Dermatology/Rheumatology) for the management of patients with PsA.
    Methods: A scientific committee of rheumatology and dermatology experts in the management of PsA, and with experience in joint care, discussed the critical aspects of multidisciplinary PsA Units. The discussion became the basis for a Delphi survey in two rounds submitted to a panel of 24 specialists in rheumatology and dermatology not involved in PsA units. The statements and practices that reached a consensus were summarized and further elaborated.
    Results: After two Delphi rounds, agreement was reached for 49 of the 50 proposed statements. These included a justification of the units, objectives, and utilities, as well as operational aspects of the units, such as the minimal and ideal premises, referral criteria, and necessary resources. The statements were compiled in 11 points to consider.
    Conclusions: This consensus offers some points to consider, including premises and recommendations, for the development of specialized Units in the management of PsA based on expert opinion. We trust these guidelines may facilitate their implementation in the future.
    Funding: Pfizer.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/therapy ; Delphi Technique ; Dermatology/methods ; Female ; Humans ; Interprofessional Relations ; Male ; Middle Aged ; Patient Care Team/organization & administration ; Patient Care Team/standards ; Practice Guidelines as Topic ; Rheumatology/methods ; Surveys and Questionnaires
    Language English
    Publishing date 2016-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-016-0429-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2101: Show issues Location:
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