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  1. Article ; Online: Resultados do transplante alogênico de células tronco hematopoiéticas em síndrome mielodisplásica do Hospital Universitário Walter Cantídio

    Missielle Duarte Cordeiro / Romélia Pinheiro Gonçalves / Fernando Barroso Duarte

    Revista de Medicina da UFC, Vol 62, Iss 1, Pp 1-

    2022  Volume 5

    Abstract: Introdução: Síndromes mielodisplásicas (SMD) são um grupo heterogêneo de distúrbios hematopoiéticos clonais que têm maior chance de progressão para Leucemia Mielóide Aguda (LMA). O Transplante Alogênico de Células Tronco Hematopoiéticas (TCTH) representa ...

    Abstract Introdução: Síndromes mielodisplásicas (SMD) são um grupo heterogêneo de distúrbios hematopoiéticos clonais que têm maior chance de progressão para Leucemia Mielóide Aguda (LMA). O Transplante Alogênico de Células Tronco Hematopoiéticas (TCTH) representa o tratamento curativo mais efetivo para SMD até o momento. Objetivos: descrever o perfil dos pacientes com SMD, que realizaram TCTH alogênico, no Hospital Universitário Walter Cantídio (HUWC) em Fortaleza, Ceará. Metodologia: estudo retrospectivo observacional e descritivo com onze pacientes com SMD de novo que realizaram TCTH alogênico no período de fevereiro de 2015 a junho de 2018. Resultados: total de onze pacientes, idade ao diagnóstico de dezenove a sessenta e seis anos (média 46 anos). Três pacientes deleção do 5q (duas com alterações adicionais), quatro hipocelulares, um com displasia de múltiplas linhagens (p53 positivo na imunohistoquímica), duas com excesso de blastos tipo 2, uma com sideroblastos em anel (baixo risco). Dez doadores aparentados com fonte das células de sangue periférico e um não aparentado com fonte de medula óssea. Óbitos: uma paciente com excesso de blastos e um paciente com displasia multilinhagem. Conclusão: é possível identificar pacientes com SMD de baixo risco que tenham indicação de TCTH alogênico. Anormalidades citogenéticas adicionais à deleção 5q não tiveram impacto negativo. Também reforçamos a importância prognóstica do p53.
    Keywords transplante de medula óssea ; síndromes mielodisplásicas ; citogenética ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Universidade Federal do Ceará
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Influence of hydroxyurea on tubular phosphate handling in sickle cell nephropathy.

    de Abreu, Gabriela Araujo / de Sousa, Duaran Lopes / Dantas, Suzzy Maria Carvalho / Martins, Alice Maria Costa / Sampaio, Tiago Lima / Lemes, Romélia Pinheiro Gonçalves

    Hematology, transfusion and cell therapy

    2024  

    Abstract: Objective: This study aims to evaluate the markers of tubular phosphate handling in adults with sickle cell anemia (SCA) and the influence of hydroxyurea (HU), the degree of anemia and Hb F concentration on these markers.: Methods: Eighty-eight ... ...

    Abstract Objective: This study aims to evaluate the markers of tubular phosphate handling in adults with sickle cell anemia (SCA) and the influence of hydroxyurea (HU), the degree of anemia and Hb F concentration on these markers.
    Methods: Eighty-eight steady state SCA patients in outpatient follow-up in Fortaleza, Ceara, Brazil and 31 healthy individuals were included in this study. Vitamin D (25OHD) was measured by enzyme-bound fluorescence assay, intact parathyroid hormone (iPTH) by electrochemiluminescence, and serum and urinary phosphate and creatinine by colorimetric methods. Details of Hb F and HU use were obtained from clinical records. Tubular reabsorption of phosphate (TRP) and maximum tubular reabsorption of phosphate (MTRP) were calculated. SCA patients were stratified according to the use of HU, degree of anemia and percentage of Hb F. The significance level was set for p-values <0.05.
    Results: Compared to controls the 25OHD level (25 ± 11 vs. 30 ± 9 pg/mL) was lower in SCA, while serum phosphate and MTRP were higher (3.86 ± 0.94 vs. 3.46 ± 0.72 and 3.6 ± 1.21 vs. 3.21 ± 0.53, respectively). There was no significant difference in iPTH, TRP and phosphaturia. Serum phosphate showed correlation with TRP (r = 0.32; p-value = 0.008) and MTRP (r = 0.9; p-value <0.001) in SCA. Patients taking HU, especially those with Hb F >10 % presented reduced serum phosphate levels, and TRP and MTRP rates. Those with mild anemia presented reduced serum phosphate levels and MTRP rates.
    Conclusion: Serum phosphate levels and renal phosphate reabsorption rate were increased in SCA. HU use, high Hb F concentration and total Hb were associated with better control of tubular phosphate handling markers.
    Language English
    Publishing date 2024-02-14
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2023.11.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comments on the clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile.

    Lemes, Romélia Pinheiro Gonçalves

    Revista brasileira de hematologia e hemoterapia

    2014  Volume 36, Issue 2, Page(s) 100–101

    Language English
    Publishing date 2014-03-26
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2105177-X
    ISSN 1806-0870 ; 1516-8484
    ISSN (online) 1806-0870
    ISSN 1516-8484
    DOI 10.5581/1516-8484.20140022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nitric oxide status in sickle cell anemia

    Romélia Pinheiro Gonçalves

    Revista Brasileira de Hematologia e Hemoterapia, Vol 34, Iss 4, Pp 255-

    2012  Volume 255

    Keywords Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Sociedade Brasileira de Hematologia e Hemoterapia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Sickle Cell Disease and the Kidney: Pathophysiology and Novel Biomarkers.

    Lemes, Romélia Pinheiro Gonçalves / Rocha Laurentino, Marilia / Castelo, Luan Rebouças / Silva Junior, Geraldo

    Contributions to nephrology

    2021  Volume 199, Page(s) 114–121

    Abstract: Clinical Background: Renal involvement in sickle cell disease (SCD), called sickle cell nephropathy (SCN), includes several renal manifestations, such as renal acidification defect, distal nephron dysfunction, renal papillary necrosis, and proteinuria ... ...

    Abstract Clinical Background: Renal involvement in sickle cell disease (SCD), called sickle cell nephropathy (SCN), includes several renal manifestations, such as renal acidification defect, distal nephron dysfunction, renal papillary necrosis, and proteinuria related to glomerular injury, leading to end-stage renal disease. Epidemiology: Many patients with SCD have a defect in urinary concentration, a problem caused by the destruction of the renal medulla that initiates in childhood. The presence of proteinuria in SCD is age-related and starts as microalbuminuria in adolescence and progresses to macroalbuminuria. Proteinuria is responsible for the progression to chronic kidney disease in some patients with SCD with glomerular filtration rate (GFR) decreased due to interactions between various processes involving the vascular, glomerular, tubular, and interstitial compartments of the kidney. Challenges: Renal complications are hardly identifiable in the early stages, as serum creatinine increases only in the final stages of SCN. Subnormal GFR and elevated serum creatinine levels develop only when there is significant proteinuria. Prevention and Treatment: The identification of biomarkers of early, non-invasive kidney injury, and their inclusion in clinical practice will contribute to the identification of the mechanisms involved in the development of renal syndromes, facilitating the development of more effective strategies in the prevention and treatment of SCD.
    MeSH term(s) Adolescent ; Anemia, Sickle Cell/complications ; Biomarkers ; Glomerular Filtration Rate ; Humans ; Kidney ; Kidney Diseases/etiology ; Renal Insufficiency, Chronic/complications
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-2782 ; 0302-5144
    ISSN (online) 1662-2782
    ISSN 0302-5144
    DOI 10.1159/000517703
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  6. Article ; Online: Comments on the clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile

    Romélia Pinheiro Gonçalves Lemes

    Revista Brasileira de Hematologia e Hemoterapia, Vol 36, Iss 2, Pp 100-

    2014  Volume 101

    Keywords Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2014-04-01T00:00:00Z
    Publisher Sociedade Brasileira de Hematologia e Hemoterapia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Hematological changes in Covid-19 infections.

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araujo / Duarte, Beatrice Araújo / Duarte, João Vitor Araujo

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 2, Page(s) 99

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Hematologic Diseases/diagnosis ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country Brazil
    Document type Letter
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.2.99
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 654: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online: Hematological changes in Covid-19 infections

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araujo / Duarte, Beatrice Araújo / Duarte, João Vitor Araujo

    Revista da Associação Médica Brasileira v.66 n.2 2020

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-02-01
    Publisher Associação Médica Brasileira
    Publishing country br
    Document type Book ; Online
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  9. Article: Hematological changes in Covid-19 infections

    Duarte, Fernando Barroso / Lemes, Romélia Pinheiro Gonçalves / Duarte, Isabella Araujo / Duarte, Beatrice Araújo / Duarte, João Vitor Araujo

    Rev Assoc Med Bras (1992)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32428139
    Database COVID19

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  10. Article ; Online: Histopathological evaluation of the bone marrow in refractory anemia with ring sideroblasts and thrombocytosis associated to the JAK2-V617F mutation

    Fernando Barroso Duarte / Francisco Dario Rocha Filho / Romelia Pinheiro Goncalves

    Revista Brasileira de Hematologia e Hemoterapia, Vol 36, Iss 1, Pp 69-

    2014  Volume 70

    Keywords Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Sociedade Brasileira de Hematologia e Hemoterapia
    Document type Article ; Online
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