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  1. Article ; Online: Comments on the clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile

    Romélia Pinheiro Gonçalves Lemes

    Revista Brasileira de Hematologia e Hemoterapia, Vol 36, Iss 2, Pp 100-

    2014  Volume 101

    Keywords Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2014-04-01T00:00:00Z
    Publisher Sociedade Brasileira de Hematologia e Hemoterapia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Renal changes in COVID-19 infection

    Pastora Maria de Araújo Duarte / Francisco André Gomes Bastos Filho / João Vitor Araujo Duarte / Beatrice Araújo Duarte / Isabella Araujo Duarte / Romélia Pinheiro Gonçalves Lemes / Fernando Barroso Duarte

    Revista da Associação Médica Brasileira, Vol 66, Iss 10, Pp 1335-

    2020  Volume 1337

    Abstract: SUMMARY The COVID-19 (SARS-CoV-2) infection started in China, Wuhan City, Hubei Province, in December 2019, and it was declared a pandemic in mid-March 2020, caused by a new coronavirus strain called SARS-CoV-2. The pathogenesis of kidney injury ... ...

    Abstract SUMMARY The COVID-19 (SARS-CoV-2) infection started in China, Wuhan City, Hubei Province, in December 2019, and it was declared a pandemic in mid-March 2020, caused by a new coronavirus strain called SARS-CoV-2. The pathogenesis of kidney injury attributed to SARS- CoV-2 is not well defined yet. Observations show that the kidney damage caused by the new virus mutation is mainly tubular, with impairment of glomerular filtration and high levels of urea and creatinine. A study with seriously ill patients with COVID-19 showed that acute kidney injury was present in 29%. In the face of this evidence, based on recent studies, we can see the great renal contribution as an impact factor in the evolution of COVID-19, not just as a complicator of severity, but maybe part of the initial cascade of the process, requiring a deeper analysis using conventional biomarkers of kidney injury and more aggressive clinical intervention in patients at risk, in an attempt to reduce mortality.
    Keywords Acute kidney injury ; Infections ; Coronavirus Infections/physiopathology ; Betacoronavirus ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Hemostasis profile in COVID-19 infection

    Fernando Barroso Duarte / Rosângela Pinheiro Gonçalves Machado / Romélia Pinheiro Gonçalves Lemes / Isabella Araújo Duarte / Beatrice Araújo Duarte / Clarissa Maria Gonçalves Machado / João Vitor Araújo Duarte / Samuel Gonçalves Machado da Rocha / Anna Thawanny Gadelha Moura / Rosangela de Albuquerque Ribeiro Rodrigues Holanda

    Revista da Associação Médica Brasileira, Vol 66, Iss 5, Pp 571-

    2020  Volume 572

    Keywords COVID-19 ; Coronavirus infections ; Hemostasis ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Immunohistochemistry contribution in the diagnosis of splenic marginal zone lymphoma

    Juliene Lima Mesquita / Yensy Mariana Zelaya Rosales / Yhasmine Delles Oliveira Garcia / Francisco Dario Rocha Filho / Beatriz Stela Gomes de Sousa Pitombeira Araujo / João Paulo de Vasconcelos Leitão / Jesus Irajacy Costa / Beatrice Araújo Duarte / João Vitor Araújo Duarte / Romélia Pinheiro Gonçalves Lemes / Fernando Barroso Duarte

    Revista da Associação Médica Brasileira, Vol 66, Iss 5, Pp 580-

    2020  Volume 582

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Influence of βS-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease

    J. A. Moreira / R. P. G. Machado / M. R. Laurentino / Romelia Pinheiro Gonçalves Lemes / M. C. Barbosa / T. E. Santos / I. C. J. Bandeira / A. M. C. Martins

    Disease Markers, Vol

    2016  Volume 2016

    Abstract: Introduction. Sickle cell disease (SCD) is characterized by hemoglobin S homozygosity, leading to hemolysis and vasoocclusion. The hemolysis releases arginase I, an enzyme that decreases the bioavailability of nitric oxide, worsening the symptoms. The ... ...

    Abstract Introduction. Sickle cell disease (SCD) is characterized by hemoglobin S homozygosity, leading to hemolysis and vasoocclusion. The hemolysis releases arginase I, an enzyme that decreases the bioavailability of nitric oxide, worsening the symptoms. The different SCD haplotypes are related to clinical symptoms and varied hemoglobin F (HbF) concentration. The aim of this study was to evaluate the impact of the βS gene haplotypes and HbF concentration on arginase I levels in SCD patients. Methods. Fifty SCD adult patients were enrolled in the study and 20 blood donors composed the control group. Arginase I was measured by ELISA. The βS haplotypes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Statistical analyses were performed with GraphPad Prism program and the significance level was p<0.05. Results. Significant increase was observed in the arginase I levels in SCD patients compared to the control group (p<0.0001). The comparison between the levels of arginase I in three haplotypes groups showed a difference between the Bantu/Bantu × Bantu/Benin groups; Bantu/Bantu × Benin/Benin, independent of HU dosage. An inverse correlation with the arginase I levels and HbF concentration was observed. Conclusion. The results support the hypothesis that arginase I is associated with HbF concentration, also measured indirectly by the association with haplotypes.
    Keywords Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Presence of new mutations in the TP53 gene in patients with low-risk myelodysplastic syndrome

    Fernando Barroso Duarte / Romélia Pinheiro Gonçalves Lemes / Talyta Ellen de Jesus dos Santos / Maritza Cavalcante Barbosa / João Paulo Leitão de Vasconcelos / Francisco Dário Rocha-Filho / Ilana Zalcberg / Diego Coutinho / Monalisa Feliciano Figueiredo / Luciana Barros Carlos / Paulo Roberto Leitão de Vasconcelos

    Journal of Medical Case Reports, Vol 11, Iss 1, Pp 1-

    two case reports

    2017  Volume 4

    Abstract: Abstract Background Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for ... ...

    Abstract Abstract Background Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present study, two mutations in this gene are presented and discussed with the clinical evolution of the patients. Case presentation The first case is a 77-year-old Brazilian woman diagnosed as having multiple lineage dysplasia myelodysplastic syndrome according to World Health Organization 2016 and classified as very low-risk by Revised International Prognostic Scoring. The second case is an 80-year-old Brazilian man also diagnosed as having multiple lineage dysplasia myelodysplastic syndrome and classified as low risk. The mutation described in the first case was already identified in some neoplasias and it is associated with a poor prognosis, but it had never been reported before in myelodysplastic syndrome. The second mutation has never been described. Conclusions This is a novel report for the scientific community and may be very helpful as we can better understand the disease and the impact of mutations through the follow-up of these patients and others in the future. Both patients are in a good clinical condition, suggesting that these mutations may not alter the clinical course of the disease or may be associated with a good prognosis, but their role in the disease must be investigated more deeply in a larger population.
    Keywords Myelodysplastic syndromes ; TP53 mutations ; Prognosis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2017-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Hematological changes in Covid-19 infections

    Fernando Barroso Duarte / Romélia Pinheiro Gonçalves Lemes / Isabella Araujo Duarte / Beatrice Araújo Duarte / João Vitor Araujo Duarte

    Revista da Associação Médica Brasileira, Vol 66, Iss 2, Pp 99-99

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Prolonged response to recombinant human erythropoietin treatment in patients with myelodysplastic syndrome at a single referral centre in Brazil

    Anna Thawanny Gadelha Moura / Fernando Barroso Duarte / Maritza Cavalcante Barbosa / Talyta Ellen de Jesus dos Santos / Romélia Pinheiro Gonçalves Lemes

    Clinics, Vol 74

    Abstract: OBJECTIVES: To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic syndrome (MDS) who were treated at a haematological referral centre in northeastern Brazil. ...

    Abstract OBJECTIVES: To evaluate the effects of epoetin (EPO) alfa treatment on overall survival, event-free survival and response duration in patients with myelodysplastic syndrome (MDS) who were treated at a haematological referral centre in northeastern Brazil. METHODS: This was a retrospective cohort study of 36 patients diagnosed with MDS and treated with EPO alfa at 30,000 to 60,000 IU per week. Clinical data were collected from medical records. The events assessed were non-response to treatment and progression to acute myeloid leukaemia (AML). Statistical analyses were performed using GraphPad Prism 7 and SPSS 24 software. RESULTS: The overall survival of patients who received EPO alfa treatment was 51.64%, with a median of 65 months of treatment, and the overall survival of this group was 100% during the first 24 months. We detected a 43.5-month median event-free survival, with a response rate of 80.5%. We observed responses from 25 to 175 months. Patients with transfusion dependence and those with a high-risk stratification, as determined by the International Prognostic Scoring System (IPSS), the Revised International Prognostic Scoring System (IPSS-R), the WHO classification-based Prognostic Scoring System (WPSS) and the WHO 2016, had a lower event-free survival than other patients. CONCLUSIONS: Despite the wide use of EPO alfa in the treatment of anaemia in patients with MDS, the median response duration is approximately only 24 months. Our data provide encouraging results concerning the benefits of using EPO alfa for the improvement of the quality of life, as patients treated with EPO showed higher overall survival, event-free survival rates and longer response durations than have been previously described in the literature.
    Keywords Myelodysplastic Syndrome ; Recombinant Human Erythropoietin ; Erythropoietin ; Epoetin Alfa ; EPO ; EPO Alfa ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Relevance of prognostic factors in the decision-making of stem cell transplantation in Myelodysplastic Syndromes

    Fernando Barroso Duarte / Talyta Ellen de Jesus dos Santos / Maritza Cavalcante Barbosa / Jacques Kaufman / João Paulo de Vasconcelos / Romélia Pinheiro Gonçalves Lemes / Francisco Dário Rocha / Diego Ferreira Coutinho / Ilana Zalcberg / Paulo Roberto Leitão de Vasconcelos

    Revista da Associação Médica Brasileira, Vol 62, Iss suppl 1, Pp 25-28

    Abstract: ABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of ... ...

    Abstract ABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS. The aim of this study is to discuss the factors that can guide the decision-making on referring or not a patient to HSCT. Three cases of MDS, two of which were submitted to HSCT are presented. We intend to report the difficulties in referring patients with MDS to transplant and the prognostic factors that contribute to define eligibility.
    Keywords Síndrome Mielodisplásica ; Transplante de Células-Tronco Hematopoéticas ; Prognóstico ; Medicine (General) ; R5-920
    Language English
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Interstitial nephritis associated with nivolumab in a patient with hodgkin lymphoma

    Deivide de Sousa Oliveira / Juliene Lima Mesquita / Yhasmine Delles Oliveira Garcia / Yensy Mariana Zelaya Rosales / Romélia Pinheiro Gonçalves Lemes / Francisco Dário Rocha Filho / Paula Frassinetti Castelo Branco Camurça Fernandes / Pastora Maria Araujo Duarte / Maria da Silva Pitombeira / Fernando Barroso Duarte

    Revista da Associação Médica Brasileira, Vol 65, Iss 7, Pp 934-936

    Keywords Nephritis ; Interstitial ; Hodgkin Disease ; Immunotherapy ; Medicine (General) ; R5-920
    Language English
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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