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Article ; Online: Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality.

Guillot, Nicolas / Roméo, Barnabé / Manesh, Shima Sepehri / Milano, Gerard / Brest, Patrick / Zitvogel, Laurence / Hofman, Paul / Mograbi, Baharia

Trends in molecular medicine

2023 Volume 29, Issue 11, Page(s) 897–911

Abstract: The past decade has witnessed a revolution in cancer treatment by shifting from conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies unleash the host immune system against the tumor and have achieved unprecedented durable ... ...

Abstract	The past decade has witnessed a revolution in cancer treatment by shifting from conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies unleash the host immune system against the tumor and have achieved unprecedented durable remission. However, 80% of patients do not respond. This review discusses how bacteria are unexpected drivers that reprogram tumor immunity. Manipulating the microbiota impacts on tumor development and reprograms the tumor microenvironment (TME) of mice on immunotherapy. We anticipate that harnessing commensals and the tumor microbiome holds promise to identify patients who will benefit from immunotherapy and guide the choice of new ICI combinations to advance treatment efficacy.
MeSH term(s)	Humans ; Animals ; Mice ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy ; Neoplasms/drug therapy ; Neoplasms/etiology ; Microbiota ; Tumor Microenvironment
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2023.08.004
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Article: KRAS and NRAS Translation Is Increased upon MEK Inhibitors-Induced Processing Bodies Dissolution.

Vidal-Cruchez, Olivia / Nicolini, Victoria J / Rete, Tifenn / Jacquet, Karine / Rezzonico, Roger / Lacoux, Caroline / Domdom, Marie-Angela / Roméo, Barnabé / Roux, Jérémie / Hubstenberger, Arnaud / Mari, Bernard / Mograbi, Baharia / Hofman, Paul / Brest, Patrick

Cancers

2023 Volume 15, Issue 12

Abstract: Overactivation of the mitogen-activated protein kinase (MAPK) pathway is a critical driver of many human cancers. However, therapies directly targeting this pathway lead to cancer drug resistance. Resistance has been linked to compensatory RAS ... ...

Abstract	Overactivation of the mitogen-activated protein kinase (MAPK) pathway is a critical driver of many human cancers. However, therapies directly targeting this pathway lead to cancer drug resistance. Resistance has been linked to compensatory RAS overexpression, but the mechanisms underlying this response remain unclear. Here, we find that MEK inhibitors (MEKi) are associated with an increased translation of the KRAS and NRAS oncogenes through a mechanism involving dissolution of processing body (P-body) biocondensates. This effect is seen across different cell types and is extremely dynamic since removal of MEKi and ERK reactivation result in reappearance of P-bodies and reduced RAS-dependent signaling. Moreover, we find that P-body scaffold protein levels negatively impact RAS expression. Overall, we describe a new feedback loop mechanism involving biocondensates such as P-bodies in the translational regulation of RAS proteins and MAPK signaling.
Language	English
Publishing date	2023-06-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15123078
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Article ; Online: Euclasta condylotricha flowers essential oils: A new source of juvenile hormones and its larvicidal activity against Anopheles gambiae s.s. (Diptera: Culicidae).

Bohounton, Roméo Barnabé / Djihinto, Oswald Yédjinnavênan / Dedome, Oronce Sedjro-Ludolphe / Yovo, Réné Mahudro / Djossou, Laurette / Koba, Koffi / Adomou, Aristide / Villeneuve, Pierre / Djogbénou, Luc Salako / Tchobo, Fidèle Paul

PloS one

2023 Volume 18, Issue 1, Page(s) e0278834

Abstract: The essential oil (EO) of plants of the Poaceae family has diverse chemical constituents with several biological properties. But, data on the chemical constituents and toxicity are still unavailable for some species belonging to this family, such as ... ...

Abstract	The essential oil (EO) of plants of the Poaceae family has diverse chemical constituents with several biological properties. But, data on the chemical constituents and toxicity are still unavailable for some species belonging to this family, such as Euclasta condylotricha Steud (Eu. condylotricha). In this study, the chemical composition of the EOs of Eu. condylotricha flowers was evaluated by gas chromatography coupled with mass spectrometry (GC-MS). The EOs larvicidal property was assessed against third instar larvae of three Anopheles gambiae laboratory strains (Kisumu, Acerkis and Kiskdr) according to the WHO standard protocol. The percentage yields of the EOs obtained from hydro distillation of Eu. condylotricha flowers varied 0.070 to 0.097%. Gas Chromatography-Mass Spectrometry (GC-MS) applied to the EOs revealed fifty-five (55) chemical constituents, representing 94.95% to 97.78% of the total essential oils. Although different chemical profiles of the dominant terpenes were observed for each sample, EOs were generally dominated by sesquiterpenoids with juvenile hormones as the major compounds. The primary compounds were juvenile hormone C16 (JH III) (35.97-48.72%), Methyl farnesoate 10,11-diol (18.56-28.73%), tau-Cadinol (18.54%), and β-Eudesmene (12.75-13.46%). Eu. condylotricha EOs showed a strong larvicidal activity with LC50 values ranging from 35.21 to 52.34 ppm after 24 hours of exposition. This study showed that Eu. Condylotricha flowers essential oils are potent sources of juvenile hormones that could be a promising tool for developing an eco-friendly malaria vector control strategy.
MeSH term(s)	Animals ; Oils, Volatile/chemistry ; Anopheles ; Juvenile Hormones ; Insecticides/chemistry ; Culex ; Mosquito Vectors ; Plant Leaves/chemistry ; Malaria ; Larva ; Flowers ; Aedes ; Poaceae
Chemical Substances	Oils, Volatile ; Juvenile Hormones ; Insecticides
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0278834
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Article ; Online: Assessment of Different Circulating Tumor Cell Platforms for Uveal Melanoma: Potential Impact for Future Routine Clinical Practice.

Martel, Arnaud / Mograbi, Baharia / Romeo, Barnabe / Gastaud, Lauris / Lalvee, Salome / Zahaf, Katia / Fayada, Julien / Nahon-Esteve, Sacha / Bonnetaud, Christelle / Salah, Myriam / Tanga, Virginie / Baillif, Stéphanie / Bertolotto, Corine / Lassalle, Sandra / Hofman, Paul

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Liquid biopsy and circulating tumor cell (CTC) screening has gained interest over the last two decades for detecting almost all solid malignancies. To date, the major limitation in terms of the applicability of CTC screening in daily clinical practice is ...

Abstract	Liquid biopsy and circulating tumor cell (CTC) screening has gained interest over the last two decades for detecting almost all solid malignancies. To date, the major limitation in terms of the applicability of CTC screening in daily clinical practice is the lack of reproducibility due to the high number of platforms available that use various technologies (e.g., label-dependent versus label-free detection). Only a few studies have compared different CTC platforms. The aim of this study was to compare the efficiency of four commercially available CTC platforms (Vortex (VTX-1), ClearCell FX, ISET, and Cellsearch) for the detection and identification of uveal melanoma cells (OMM 2.3 cell line). Tumor cells were seeded in RPMI medium and venous blood from healthy donors, and then processed similarly using these four platforms. Melan-A immunochemistry was performed to identify tumor cells, except when the Cellsearch device was used (automated identification). The mean overall recovery rates (with mean recovered cells) were 39.2% (19.92), 22.2% (11.31), 8.9% (4.85), and 1.1% (0.20) for the ISET, Vortex (VTX-1), ClearCell FX, and CellSearch platforms, respectively. Although paramount, the recovery rate is not sufficient to assess a CTC platform. Other parameters, such as the purpose for using a platform (diagnosis, genetics, drug sensitivity, or patient-derived xenograft models), reproducibility, purity, user-friendliness, cost-effectiveness, and ergonomics, should also be considered before they can be used in daily clinical practice and are discussed in this article.
MeSH term(s)	Humans ; Neoplastic Cells, Circulating/pathology ; Reproducibility of Results ; Melanoma/pathology ; Uveal Neoplasms/diagnosis ; Uveal Neoplasms/pathology ; Biomarkers, Tumor/metabolism
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241311075
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Article: Chemical composition and the insecticidal activity of Aeollanthus pubescens leaf essential oil against Anopheles gambiae sensu stricto

Bohounton, Roméo Barnabé / Djogbénou, Luc Salako / Djihinto, Oswald Yédjinnavênan / Dedome, Oronce Sedjro-Ludolphe / Sovegnon, Pierre Marie / Barea, Bruno / Adomou, Aristide / Villeneuve, Pierre / Tchobo, Fidèle Paul

Parasites & vectors. 2021 Dec., v. 14, no. 1

2021

Abstract: BACKGROUND: The excessive use of synthetic insecticides is responsible for many cases of resistance in insects. Therefore, the use of natural molecules of ecological interest with insecticidal properties is an alternative approach to the use of synthetic ...

Abstract	BACKGROUND: The excessive use of synthetic insecticides is responsible for many cases of resistance in insects. Therefore, the use of natural molecules of ecological interest with insecticidal properties is an alternative approach to the use of synthetic insecticides. The aim of this study is to investigating the larvicidal and adulticidal activity and the chemical composition of the essential oil of Aeollanthus pubescens on the major malaria vector, Anopheles gambiae. METHODS: Three reference strains of Anopheles gambiae sensu stricto (Kisumu, Kiskdr and Acerkis) were used in this study. The leaves of A. pubescens were collected in southern Benin. The standard World Health Organisation (WHO) guidelines for larvicide evaluation were used, and the chemical composition of the essential oil was analysed by gas chromatography coupled to mass spectrometry. Adult mosquitoes of each strain were exposed to pieces of net coated with the essential oil for 3 min using the WHO cone bioassay method. Probit regression analysis was used to determine the concentrations that would kill 50 and 95% of each test population (LC₅₀, LC₉₅) and the knockdown time for 50 and 95% of each test population (KDT₅₀, and KDT₉₅). The difference between the mortality–dose regressions for the different strains was analysed using the likelihood ratio test (LRT). The log-rank test was performed to evaluate the difference in survival between the strains. RESULTS: A total of 14 components were identified, accounting for 98.3% of total oil content. The major components were carvacrol (51.1%), thymyle acetate (14.0%) and ɣ-terpinene (10.6%). The essential oil showed larvicidal properties on the Kisumu, Acerkis and Kiskdr strains, with LC₅₀ of 29.6, 22.9 and 28.4 ppm, respectively. With pieces of netting treated at 165 µg/cm², the KDT₅₀ of both Acerkis (1.71 s; Z = 3.34, P < 0.001) and Kiskdr (2.67 s; Z = 3.49, P < 0.001) individuals were significantly lower than that of Kisumu (3.8 s). The lifespan of the three mosquito strains decreased to 1 day for Kisumu (χ² = 99, df = 1, P < 0.001), 2 days for Acerkis (χ² = 117, df = 1, P < 0.001) and 3 days for Kiskdr (χ² = 96.9, df = 1, P < 0.001). CONCLUSION: Our findings show that A. pubescens essential oil has larvicide and adulticide properties against the malaria vector An. gambiae sensu stricto, suggesting that this essential oil may be a potential candidate for the control of the resistant malaria-transmitting vectors.
Keywords	Aeollanthus ; Anopheles gambiae ; World Health Organization ; acetates ; adulticides ; adults ; bioassays ; carvacrol ; essential oils ; gas chromatography ; insecticidal properties ; larvicides ; leaves ; lipid content ; longevity ; mass spectrometry ; mosquito vectors ; regression analysis ; Benin
Language	English
Dates of publication	2021-12
Size	p. 518.
Publishing place	BioMed Central
Document type	Article
ZDB-ID	2409480-8
ISSN	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-021-05012-w
Database	NAL-Catalogue (AGRICOLA)

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Article: Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives.

Martel, Arnaud / Baillif, Stephanie / Nahon-Esteve, Sacha / Gastaud, Lauris / Bertolotto, Corine / Roméo, Barnabé / Mograbi, Baharia / Lassalle, Sandra / Hofman, Paul

Cancers

2020 Volume 12, Issue 11

Abstract: Tissue biopsy is considered the gold standard when establishing a diagnosis of cancer. However, tissue biopsies of intraocular ophthalmic malignancies are hard to collect and are thought to be associated with a non-negligible risk of extraocular ... ...

Abstract	Tissue biopsy is considered the gold standard when establishing a diagnosis of cancer. However, tissue biopsies of intraocular ophthalmic malignancies are hard to collect and are thought to be associated with a non-negligible risk of extraocular dissemination. Recently, the liquid biopsy (LB) has emerged as a viable, non-invasive, repeatable, and promising way of obtaining a diagnosis, prognosis, and theragnosis of patients with solid tumors. LB refers to blood, as well as any human liquid. The natural history of uveal melanoma (UM) and retinoblastoma (RB) are radically opposed. On the one hand, UM is known to disseminate through the bloodstream, and is, therefore, more accessible to systemic venous liquid biopsy. On the other hand, RB rarely disseminates hematogenous, and is, therefore, more accessible to local liquid biopsy by performing an anterior chamber puncture. In this review, we summarize the current knowledge concerning LB in UM, RB, conjunctival tumors, and choroidal metastases. We also develop the current limitations encountered, as well as the perspectives.
Language	English
Publishing date	2020-11-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12113284
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Article ; Online: A multifactorial score including autophagy for prognosis and care of COVID-19 patients.

Domdom, Marie-Angela / Brest, Patrick / Grosjean, Iris / Roméo, Barnabé / Landi, Maria Teresa / Gal, Jocelyn / Klionsky, Daniel J / Hofman, Paul / Mograbi, Baharia

Autophagy

2020 Volume 16, Issue 12, Page(s) 2276–2281

Abstract: In less than eleven months, the world was brought to a halt by the COVID-19 outbreak. With hospitals becoming overwhelmed, one of the highest priorities concerned critical care triage to ration the scarce resources of intensive care units. Which patient ... ...

Abstract	In less than eleven months, the world was brought to a halt by the COVID-19 outbreak. With hospitals becoming overwhelmed, one of the highest priorities concerned critical care triage to ration the scarce resources of intensive care units. Which patient should be treated first? Based on what clinical and biological criteria? A global joint effort rapidly led to sequencing the genomes of tens of thousands of COVID-19 patients to determine the patients' genetic signature that causes them to be at risk of suddenly developing severe disease. In this commentary, we would like to consider some points concerning the use of a multifactorial risk score for COVID-19 severity. This score includes macroautophagy (hereafter referred to as autophagy), a critical host process that controls all steps harnessed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus.
MeSH term(s)	Animals ; Autophagy/genetics ; Autophagy/physiology ; Autophagy-Related Proteins/analysis ; Autophagy-Related Proteins/genetics ; Biomarkers/analysis ; Biomarkers/metabolism ; COVID-19/diagnosis ; COVID-19/genetics ; COVID-19/pathology ; COVID-19/therapy ; Genetic Predisposition to Disease ; Humans ; Infectious bronchitis virus/physiology ; Mice ; Middle East Respiratory Syndrome Coronavirus/physiology ; Molecular Diagnostic Techniques/methods ; Prognosis ; Research Design ; Risk Factors ; SARS-CoV-2/physiology ; Severity of Illness Index ; Transcriptome/physiology
Chemical Substances	Autophagy-Related Proteins ; Biomarkers
Language	English
Publishing date	2020-11-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2020.1844433
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Article ; Online: Chemical composition and the insecticidal activity of Aeollanthus pubescens leaf essential oil against Anopheles gambiae sensu stricto.

Parasites & vectors

2021 Volume 14, Issue 1, Page(s) 518

Abstract: Background: The excessive use of synthetic insecticides is responsible for many cases of resistance in insects. Therefore, the use of natural molecules of ecological interest with insecticidal properties is an alternative approach to the use of ... ...

Abstract	Background: The excessive use of synthetic insecticides is responsible for many cases of resistance in insects. Therefore, the use of natural molecules of ecological interest with insecticidal properties is an alternative approach to the use of synthetic insecticides. The aim of this study is to investigating the larvicidal and adulticidal activity and the chemical composition of the essential oil of Aeollanthus pubescens on the major malaria vector, Anopheles gambiae. Methods: Three reference strains of Anopheles gambiae sensu stricto (Kisumu, Kiskdr and Acerkis) were used in this study. The leaves of A. pubescens were collected in southern Benin. The standard World Health Organisation (WHO) guidelines for larvicide evaluation were used, and the chemical composition of the essential oil was analysed by gas chromatography coupled to mass spectrometry. Adult mosquitoes of each strain were exposed to pieces of net coated with the essential oil for 3 min using the WHO cone bioassay method. Probit regression analysis was used to determine the concentrations that would kill 50 and 95% of each test population (LC Results: A total of 14 components were identified, accounting for 98.3% of total oil content. The major components were carvacrol (51.1%), thymyle acetate (14.0%) and ɣ-terpinene (10.6%). The essential oil showed larvicidal properties on the Kisumu, Acerkis and Kiskdr strains, with LC Conclusion: Our findings show that A. pubescens essential oil has larvicide and adulticide properties against the malaria vector An. gambiae sensu stricto, suggesting that this essential oil may be a potential candidate for the control of the resistant malaria-transmitting vectors.
MeSH term(s)	Animals ; Anopheles/classification ; Anopheles/drug effects ; Biological Assay ; Female ; Gas Chromatography-Mass Spectrometry ; Insecticides/pharmacology ; Lamiaceae/chemistry ; Lamiaceae/classification ; Larva/drug effects ; Mosquito Control/methods ; Mosquito Vectors/drug effects ; Oils, Volatile/analysis ; Oils, Volatile/chemistry ; Oils, Volatile/pharmacology ; Plant Leaves/chemistry
Chemical Substances	Insecticides ; Oils, Volatile
Language	English
Publishing date	2021-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-021-05012-w
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Article ; Online: Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases.

Grosjean, Iris / Roméo, Barnabé / Domdom, Marie-Angela / Belaid, Amine / D'Andréa, Grégoire / Guillot, Nicolas / Gherardi, Romain K / Gal, Jocelyn / Milano, Gérard / Marquette, Charles Hugo / Hung, Rayjean J / Landi, Maria Teresa / Han, Younghun / Brest, Patrick / Von Bergen, Martin / Klionsky, Daniel J / Amos, Christopher I / Hofman, Paul / Mograbi, Baharia

Autophagy

2022 Volume 18, Issue 11, Page(s) 2519–2536

Abstract: At a time when complex diseases affect globally 280 million people and claim 14 million lives every year, there is an urgent need to rapidly increase our knowledge into their underlying etiologies. Though critical in identifying the people at risk, the ... ...

Abstract	At a time when complex diseases affect globally 280 million people and claim 14 million lives every year, there is an urgent need to rapidly increase our knowledge into their underlying etiologies. Though critical in identifying the people at risk, the causal environmental factors (microbiome and/or pollutants) and the affected pathophysiological mechanisms are not well understood. Herein, we consider the variations of autophagy-related (
MeSH term(s)	Humans ; Autophagy/genetics ; Precision Medicine ; Genome-Wide Association Study ; Carcinoma, Hepatocellular ; Carcinoma, Non-Small-Cell Lung ; Amyotrophic Lateral Sclerosis ; Frontotemporal Dementia ; Liver Neoplasms ; Lung Neoplasms ; Squamous Cell Carcinoma of Head and Neck ; Head and Neck Neoplasms ; Polymorphism, Genetic
Language	English
Publishing date	2022-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2022.2039994
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Article ; Online: Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition.

Zangari, Joséphine / Ilie, Marius / Rouaud, Florian / Signetti, Laurie / Ohanna, Mickaël / Didier, Robin / Roméo, Barnabé / Goldoni, Dana / Nottet, Nicolas / Staedel, Cathy / Gal, Jocelyn / Mari, Bernard / Mograbi, Baharia / Hofman, Paul / Brest, Patrick

Nucleic acids research

2018 Volume 46, Issue 7, Page(s) 3813–3814

Language	English
Publishing date	2018-03-21
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gky213
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