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  1. Book ; Online: Differentiation and Mechanisms of Activation of Innate Lymphoid Cells

    Cella, Marina / Romagnani, Chiara

    2019  

    Keywords Medicine ; Immunology ; innate lymphoid cells ; ILCs ; ILC development ; ILC function ; ILC plasticity
    Size 1 electronic resource (129 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230500
    ISBN 9782889459759 ; 2889459756
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: In Memoriam of Professor Alessandro Moretta

    Vivier, Eric / Olive, Daniel / Romagnani, Chiara

    2020  

    Keywords Medicine ; Immunology ; natural kill cell ; transplanation ; immune deficiency ; infection - immunology ; cancer biology
    Size 1 electronic resource (91 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230213
    ISBN 9782889637041 ; 2889637042
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: The Second Life of Natural Killer (NK) Cells

    Colonna, Marco / Sun, Joseph C. / Romagnani, Chiara

    2018  

    Abstract: Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of "Innate lymphoid cells" (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability ... ...

    Abstract Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of "Innate lymphoid cells" (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability which mainly react in response to microbial and cell stress stimuli, thus playing a central role in the defense against pathogen infection, in tumor surveillance and in regulating immune homeostasis. Despite these established concepts, our understanding of the complexity of NK cells, also in view of their developmental and functional relationship with other ILC subsets, is only recently emerging. This Research Topic highlights the recent advances in NK cell (and ILC) research in human and mouse from basic research to clinical applications
    Keywords Medicine (General) ; Immunologic diseases. Allergy
    Size 1 electronic resource (118 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101860
    ISBN 9782889455461 ; 2889455467
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Extrinsic and intrinsic drivers of natural killer cell clonality.

    Rückert, Timo / Romagnani, Chiara

    Immunological reviews

    2024  

    Abstract: Clonal expansion of antigen-specific lymphocytes is the fundamental mechanism enabling potent adaptive immune responses and the generation of immune memory. Accompanied by pronounced epigenetic remodeling, the massive proliferation of individual cells ... ...

    Abstract Clonal expansion of antigen-specific lymphocytes is the fundamental mechanism enabling potent adaptive immune responses and the generation of immune memory. Accompanied by pronounced epigenetic remodeling, the massive proliferation of individual cells generates a critical mass of effectors for the control of acute infections, as well as a pool of memory cells protecting against future pathogen encounters. Classically associated with the adaptive immune system, recent work has demonstrated that innate immune memory to human cytomegalovirus (CMV) infection is stably maintained as large clonal expansions of natural killer (NK) cells, raising questions on the mechanisms for clonal selection and expansion in the absence of re-arranged antigen receptors. Here, we discuss clonal NK cell memory in the context of the mechanisms underlying clonal competition of adaptive lymphocytes and propose alternative selection mechanisms that might decide on the clonal success of their innate counterparts. We propose that the integration of external cues with cell-intrinsic sources of heterogeneity, such as variegated receptor expression, transcriptional states, and somatic variants, compose a bottleneck for clonal selection, contributing to the large size of memory NK cell clones.
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Communication and transparency at EJI: Supporting authors through their publishing experience.

    Romagnani, Chiara / Bakocevic, Nadja

    European journal of immunology

    2023  Volume 53, Issue 7, Page(s) e2370074

    MeSH term(s) Publishing ; Communication
    Language English
    Publishing date 2023-06-07
    Publishing country Germany
    Document type Editorial
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202370074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: To kill or not to kill - The role of the tumor microenvironment in shaping group 1 ILC functions.

    Müller, Nils Christian / Romagnani, Chiara

    Seminars in immunology

    2022  Volume 61-64, Page(s) 101670

    Abstract: Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this ... ...

    Abstract Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this review, we will outline the commonalities and differences between group 1 ILC subsets in both mice and humans, discuss how the tissue and tumor microenvironment shapes their phenotype and functions, as well as describe their contrasting roles in the response to different cancers.
    Language English
    Publishing date 2022-11-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2022.101670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2843: Show issues Location:
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  7. Article ; Online: Rolle von angeborenen Rezeptoren bei chronischen Entzündungen und Autoimmunität.

    Babic, Marina / Romagnani, Chiara

    Zeitschrift fur Rheumatologie

    2022  Volume 81, Issue 8, Page(s) 628–634

    Abstract: Elucidating the basis of chronic disease courses and the development of appropriate treatment methods for inflammatory diseases still represent a big challenge for medical science, as the mechanisms driving aberrant immune reactions are mostly still ... ...

    Title translation Role of innate receptors in chronic inflammation and autoimmunity.
    Abstract Elucidating the basis of chronic disease courses and the development of appropriate treatment methods for inflammatory diseases still represent a big challenge for medical science, as the mechanisms driving aberrant immune reactions are mostly still unknown. Of particular interest is the identification of checkpoints that regulate the function and differentiation of proinflammatory cells during the pathogenesis, along with methods for modulation of specific checkpoints as a treatment approach. Innate receptors, such as members of the natural killer group 2 family (NKG2X), natural cytotoxicity receptors (NCR) or Toll-like receptors (TLRs), play an important role in modulating the immune response. NKG2 member D (NKG2D) is a potent activating receptor of the immune system, known as a sentinel for cellular danger signals presented by cells exposed to endoplasmic reticulum (ER) stress, cell death or an inflammatory cytokine milieu. NKG2A/C bind the non-classical HLA class I molecule, sense changes in ligand expression associated with malignant transformation and cellular stress and their main function is to send inhibitory or activating signals to NK cells and subsets of T cells. In this review, we present our latest knowledge on the understanding of the role of innate receptors in the context of chronic inflammation and autoimmunity with special emphasis on danger sensor receptors NKG2D and NKG2A/C.
    MeSH term(s) Autoimmunity ; Carrier Proteins ; Cytokines/metabolism ; Humans ; Inflammation ; Ligands ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Toll-Like Receptors
    Chemical Substances Carrier Proteins ; Cytokines ; Ligands ; NK Cell Lectin-Like Receptor Subfamily K ; Toll-Like Receptors
    Language German
    Publishing date 2022-04-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-022-01185-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: How regulatory T cells are primed to aid tolerance of gut bacteria.

    Travis, Mark A / Romagnani, Chiara

    Nature

    2022  Volume 610, Issue 7933, Page(s) 638–640

    MeSH term(s) T-Lymphocytes, Regulatory ; Immune Tolerance ; Bacteria
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-03368-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 244: Show issues

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  9. Article ; Online: A natural killer's hike through epigenetic landscapes.

    Rückert, Timo / Romagnani, Chiara

    Science immunology

    2021  Volume 6, Issue 57

    Abstract: The transcription factor BCL11B guides NK cells along their differentiation trajectory (see the related Research Article by ... ...

    Abstract The transcription factor BCL11B guides NK cells along their differentiation trajectory (see the related Research Article by Holmes
    MeSH term(s) Cell Differentiation ; Epigenesis, Genetic ; Killer Cells, Natural
    Language English
    Publishing date 2021-03-06
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abf8019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial: Lineage tracing, hematopoietic stem cell and immune cell dynamics.

    Lareau, Caleb A / Romagnani, Chiara / Ludwig, Leif S

    Frontiers in immunology

    2022  Volume 13, Page(s) 1062415

    MeSH term(s) Hematopoietic Stem Cells ; Cell Lineage
    Language English
    Publishing date 2022-10-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1062415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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