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Article ; Online: Aortic Dissection Risk in Marfan Syndrome.

Roman, Mary J / Devereux, Richard B

Journal of the American College of Cardiology

2020 Volume 75, Issue 8, Page(s) 854–856

MeSH term(s)	Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/epidemiology ; Aneurysm, Dissecting/etiology ; DNA Mutational Analysis ; Fibrillin-1/genetics ; Genetic Variation ; Humans ; Marfan Syndrome/complications ; Marfan Syndrome/diagnosis
Chemical Substances	FBN1 protein, human ; Fibrillin-1
Language	English
Publishing date	2020-03-13
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2019.12.042
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Bicuspid Aortic Valve in Marfan Syndrome.

Braverman, Alan C / Roman, Mary J

Circulation. Cardiovascular imaging

2019 Volume 12, Issue 3, Page(s) e008860

MeSH term(s)	Aorta ; Aortic Valve/abnormalities ; Bicuspid Aortic Valve Disease ; Heart Valve Diseases ; Humans ; Marfan Syndrome
Language	English
Publishing date	2019-03-03
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2435045-X
ISSN	1942-0080 ; 1941-9651
ISSN (online)	1942-0080
ISSN	1941-9651
DOI	10.1161/CIRCIMAGING.119.008860
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Zs.A 6743: Show issues

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Article ; Online: Hereditary thoracic aortic disease: How to save lives.

Roman, Mary J / De Backer, Julie

The Journal of thoracic and cardiovascular surgery

2021 Volume 163, Issue 1, Page(s) 39–45

MeSH term(s)	Aorta, Thoracic/abnormalities ; Aorta, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/etiology ; Aortic Aneurysm, Thoracic/therapy ; Aortic Diseases/congenital ; Aortic Diseases/diagnosis ; Aortic Diseases/genetics ; Aortic Diseases/surgery ; Early Diagnosis ; Genetic Testing/methods ; Humans ; Mass Screening/methods ; Medical History Taking/methods ; Preventive Health Services/methods ; Preventive Health Services/organization & administration ; Time-to-Treatment
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Editorial
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2021.01.075
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Article ; Online: Risk of Type B Dissection in Marfan Syndrome: The Cornell Aortic Aneurysm Registry.

Narula, Nupoor / Devereux, Richard B / Arbustini, Eloisa / Ma, Xiaoyue / Weinsaft, Jonathan W / Girardi, Leonard / Malonga, Grace P / Roman, Mary J

Journal of the American College of Cardiology

2023

Abstract: Background: With preventive aortic grafting decreasing the incidence of type A dissections in Marfan syndrome (MFS), most dissections are now type B, for which risk factors remain largely uncertain.: Objectives: We explored the determinants of type B ...

Abstract	Background: With preventive aortic grafting decreasing the incidence of type A dissections in Marfan syndrome (MFS), most dissections are now type B, for which risk factors remain largely uncertain. Objectives: We explored the determinants of type B dissection risk in a large, single-center MFS registry. Methods: Demographic and anthropometric features, cardiovascular disease, and surgical history were compared in patients with MFS with and without type B dissection. Results: Of 336 patients with MFS, 47 (14%) experienced a type B dissection (vs type A in 9%). Patients with type B dissection were more likely to have undergone elective aortic root replacement (ARR) (79 vs 46%; P < 0.001). Of the patients, 55% had type B dissection a mean of 13.3 years after ARR, whereas 45% experienced type B dissection before or in the absence of ARR; 41 patients (87%) were aware of their MFS diagnosis before type B dissection. Among those with predissection imaging, the descending aorta was normal or minimally dilated (<4.0 cm) in 88%. In multivariable analyses, patients with type B dissection were more likely to have undergone ARR and independent mitral valve surgery, to have had a type II dissection, and to have lived longer. Conclusions: In our contemporary cohort, type B dissections are more common than type A dissections and occur at traditional nonsurgical thresholds. The associations of type B dissection with ARR, independent mitral valve surgery, and type II dissection suggest a more severe phenotype in the setting of prolonged life expectancy.
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2023.08.055
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Association of central and peripheral pulse pressure with intermediate cardiovascular phenotypes.

Roman, Mary J

Journal of hypertension

2012 Volume 30, Issue 4, Page(s) 834–5; author reply 835

MeSH term(s)	Blood Pressure ; Female ; Heart Rate ; Humans ; Hypertension/physiopathology ; Male
Language	English
Publishing date	2012-04
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0b013e328350e569
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 614: Show issues

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Article ; Online: Dyslipidemia in American Indian Adolescents and Young Adults: Strong Heart Family Study.

Reese, Jessica A / Roman, Mary J / Deen, Jason F / Ali, Tauqeer / Cole, Shelley A / Devereux, Richard B / Fretts, Amanda M / Howard, Wm James / Lee, Elisa T / Malloy, Kimberly / Umans, Jason G / Zhang, Ying

Journal of the American Heart Association

2024 Volume 13, Issue 6, Page(s) e031741

Abstract: Background: Although many studies on the association between dyslipidemia and cardiovascular disease (CVD) exist in older adults, data on the association among adolescents and young adults living with disproportionate burden of cardiometabolic disorders ...

Abstract	Background: Although many studies on the association between dyslipidemia and cardiovascular disease (CVD) exist in older adults, data on the association among adolescents and young adults living with disproportionate burden of cardiometabolic disorders are scarce. Methods and results: The SHFS (Strong Heart Family Study) is a multicenter, family-based, prospective cohort study of CVD in an American Indian populations, including 12 communities in central Arizona, southwestern Oklahoma, and the Dakotas. We evaluated SHFS participants, who were 15 to 39 years old at the baseline examination in 2001 to 2003 (n=1440). Lipids were measured after a 12-hour fast. We used carotid ultrasounds to detect plaque at baseline and follow-up in 2006 to 2009 (median follow-up=5.5 years). We identified incident CVD events through 2020 with a median follow-up of 18.5 years. We used shared frailty proportional hazards models to assess the association between dyslipidemia and subclinical or clinical CVD, while controlling for covariates. Baseline dyslipidemia prevalence was 55.2%, 73.6%, and 78.0% for participants 15 to 19, 20 to 29, and 30 to 39 years old, respectively. Approximately 2.8% had low-density lipoprotein cholesterol ≥160 mg/dL, which is higher than the recommended threshold for lifestyle or medical interventions in young adults of 20 to 39 years old. During follow-up, 9.9% had incident plaque (109/1104 plaque-free participants with baseline and follow-up ultrasounds), 11.0% had plaque progression (128/1165 with both baseline and follow-up ultrasounds), and 9% had incident CVD (127/1416 CVD-free participants at baseline). Plaque incidence and progression were higher in participants with total cholesterol ≥200 mg/dL, low-density lipoprotein cholesterol ≥160 mg/dL, or non-high-density lipoprotein cholesterol ≥130 mg/dL, while controlling for covariates. CVD risk was independently associated with low-density lipoprotein cholesterol ≥160 mg/dL. Conclusions: Dyslipidemia is a modifiable risk factor that is associated with both subclinical and clinical CVD, even among the younger American Indian population who have unexpectedly high rates of significant CVD events. Therefore, this population is likely to benefit from a variety of evidence-based interventions including screening, educational, lifestyle, and guideline-directed medical therapy at an early age.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Aged ; Adult ; American Indian or Alaska Native ; Prospective Studies ; Risk Factors ; Dyslipidemias/drug therapy ; Cardiovascular Diseases/etiology ; Plaque, Atherosclerotic/complications ; Cholesterol ; Lipoproteins, LDL
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Lipoproteins, LDL
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.031741
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Article ; Online: A wide QRS complex tachycardia: What is the mechanism?

Patel, Rohan K / Roman, Mary J / Lerman, Bruce B / Cheung, Jim W

Heart rhythm

2020 Volume 17, Issue 5 Pt A, Page(s) 831–832

MeSH term(s)	Electrocardiography ; Heart Conduction System/physiopathology ; Heart Rate/physiology ; Humans ; Male ; Tachycardia, Atrioventricular Nodal Reentry/physiopathology ; Young Adult
Language	English
Publishing date	2020-04-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2019.12.014
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Zs.A 6278: Show issues

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Article ; Online: Pregnancy-Related Aortic Complications in Women With Marfan Syndrome.

Narula, Nupoor / Devereux, Richard B / Malonga, Grace P / Hriljac, Ingrid / Roman, Mary J

Journal of the American College of Cardiology

2021 Volume 78, Issue 9, Page(s) 870–879

Abstract: Background: The risk of pregnancy-associated vascular complications in Marfan syndrome (MFS) is uncertain because of ascertainment bias, prepartum lack of knowledge of diagnosis, and insufficient peripartum imaging data. Furthermore, U.S. and European ... ...

Abstract	Background: The risk of pregnancy-associated vascular complications in Marfan syndrome (MFS) is uncertain because of ascertainment bias, prepartum lack of knowledge of diagnosis, and insufficient peripartum imaging data. Furthermore, U.S. and European guidelines differ in pregnancy recommendations in MFS. Objectives: This study describes a single-center experience of 169 MFS women to address these gaps. Methods: Clinical, imaging, and pregnancy history were compared in never vs ever-pregnant MFS women, and pregnancy-associated vascular complications were described. Results: A total of 74 ever-pregnant women had 112 live births. Elective aortic root replacement occurred at a younger age in never-pregnant women (33 years vs 42 years; P = 0.0026). Although aortic dissection prevalence did not differ between never-pregnant vs ever-pregnant women (23% vs 31%; P = 0.25), it tended to occur at an earlier age in the former group (38 years vs 45 years; P = 0.07). Of observed "sanctioned" pregnancies with prepartum diameters ≤4.5 cm, mean pregnancy-related aortic diameters remained stable. In total, 5 dissections were associated with pregnancy: 2 type A in women unaware of their diagnosis; and 2 type B and 1 isolated coronary artery dissection in women aware of their diagnosis. Dissection rates were 5-fold higher in the pregnancy vs nonpregnancy period. Conclusions: Pregnancy-related type A dissection only occurred in patients unaware of their diagnosis. Type B dissection remains an unpredictable complication. Although there were baseline differences between the never- and ever-pregnant groups, no difference in dissection risk was observed outside the peripartum period. Those with prepartum aortic diameters between 4.0 and 4.5 cm demonstrated stable aortic dimensions throughout pregnancy. These findings provide a rationale to update existing U.S. guidelines for the management of pregnancy in MFS.
MeSH term(s)	Adult ; Aneurysm, Dissecting/diagnosis ; Aneurysm, Dissecting/etiology ; Aneurysm, Dissecting/prevention & control ; Aorta/diagnostic imaging ; Aorta/pathology ; Aortic Diseases/complications ; Aortic Diseases/diagnosis ; Aortic Diseases/etiology ; Coronary Vessel Anomalies/diagnosis ; Coronary Vessel Anomalies/etiology ; Coronary Vessel Anomalies/prevention & control ; Female ; Humans ; Marfan Syndrome/complications ; Marfan Syndrome/diagnosis ; Organ Size ; Pregnancy ; Pregnancy Complications, Cardiovascular/diagnosis ; Pregnancy Complications, Cardiovascular/etiology ; Prognosis ; Reproductive History ; Risk Assessment ; Vascular Diseases/congenital ; Vascular Diseases/diagnosis ; Vascular Diseases/etiology ; Vascular Diseases/prevention & control
Language	English
Publishing date	2021-08-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2021.06.034
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Article ; Online: Niacin compared with ezetimibe.

Roman, Mary J

The New England journal of medicine

2010 Volume 362, Issue 11, Page(s) 1047–8; author reply 1048

MeSH term(s)	Anticholesteremic Agents/therapeutic use ; Azetidines/therapeutic use ; Carotid Arteries/anatomy & histology ; Carotid Arteries/drug effects ; Coronary Disease/drug therapy ; Drug Therapy, Combination ; Ezetimibe ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Niacin/therapeutic use ; Tunica Intima/drug effects ; Tunica Media/drug effects
Chemical Substances	Anticholesteremic Agents ; Azetidines ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Niacin (2679MF687A) ; Ezetimibe (EOR26LQQ24)
Language	English
Publishing date	2010-03-18
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
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Article ; Online: Wideband External Pulse Recorded During Cuff Blood Pressure Measurement: A New Technique for Cardiovascular Assessment.

Blank, Seymour G / James, Gary D / Roman, Mary J

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

2018 Volume 25, Issue 3, Page(s) 317–326

Abstract: Introduction: The wideband external pulse (WEP) recorded during blood pressure measurement reveals three components (K1, K2, K3). K1 is recorded with cuff pressure (CP) above systolic (SP).: Aim: To assess whether the K1 pattern contains information ... ...

Abstract	Introduction: The wideband external pulse (WEP) recorded during blood pressure measurement reveals three components (K1, K2, K3). K1 is recorded with cuff pressure (CP) above systolic (SP). Aim: To assess whether the K1 pattern contains information about the functional and structural properties of the cardiovascular system. Methods: WEP analysis, echocardiography, carotid artery (CA) ultrasonography and applanation tonometry were conducted on 178 hypertensives. K1R, a feature of K1, was defined to provide a measure between the arterial incident and backward reflective waves. Results: K1R was strongly correlated to vascular functional and structural parameters compatible with vascular effects of aging and hypertension. ANOVA analysis (K1R < 0 vs K1R > 0) showed that K1R < 0 participants: (1) were older, shorter, weighed less, had a smaller body surface area; (2) had higher SP, pulse (PP) and mean (MP) pressure, lower heart rate (HR), greater total peripheral resistance (TPR), lower cardiac output (CO), and a stiffer arterial system; (3) had a greater left ventricular (LV) relative wall thickness (LVRWT), carotid artery (CA) relative wall thickness (CARWT), CA far-wall intima-media thickness at end diastole (CIMTd) and CA cross-sectional area (CSA) (all p < 0.001). Regressions revealed that age, TPR, SP, gender, and HR predicted K1R (R Conclusions: K1R is related to vascular functional properties, with suggestive evidence that K1R is also related to vascular structural properties and perhaps subsequent cardiovascular risk.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Arterial Pressure ; Blood Pressure Determination/instrumentation ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/physiopathology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Echocardiography ; Equipment Design ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/physiopathology ; Male ; Manometry ; Middle Aged ; Predictive Value of Tests ; Pulse Wave Analysis/instrumentation ; Risk Assessment ; Risk Factors ; Sphygmomanometers
Language	English
Publishing date	2018-07-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	1236337-6
ISSN	1179-1985 ; 1120-9879
ISSN (online)	1179-1985
ISSN	1120-9879
DOI	10.1007/s40292-018-0273-0
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