Article ; Online: Von Willebrand factor and the thrombophilia of severe COVID-19:
Research and practice in thrombosis and haemostasis
2023 Volume 7, Issue 4, Page(s) 100182
Abstract: Background: COVID-19 is accompanied by a hypercoagulable state and characterized by microvascular and macrovascular thrombotic complications. In plasma samples from patients with COVID-19, von Willebrand factor (VWF) levels are highly elevated and ... ...
| Abstract | Background: COVID-19 is accompanied by a hypercoagulable state and characterized by microvascular and macrovascular thrombotic complications. In plasma samples from patients with COVID-19, von Willebrand factor (VWF) levels are highly elevated and predictive of adverse outcomes, especially mortality. Yet, VWF is usually not included in routine coagulation analyses, and histologic evidence of its involvement in thrombus formation is lacking. Objectives: To determine whether VWF, an acute-phase protein, is a bystander, ie, a biomarker of endothelial dysfunction, or a causal factor in the pathogenesis of COVID-19. Methods: We compared autopsy samples from 28 patients with lethal COVID-19 to those from matched controls and systematically assessed for VWF and platelets by immunohistochemistry. The control group comprised 24 lungs, 23 lymph nodes, and 9 hearts and did not differ significantly from the COVID-19 group in age, sex, body mass index (BMI), blood group, or anticoagulant use. Results: In lungs, assessed for platelets by immunohistochemistry for CD42b, microthrombi were more frequent in patients with COVID-19 (10/28 [36%] vs 2/24 [8%]; Conclusion: We provide |
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| Language | English |
| Publishing date | 2023-05-18 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2475-0379 |
| ISSN (online) | 2475-0379 |
| DOI | 10.1016/j.rpth.2023.100182 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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