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  1. AU="Romano, Raffaella"
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  1. Artikel: The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational study

    Tumminia, Andrea / Romano, Raffaella / Brugaletta, Giuseppe / Scicali, Roberto / Biondi, Giuseppina / Oliveri, Rosario / Romano, Marcello / San Lio, Paola Magnano

    The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2022 Apr. 04,

    2022  

    Abstract: Remdesivir (GS-5734), an inhibitor of the viral RNA-dependent, RNA polymerase was early identified as a promising therapeutic candidate against COVID-19. Our aim was to evaluate the impact of several metabolic parameters on Remdesivir effectiveness among ...

    Abstract Remdesivir (GS-5734), an inhibitor of the viral RNA-dependent, RNA polymerase was early identified as a promising therapeutic candidate against COVID-19. Our aim was to evaluate the impact of several metabolic parameters on Remdesivir effectiveness among hospitalized COVID-19 patients. We conducted an observational study on patients with SARS-CoV-2-related pneumonia admitted between May 2020 and September 2021 to the COVID-19 Units of Internal Medicine, Pneumology and Intensive Care of Garibaldi Hospital, Catania, Italy, and treated with Remdesivir. The “Ordinal Scale For Clinical Improvement” was used to assess patients’ clinical improvement within 28 days of hospitalization. Short-term mortality rate was also evaluated. A total of 142 patients with SARS-CoV-2-related pneumonia were studied. The prevalence of obesity (20.7% vs. 41.9%, p = 0.03), the average BMI (27.1 ± 4.4 vs. 31.1 ± 6.1, p < 0.01) and the mean LDL-C levels (78 ± 19 mg/dl vs. 103 ± 18 mg/dl, p = 0.03) were significantly lower in early-improved (EI) compared to not-improved (NI) individuals. Obesity was negatively associated to clinical improvement after Remdesivir (OR 0.48, 95%CI 0.17–0.97, p = 0.04). Both obesity (OR 2.82, 95% CI 1.05–7.71, p = 0.04) and dyslipidemia (OR 2.78, 95%CI 1.17–7.16, p = 0.03) were significantly related to patients’ mortality. Dyslipidemic subjects experienced a slower clinical improvement than non-dyslipidemic ones (Long-Rank p = 0.04). Our study showed that unfavorable metabolic conditions such as obesity and dyslipidemia could predict a worse clinical response to Remdesivir as well as the mortality in hospitalized COVID-19 patients. Further prospective and larger-scale studies are needed to confirm these preliminary findings.
    Schlagwörter COVID-19 infection ; DNA-directed RNA polymerase ; hospitals ; hyperlipidemia ; medicine ; metabolism ; mortality ; nutrition ; obesity ; observational studies ; pneumonia ; therapeutics ; Italy
    Sprache Englisch
    Erscheinungsverlauf 2022-0404
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 1067704-5
    ISSN 0939-4753
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2022.04.005
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational study.

    Tumminia, Andrea / Romano, Raffaella / Brugaletta, Giuseppe / Scicali, Roberto / Biondi, Giuseppina / Oliveri, Rosario / Romano, Marcello / San Lio, Paola Magnano

    Nutrition, metabolism, and cardiovascular diseases : NMCD

    2022  Band 32, Heft 7, Seite(n) 1635–1641

    Abstract: Background and aims: Remdesivir (GS-5734), an inhibitor of the viral RNA-dependent, RNA polymerase was early identified as a promising therapeutic candidate against COVID-19. Our aim was to evaluate the impact of several metabolic parameters on ... ...

    Abstract Background and aims: Remdesivir (GS-5734), an inhibitor of the viral RNA-dependent, RNA polymerase was early identified as a promising therapeutic candidate against COVID-19. Our aim was to evaluate the impact of several metabolic parameters on Remdesivir effectiveness among hospitalized COVID-19 patients.
    Methods and results: We conducted an observational study on patients with SARS-CoV-2-related pneumonia admitted between May 2020 and September 2021 to the COVID-19 Units of Internal Medicine, Pneumology and Intensive Care of Garibaldi Hospital, Catania, Italy, and treated with Remdesivir. The "Ordinal Scale For Clinical Improvement" was used to assess patients' clinical improvement within 28 days of hospitalization. Short-term mortality rate was also evaluated. A total of 142 patients with SARS-CoV-2-related pneumonia were studied. The prevalence of obesity (20.7% vs. 41.9%, p = 0.03), the average BMI (27.1 ± 4.4 vs. 31.1 ± 6.1, p < 0.01) and the mean LDL-C levels (78 ± 19 mg/dl vs. 103 ± 18 mg/dl, p = 0.03) were significantly lower in early-improved (EI) compared to not-improved (NI) individuals. Obesity was negatively associated to clinical improvement after Remdesivir (OR 0.48, 95%CI 0.17-0.97, p = 0.04). Both obesity (OR 2.82, 95% CI 1.05-7.71, p = 0.04) and dyslipidemia (OR 2.78, 95%CI 1.17-7.16, p = 0.03) were significantly related to patients' mortality. Dyslipidemic subjects experienced a slower clinical improvement than non-dyslipidemic ones (Long-Rank p = 0.04).
    Conclusion: Our study showed that unfavorable metabolic conditions such as obesity and dyslipidemia could predict a worse clinical response to Remdesivir as well as the mortality in hospitalized COVID-19 patients. Further prospective and larger-scale studies are needed to confirm these preliminary findings.
    Mesh-Begriff(e) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; Antiviral Agents/adverse effects ; COVID-19/drug therapy ; Dyslipidemias/diagnosis ; Dyslipidemias/drug therapy ; Dyslipidemias/epidemiology ; Humans ; Obesity/diagnosis ; Obesity/drug therapy ; SARS-CoV-2
    Chemische Substanzen Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Sprache Englisch
    Erscheinungsdatum 2022-04-10
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 1067704-5
    ISSN 1590-3729 ; 0939-4753
    ISSN (online) 1590-3729
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2022.04.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Neurocognitive assessment in adult-onset primary cranial cervical dystonia - response to the letter.

    Romano, Raffaella / Defazio, Giovanni

    Parkinsonism & related disorders

    2014  Band 20, Heft 8, Seite(n) 941

    Mesh-Begriff(e) Cognition Disorders/etiology ; Female ; Humans ; Male ; Torticollis/congenital
    Sprache Englisch
    Erscheinungsdatum 2014-08
    Erscheinungsland England
    Dokumenttyp Comment ; Letter
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2014.04.014
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  4. Artikel ; Online: Heritability of amygdala reactivity to angry faces and its replicable association with the schizophrenia risk locus of

    Quarto, Tiziana / Lella, Annalisa / Di Carlo, Pasquale / Rampino, Antonio / Paladini, Vittoria / Papalino, Marco / Romano, Raffaella / Fazio, Leonardo / Marvulli, Daniela / Popolizio, Teresa / Blasi, Giuseppe / Pergola, Giulio / Bertolino, Alessandro

    Journal of psychiatry & neuroscience : JPN

    2023  Band 48, Heft 5, Seite(n) E357–E366

    Abstract: Background: Among healthy participants, the interindividual variability of brain response to facial emotions is associated with genetic variation, including common risk variants for schizophrenia, a heritable brain disorder characterized by anomalies in ...

    Abstract Background: Among healthy participants, the interindividual variability of brain response to facial emotions is associated with genetic variation, including common risk variants for schizophrenia, a heritable brain disorder characterized by anomalies in emotion processing. We aimed to identify genetic variants associated with heritable brain activity during processing of facial emotions among healthy participants and to explore the impact of these identified variants among patients with schizophrenia.
    Methods: We conducted a data-driven stepwise study including samples of healthy twins, unrelated healthy participants and patients with schizophrenia. Participants approached or avoided pictures of faces with negative emotional valence during functional magnetic resonance imaging (fMRI).
    Results: We investigated 3 samples of healthy participants - including 28 healthy twin pairs, 289 unrelated healthy participants (genome-wide association study [GWAS] discovery sample) and 90 unrelated healthy participants (replication sample) - and 1 sample of 48 patients with schizophrenia. Among healthy twins, we identified the amygdala as the brain region with the highest heritability during processing of angry faces (heritability estimate 0.54,
    Limitations: The limited sample size available for GWAS analyses may require further replication of results.
    Conclusion: Our data-driven approach shows preliminary evidence that amygdala activity, as evaluated with our task, is heritable. Our genetic associations preliminarily suggest a role for
    Mesh-Begriff(e) Humans ; Amygdala/diagnostic imaging ; Anger ; Genome-Wide Association Study ; MicroRNAs ; Schizophrenia/diagnostic imaging ; Schizophrenia/genetics ; Case-Control Studies
    Chemische Substanzen MicroRNAs ; MIRN137 microRNA, human
    Sprache Englisch
    Erscheinungsdatum 2023-09-26
    Erscheinungsland Canada
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Twin Study
    ZDB-ID 1077443-9
    ISSN 1488-2434 ; 1180-4882
    ISSN (online) 1488-2434
    ISSN 1180-4882
    DOI 10.1503/jpn.230013
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  5. Artikel: Can circulating PD-1, PD-L1, BTN3A1, pan-BTN3As, BTN2A1 and BTLA levels enhance prognostic power of CA125 in patients with advanced high-grade serous ovarian cancer?

    Fanale, Daniele / Corsini, Lidia Rita / Brando, Chiara / Cutaia, Sofia / Di Donna, Mariano Catello / Filorizzo, Clarissa / Lisanti, Maria Chiara / Randazzo, Ugo / Magrin, Luigi / Romano, Raffaella / Bazan Russo, Tancredi Didier / Olive, Daniel / Vieni, Salvatore / Pantuso, Gianni / Chiantera, Vito / Russo, Antonio / Bazan, Viviana / Iovanna, Juan Lucio

    Frontiers in oncology

    2022  Band 12, Seite(n) 946319

    Abstract: The most common subtype of ovarian cancer (OC) is the high-grade serous ovarian carcinoma (HGSOC), accounting for 70%-80% of all OC deaths. Although HGSOC is a potentially immunogenic tumor, clinical studies assessing the effectiveness of inhibitors of ... ...

    Abstract The most common subtype of ovarian cancer (OC) is the high-grade serous ovarian carcinoma (HGSOC), accounting for 70%-80% of all OC deaths. Although HGSOC is a potentially immunogenic tumor, clinical studies assessing the effectiveness of inhibitors of programmed death protein and its ligand (PD-1/PD-L1) in OC patients so far showed only response rates <15%. However, recent studies revealed an interesting prognostic role of plasma PD-1/PD-L1 and other circulating immunoregulatory molecules, such as the B- and T-lymphocyte attenuator (BTLA), butyrophilin sub-family 3A/CD277 receptors (BTN3A), and butyrophilin sub-family 2 member A1 (BTN2A1), in several solid tumors. Since evidence showed the prognostic relevance of pretreatment serum CA125 levels in OC, the aim of our study was to investigate if soluble forms of inhibitory immune checkpoints can enhance prognostic power of CA125 in advanced HGSOC women. Using specific ELISA tests, we examined the circulating PD-1, PD-L1, pan-BTN3As, BTN3A1, BTN2A1, and BTLA levels in 100 advanced HGSOC patients before treatment, correlating them with baseline serum CA125, age at diagnosis, body mass index (BMI), and peritoneal carcinomatosis. A multivariate analysis revealed that plasma BTN3A1 ≤4.75 ng/ml (HR, 1.94; 95% CI, 1.23-3.07; p=0.004), age at diagnosis ≤60 years (HR, 1.65; 95% CI, 1.05-2.59; p=0.03) and absence of peritoneal carcinomatosis (HR, 2.65; 95% CI, 1.66-4.22; p<0.0001) were independent prognostic factors for a longer progression-free survival (PFS) (≥30 months) in advanced HGSOC women. However, further two-factor multivariate analyses highlighted that baseline serum CA125 levels >401 U/ml and each soluble protein above respective concentration cutoff were covariates associated with shorter PFS (<30 months) and unfavorable clinical outcome, suggesting that contemporary measurement of both biomarkers than CA125 only could strengthen prognostic power of serum CA125 in predicting PFS of advanced HGSOC women. Plasma PD-L1, PD-1, BTN3A1, pan-sBTN3As, BTN2A1, or BTLA levels could be helpful biomarkers to increase prognostic value of CA125.
    Sprache Englisch
    Erscheinungsdatum 2022-09-21
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.946319
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  6. Artikel ; Online: Low plasma PD-L1 levels, early tumor onset and absence of peritoneal carcinomatosis improve prognosis of women with advanced high-grade serous ovarian cancer.

    Fanale, Daniele / Brando, Chiara / Corsini, Lidia Rita / Cutaia, Sofia / Di Donna, Mariano Catello / Randazzo, Ugo / Filorizzo, Clarissa / Lisanti, Chiara / Magrin, Luigi / Gurrera, Vittorio / Romano, Raffaella / Dimino, Alessandra / Bazan Russo, Tancredi Didier / Olive, Daniel / Vieni, Salvatore / Pantuso, Gianni / Giordano, Antonio / Chiantera, Vito / Russo, Antonio /
    Bazan, Viviana / Iovanna, Juan Lucio

    BMC cancer

    2023  Band 23, Heft 1, Seite(n) 437

    Abstract: Background: The most common subtype of ovarian cancer (OC) showing immunogenic potential is represented by the high-grade serous ovarian cancer (HGSOC), which is characterized by the presence of tumor-infiltrating immune cells able to modulate immune ... ...

    Abstract Background: The most common subtype of ovarian cancer (OC) showing immunogenic potential is represented by the high-grade serous ovarian cancer (HGSOC), which is characterized by the presence of tumor-infiltrating immune cells able to modulate immune response. Because several studies showed a close correlation between OC patient's clinical outcome and expression of programmed cell death protein-1 or its ligand (PD-1/PD-L1), the aim of our study was to investigate if plasma levels of immunomodulatory proteins may predict prognosis of advanced HGSOC women.
    Patients and methods: Through specific ELISA tests, we analyzed plasma concentrations of PD-L1, PD-1, butyrophilin sub-family 3A/CD277 receptor (BTN3A1), pan-BTN3As, butyrophilin sub-family 2 member A1 (BTN2A1), and B- and T-lymphocyte attenuator (BTLA) in one hundred patients affected by advanced HGSOC, before surgery and therapy. The Kaplan-Meier method was used to generate the survival curves, while univariate and multivariate analysis were performed using Cox proportional hazard regression models.
    Results: For each analyzed circulating biomarker, advanced HGSOC women were discriminated based on long (≥ 30 months) versus short progression-free survival (PFS < 30 months). The concentration cut-offs, obtained by receiver operating characteristic (ROC) analysis, allowed to observe that poor clinical outcome and median PFS ranging between 6 and 16 months were associated with higher baseline levels of PD-L1 (> 0.42 ng/mL), PD-1 (> 2.48 ng/mL), BTN3A1 (> 4.75 ng/mL), pan-BTN3As (> 13.06 ng/mL), BTN2A1 (> 5.59 ng/mL) and BTLA (> 2.78 ng/mL). Furthermore, a lower median PFS was associated with peritoneal carcinomatosis, age at diagnosis > 60 years or Body Mass Index (BMI) > 25. A multivariate analysis also suggested that plasma concentrations of PD-L1 ≤ 0.42 ng/mL (HR: 2.23; 95% CI: 1.34 to 3.73; p = 0.002), age at diagnosis ≤ 60 years (HR: 1.70; 95% CI: 1.07 to 2.70; p = 0.024) and absence of peritoneal carcinomatosis (HR: 1.87; 95% CI: 1.23 to 2.85; p = 0.003) were significant prognostic marker for a longer PFS in advanced HGSOC patients.
    Conclusions: The identification of high-risk HGSOC women could be improved through determination of the plasma PD-L1, PD-1, BTN3A1, pan-BTN3As, BTN2A1 and BTLA levels.
    Mesh-Begriff(e) Humans ; Female ; Middle Aged ; Programmed Cell Death 1 Receptor/therapeutic use ; Peritoneal Neoplasms ; B7-H1 Antigen/metabolism ; Prognosis ; Ovarian Neoplasms/metabolism ; Butyrophilins ; Antigens, CD
    Chemische Substanzen Programmed Cell Death 1 Receptor ; B7-H1 Antigen ; BTN3A1 protein, human ; Butyrophilins ; Antigens, CD
    Sprache Englisch
    Erscheinungsdatum 2023-05-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-023-10911-5
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  7. Artikel ; Online: The Relationships Between Ataxia and Cognition in Spinocerebellar Ataxia Type 2.

    Gigante, Angelo Fabio / Lelli, Giuseppina / Romano, Raffaella / Pellicciari, Roberta / Di Candia, Andrea / Mancino, Paola Vincenza / Pau, Massimiliano / Fiore, Pietro / Defazio, Giovanni

    Cerebellum (London, England)

    2019  Band 19, Heft 1, Seite(n) 40–47

    Abstract: The clinical spectrum of spinocerebellar ataxia type 2 includes motor manifestations and cognitive disturbances in executive functions, memory, and visuoconstructive skills. The relationships between severity of motor disturbances and altered cognition ... ...

    Abstract The clinical spectrum of spinocerebellar ataxia type 2 includes motor manifestations and cognitive disturbances in executive functions, memory, and visuoconstructive skills. The relationships between severity of motor disturbances and altered cognition are poorly known. In this study, we assessed patients with spinocerebellar ataxia type 2 and age- and sex-matched healthy control subjects by a test battery including the Mini-mental State Examination, the Wisconsin Card Sorting test, and the Wechsler Memory Scale-Revised. The correlation between severity of motor ataxia (as assessed by a validated and widely used severity scale, the SARA scale, and by an objective automated computerized system of gait analysis) and altered cognition was then evaluated by Spearman correlation analysis. Patients performed worse than healthy controls in almost all administered neuropsychological tests. Nevertheless, only global intellectual abilities and executive functions significantly correlated with the overall severity of ataxia as assessed by the SARA scale, and impaired executive functions alone correlated with performance on several spatio-temporal gait analysis parameters. Our findings would probably suggest a prominent influence of executive functions on motor abilities in patients with spinocerebellar ataxia type 2 and raise the possibility that cognitive pharmaceutical or rehabilitative interventions may be of benefit in the management of motor problems in these patients.
    Mesh-Begriff(e) Adult ; Aged ; Case-Control Studies ; Cognition/physiology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/psychology ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Spinocerebellar Ataxias/diagnosis ; Spinocerebellar Ataxias/epidemiology ; Spinocerebellar Ataxias/psychology
    Sprache Englisch
    Erscheinungsdatum 2019-10-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2112586-7
    ISSN 1473-4230 ; 1473-4222
    ISSN (online) 1473-4230
    ISSN 1473-4222
    DOI 10.1007/s12311-019-01079-5
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  8. Artikel ; Online: A miR-137-Related Biological Pathway of Risk for Schizophrenia Is Associated With Human Brain Emotion Processing.

    Pergola, Giulio / Rampino, Antonio / Sportelli, Leonardo / Borcuk, Christopher James / Passiatore, Roberta / Di Carlo, Pasquale / Marakhovskaia, Aleksandra / Fazio, Leonardo / Amoroso, Nicola / Castro, Mariana Nair / Domenici, Enrico / Gennarelli, Massimo / Khlghatyan, Jivan / Kikidis, Gianluca Christos / Lella, Annalisa / Magri, Chiara / Monaco, Alfonso / Papalino, Marco / Parihar, Madhur /
    Popolizio, Teresa / Quarto, Tiziana / Romano, Raffaella / Torretta, Silvia / Valsecchi, Paolo / Zunuer, Hailiqiguli / Blasi, Giuseppe / Dukart, Juergen / Beaulieu, Jean Martin / Bertolino, Alessandro

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2023  Band 9, Heft 3, Seite(n) 356–366

    Abstract: Background: miR-137 is a microRNA involved in brain development, regulating neurogenesis and neuronal maturation. Genome-wide association studies have implicated miR-137 in schizophrenia risk but do not explain its involvement in brain function and ... ...

    Abstract Background: miR-137 is a microRNA involved in brain development, regulating neurogenesis and neuronal maturation. Genome-wide association studies have implicated miR-137 in schizophrenia risk but do not explain its involvement in brain function and underlying biology. Polygenic risk for schizophrenia mediated by miR-137 targets is associated with working memory, although other evidence points to emotion processing. We characterized the functional brain correlates of miR-137 target genes associated with schizophrenia while disentangling previously reported associations of miR-137 targets with working memory and emotion processing.
    Methods: Using RNA sequencing data from postmortem prefrontal cortex (N = 522), we identified a coexpression gene set enriched for miR-137 targets and schizophrenia risk genes. We validated the relationship of this set to miR-137 in vitro by manipulating miR-137 expression in neuroblastoma cells. We translated this gene set into polygenic scores of coexpression prediction and associated them with functional magnetic resonance imaging activation in healthy volunteers (n
    Results: In 4652 human participants, we found that 1) schizophrenia risk genes were coexpressed in a biologically validated set enriched for miR-137 targets; 2) increased expression of miR-137 target risk genes was mediated by low prefrontal miR-137 expression; 3) alleles that predict greater gene set coexpression were associated with greater prefrontal activation during emotion processing in 3 independent healthy cohorts (n
    Conclusions: The functional translation of miR-137 target gene expression linked with schizophrenia involves the neural substrates of emotion processing.
    Mesh-Begriff(e) Humans ; Schizophrenia ; Genome-Wide Association Study ; Brain ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Emotions
    Chemische Substanzen MicroRNAs ; MIRN137 microRNA, human
    Sprache Englisch
    Erscheinungsdatum 2023-11-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2023.11.001
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  9. Artikel ; Online: Impaired cognitive functions in adult-onset primary cranial cervical dystonia.

    Romano, Raffaella / Bertolino, Alessandro / Gigante, Angelo / Martino, Davide / Livrea, Paolo / Defazio, Giovanni

    Parkinsonism & related disorders

    2014  Band 20, Heft 2, Seite(n) 162–165

    Abstract: Background: Adult-onset primary dystonia is thought to be a purely motor disorder. Nevertheless, several studies provided evidence that sensory and psychiatric disturbances may contribute to the clinical spectrum of of dystonia, whereas evidence ... ...

    Abstract Background: Adult-onset primary dystonia is thought to be a purely motor disorder. Nevertheless, several studies provided evidence that sensory and psychiatric disturbances may contribute to the clinical spectrum of of dystonia, whereas evidence supporting cognitive impairment is still limited.
    Methods: A set of neuropsychological tests was administered to non depressed, non demented patients with cranial-cervical dystonia and healthy control subjects. The test battery included n-Back Task, Wechsler Memory Scale, Trail Making Test version A and B, and Wisconsin Card Sorting Test.
    Results: As compared with healthy control subjects of similar age, sex and socio-economic status, patients with cranial-cervical dystonia showed deficit on working memory functions revealed by n-Back task, impairment of mental control and visual reproduction subtests of Wechsler memory scale, deficit on information processing speed and set-shifting capacity revealed by Trail Making Test A and B.
    Conclusion: Patients with cranial-cervical dystonia may have impairment in specific cognitive domains relative to working memory, processing speed, visual motor ability and short term memory. Probably, these deficits are not dependent on the clinical expression of dystonia but might rather reflect the cortical and subcortical changes highlighted by functional and VBM imaging studies in patients with different forms of dystonia.
    Mesh-Begriff(e) Adult ; Cognition Disorders/etiology ; Dystonia/congenital ; Dystonic Disorders/complications ; Dystonic Disorders/psychology ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Torticollis/complications ; Torticollis/congenital ; Torticollis/psychology
    Sprache Englisch
    Erscheinungsdatum 2014-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2013.10.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: The interaction between cannabis use and a CB1-related polygenic co-expression index modulates dorsolateral prefrontal activity during working memory processing.

    Taurisano, Paolo / Pergola, Giulio / Monda, Anna / Antonucci, Linda A / Di Carlo, Pasquale / Piarulli, Francesco / Passiatore, Roberta / Papalino, Marco / Romano, Raffaella / Monaco, Alfonso / Rampino, Antonio / Bonvino, Aurora / Porcelli, Annamaria / Popolizio, Teresa / Bellotti, Roberto / Bertolino, Alessandro / Blasi, Giuseppe

    Brain imaging and behavior

    2020  Band 15, Heft 1, Seite(n) 288–299

    Abstract: Convergent findings indicate that cannabis use and variation in the cannabinoid CB1 receptor coding gene (CNR1) modulate prefrontal function during working memory (WM). Other results also suggest that cannabis modifies the physiological relationship ... ...

    Abstract Convergent findings indicate that cannabis use and variation in the cannabinoid CB1 receptor coding gene (CNR1) modulate prefrontal function during working memory (WM). Other results also suggest that cannabis modifies the physiological relationship between genetically induced expression of CNR1 and prefrontal WM processing. However, it is possible that cannabis exerts its modifying effect on prefrontal physiology by interacting with complex molecular ensembles co-regulated with CB1. Since co-regulated genes are likely co-expressed, we investigated how genetically predicted co-expression of a molecular network including CNR1 interacts with cannabis use in modulating WM processing in humans. Using post-mortem human prefrontal data, we first computed a polygenic score (CNR1-PCI), combining the effects of single nucleotide polymorphisms (SNPs) on co-expression of a cohesive gene set including CNR1, and positively correlated with such co-expression. Then, in an in vivo study, we computed CNR1-PCI in 88 cannabis users and 147 non-users and investigated its interaction with cannabis use on brain activity during WM. Results revealed an interaction between cannabis use and CNR1-PCI in the dorsolateral prefrontal cortex (DLPFC), with a positive relationship between CNR1-PCI and DLPFC activity in cannabis users and a negative relationship in non-users. Furthermore, DLPFC activity in cannabis users was positively correlated with the frequency of cannabis use. Taken together, our results suggest that co-expression of a CNR1-related network predicts WM-related prefrontal activation as a function of cannabis use. Furthermore, they offer novel insights into the biological mechanisms associated with the use of cannabis.
    Mesh-Begriff(e) Cannabis ; Humans ; Magnetic Resonance Imaging ; Memory, Short-Term ; Multifactorial Inheritance ; Percutaneous Coronary Intervention ; Prefrontal Cortex
    Sprache Englisch
    Erscheinungsdatum 2020-03-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2377165-3
    ISSN 1931-7565 ; 1931-7557
    ISSN (online) 1931-7565
    ISSN 1931-7557
    DOI 10.1007/s11682-020-00256-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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