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Article ; Online: Assessment of Esophageal Shifts during Catheter Ablation of Atrial Fibrillation Using Intracardiac Ultrasound Integrated with 3-Dimensional Electroanatomical Mapping System.

Pernat, Andrej / Zavrtanik, Mark / Robles, Antonio Gianluca / Romano, Silvio / Sciarra, Luigi / Antolič, Bor

Journal of cardiovascular development and disease

2024 Volume 11, Issue 4

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2024-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd11040110
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sport in ischemic heart disease: Focus on primary and secondary prevention.

Romano, Silvio / Minardi, Simona / Patrizi, Giampiero / Palamà, Zefferino / Sciahbasi, Alessandro

Clinical cardiology

2023 Volume 46, Issue 9, Page(s) 1021–1027

Abstract: Ischemic heart disease (IHD) is one of the leading causes of death and morbidity in the world. The role of primary prevention is particularly relevant since IHD can be for a long time asymptomatic until the occurrence of a condition that could lead to ... ...

Abstract	Ischemic heart disease (IHD) is one of the leading causes of death and morbidity in the world. The role of primary prevention is particularly relevant since IHD can be for a long time asymptomatic until the occurrence of a condition that could lead to plaque instabilization or increased oxygen demand. Secondary prevention is also essential to improve patients' prognosis and quality of life. The aim of this review is to provide a detailed and updated description of the role of sport and physical activity both in primary prevention and secondary prevention. In primary prevention, sport and physical activity are effective through the control of the main cardiovascular risk factors, such as hypertension and dyslipidemia. In secondary prevention, sport and physical activity can lead to a reduction in subsequent coronary events. Every effort must be made to encourage the performance of physical and sports activity both in asymptomatic subjects at risk and those with a history of IHD.
MeSH term(s)	Humans ; Secondary Prevention ; Quality of Life ; Myocardial Ischemia/prevention & control ; Myocardial Ischemia/epidemiology ; Sports ; Exercise ; Risk Factors ; Primary Prevention
Language	English
Publishing date	2023-05-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.24052
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Article ; Online: Vaccination and variants: Retrospective model for the evolution of Covid-19 in Italy.

Fierro, Annalisa / Romano, Silvio / Liccardo, Antonella

PloS one

2022 Volume 17, Issue 7, Page(s) e0265159

Abstract: The last year of Covid-19 pandemic has been characterized by the continuous chase between the vaccination campaign and the appearance of new variants that puts further obstacles to the possibility of eradicating the virus and returning to normality in a ... ...

Abstract	The last year of Covid-19 pandemic has been characterized by the continuous chase between the vaccination campaign and the appearance of new variants that puts further obstacles to the possibility of eradicating the virus and returning to normality in a short period. In the present paper we develop a deterministic compartmental model to describe the evolution of the Covid-19 in Italy as a combined effect of vaccination campaign, new variant spreading and mobility restrictions. Particular attention is given to the mechanism of waning immunity, appropriately timed with respect to the effective progress of the vaccination campaign in Italy. We perform a retrospective analysis in order to explore the role that different mechanisms, such as behavioral changes, variation of the population mobility, seasonal variability of the virus infectivity, and spreading of new variants have had in shaping the epidemiological curve. We find that, in the large time window considered, the most relevant mechanism is the seasonal variation in the stability of the virus, followed by the awareness mechanism, that induces individuals to increase/relax self-protective measures when the number of active cases increases/decreases. The appearance of the Delta variant and the mobility variations have had instead only marginal effects. In absence of vaccines the emerging scenario would have been dramatic with a percentage difference in the number of total infections and total deaths, in both cases, larger than fifty per cent. The model also predicts the appearance of a more contagious variant (the Omicron variant) and its becoming dominant in January 2022.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Humans ; Pandemics/prevention & control ; Retrospective Studies ; SARS-CoV-2 ; Vaccination
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0265159
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Article ; Online: Coronary artery fistula: an innocent bystander or harmful company?

Romano, Silvio / Petroni, Renata

Kardiologia polska

2019 Volume 77, Issue 11, Page(s) 1009–1010

MeSH term(s)	Coronary Angiography ; Coronary Artery Disease ; Coronary Vessel Anomalies ; Fistula ; Humans
Language	English
Publishing date	2019-11-22
Publishing country	Poland
Document type	Editorial ; Comment
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.15068
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Article ; Online: Cardiovascular risk and biopsychosocial interplay: Association among hypertension, anxiety, and emotional dysregulation-observational study in primary care setting for efficient self-care.

Di Giacomo, Dina / Ranieri, Jessica / Guerra, Federica / Cilli, Eleonora / Sciarra, Luigi / Romano, Silvio

Clinical cardiology

2023 Volume 47, Issue 1, Page(s) e24152

Abstract: Background: Aim of the study was to explore the relationship between emotional dimensions of hypertensive patients and the self-care skills; we tried to draw the psychological aspects could impact the health management in hypertension analyzing the ... ...

Abstract	Background: Aim of the study was to explore the relationship between emotional dimensions of hypertensive patients and the self-care skills; we tried to draw the psychological aspects could impact the health management in hypertension analyzing the effect of emotional regulation on self-care skills: our scope was to highlight the psychological dynamics into behavioral medicine approach. Methods: In an observational study design, patients were collected. Patients with diagnosis of hypertension were recruited in primary care setting. Inclusion criteria included patients older than 18 years, with known and medically treated primary hypertension undergoing antihypertensive medication. Results: Statistical analysis was carried out based on the data of 28 primary hypertensive patients (seven females, 21 males, mean age ± SD: 49.8 ± 7.8 years mean; clinic blood pressure: mean systolic blood pressure: 137.2 ± 13.1 mmHg, mean diastolic blood pressure: 82.1 ± 9.9 mmHg). Mean duration of hypertension in the sample was 13.1 years (±8.2 years). Correlations among the main variables of interest showed a positive and significant relationship between emotional dysregulation indexes, psychological distress, and self-care domains: awareness resulted negatively and significantly correlated to self-efficacy; nonacceptance, goals and impulse indexes seemed positively and significantly correlated to anxiety and depression; finally, stress was correlated positively and significantly to awareness and impulse. Conclusions: Evidencing the role of emotion dysregulation on self-care skills and psychological outcomes, and specifically highlighting the impact of emotion dysregulation on self-care, our findings could inform the development and implementation of psychological interventions aimed at promoting psychological well-being and healthy behavior by focusing on the promotion of emotion regulation strategies, to reduce the risk for co-morbidity and/or severe cardiovascular diseases.
MeSH term(s)	Male ; Female ; Humans ; Cardiovascular Diseases ; Self Care ; Risk Factors ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/therapy ; Anxiety/diagnosis ; Anxiety/epidemiology ; Anxiety/psychology ; Blood Pressure/physiology ; Heart Disease Risk Factors ; Primary Health Care
Language	English
Publishing date	2023-09-28
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.24152
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Article ; Online: Non-Pharmacological Treatment of Heart Failure-From Physical Activity to Electrical Therapies: A Literature Review.

Scarà, Antonio / Palamà, Zefferino / Robles, Antonio Gianluca / Dei, Lorenzo-Lupo / Borrelli, Alessio / Zanin, Federico / Pignalosa, Leonardo / Romano, Silvio / Sciarra, Luigi

Journal of cardiovascular development and disease

2024 Volume 11, Issue 4

Abstract: Heart failure (HF) represents a significant global health challenge that is still responsible for increasing morbidity and mortality despite advancements in pharmacological treatments. This review investigates the effectiveness of non-pharmacological ... ...

Abstract	Heart failure (HF) represents a significant global health challenge that is still responsible for increasing morbidity and mortality despite advancements in pharmacological treatments. This review investigates the effectiveness of non-pharmacological interventions in the management of HF, examining lifestyle measures, physical activity, and the role of some electrical therapies such as catheter ablation, cardiac resynchronization therapy (CRT), and cardiac contractility modulation (CCM). Structured exercise training is a cornerstone in this field, demonstrating terrific improvements in functional status, quality of life, and mortality risk reduction, particularly in patients with HF with reduced ejection fraction (HFrEF). Catheter ablation for atrial fibrillation, premature ventricular beats, and ventricular tachycardia aids in improving left ventricular function by reducing arrhythmic burden. CRT remains a key intervention for selected HF patients, helping achieve left ventricular reverse remodeling and improving symptoms. Additionally, the emerging therapy of CCM provides a novel opportunity for patients who do not meet CRT criteria or are non-responders. Integrating non-pharmacological interventions such as digital health alongside specific medications is key for optimizing outcomes in HF management. It is imperative to tailor approaches to individual patients in this diverse patient population to maximize benefits. Further research is warranted to improve treatment strategies and enhance patient outcomes in HF management.
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd11040122
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Article ; Online: Vaccination and Variants: retrospective model for the evolution of Covid-19 in Italy

Fierro, Annalisa / Romano, Silvio / Liccardo, Antonella

medRxiv

Abstract: The last year of Covid-19 pandemic has been characterized by the continuous chase between the vaccination campaign and the appearance of new variants that put further obstacles to the possibility of eradicating the virus and returning to normality in a ... ...

Abstract	The last year of Covid-19 pandemic has been characterized by the continuous chase between the vaccination campaign and the appearance of new variants that put further obstacles to the possibility of eradicating the virus and returning to normality in a short period. In the present paper we consider a deterministic compartmental model to discuss the evolution of the Covid-19 in Italy as a combined effect of vaccination campaign, new variant spreading, waning immunity and mobility restrictions. We analyze the role that different mechanisms, such as behavioral changes due to variable risk perception, variation of the population mobility, seasonal variability of the virus infectivity, and spreading of new variants have had in shaping the epidemiological curve. The fundamental impact of vaccines in drastically reducing the total increase in infections and deaths is also estimated. This work further underlines the crucial importance of vaccination and adoption of adequate individual protective measures in containing the pandemic.
Keywords	covid19
Language	English
Publishing date	2022-02-28
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.02.27.22271593
Database	COVID19

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Article ; Online: Beyond the peak: A deterministic compartment model for exploring the Covid-19 evolution in Italy.

Romano, Silvio / Fierro, Annalisa / Liccardo, Antonella

PloS one

2020 Volume 15, Issue 11, Page(s) e0241951

Abstract: Novel Covid-19 has had a huge impact on the world's population since December 2019. The very rapid spreading of the virus worldwide, with its heavy toll of death and overload of the healthcare systems, induced the scientific community to focus on ... ...

Abstract	Novel Covid-19 has had a huge impact on the world's population since December 2019. The very rapid spreading of the virus worldwide, with its heavy toll of death and overload of the healthcare systems, induced the scientific community to focus on understanding, monitoring and foreseeing the epidemic evolution, weighing up the impact of different containment measures. An immense literature was produced in few months. Many papers were focused on predicting the peak features through a variety of different models. In the present paper, combining the surveillance data-set with data on mobility and testing, we develop a deterministic compartment model aimed at performing a retrospective analysis to understand the main modifications occurred to the characteristic parameters that regulate the epidemic spreading. We find that, besides self-protective behaviors, a reduction of susceptibility should have occurred in order to explain the fast descent of the epidemic after the peak. A sensitivity analysis of the basic reproduction number, in response to variations of the epidemiological parameters that can be influenced by policy-makers, shows the primary importance of a rigid isolation procedure for the diagnosed cases, combined with an intensive effort in performing extended testing campaigns. Future scenarios depend on the ability to protect the population from the injection of new cases from abroad, and to pursue in applying rigid self-protective measures.
MeSH term(s)	Basic Reproduction Number ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Disease Susceptibility ; Humans ; Italy/epidemiology ; Models, Statistical ; Pandemics ; Pneumonia, Viral/epidemiology ; Retrospective Studies ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0241951
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Article ; Online: Long-Term Sports Practice and Atrial Fibrillation: An Updated Review of a Complex Relationship.

Petrungaro, Mattia / Fusco, Liuba / Cavarretta, Elena / Scarà, Antonio / Borrelli, Alessio / Romano, Silvio / Petroni, Renata / D'Ascenzi, Flavio / Sciarra, Luigi

Journal of cardiovascular development and disease

2023 Volume 10, Issue 5

Abstract: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, and it is an enormous burden worldwide because of its high morbidity, disability and mortality. It is generally acknowledged that physical activity (PA) is strongly ... ...

Abstract	Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, and it is an enormous burden worldwide because of its high morbidity, disability and mortality. It is generally acknowledged that physical activity (PA) is strongly associated with a significant reduction in the risk of cardiovascular (CV) disease and all-cause mortality. Moreover, it has been observed that moderate and regular physical activity has the potential to reduce the risk of AF, in addition to improving overall well-being. Nevertheless, some studies have associated intense physical activity with an increased risk of AF. This paper aims to review the main related literature to investigate the association between PA and AF incidence and draw pathophysiological and epidemiological conclusions.
Language	English
Publishing date	2023-05-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd10050218
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Article ; Online: Efficacy and Safety of Nonvitamin K Oral Anticoagulants in Patients with Atrial Fibrillation and Cancer: A Study-Level Meta-Analysis.

Cavallari, Ilaria / Verolino, Giuseppe / Romano, Silvio / Patti, Giuseppe

Thrombosis and haemostasis

2019 Volume 120, Issue 2, Page(s) 314–321

Abstract: Objectives: In this study-level meta-analysis, we evaluated the clinical outcome with nonvitamin K antagonist oral anticoagulants (NOACs) versus vitamin K antagonists (VKAs) in atrial fibrillation (AF) patients with cancer.: Background: ... ...

Abstract	Objectives: In this study-level meta-analysis, we evaluated the clinical outcome with nonvitamin K antagonist oral anticoagulants (NOACs) versus vitamin K antagonists (VKAs) in atrial fibrillation (AF) patients with cancer. Background: Anticoagulation in AF patients with cancer is challenging given the coexistence of elevated thrombotic and bleeding risk. The efficacy and safety of NOACs in this setting remain unclear. Methods: We included three randomized trials in our primary analysis ( Results: In the primary analysis, the use of NOACs was associated with similar incidence of stroke/systemic embolism (odds ratio [OR] 0.70, 95% confidence interval 0.45-1.09; Conclusion: In AF patients with malignancy, NOACs appear at least as effective as VKAs in preventing thrombotic events and reduce intracranial bleeding. NOACs may represent a valid and more practical alternative to VKAs in this setting of high-risk patients.
MeSH term(s)	Administration, Oral ; Anticoagulants/administration & dosage ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Data Interpretation, Statistical ; Embolism/drug therapy ; Hemorrhage/drug therapy ; Humans ; Intracranial Hemorrhages/prevention & control ; Neoplasms/complications ; Observational Studies as Topic ; Odds Ratio ; Patient Safety ; Randomized Controlled Trials as Topic ; Risk ; Risk Factors ; Stroke/prevention & control ; Thromboembolism/prevention & control ; Venous Thromboembolism/drug therapy ; Vitamin K/antagonists & inhibitors
Chemical Substances	Anticoagulants ; Vitamin K (12001-79-5)
Language	English
Publishing date	2019-11-30
Publishing country	Germany
Document type	Letter ; Meta-Analysis ; Systematic Review
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0039-3400300
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