Article ; Online: Factors related to the development of high antibody titres against SARS-CoV-2 in convalescent plasma donors from the ConPlas-19 trial.
2023 Volume 119, Issue 1, Page(s) 27–33
Abstract: Background and objectives: The efficacy of COVID-19 convalescent plasma (CP) associates with high titres of antibodies. ConPlas-19 clinical trial showed that CP reduces the risk of progression to severe COVID-19 at 28 days. Here, we aim to study ConPlas- ...
| Abstract | Background and objectives: The efficacy of COVID-19 convalescent plasma (CP) associates with high titres of antibodies. ConPlas-19 clinical trial showed that CP reduces the risk of progression to severe COVID-19 at 28 days. Here, we aim to study ConPlas-19 donors and characteristics that associate with high anti-SARS-CoV-2 antibody levels. Materials and methods: Four-hundred donors were enrolled in ConPlas-19. The presence and titres of anti-SARS-CoV-2 antibodies were evaluated by EUROIMMUN anti-SARS-CoV-2 S1 IgG ELISA. Results: A majority of 80.3% of ConPlas-19 donor candidates had positive EUROIMMUN test results (ratio ≥1.1), and of these, 51.4% had high antibody titres (ratio ≥3.5). Antibody levels decline over time, but nevertheless, out of 37 donors tested for an intended second CP donation, over 90% were still EUROIMMUN positive, and nearly 75% of those with high titres maintained high titres in the second sample. Donors with a greater probability of developing high titres of anti-SARS-CoV-2 antibodies include those older than 40 years of age (RR 2.06; 95% CI 1.24-3.42), with more than 7 days of COVID-19 symptoms (RR 1.89; 95% CI 1.05-3.43) and collected within 4 months from infection (RR 2.61; 95% CI 1.16-5.90). Male donors had a trend towards higher titres compared with women (RR 1.67; 95% CI 0.91-3.06). Conclusion: SARS-CoV-2 CP candidate donors' age, duration of COVID-19 symptoms and time from infection to donation associate with the collection of CP with high antibody levels. Beyond COVID-19, these data are relevant to inform decisions to optimize the CP donor selection process in potential future outbreaks. |
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| MeSH term(s) | Female ; Humans ; Male ; Antibodies, Neutralizing ; Antibodies, Viral ; Blood Donors ; COVID-19/therapy ; COVID-19 Serotherapy ; Immunization, Passive/methods ; Immunoglobulin G ; SARS-CoV-2 ; Clinical Trials as Topic |
| Chemical Substances | Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G |
| Language | English |
| Publishing date | 2023-11-20 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 80313-3 |
| ISSN | 1423-0410 ; 0042-9007 |
| ISSN (online) | 1423-0410 |
| ISSN | 0042-9007 |
| DOI | 10.1111/vox.13561 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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