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  1. Article: Lower gastrointestinal bleeding in a patient receiving sevelamer: Case report.

    Schoot, Tessa S / Römkens, Tessa Eh / Hoogeveen, Ellen K

    SAGE open medical case reports

    2021  Volume 9, Page(s) 2050313X211000488

    Abstract: Phosphate binders such as sevelamer are widely used in patients with chronic kidney disease to lower serum phosphate levels. We present a case of a 67-year-old woman with lower gastrointestinal bleeding after 9 days of using sevelamer carbonate ( ... ...

    Abstract Phosphate binders such as sevelamer are widely used in patients with chronic kidney disease to lower serum phosphate levels. We present a case of a 67-year-old woman with lower gastrointestinal bleeding after 9 days of using sevelamer carbonate (Renvela
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X211000488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: External Validity and Consistency over Time of Patient Segmentation Based on Disease Acceptance and Perceived Control in Inflammatory Bowel Disease.

    Van Erp, Liselot Willemijn / Thomas, Pepijn Wa / Groenen, Marcel Jm / Bloem, Sjaak / Russel, Maurice Gvm / Römkens, Tessa Eh / Wahab, Peter J

    Journal of gastrointestinal and liver diseases : JGLD

    2023  Volume 32, Issue 3, Page(s) 306–314

    Abstract: Background and aims: The patient segmentation model based on disease acceptance and perceived control may guide personalized care in inflammatory bowel disease (IBD). We aimed to investigate the external validity of the segmentation model and its ... ...

    Abstract Background and aims: The patient segmentation model based on disease acceptance and perceived control may guide personalized care in inflammatory bowel disease (IBD). We aimed to investigate the external validity of the segmentation model and its consistency over time.
    Methods: This is a multicenter longitudinal cohort study of adult IBD patients with questionnaires on disease acceptance and perceived control (6-items, 7-point Likert scale) and health-related quality of life (HRQoL) (Short IBD questionnaire, range 10-70). Segments were created based on mean scores (cut-off>5): (I) high acceptance, high control; (II) high acceptance, low control; (III) low acceptance, high control and; (IV) low acceptance, low control.
    Results: The external validation cohort included 921 IBD patients. The acceptance and control scale were unidimensional and internally consistent. Segments differed significantly in gender, disease duration, IBD medication and clinical disease activity. High acceptance and/or high control were significantly associated with a higher HRQoL compared with low acceptance and low control (i.e., segment IV) (Beta (95%CI) segment I=11.7 (10.4-13.1), segment II=9.3 (7.7-10.9) and segment III=3.8 (1.6-6.0), p≤0.001). The follow-up cohort included 783 patients: 58% remained in the same segment while 42% differed in segment over time. Changes in segment were positively correlated with changes in HRQoL over time (Spearman rho 0.38, p<0.001).
    Conclusions: The patient segmentation model based on disease acceptance and perceived control was externally valid and showed consistency over time. The different segments were independently associated with HRQoL. Future interventions should aim to personalize care based on segments and improve disease acceptance and perceived control of IBD patients.
    MeSH term(s) Adult ; Humans ; Quality of Life ; Longitudinal Studies ; Inflammatory Bowel Diseases/diagnosis ; Surveys and Questionnaires ; Severity of Illness Index
    Language English
    Publishing date 2023-09-28
    Publishing country Romania
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2427021-0
    ISSN 1842-1121 ; 1841-8724
    ISSN (online) 1842-1121
    ISSN 1841-8724
    DOI 10.15403/jgld-4855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Endoscopic and surgical treatment outcomes of colitis-associated advanced colorectal neoplasia: a multicenter cohort study.

    Derks, Monica Ew / Te Groen, Maarten / Peters, Charlotte P / Dijkstra, Gerard / de Vries, Annemarie C / Romkens, Tessa Eh / Horjus, Carmen S / de Boer, Nanne Kh / Bemelman, Willem A / Nagtegaal, Iris D / Derikx, Lauranne Aap / Hoentjen, Frank

    International journal of surgery (London, England)

    2023  Volume 109, Issue 7, Page(s) 1961–1969

    Abstract: Background: Inflammatory bowel disease (IBD) patients are at increased risk of advanced neoplasia (high-grade dysplasia or colorectal cancer). The authors aimed to (1) assess synchronous and metachronous neoplasia following (sub)total or proctocolectomy, ...

    Abstract Background: Inflammatory bowel disease (IBD) patients are at increased risk of advanced neoplasia (high-grade dysplasia or colorectal cancer). The authors aimed to (1) assess synchronous and metachronous neoplasia following (sub)total or proctocolectomy, partial colectomy or endoscopic resection for advanced neoplasia in IBD, and (2) identify factors associated with treatment choice.
    Material and methods: In this retrospective multicenter cohort study, the authors used the Dutch nationwide pathology databank (PALGA) to identify patients diagnosed with IBD and colonic advanced neoplasia (AN) between 1991 and 2020 in seven hospitals in the Netherlands. Logistic and Fine & Gray's subdistribution hazard models were used to assess adjusted subdistribution hazard ratios for metachronous neoplasia and associations with treatment choice.
    Results: The authors included 189 patients (high-grade dysplasia n =81; colorectal cancer n =108). Patients were treated with proctocolectomy ( n =33), (sub)total colectomy ( n =45), partial colectomy ( n =56) and endoscopic resection ( n =38). Partial colectomy was more frequently performed in patients with limited disease and older age, with similar patient characteristics between Crohn's disease and ulcerative colitis. Synchronous neoplasia was found in 43 patients (25.0%; (sub)total or proctocolectomy n =22, partial colectomy n =8, endoscopic resection n =13). The authors found a metachronous neoplasia rate of 6.1, 11.5 and 13.7 per 100 patient-years after (sub)total colectomy, partial colectomy and endoscopic resection, respectively. Endoscopic resection, but not partial colectomy, was associated with an increased metachronous neoplasia risk (adjusted subdistribution hazard ratios 4.16, 95% CI 1.64-10.54, P <0.01) compared with (sub)total colectomy.
    Conclusion: After confounder adjustment, partial colectomy yielded a similar metachronous neoplasia risk compared to (sub)total colectomy. High metachronous neoplasia rates after endoscopic resection underline the importance of strict subsequent endoscopic surveillance.
    MeSH term(s) Humans ; Cohort Studies ; Colonoscopy ; Colorectal Neoplasms/pathology ; Colitis/etiology ; Colitis/pathology ; Colitis/surgery ; Colitis, Ulcerative/surgery ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/pathology ; Inflammatory Bowel Diseases/surgery ; Colonic Neoplasms/surgery ; Colectomy/adverse effects ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The diagnostic work-up and outcomes of 'presumed' idiopathic acute pancreatitis: A post-hoc analysis of a multicentre observational cohort.

    Hallensleben, Nora D / Umans, Devica S / Bouwense, Stefan Aw / Verdonk, Robert C / Romkens, Tessa Eh / Witteman, Ben J / Schwartz, Matthijs P / Spanier, Marcel B / Laheij, Robert / van Santvoort, Hjalmar C / Besselink, Marc G / van Hooft, Jeanin E / Bruno, Marco J

    United European gastroenterology journal

    2019  Volume 8, Issue 3, Page(s) 340–350

    Abstract: Introduction: After standard diagnostic work-up, the aetiology of acute pancreatitis remains unknown in 16-27% of cases, a condition referred to as idiopathic acute pancreatitis (IAP). Determining the aetiology of pancreatitis is essential, as it may ... ...

    Abstract Introduction: After standard diagnostic work-up, the aetiology of acute pancreatitis remains unknown in 16-27% of cases, a condition referred to as idiopathic acute pancreatitis (IAP). Determining the aetiology of pancreatitis is essential, as it may direct treatment in the acute phase and guides interventions to prevent recurrent pancreatitis.
    Methods: Between 2008 and 2015, patients with acute pancreatitis were registered prospectively in 19 Dutch hospitals. Patients who had a negative initial diagnostic work-up with regard to the underlying aetiology of their pancreatitis were labelled 'presumed' IAP. The aim of this study was to assess the use of diagnostic modalities and their yield to establish an aetiology in 'presumed' IAP, and to assess recurrence rates both with and without treatment.
    Results: Out of the 1632 registered patients, 191 patients had a first episode of 'presumed' IAP, of whom 176 (92%) underwent additional diagnostic testing: CT (
    Conclusion: Additional diagnostic testing revealed an aetiology in one-third of 'presumed' IAP patients. The aetiology found was mostly biliary, but occasionally neoplasms were found. Identification of an aetiology with subsequent treatment reduced the rate of recurrence.
    MeSH term(s) Adult ; Aged ; Cholangiopancreatography, Endoscopic Retrograde/standards ; Cholangiopancreatography, Endoscopic Retrograde/statistics & numerical data ; Cholangiopancreatography, Magnetic Resonance/standards ; Cholangiopancreatography, Magnetic Resonance/statistics & numerical data ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Guideline Adherence/statistics & numerical data ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Pancreas/diagnostic imaging ; Pancreas/pathology ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatitis/diagnosis ; Pancreatitis/etiology ; Pancreatitis/mortality ; Pancreatitis/therapy ; Practice Guidelines as Topic ; Prospective Studies ; Recurrence ; Secondary Prevention/standards ; Secondary Prevention/statistics & numerical data ; Tomography, X-Ray Computed/standards ; Tomography, X-Ray Computed/statistics & numerical data ; Treatment Outcome ; Ultrasonography/standards ; Ultrasonography/statistics & numerical data
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2019-11-14
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1177/2050640619890462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of endoscopic ultrasonography in the diagnostic work-up of idiopathic acute pancreatitis (PICUS): study protocol for a nationwide prospective cohort study.

    Umans, Devica S / Timmerhuis, Hester C / Hallensleben, Nora D / Bouwense, Stefan A / Anten, Marie-Paule Gf / Bhalla, Abha / Bijlsma, Rina A / Boermeester, Marja A / Brink, Menno A / Hol, Lieke / Bruno, Marco J / Curvers, Wouter L / van Dullemen, Hendrik M / van Eijck, Brechje C / Erkelens, G Willemien / Fockens, Paul / van Geenen, Erwin J M / Hazen, Wouter L / Hoge, Chantal V /
    Inderson, Akin / Kager, Liesbeth M / Kuiken, Sjoerd D / Perk, Lars E / Poley, Jan-Werner / Quispel, Rutger / Römkens, Tessa Eh / van Santvoort, Hjalmar C / Tan, Adriaan Citl / Thijssen, Annemieke Y / Venneman, Niels G / Vleggaar, Frank P / Voorburg, Annet McJ / van Wanrooij, Roy Lj / Witteman, Ben J / Verdonk, Robert C / Besselink, Marc G / van Hooft, Jeanin E

    BMJ open

    2020  Volume 10, Issue 8, Page(s) e035504

    Abstract: Introduction: Idiopathic acute pancreatitis (IAP) remains a dilemma for physicians as it is uncertain whether patients with IAP may actually have an occult aetiology. It is unclear to what extent additional diagnostic modalities such as endoscopic ... ...

    Abstract Introduction: Idiopathic acute pancreatitis (IAP) remains a dilemma for physicians as it is uncertain whether patients with IAP may actually have an occult aetiology. It is unclear to what extent additional diagnostic modalities such as endoscopic ultrasonography (EUS) are warranted after a first episode of IAP in order to uncover this aetiology. Failure to timely determine treatable aetiologies delays appropriate treatment and might subsequently cause recurrence of acute pancreatitis. Therefore, the aim of the Pancreatitis of Idiopathic origin: Clinical added value of endoscopic UltraSonography (PICUS) Study is to determine the value of routine EUS in determining the aetiology of pancreatitis in patients with a first episode of IAP.
    Methods and analysis: PICUS is designed as a multicentre prospective cohort study of 106 patients with a first episode of IAP after complete standard diagnostic work-up, in whom a diagnostic EUS will be performed. Standard diagnostic work-up will include a complete personal and family history, laboratory tests including serum alanine aminotransferase, calcium and triglyceride levels and imaging by transabdominal ultrasound, magnetic resonance imaging or magnetic resonance cholangiopancreaticography after clinical recovery from the acute pancreatitis episode. The primary outcome measure is detection of aetiology by EUS. Secondary outcome measures include pancreatitis recurrence rate, severity of recurrent pancreatitis, readmission, additional interventions, complications, length of hospital stay, quality of life, mortality and costs, during a follow-up period of 12 months.
    Ethics and dissemination: PICUS is conducted according to the Declaration of Helsinki and Guideline for Good Clinical Practice. Five medical ethics review committees assessed PICUS (Medical Ethics Review Committee of Academic Medical Center, University Medical Center Utrecht, Radboud University Medical Center, Erasmus Medical Center and Maastricht University Medical Center). The results will be submitted for publication in an international peer-reviewed journal.
    Trial registration number: Netherlands Trial Registry (NL7066). Prospectively registered.
    MeSH term(s) Acute Disease ; Endosonography ; Humans ; Multicenter Studies as Topic ; Netherlands ; Pancreatitis/diagnostic imaging ; Prospective Studies ; Quality of Life
    Language English
    Publishing date 2020-08-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2019-035504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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