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  1. Article ; Online: An exploitable Achilles heel of MITF?

    Silva, Carolina / Ronai, Ze'ev A

    Cell research

    2022  Volume 33, Issue 3, Page(s) 195–196

    Language English
    Publishing date 2022-12-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-022-00762-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5283: Show issues Location:
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  2. Article ; Online: Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers.

    Pathria, Gaurav / Ronai, Ze'ev A

    Cell metabolism

    2021  Volume 33, Issue 1, Page(s) 9–20

    Abstract: Sustained proliferative potential of cancer cells creates heightened energetic and biosynthetic demands. The resulting overt dependence of cancer cells on unperturbed nutrient supply has prompted a widespread interest in amino acid restriction strategies ...

    Abstract Sustained proliferative potential of cancer cells creates heightened energetic and biosynthetic demands. The resulting overt dependence of cancer cells on unperturbed nutrient supply has prompted a widespread interest in amino acid restriction strategies as potential cancer therapeutics. However, owing to rapid signaling and metabolic reprogramming in cancer cells, the prospects for success of amino acid restriction approaches remain unclear. We thus recognize that the identification of co-vulnerabilities of amino acid-restricted cancers may inform actionable targets for effective combined interventions. In this perspective, we outline the current state of key cellular mechanisms underlying adaptation to amino acid restriction and discuss the role of signal transduction pathways governing cancer cell resistance to amino acid restriction, with potential ramifications for the design of future therapeutic efforts.
    MeSH term(s) Amino Acids/metabolism ; Animals ; Humans ; Neoplasms/metabolism
    Chemical Substances Amino Acids
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2020.12.009
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    Zs.A 6169: Show issues Location:
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  3. Article ; Online: Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer.

    Khateb, Ali / Ronai, Ze'ev A

    The EMBO journal

    2021  Volume 40, Issue 22, Page(s) e109683

    Abstract: While canonical and non-canonical functions of pyruvate kinase M2 (PKM2) are recognized to mediate often-opposing roles in cancer, its contribution to cellular and systemic fatty acid homeostasis remains poorly understood. A new study by Liu et al (2021) ...

    Abstract While canonical and non-canonical functions of pyruvate kinase M2 (PKM2) are recognized to mediate often-opposing roles in cancer, its contribution to cellular and systemic fatty acid homeostasis remains poorly understood. A new study by Liu et al (2021) uncovers ER transmembrane protein TMEM33 as a novel target of PKM2, which is essential for regulation of cancer cell cholesterol metabolism. These findings highlight the diversity of tissue-specific functions of PKM2 and potential implications for cancer treatment.
    MeSH term(s) Homeostasis ; Humans ; Leukemia, Myeloid, Acute ; Lipid Metabolism ; Pyruvate Kinase/metabolism
    Chemical Substances Pyruvate Kinase (EC 2.7.1.40)
    Language English
    Publishing date 2021-10-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2021109683
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    Zs.MG 100: Show issues

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  4. Article ; Online: PRMT5 function and targeting in cancer.

    Kim, Hyungsoo / Ronai, Ze'ev A

    Cell stress

    2020  Volume 4, Issue 8, Page(s) 199–215

    Abstract: Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic ... ...

    Abstract Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic processes including tumor intrinsic, as well as extrinsic microenvironmental signaling pathways. We discuss PRMT5 effect on histone methylation and methylation of regulatory proteins including those involved in RNA splicing, cell cycle, cell death and metabolic signaling. In all, we highlight the importance of PRMT5 regulation and function in cancer, which provide the foundation for therapeutic modalities targeting PRMT5.
    Language English
    Publishing date 2020-07-13
    Publishing country Austria
    Document type Journal Article ; Review
    ISSN 2523-0204
    ISSN (online) 2523-0204
    DOI 10.15698/cst2020.08.228
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  5. Article ; Online: Unfolded Protein Response in Leukemia: From Basic Understanding to Therapeutic Opportunities.

    Khateb, Ali / Ronai, Ze'ev A

    Trends in cancer

    2020  Volume 6, Issue 11, Page(s) 960–973

    Abstract: Understanding genetic and epigenetic changes that underlie abnormal proliferation of hematopoietic stem and progenitor cells is critical for development of new approaches to monitor and treat leukemia. The unfolded protein response (UPR) is a conserved ... ...

    Abstract Understanding genetic and epigenetic changes that underlie abnormal proliferation of hematopoietic stem and progenitor cells is critical for development of new approaches to monitor and treat leukemia. The unfolded protein response (UPR) is a conserved adaptive signaling pathway that governs protein folding, secretion, and energy production and serves to maintain protein homeostasis in various cellular compartments. Deregulated UPR signaling, which often occurs in hematopoietic stem cells and leukemia, defines the degree of cellular toxicity and perturbs protein homeostasis, and at the same time, offers a novel therapeutic target. Here, we review current knowledge related to altered UPR signaling in leukemia and highlight possible strategies for exploiting the UPR as treatment for this disease.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Carcinogenesis/drug effects ; Carcinogenesis/genetics ; Cell Self Renewal/drug effects ; Cell Self Renewal/genetics ; Disease Models, Animal ; Disease Progression ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Endoplasmic Reticulum Stress/drug effects ; Endoplasmic Reticulum Stress/genetics ; Epigenesis, Genetic/drug effects ; Gene Expression Regulation, Leukemic/drug effects ; Hematopoietic Stem Cells/drug effects ; Hematopoietic Stem Cells/pathology ; Humans ; Leukemia/drug therapy ; Leukemia/genetics ; Leukemia/pathology ; Proteostasis/drug effects ; Proteostasis/genetics ; Unfolded Protein Response/drug effects ; Unfolded Protein Response/genetics
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2020-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2020.05.012
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  6. Article ; Online: Monoubiquitination in proteasomal degradation.

    Ronai, Ze'ev A

    Proceedings of the National Academy of Sciences of the United States of America

    2016  Volume 113, Issue 32, Page(s) 8894–8896

    MeSH term(s) Humans ; Proteasome Endopeptidase Complex/metabolism ; Proteins/metabolism ; Ubiquitination
    Chemical Substances Proteins ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2016-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1610186113
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    Zs.A 1148: Show issues Location:
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  7. Article ; Online: CALPA-IN NF1.

    Lazar, Ikrame / Ronai, Ze'ev A

    Oncotarget

    2018  Volume 9, Issue 69, Page(s) 33051

    Language English
    Publishing date 2018-09-04
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.25990
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  8. Article ; Online: Rewired Notch/p53 by Numb'ing Mdm2.

    Kim, Hyungsoo / Ronai, Ze'ev A

    The Journal of cell biology

    2018  Volume 217, Issue 2, Page(s) 445–446

    Abstract: Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53-Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018. ...

    Abstract Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53-Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018.
    MeSH term(s) Breast Neoplasms ; Humans ; Membrane Proteins ; Nerve Tissue Proteins ; Protein Isoforms ; Proto-Oncogene Proteins c-mdm2 ; Tumor Suppressor Protein p53
    Chemical Substances Membrane Proteins ; Nerve Tissue Proteins ; Protein Isoforms ; Tumor Suppressor Protein p53 ; MDM2 protein, human (EC 2.3.2.27) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27)
    Language English
    Publishing date 2018-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201712007
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    Ub I Zs.190: Show issues Location:
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  9. Article ; Online: BRN 2 Invade.

    Pathria, Gaurav / Ronai, Ze'ev A

    Cancer cell

    2018  Volume 34, Issue 1, Page(s) 1–3

    Abstract: One of the remaining challenges in treating melanoma is its strong propensity to metastasize. Thus, there is considerable interest in understanding the alterations that drive progression of the disease. In this issue of Cancer Cell, Shain et al. and ... ...

    Abstract One of the remaining challenges in treating melanoma is its strong propensity to metastasize. Thus, there is considerable interest in understanding the alterations that drive progression of the disease. In this issue of Cancer Cell, Shain et al. and Zheng et al. provide insights implicating p16
    MeSH term(s) Cyclin-Dependent Kinase Inhibitor p16 ; Genomics ; Humans ; Melanoma ; Signal Transduction
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p16
    Language English
    Publishing date 2018-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2018.06.010
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  10. Article ; Online: Takashi Sugimura (1926-2020).

    Harris, Curtis C / Ronai, Ze'ev A

    Cancer cell

    2020  Volume 38, Issue 6, Page(s) 749–750

    MeSH term(s) History, 20th Century ; History, 21st Century ; Hospital Administration ; Humans ; Male ; Neoplasms/therapy
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2020.11.001
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