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  1. Book ; Online: Multimodal Therapy of Upper Gastrointestinal Malignancies

    Ronellenfitsch, Ulrich

    2021  

    Keywords Public health & preventive medicine ; gastric cancer ; gastrectomy ; complications ; outcome ; survival ; lymph node ratio ; neoadjuvant chemotherapy ; conversion surgery ; cancer dormancy ; nuclear receptor NR2F1 ; clinical pathways ; gastric surgery ; oncological gastrectomy ; quality of care ; outcomes ; standardization ; adjuvant therapy ; gastrointestinal tract ; genetic diagnosis ; radiosensitivity ; mortality ; failure to rescue ; immunotherapy ; genetics ; esophageal cancer ; multidisciplinary ; gastric/gastroesophageal cancer ; perioperative chemotherapy ; overall survival ; relapse-free survival ; skeletal muscle index ; esophagectomy ; nutritional status ; sarcopenia ; esophageal anastomosis ; minimally invasive surgery ; induction chemotherapy ; chemo-radiotherapy ; neoadjuvant treatment ; esophageal squamous cell carcinoma ; multimodal treatment ; neoadjuvant chemoradiotherapy ; definitive chemoradiotherapy ; Lauren histotype ; gastrointestinal stromal tumor ; neuroendocrine tumor ; MALT lymphoma ; mucosal resection ; submucosal dissection ; GIST ; stomach ; neoadjuvant therapy ; imatinib ; organ preservation ; squamous cell esophageal cancer ; gastro-esophageal reflux disease ; Barrett's esophagus ; early adenocarcinoma of esophagus ; endoscopic submucosal dissection ; endoscopic mucosal resection ; n/a
    Size 1 electronic resource (272 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291534
    ISBN 9783036509211 ; 3036509216
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Thrombendarteriektomie versus endovaskuläre Therapie bei Stenosen der Femoralisgabel

    Görg, Nadine / Ronellenfitsch, Ulrich

    systematische Übersichtsarbeit und Meta-Analyse mit individuellen Patientendaten (IPD)

    2022  

    Institution Universität Heidelberg
    Author's details vorgelegt von Nadine Görg ; Doktorvater: apl. Prof. Dr. med. Ulrich Ronellenfitsch
    Language German
    Size 130 Blätter, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2023
    HBZ-ID HT030626276
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 81 order for loan Magazin

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  3. Article: Surgical Treatment of Gastrointestinal Cancers.

    Ronellenfitsch, Ulrich

    Cancers

    2023  Volume 15, Issue 14

    Abstract: Even though there have been remarkable advances in systemic treatment of gastrointestinal malignancies over the last few decades, in the vast majority of instances, surgery remains the sole therapeutic approach offering a chance for a definite cure [ ... ]. ...

    Abstract Even though there have been remarkable advances in systemic treatment of gastrointestinal malignancies over the last few decades, in the vast majority of instances, surgery remains the sole therapeutic approach offering a chance for a definite cure [...].
    Language English
    Publishing date 2023-07-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15143743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Cardiovascular mortality among ethnic German immigrants from the Former Soviet Union to Germany

    Ronellenfitsch, Ulrich

    a retrospective cohort study

    2005  

    Author's details submitted by Ulrich Ronellenfitsch
    Language English
    Size 195 S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2006
    HBZ-ID HT014816319
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 E 1277 order for loan Magazin

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  5. Article: Editorial: Blood vessel management in surgical oncology.

    Ronellenfitsch, Ulrich / Jakob, Jens

    Frontiers in oncology

    2023  Volume 13, Page(s) 1180216

    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1180216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: AI and imaging-based cancer screening: getting ready for prime time.

    Kleeff, Jörg / Ronellenfitsch, Ulrich

    Nature medicine

    2023  Volume 29, Issue 12, Page(s) 3002–3003

    MeSH term(s) Humans ; Early Detection of Cancer ; Neoplasms/diagnostic imaging ; Diagnostic Imaging
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-023-02630-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  7. Article ; Online: Ergebnisse eines monozentrischen Gefäßscreeningprogramms in Deutschland.

    Passek, K / Ronellenfitsch, U / Meisenbacher, K / Peters, A / Böckler, D

    Chirurgie (Heidelberg, Germany)

    2023  Volume 94, Issue 4, Page(s) 342–348

    Abstract: Background: Cardiovascular diseases are the main cause of death in Europe with a relevant socioeconomic burden. A screening program for vascular diseases in asymptomatic persons with a defined risk constellation can lead to an early diagnosis.: ... ...

    Title translation Results of a single center vascular screening program in Germany.
    Abstract Background: Cardiovascular diseases are the main cause of death in Europe with a relevant socioeconomic burden. A screening program for vascular diseases in asymptomatic persons with a defined risk constellation can lead to an early diagnosis.
    Objective: The study examined a screening program for carotid stenosis, peripheral arterial occlusive disease (PAOD) and abdominal aortic aneurysms (AAA) in persons without any known vascular disease with respect to demographic data, risk factors, pre-existing conditions, medication intake, detection of pathological findings and/or findings requiring treatment.
    Material and methods: Test subjects were invited using various information material and filled in a questionnaire on cardiovascular risk factors. The screening took place with measurement of the ABI and duplex sonography as a monocentric prospective single arm study within 1 year. Endpoints were the prevalence of risk factors and pathological and/or results requiring treatment.
    Results: A total of 391 persons participated, 36% presented with at least 1 cardiovascular risk factor, 35.5% with 2 and 14.4% with 3 or more. The sonography showed results requiring control with a carotid stenosis of < 50-> 75% or occlusion in 9%. An AAA with a diameter of 3.0-4.5 cm was diagnosed in 0.9% and a pathological ABI < 0.9 or > 1.3 in 12.3%. The indications for a pharmacotherapy were found in 17% and no operation was recommended.
    Conclusion: The practicability of a screening program for carotid stenosis, PAOD and AAA of a defined risk population was shown. Vascular pathologies that required treatment were hardly found in the catchment area of the hospital. Consequently, the implementation of this screening program in Germany based on the collected data cannot currently be recommended in this form.
    MeSH term(s) Humans ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/epidemiology ; Prospective Studies ; Cardiovascular Diseases ; Germany/epidemiology
    Language German
    Publishing date 2023-02-20
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ISSN 2731-698X
    ISSN (online) 2731-698X
    DOI 10.1007/s00104-023-01821-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Is it feasible and ethical to randomize patients between surgery and non-surgical treatments for gastrointestinal cancers?

    Rebelo, Artur / Klose, Johannes / Kleeff, Jörg / Ronellenfitsch, Ulrich

    Frontiers in oncology

    2023  Volume 13, Page(s) 1119436

    Abstract: Background: In several settings in the treatment of gastrointestinal cancers, it is unclear if the addition of surgery to a multimodal treatment strategy, or in some circumstances its omission, lead to a better outcome for patients. In such situations ... ...

    Abstract Background: In several settings in the treatment of gastrointestinal cancers, it is unclear if the addition of surgery to a multimodal treatment strategy, or in some circumstances its omission, lead to a better outcome for patients. In such situations of clinical equipoise, high-quality evidence from randomised-controlled trials is needed to decide which treatment approach is preferable.
    Objective: In this article, we outline the importance of randomised trials comparing surgery with non-surgical therapies for specific scenarios in the treatment of gastrointestinal cancers. We explain the difficulties and solutions of designing these trials and recruiting patients in this context.
    Methods: We performed a selective review based on a not systematic literature search in core databases, supplemented by browsing health information journals and citation searching. Only articles in English were selected. Based on this search, we discuss the results and methodological characteristics of several trials which randomised patients with gastrointestinal cancers between surgery and non-surgical treatments, highlighting their differences, advantages, and limitations.
    Results and conclusions: Innovative and effective cancer treatment requires randomised trials, also comparing surgery and non-surgical treatments for defined scenarios in the treatment of gastrointestinal malignancies. Nevertheless, potential obstacles to designing and carrying out these trials must be recognised ahead of time to avoid problems before or during the trial.
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1119436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Editorial: Perioperative optimization of patients undergoing pancreatic surgery.

    Kleeff, Jorg / Klose, Johannes / Rebelo, Artur / Ronellenfitsch, Ulrich

    Frontiers in oncology

    2023  Volume 13, Page(s) 1170409

    Language English
    Publishing date 2023-03-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1170409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Fibroblast Activation Protein Overexpression in Gastrointestinal Tumors: Protocol for a Systematic Review and Meta-analysis.

    Sunami, Yoshiaki / Ronellenfitsch, Ulrich / Kleeff, Jorg / Rebelo, Artur

    JMIR research protocols

    2023  Volume 12, Page(s) e45176

    Abstract: Background: A hallmark of gastrointestinal cancer, especially pancreatic cancer, is the dense stromal tumor microenvironment in which cancer-associated fibroblasts (CAFs) represent the major stromal cell type. Preclinical studies have demonstrated that ... ...

    Abstract Background: A hallmark of gastrointestinal cancer, especially pancreatic cancer, is the dense stromal tumor microenvironment in which cancer-associated fibroblasts (CAFs) represent the major stromal cell type. Preclinical studies have demonstrated that depletion of fibroblast activation protein (FAP)-positive CAFs results in increased survival.
    Objective: We present the protocol for a systematic review and meta-analysis that aim to assess the currently available evidence on the effect of FAP expression on survival and clinical characteristics in gastrointestinal cancers.
    Methods: The literature search and data analysis will be conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 statement. The databases PubMed/MEDLINE, Web of Science Core Collection, Cochrane Library, and ClinicalTrials.gov will be searched via their respective online search engines. A meta-analysis comparing patients with and without FAP overexpression with the following outcomes will be performed: postoperative survival (overall and median survival; 1-, 2-, 3-, and 5-year survival rates), histological differentiation (grading), local tumor invasion, lymph node metastases, and distant metastases. Odds ratios will be calculated for binary data, and weighted mean differences and relative SD differences will be determined for continuous data. The 95% CI, heterogeneity measures, and statistical significance will be reported for each outcome. The chi-square and Kruskal-Wallis tests will be used to evaluate statistical significance. A P value of <.05 will be considered statistically significant.
    Results: Database searches will commence in April 2023. The meta-analysis will be completed by December 2023.
    Conclusions: In recent years, several publications on FAP overexpression in gastrointestinal tumors have been published. The only published meta-analysis on this topic dates to 2015. It included 15 studies on various solid tumors and only 8 studies focusing exclusively on gastrointestinal tumors. The expected results of the present analysis will provide new evidence on the prognostic value of FAP in gastrointestinal tumors and thereby support health care professionals and patients in their decision-making.
    Trial registration: PROSPERO CRD42022372194; https://tinyurl.com/352ae8b8.
    International registered report identifier (irrid): PRR1-10.2196/45176.
    Language English
    Publishing date 2023-04-26
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2719222-2
    ISSN 1929-0748
    ISSN 1929-0748
    DOI 10.2196/45176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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