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Article ; Online: Clinical Study on the Eradication of Helicobacter pylori by Vonoprazan Combined with Amoxicillin for 10-Day Dual Therapy.

Yan, Kunfeng / Dai, Xiaorong / Li, Zhenxing / Rong, Weiwei / Chen, Lei / Diao, Xinxin

Clinical pharmacology in drug development

2024 Volume 13, Issue 3, Page(s) 240–247

Abstract: Vonoprazan holds significant research promise for Helicobacter pylori eradication, with the goal of determining the most effective drug regimen. In this study, H. pylori patients (426) were enrolled and randomized into 3 groups: an EA14 group (20 mg of ... ...

Abstract	Vonoprazan holds significant research promise for Helicobacter pylori eradication, with the goal of determining the most effective drug regimen. In this study, H. pylori patients (426) were enrolled and randomized into 3 groups: an EA14 group (20 mg of esomeprazole qid and 1000 mg of amoxicillin tid for 14 days), a VA14 group (20 mg of vonoprazan bid and 750 mg of amoxicillin qid for 14 days), and a VA10 group (20 mg of vonoprazan bid and 1000 mg of amoxicillin tid for 10 days). Key outcomes encompassed the H. pylori eradication rate, patient adverse effects, and compliance. In the EA14, VA14, and VA10 groups, H. pylori eradication rates were 89.4%, 90.1%, and 88.7% in intention-to-treat analysis, and 94.2%, 94.4%, and 94.6% in per-protocol analysis, respectively. Adverse events incidences were 14.8%, 12.7%, and 5.6%, while compliance rates were 88.7%, 90.9%, and 95.8%, respectively. Notably, the VA10 regimen demonstrated comparable H. pylori eradication rates, adverse effect incidences, and compliance levels to the EA14 and VA14 regimens.
MeSH term(s)	Humans ; Amoxicillin/adverse effects ; Helicobacter pylori ; Helicobacter Infections/drug therapy ; Helicobacter Infections/chemically induced ; Proton Pump Inhibitors/adverse effects ; Metronidazole/adverse effects ; Pyrroles ; Sulfonamides
Chemical Substances	Amoxicillin (804826J2HU) ; 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Proton Pump Inhibitors ; Metronidazole (140QMO216E) ; Pyrroles ; Sulfonamides
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649010-9
ISSN	2160-7648 ; 2160-763X
ISSN (online)	2160-7648
ISSN	2160-763X
DOI	10.1002/cpdd.1357
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Article ; Online: Fructus choerospondiatis: A comprehensive review of its traditional uses, chemical composition, pharmacological activities, and clinical studies.

Rong, Weiwei / Shi, Qilin / Yang, Yuru / Su, Weiyi / Li, Mingna / Qin, Minni / Bai, Shuang / Zhu, Qing / Wang, Andong

Journal of ethnopharmacology

2024 Volume 323, Page(s) 117696

Abstract: Ethnopharmacological relevance: Fructus Choerospondiatis is the dried and mature fruit of Choerospondias axillaris (Roxb.) Burtt et Hill. It has been used for a long time in Tibetan and Mongolian medicine, first recorded in the ancient Tibetan medicine ... ...

Abstract	Ethnopharmacological relevance: Fructus Choerospondiatis is the dried and mature fruit of Choerospondias axillaris (Roxb.) Burtt et Hill. It has been used for a long time in Tibetan and Mongolian medicine, first recorded in the ancient Tibetan medicine book "Medicine Diagnosis of the King of the Moon" in the early 8th century. Fructus Choerospondiatis shows multiple pharmacological activities, especially in treating cardiovascular diseases. Aim of this review: This paper reviews the progress in research on the botanical characteristics, traditional uses, chemical constituents, pharmacological activity, clinical studies, and quality control of Fructus Choerospondiatis. This review aims to summarize current research and provide a reference for further development and utilization of Fructus Choerospondiatis resources. Method: The sources for this review include the Pharmacopeia of the People's Republic of China (2020), theses, and peer-reviewed papers (in both English and Chinese). Theses and papers were downloaded from electronic databases including Web of Science, PubMed, SciFinder, Scholar, Springer, and China National Knowledge Infrastructure.The search terms used were "Choerospondias axillaris", "C. axillaris", "Choerospondias axillaris (Roxb.) Burtt et Hill", "Fructus choerospondiatis", "Guangzao", "Lapsi", and "Lupsi". Results: Fructus Choerospondiatis contains polyphenols, organic acids, amino acids, fatty acids, polysaccharides, and other chemical components. These ingredients contribute to its diverse pharmacological activities such as antioxidant activity, protection against myocardial ischemia-reperfusion injury, anti-myocardial fibrosis, heart rhythm regulation, anti-tumor, liver protection, and immunity enhancement. It also affects the central nervous system, with the ability to repair damaged nerve cells. Conclusion: Fructus Choerospondiatis, with its various chemical compositions and pharmacological activities, is a promising medicinal resource. However, it remains under-researched, particularly in pharmacodynamic material basis and quality control. These areas require further exploration by researchers in the future.
MeSH term(s)	Humans ; Fruit ; China ; Cardiovascular Diseases/drug therapy ; Quality Control ; Anacardiaceae ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Ethnopharmacology ; Medicine, Chinese Traditional ; Drugs, Chinese Herbal/pharmacology
Chemical Substances	Phytochemicals ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-01
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117696
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Article ; Online: Citrullus colocynthis

Cheng, Xiaotian / Qin, Minni / Chen, Rongrong / Jia, Yunxia / Zhu, Qing / Chen, Guangtong / Wang, Andong / Ling, Bai / Rong, Weiwei

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 17

Abstract: Citrullus ... ...

Abstract	Citrullus colocynthis
MeSH term(s)	Citrullus colocynthis ; Flavonoids ; Hypoglycemic Agents/pharmacology ; Insecticides ; Pharmaceutical Preparations
Chemical Substances	Flavonoids ; Hypoglycemic Agents ; Insecticides ; Pharmaceutical Preparations
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28176221
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Article: The protective effect of Xanthoceras sorbifolia Bunge husks on cognitive disorder based on metabolomics and gut microbiota analysis

Rong, Weiwei / Han, Kefei / Zhao, Zihan / An, Junying / Li, Qing / Bi, Kaishun

Journal of ethnopharmacology. 2021 Oct. 28, v. 279

2021

Abstract: The husks of Xanthoceras sorbifolia Bunge mainly used in north China as folk medicine were reported to have potential protective effect on cognitive impairment. However, the mechanism remains unclear. In order to fully understand the mechanism of the ... ...

Abstract	The husks of Xanthoceras sorbifolia Bunge mainly used in north China as folk medicine were reported to have potential protective effect on cognitive impairment. However, the mechanism remains unclear. In order to fully understand the mechanism of the protection, a complementary study of the husks was conducted.The urinary and fecal metabolomics were used to analyze the potential biomarkers by the liquid chromatography-tandem time of flight mass spectrometry, and the16S rDNA technology was applied to conduct the analysis of microbiota species in the fecal samples of the rats, which is a significant influencing factor for the development of cognitive impairment.In metabolomics study, ten potential metabolic biomarkers, which are hippuric acid, kynurenic acid, creatinine, phenylalanine, xanthurenic acid, phenylacetylglycine, succinyladenosine, cresol sulfate, tryptophan 2-C-mannoside and N4-Acetylcytidine in urine, along with two, including isoleucine and phenylalanine in feces, were preliminarily identified, involving multiple pathways such as tryptophan, purine, kynurenine, and phenylalanine metabolism. The perturbation of these metabolic pathways could be related with insulin resistance, oxidative stress, energy metabolism deficit and neuroinflammation, which were risk factors to cause cognitive impairment. In gut microbiota analysis, the relative abundance of c_Bacteroidia, c_Alphaproteobacteria, f_Prevotellaceae, f_Sphingomonadaceae, f_Burkholderiaceae, g_Prevotellaceae_NK3B31_group and p_Bacteroidetes was significantly changed in the rats with cognitive impairment. Spearman's analysis showed obvious correlation between the metabolites and the microbiota species. In the rats with pretreatment of the husks extract, metabolites maintained a relative normal level, and the husks extract could regulate the gut microbiota, especially f_Prevotellaceae and g_Prevotellaceae_NK3B31_group, indicating the effect of the husks on the metabolic pathways via GMs. Such amino acids as isoleucine and phenylalanine failed to show any significant correlation with the microbiota species, indicating that the husks exhibited the potential protective effect through gut microbiota and other pathways.The husks extract could improve the intestinal microenvironment, and the stability of intestinal microenvironment was associated with normality of tryptophan, purine, kynurenine and phenylalanine metabolic pathways etc, which probably had an effect on cognitive function. This complementary work suggested that gut microbiotas were potential targets of the husks to exert its effect on cognitive impairment.
Keywords	Xanthoceras sorbifolium ; biomarkers ; cognition ; cognitive disorders ; creatinine ; energy metabolism ; feces ; hippuric acid ; insulin resistance ; intestinal microorganisms ; intestines ; isoleucine ; kynurenine ; liquid chromatography ; mass spectrometry ; metabolites ; metabolomics ; oxidative stress ; phenylalanine ; protective effect ; sulfates ; traditional medicine ; tryptophan ; urine ; xanthurenic acid ; China
Language	English
Dates of publication	2021-1028
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113094
Database	NAL-Catalogue (AGRICOLA)

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Article: Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy.

Rong, Weiwei / Li, Jiejia / Wang, Lifeng / Luo, Shanshan / Liang, Tulu / Qian, Xunjia / Zhang, Xiaodan / Zhou, Qinbei / Zhu, Yizhun / Zhu, Qing

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 969553

Abstract: Background: Leonurus japonicus Houtt has an obvious efficacy on cardiovascular diseases. As the most representative component in the herb, leonurine has attracted increasing attention for its potential in myocardial ischemia. However, its protective ... ...

Abstract	Background: Leonurus japonicus Houtt has an obvious efficacy on cardiovascular diseases. As the most representative component in the herb, leonurine has attracted increasing attention for its potential in myocardial ischemia. However, its protective mechanism against myocardial ischemia remains incompletely elucidated. Objectives: The present study aimed to reveal the potential mechanism of leonurine in acute myocardial ischemia using a strategy combining metabolomics and network pharmacology. Methods: First, a metabolomics method was proposed to identify the differential metabolites of plasma in rats. Then, network pharmacology was performed to screen candidate targets of leonurine against acute myocardial ischemia. A compound-reaction-enzyme-gene network was thus constructed with the differential metabolites and targets. Finally, molecular docking was carried out to predict the binding capability of leonurine with key targets. Results: A total of 32 differential metabolites were identified in rat plasma, and 16 hub genes were detected through network pharmacology. According to the results of compound-reaction-enzyme-gene network and molecular docking, what was screened included six key targets (GSR, CYP2C9, BCHE, GSTP1, TGM2, and PLA2G2A) and seven differential metabolites (glycerylphosphorylcholine, lysophosphatidylcholine, choline phosphate, linoleic acid, 13-HpODE, tryptophan and glutamate) with four important metabolic pathways involved: glycerophospholopid metabolism, linoleic acid metabolism, tryptophan metabolism and glutamate metabolism. Among them, glycerophospholipid and tryptophan metabolism were shown to be important, since the regulation of leonurine on these two pathways was also observed in our previous metabolomics study conducted on clinical hyperlipidemia patients. Conclusion: This is the first study of its kind to reveal the underlying mechanism of leonurine against acute myocardial ischemia through a strategy combining metabolomics and network pharmacology, which provides a valuable reference for the research on its future application.
Language	English
Publishing date	2022-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.969553
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Article ; Online: Cardioprotective Mechanism of Leonurine against Myocardial Ischemia through a Liver-Cardiac Crosstalk Metabolomics Study.

Rong, Weiwei / Li, Jiejia / Pan, Dingyi / Zhou, Qinbei / Zhang, Yexuan / Lu, Qianxing / Wang, Liyun / Wang, Andong / Zhu, Yizhun / Zhu, Qing

Biomolecules

2022 Volume 12, Issue 10

Abstract: Leonurine has been shown to have excellent anti-myocardial ischemia effects. Our previous studies suggested that cardiac protection by leonurine during myocardial ischemia appeared to be inextricably linked to its regulation of the liver. At present, ... ...

Abstract	Leonurine has been shown to have excellent anti-myocardial ischemia effects. Our previous studies suggested that cardiac protection by leonurine during myocardial ischemia appeared to be inextricably linked to its regulation of the liver. At present, however, there are few mechanistic studies of leonurine and its regulation of hepatic metabolism against ischemic injury. In this study, a metabolomics approach was developed to give a global view of the metabolic profiles of the heart and liver during myocardial ischemia. Principal component analysis and orthogonal partial least squares discrimination analysis were applied to filter differential metabolites, and a debiased sparse partial correlation analysis was used to analyze the correlation of the differential metabolites between heart and liver. As a result, a total of thirty-one differential metabolites were identified, six in the myocardial tissue and twenty-five in the hepatic tissue, involving multiple metabolic pathways including glycine, serine and threonine, purine, fatty acid, and amino acid metabolic pathways. Correlation analysis revealed a net of these differential metabolites, suggesting an interaction between hepatic and myocardial metabolism. These results suggest that leonurine may reduce myocardial injury during myocardial ischemia by regulating the metabolism of glycine, serine and threonine, purine, fatty acids, and amino acids in the liver and heart.
MeSH term(s)	Animals ; Rats ; Amino Acids ; Coronary Artery Disease ; Fatty Acids ; Glycine ; Liver/metabolism ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/metabolism ; Purines ; Rats, Sprague-Dawley ; Serine ; Threonine ; Metabolomics
Chemical Substances	Amino Acids ; Fatty Acids ; Glycine (TE7660XO1C) ; leonurine (09Q5W34QDA) ; Purines ; Serine (452VLY9402) ; Threonine (2ZD004190S)
Language	English
Publishing date	2022-10-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12101512
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Article ; Online: Five-lncRNA signature in plasma exosomes serves as diagnostic biomarker for esophageal squamous cell carcinoma.

Jiao, Zichen / Yu, Ao / Rong, Weiwei / He, Xiaofeng / Zen, Ke / Shi, Minke / Wang, Tao

Aging

2020 Volume 12, Issue 14, Page(s) 15002–15010

Abstract: Changes in expression of long non-coding RNAs (lncRNAs) in plasma exosomes can be useful for diagnosis of cancer patients. Here, we conducted a four-stage study to identify plasma exosome lncRNAs with diagnostic potential in esophageal squamous cell ... ...

Abstract	Changes in expression of long non-coding RNAs (lncRNAs) in plasma exosomes can be useful for diagnosis of cancer patients. Here, we conducted a four-stage study to identify plasma exosome lncRNAs with diagnostic potential in esophageal squamous cell carcinoma (ESCC). First, plasma exosome lncRNA expression profiles were examined in ESCC patients, esophagitis patients, and healthy controls using RNA sequencing. Differentially expressed plasma exosome lncRNAs from the lncRNA expression profile were then evaluated by qRT-PCR in a large cohort of ESCC patients, esophagitis patients, and healthy controls. Expression levels of the lncRNAs NR_039819, NR_036133, NR_003353, ENST00000442416.1, and ENST00000416100.1 were significantly higher in exosomes from ESCC patients than non-cancer controls. We also confirmed that levels of these five plasma exosome lncRNAs decreased markedly in ESCC patients after surgery. Our results suggest that these five exosome lncRNAs may serve as highly effective, noninvasive biomarkers for ESCC diagnosis.
MeSH term(s)	Adult ; Biomarkers, Tumor/blood ; Cell-Free Nucleic Acids/blood ; Esophageal Neoplasms/blood ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/blood ; Esophageal Squamous Cell Carcinoma/genetics ; Esophageal Squamous Cell Carcinoma/pathology ; Esophagitis/blood ; Esophagitis/genetics ; Exosomes/metabolism ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Neoplasm Staging ; RNA, Long Noncoding/analysis ; Sequence Analysis, RNA
Chemical Substances	Biomarkers, Tumor ; Cell-Free Nucleic Acids ; RNA, Long Noncoding
Language	English
Publishing date	2020-06-28
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.103559
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Article: Investigation of preclinical pharmacokinetics of

Yu, Lulu / Qian, Xunjia / Feng, Yiheng / Yin, Yujian / Zhang, Xiao-Dan / Wei, Qianqian / Wang, Liyun / Rong, Weiwei / Li, Jie-Jia / Li, Jun-Xu / Zhu, Qing

Frontiers in chemistry

2023 Volume 11, Page(s) 1222560

Abstract: N- ...

Abstract	N-
Language	English
Publishing date	2023-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2023.1222560
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Article ; Online: A Novel Pathway of Functional microRNA Uptake and Mitochondria Delivery.

Liu, Jiachen / Li, Weili / Li, Jianfeng / Song, Eli / Liang, Hongwei / Rong, Weiwei / Jiang, Xinli / Xu, Nuo / Wang, Wei / Qu, Shuang / Gu, Shouyong / Zhang, Yujing / Yu Zhang, Chen- / Zen, Ke

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 24, Page(s) e2300452

Abstract: Extracellular microRNAs (miRNAs) play a critical role in horizontal gene regulation. Uptake of extracellular miRNAs by recipient cells and their intracellular transport, however, remains elusive. Here RNA phase separation is shown as a novel pathway of ... ...

Abstract	Extracellular microRNAs (miRNAs) play a critical role in horizontal gene regulation. Uptake of extracellular miRNAs by recipient cells and their intracellular transport, however, remains elusive. Here RNA phase separation is shown as a novel pathway of miRNA uptake. In the presence of serum, synthetic miRNAs rapidly self-assembly into ≈110 nm discrete nanoparticles, which enable miRNAs' entry into different cells. Depleting serum cationic proteins prevents the formation of such nanoparticles and thus blocks miRNA uptake. Different from lipofectamine-mediated miRNA transfection in which majority of miRNAs are accumulated in lysosomes of transfected cells, nanoparticles-mediated miRNA uptake predominantly delivers miRNAs into mitochondria in a polyribonucleotide nucleotidyltransferase 1(PNPT1)-dependent manner. Functional assays further show that the internalized miR-21 via miRNA phase separation enhances mitochondrial translation of cytochrome b (CYB), leading to increase in adenosine triphosphate (ATP) and reactive oxygen species (ROS) reduction in HEK293T cells. The findings thus reveal a previously unrecognized mechanism for uptake and delivery functional extracellular miRNAs into mitochondria.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; HEK293 Cells ; Gene Expression Regulation ; Biological Transport ; Mitochondria/metabolism ; Exoribonucleases/genetics ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism
Chemical Substances	MicroRNAs ; PNPT1 protein, human (EC 3.1.13.-) ; Exoribonucleases (EC 3.1.-) ; Mitochondrial Proteins
Language	English
Publishing date	2023-06-25
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202300452
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Article ; Online: Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis.

Zhu, Yujie / Zhang, Mingchao / Wang, Weiran / Qu, Shuang / Liu, Minghui / Rong, Weiwei / Yang, Wenwen / Liang, Hongwei / Zeng, Caihong / Zhu, Xiaodong / Li, Limin / Liu, Zhihong / Zen, Ke

Nature communications

2023 Volume 14, Issue 1, Page(s) 1223

Abstract: Renal tubular atrophy is a hallmark of chronic kidney disease. The cause of tubular atrophy, however, remains elusive. Here we report that reduction of renal tubular cell polynucleotide phosphorylase (PNPT1) causes renal tubular translation arrest and ... ...

Abstract	Renal tubular atrophy is a hallmark of chronic kidney disease. The cause of tubular atrophy, however, remains elusive. Here we report that reduction of renal tubular cell polynucleotide phosphorylase (PNPT1) causes renal tubular translation arrest and atrophy. Analysis of tubular atrophic tissues from renal dysfunction patients and male mice with ischemia-reperfusion injuries (IRI) or unilateral ureteral obstruction (UUO) treatment shows that renal tubular PNPT1 is markedly downregulated under atrophic conditions. PNPT1 reduction leads to leakage of mitochondrial double-stranded RNA (mt-dsRNA) into the cytoplasm where it activates protein kinase R (PKR), followed by phosphorylation of eukaryotic initiation factor 2α (eIF2α) and protein translational termination. Increasing renal PNPT1 expression or inhibiting PKR activity largely rescues IRI- or UUO-induced mouse renal tubular injury. Moreover, tubular-specific PNPT1-knockout mice display Fanconi syndrome-like phenotypes with impaired reabsorption and significant renal tubular injury. Our results reveal that PNPT1 protects renal tubules by blocking the mt-dsRNA-PKR-eIF2α axis.
MeSH term(s)	Animals ; Male ; Mice ; Atrophy ; Eukaryotic Initiation Factor-2 ; Kidney ; Mice, Knockout ; Polyribonucleotide Nucleotidyltransferase ; Protein Kinases ; RNA, Double-Stranded ; Renal Insufficiency, Chronic/genetics ; Humans
Chemical Substances	Eukaryotic Initiation Factor-2 ; Polyribonucleotide Nucleotidyltransferase (EC 2.7.7.8) ; Protein Kinases (EC 2.7.-) ; RNA, Double-Stranded ; PNPT1 protein, human (EC 3.1.13.-)
Language	English
Publishing date	2023-03-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-36664-0
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