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Article ; Online: miR-146a-5p affects inflammation response of trophoblast by inhibiting TRAF6/NF-кB signaling pathway

Fang-Rong Chen

Journal of Hainan Medical University, Vol 27, Iss 6, Pp 10-

2021 Volume 14

Abstract: Objective: To investigate the association of Micro-rna (miR)-146a-5p expression with preeclampsia, and further explore the potential mechanism involved. Methods: Compared with the blank control group, the expressions of miR-146a-5p and TRAF6 were ... ...

Abstract	Objective: To investigate the association of Micro-rna (miR)-146a-5p expression with preeclampsia, and further explore the potential mechanism involved. Methods: Compared with the blank control group, the expressions of miR-146a-5p and TRAF6 were detected in lipopolysaccharide (LPS)-induced JEG-3 cells. Chorionic carcinoma cell JEG-3 in vitro culture are divided into control, miR-146a-5p mimic + lipopolysaccharide (lps), miR-146a-5p mimic and miR-146a-5p inhibitor groups. qRT-PCR analysis were used to detect the mRNA of miR- 146a-5p,IL-1β,IL-6, IL-8 and TNF-α. Western blot assays were carried out to determine the protein expression of TRAF6/NF-кB pathway related proteins. Results: 1.miR-146a expression in miR-146a mimic group were significantly higher than the other three groups(P <0.05). 2.Compared with the control group, the expression level of miR-146a-5p in JEG-3 cells induced by LPS was significantly increased, and the expression level of TRAF6 was significantly reduced (P <0.05). 3.Compared with the control group, the mRNA expression levels of IL-1β, IL-6, IL-8, and TNF-αdecreased significantly after using miR-146a mimic (P <0.05). After adding miR-146a inhibitor, the mRNA expression levels of IL-1β, IL-6, IL-8, and TNF-α were significantly increased (P <0.05). However, compared with the mimic + LPS group, the difference was not statistically significant (all P > 0.05). The results of Western Blot showed that the expression of TRAF6 and NF-κB protein in JEG-3 cells decreased significantly after adding miR-146a mimic and increased after adding miR-146a inhibitor. Conclusion: MiR-146-5p can affect the inflammation response of Maternal-fetal interface by inhibiting TRAF6 / NF-кB signaling pathway in preeclampsia.
Keywords	mir-146-5p ; traf6/nf-кb signaling pathway ; trophoblast ; inflammation ; Medicine ; R
Subject code	630
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Population size spatial distribution adjustment at different urban hierarchies in China

Kunhui Ye / Yanming Lyu / Rong Chen

International Journal of Digital Earth, Vol 16, Iss 2, Pp 4368-

2023 Volume 4384

Abstract: Urban population size dynamic adjustment has been widely studied for a long time; however, the dynamic adjustment at the urban hierarchy level remains unknown. This study utilises China’s urban population data to investigate the dynamic adjustment. ... ...

Abstract	Urban population size dynamic adjustment has been widely studied for a long time; however, the dynamic adjustment at the urban hierarchy level remains unknown. This study utilises China’s urban population data to investigate the dynamic adjustment. Specifically, we utilise methods of the Gini coefficient, linear regression, and coefficients of Spearman, and Moran’s I to explore the dynamic adjustment tendency, adjustment rate and correlation of urban population size distribution of different urban hierarchies and groups of different urban hierarchies. We find that the urban population size spatial distribution is gradually even within the same urban hierarchy. The adjustment rate to be even of Megacity II is the highest, and Megacity I is the bottom. We also find the population size spatial distribution of the whole urban system is gradually uneven. We explore the dynamic process by sorting urban hierarchies into six groups. Furthermore, we find there is a complex correlation between different urban hierarchies and global spatial correlation among China cities. These results are valuable as references for Chinese policy-makers and practitioners and will enable them to adopt sustainable land use and urban population management measures. The study outcomes will also benefit future studies on spatial population size distribution in international communities.
Keywords	population size ; urban hierarchy ; spatial distribution ; china cities ; dynamic adjustment ; Mathematical geography. Cartography ; GA1-1776
Subject code	910
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Self-Assembly of Porous Hierarchical BiOBr Sub-Microspheres for Efficient Aerobic Photooxidation of Benzyl Alcohol under Simulated Sunlight Irradiation

Zhigang Wang / Cheng Liu / Fengxi Chen / Rong Chen

Catalysts, Vol 13, Iss 958, p

2023 Volume 958

Abstract: Semiconductor photocatalytic performances can be modulated through morphology modification. Herein porous hierarchical BiOBr microspheres (BiOBr-MS) of ~3 μm was firstly self-assembled without the assistance of a template via a facile solvothermal ... ...

Abstract	Semiconductor photocatalytic performances can be modulated through morphology modification. Herein porous hierarchical BiOBr microspheres (BiOBr-MS) of ~3 μm was firstly self-assembled without the assistance of a template via a facile solvothermal synthesis in triethylene glycol (TEG) at 150 °C for 3 h. KBrO 3 was exploited as a bromine source, which slowly provided bromide ions upon reduction in TEG and controlled the growth and self-assembly of primary BiOBr nanoplates. The addition of PVP during solvothermal synthesis of BiOBr-MS reduced the particle size by about three-fold to generate BiOBr sub-microspheres (BiOBr-sMS) of <1 μm. BiOBr-sMS exhibited significantly higher photocatalytic activity than BiOBr-MS for aerobic photooxidation of benzyl alcohol (BzOH) to benzaldehyde (BzH) under simulated sunlight irradiation (conversions of BzOH (50 mM) over BiOBr-sMS and BiOBr-MS were, respectively, 51.3% and 29.6% with 100% selectivity to BzH after Xenon illumination for 2 h at 25 °C). The photogenerated holes and ·O 2 − were found to be main reactive species for the BzOH oxidation over BiOBr spheres by scavenging tests and spin-trapping EPR spectra. The higher photocatalytic activity of BiOBr-sMS was attributed to its more open hierarchical structure, efficient charge separation, more negative conduction-band position and the generation of larger amounts of ·O 2 − .
Keywords	BiOBr spheres ; hierarchical nanostructures ; photocatalysis ; benzaldehyde ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss

Mingshan Zou / Mao Huang / Jianyun Zhang / Rong Chen

Frontiers in Public Health, Vol

2022 Volume 10

Abstract: Many environmental factors, such as noise, chemicals, and heavy metals, are mostly produced by human activities and easily induce acquired hearing loss. Organophosphorus pesticides (OPs) constitute a large variety of chemicals and have high usage with ... ...

Abstract	Many environmental factors, such as noise, chemicals, and heavy metals, are mostly produced by human activities and easily induce acquired hearing loss. Organophosphorus pesticides (OPs) constitute a large variety of chemicals and have high usage with potentiate damage to human health. Moreover, their metabolites also show a serious potential contamination of soil, water, and air, leading to a serious impact on people's health. Hearing loss affects 430 million people (5.5% of the global population), bringing a heavy burden to individual patients and their families and society. However, the potential risk of hearing damage by OPs has not been taken seriously. In this study, we summarized the effects of OPs on hearing loss from epidemiological population studies and animal experiments. Furthermore, the possible mechanisms of OP-induced hearing loss are elucidated from oxidative stress, DNA damage, and inflammatory response. Overall, this review provides an overview of OP exposure alone or with noise that leads to hearing loss in human and experimental animals.
Keywords	organophosphorus pesticides ; sensorineural hearing loss ; oxidative stress ; DNA damage ; inflammatory response ; Public aspects of medicine ; RA1-1270
Subject code	390
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Recent Advances in Visible-Light-Mediated Amide Synthesis

Bin Lu / Wen-Jing Xiao / Jia-Rong Chen

Molecules, Vol 27, Iss 517, p

2022 Volume 517

Abstract: Visible-light photoredox catalysis has attracted tremendous interest within the synthetic community. As such, the activation mode potentially provides a more sustainable and efficient platform for the activation of organic molecules, enabling the ... ...

Abstract	Visible-light photoredox catalysis has attracted tremendous interest within the synthetic community. As such, the activation mode potentially provides a more sustainable and efficient platform for the activation of organic molecules, enabling the invention of many controlled radical-involved reactions under mild conditions. In this context, amide synthesis via the strategy of photoredox catalysis has received growing interest due to the ubiquitous presence of this structural motif in numerous natural products, pharmaceuticals and functionalized materials. Employing this strategy, a wide variety of amides can be prepared effectively from halides, arenes and even alkanes under irradiation of visible light. These methods provide a robust alternative to well-established strategies for amide synthesis that involve condensation between a carboxylic acid and amine mediated by a stoichiometric activating agent. In this review, the representative progresses made on the synthesis of amides through visible light-mediated radical reactions are summarized.
Keywords	visible light ; photoredox catalysis ; photochemistry ; radical chemistry ; amide synthesis ; amides ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients.

Luhong Wang / Yinan Ding / Chuanyong Zhang / Rong Chen

PLoS ONE, Vol 17, Iss 5, p e

2022 Volume 0269249

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the coronavirus disease (COVID-19), which poses a major threat to humans worldwide. With the continuous progress of the pandemic, a growing number of people are infected with ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the coronavirus disease (COVID-19), which poses a major threat to humans worldwide. With the continuous progress of the pandemic, a growing number of people are infected with SARS-CoV-2, including hepatocellular carcinoma (HCC) patients. However, the relationship between COVID-19 and HCC has not been fully elucidated. In order to provide better treatment for HCC patients infected with SARS-CoV-2, it's urgently needed to identify common targets and find effective drugs for both. In our study, transcriptomic analysis was performed on both selected lung epithelial cell datasets of COVID-19 patients and the datasets of HCC patients to identify the synergistic effect of COVID-19 in HCC patients. What's more, common differentially expressed genes were identified, and a protein-protein interactions network was designed. Then, hub genes and basic modules were detected based on the protein-protein interactions network. Next, functional analysis was performed using gene ontology terminology and the Kyoto Encyclopedia of Genes and Genomes pathway. Finally, protein-protein interactions revealed COVID-19 interaction with key proteins associated with HCC and further identified transcription factor (TF) genes and microRNAs (miRNA) with differentially expressed gene interactions and transcription factor activity. This study reveals that COVID-19 and HCC are closely linked at the molecular level and proposes drugs that may play an important role in HCC patients with COVID-19. More importantly, according to the results of our research, two critical drugs, Ilomastat and Palmatine, may be effective for HCC patients with COVID-19, which provides clinicians with a novel therapeutic idea when facing possible complications in HCC patients with COVID-19.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Deep Learning Enabled Diagnosis of Children’s ADHD Based on the Big Data of Video Screen Long-Range EEG

Dingfu Zhou / Zhihang Liao / Rong Chen

Journal of Healthcare Engineering, Vol

2022 Volume 2022

Abstract: Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children. At the same time, ADHD is prone to coexist with other mental disorders, so the diagnosis of ADHD in children is very important. Electroencephalogram (EEG) ...

Abstract	Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children. At the same time, ADHD is prone to coexist with other mental disorders, so the diagnosis of ADHD in children is very important. Electroencephalogram (EEG) is the sum of the electrical activity of local neurons recorded from the extracranial scalp or intracranial. At present, there are two main methods of long-range EEG monitoring commonly used in clinical practice: one is ambulatory EEG monitoring, and the other is long-range video EEG monitoring. The purpose of this study is to summarize the brain electrical activity and clinical characteristics of children with ADHD through the video long-range computer graphics data of children with ADHD and to explore the clinical significance of video long-range EEG in the diagnosis of children with ADHD. For a more effective analysis, this study further processed the video data of long-range computer graphics of children with ADHD and constructed several neural network algorithm models based on deep learning, mainly including fully connected neural network models and two-dimensional convolutional neural networks. Model and long- and short-term memory neural network model. By comparing the recognition effects of these several algorithms, find the appropriate recognition algorithm to improve the accuracy and then establish a recognition method for the diagnosis of children’s ADHD based on deep learning long-range EEG big data. Finally, it is concluded that long-term video EEG can analyze the EEG relationship of children with ADHD and provide a diagnostic basis for the diagnosis of ADHD.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Subject code	616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients

Luhong Wang / Yinan Ding / Chuanyong Zhang / Rong Chen

PLoS ONE, Vol 17, Iss

2022 Volume 5

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the coronavirus disease (COVID-19), which poses a major threat to humans worldwide. With the continuous progress of the pandemic, a growing number of people are infected with SARS-CoV-2, including hepatocellular carcinoma (HCC) patients. However, the relationship between COVID-19 and HCC has not been fully elucidated. In order to provide better treatment for HCC patients infected with SARS-CoV-2, it’s urgently needed to identify common targets and find effective drugs for both. In our study, transcriptomic analysis was performed on both selected lung epithelial cell datasets of COVID-19 patients and the datasets of HCC patients to identify the synergistic effect of COVID-19 in HCC patients. What’s more, common differentially expressed genes were identified, and a protein-protein interactions network was designed. Then, hub genes and basic modules were detected based on the protein-protein interactions network. Next, functional analysis was performed using gene ontology terminology and the Kyoto Encyclopedia of Genes and Genomes pathway. Finally, protein-protein interactions revealed COVID-19 interaction with key proteins associated with HCC and further identified transcription factor (TF) genes and microRNAs (miRNA) with differentially expressed gene interactions and transcription factor activity. This study reveals that COVID-19 and HCC are closely linked at the molecular level and proposes drugs that may play an important role in HCC patients with COVID-19. More importantly, according to the results of our research, two critical drugs, Ilomastat and Palmatine, may be effective for HCC patients with COVID-19, which provides clinicians with a novel therapeutic idea when facing possible complications in HCC patients with COVID-19.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of virtual reality balance games combined with muscle strength training on balance function and motor ability of Parkinson's patients

Li-Chun Sun / Rong Chen

Journal of Hainan Medical University, Vol 26, Iss 9, Pp 15-

2020 Volume 18

Abstract: Objective To investigate the effects of virtual reality balance games combined with strengthening muscle training on balance function and exercise capacity in patients with Parkinson's disease. Methods Sixty patients with Parkinson's disease were ... ...

Abstract	Objective To investigate the effects of virtual reality balance games combined with strengthening muscle training on balance function and exercise capacity in patients with Parkinson's disease. Methods Sixty patients with Parkinson's disease were selected from January 2018 to October 2019. The random number table method was divided into the control group (n = 30) and the observation group (n = 30). Both groups were given conventional drugs and For rehabilitation training, the observation group was given a virtual reality balance game combined with strengthening muscle training. The upper limbs, lower limbs, balance function, comprehensive rehabilitation effect and daily living ability were compared before and after training. Results After training, the Brunnstrom score, FMA-UE, FMA-LE score, and cadence score of the two groups of patients increased. The common contraction rate (CR) of the biceps brachii in elbow flexion and the three heads of the brachii in elbow extension Muscle CR, standing walking test, 10m walking test, reduced left and right step difference, and the observation group was better than the control group, which was significant (P <0.05). Conclusion Patients with Parkinson's disease have improved their upper and lower extremity motor capacity and balance function through virtual reality balance games combined with strengthening muscle training, which can improve the overall rehabilitation effect and ability of daily living.
Keywords	parkinson's disease ; balance movement ; virtual reality balance games ; strengthen muscle strength trainin ; Medicine ; R
Subject code	796
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Editorial Board of Journal of Hainan Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A new equation for estimating low-density lipoprotein cholesterol concentration based on machine learning.

Chen, Lei / Rong, Chen / Ma, Peidu / Li, Yiyang / Deng, Xue / Hua, Muxing

Medicine

2024 Volume 103, Issue 15, Page(s) e37766

Abstract: Low-density lipoprotein cholesterol (LDL-C) is a crucial marker of cardiovascular system damage. In the Chinese population, the estimation of LDL-C concentration by Friedewald, Martin-Hopkins or Sampson equations is not accurate. The aim of this study ... ...

Abstract	Low-density lipoprotein cholesterol (LDL-C) is a crucial marker of cardiovascular system damage. In the Chinese population, the estimation of LDL-C concentration by Friedewald, Martin-Hopkins or Sampson equations is not accurate. The aim of this study was to develop a group of new equations for calculating LDL-C concentration using machine learning techniques and to evaluate their efficacy. A total of 182,901 patient samples were collected with standard lipid panel measurements. These samples were collated and randomly divided into a training set and a test set. In the training set, a new equation was constructed using polynomial ridge-regression and compared to the Friedewald, Martin/Hopkins and extended Martin/Hopkins, or Sampson equations in the test set. Subsequently, an additional set of 17,285 patient samples were collected to evaluate the performance of the new equation in clinical practice. The new equation, a ternary cubic equation, was accurate and easy to use, with a goodness-of-fit R2 of 0.9815 and an uncertainty MSE of 37.4250 on the testing set. The difference between the calculated value by the new equation and the measured value of LDL-C was small (0.0424 ± 5.1161 vs Friedewald equation: -13.3647 ± 17.9198, vs Martin/Hopkins and extended Martin/Hopkins equation: -6.4737 ± 8.1036, vs Sampson equation: -8.9252 ± 12.6522, P < .001). It could accurately calculate LDL-C concentration even at high triglyceride and low LDL-C. Furthermore, the new equation could also precisely calculate LDL-C concentration in actual clinical use (R2 = 0.9780, MSE = 24.8482). The new equation developed in this study can accurately calculate LDL-C concentration within the full concentration range of triglyceride and LDL-C, and can serve as a supplement to the direct determination of LDL-C concentration for the prevention, treatment, evaluation, and monitoring of atherosclerotic diseases, compared to the Friedewald, Martin/Hopkins and extended Martin/Hopkins, or Sampson equations.
MeSH term(s)	Humans ; Cholesterol, LDL ; Asian People ; Dietary Supplements ; Machine Learning ; Triglycerides
Chemical Substances	Cholesterol, LDL ; Triglycerides
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037766
Database	MEDical Literature Analysis and Retrieval System OnLINE

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