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  1. Article ; Online: Dual inhibition of CDK4 and FYN leads to selective cell death in KRAS-mutant colorectal cancer

    Yan Wang / Rongjie Lin / Huan Ling / Yuan Ke / Yangyang Zeng / Yudi Xiong / Qian Zhou / Fuxiang Zhou / Yunfeng Zhou

    Signal Transduction and Targeted Therapy, Vol 4, Iss 1, Pp 1-

    2019  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Future changes in Yuan River ecohydrology: Individual and cumulative impacts of climates change and cascade hydropower development on runoff and aquatic habitat quality

    Wen, Xin / Chao Wang / Guohua Fang / Jin Quan / Qiaofeng Tan / Rongjie Lin / Xiaohui Lei / Yu Tian / Zhehua Liu

    Science of the total environment. 2018 Aug. 15, v. 633

    2018  

    Abstract: The eco-hydrological system in southwestern China is undergoing great changes in recent decades owing to climate change and extensive cascading hydropower exploitation. With a growing recognition that multiple drivers often interact in complex and ... ...

    Abstract The eco-hydrological system in southwestern China is undergoing great changes in recent decades owing to climate change and extensive cascading hydropower exploitation. With a growing recognition that multiple drivers often interact in complex and nonadditive ways, the purpose of this study is to predict the potential future changes in streamflow and fish habitat quality in the Yuan River and quantify the individual and cumulative effect of cascade damming and climate change. The bias corrected and spatial downscaled Coupled Model Intercomparison Project Phase 5 (CMIP5) General Circulation Model (GCM) projections are employed to drive the Soil and Water Assessment Tool (SWAT) hydrological model and to simulate and predict runoff responses under diverse scenarios. Physical habitat simulation model is established to quantify the relationship between river hydrology and fish habitat, and the relative change rate is used to assess the individual and combined effects of cascade damming and climate change. Mean annual temperature, precipitation and runoff in 2015–2100 show an increasing trend compared with that in 1951–2010, with a particularly pronounced difference between dry and wet years. The ecological habitat quality is improved under cascade hydropower development since that ecological requirement has been incorporated in the reservoir operation policy. As for middle reach, the runoff change from January to August is determined mainly by damming, and climate change influence becomes more pronounced in dry seasons from September to December. Cascade development has an effect on runoff of lower reach only in dry seasons due to the limited regulation capacity of reservoirs, and climate changes have an effect on runoff in wet seasons. Climate changes have a less significant effect on fish habitat quality in middle reach than damming, but a more significant effect in lower reach. In addition, the effect of climate changes on fish habitat quality in lower reach is high in dry seasons but low in flood seasons.
    Keywords aquatic habitat ; climate change ; dams (hydrology) ; dry season ; fish ; General Circulation Models ; issues and policy ; rivers ; runoff ; simulation models ; Soil and Water Assessment Tool model ; stream flow ; temperature ; water power ; wet season ; China
    Language English
    Dates of publication 2018-0815
    Size p. 1403-1417.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2018.03.309
    Database NAL-Catalogue (AGRICOLA)

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