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  1. Article ; Online: Alkaline phosphatase treatment of acute kidney injury - an update.

    Steenvoorden, Thei S / Rood, Janneke A J / Bemelman, Frederike J / Armstrong-Jr, Roberto / Leuvenink, Henri G D / van der Heijden, Joost W / Vogt, Liffert

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2024  

    Abstract: Through improved insight in the increasing incidence and detrimental effects of acute kidney injury (AKI), its clinical relevance has become more and more apparent. Although treatment strategies for AKI have also somewhat improved, an adequate remedy ... ...

    Abstract Through improved insight in the increasing incidence and detrimental effects of acute kidney injury (AKI), its clinical relevance has become more and more apparent. Although treatment strategies for AKI have also somewhat improved, an adequate remedy still does not exist. Finding one is complicated by a multifactorial pathophysiology and by heterogeneity in the patient population. Alkaline phosphatase (AP) has been suggested as a therapy for sepsis-associated AKI because of its protective effects against lipopolysaccharide (LPS) induced inflammation and kidney injury in animals. However, translation of these protective effects into tangible clinical benefit has proven difficult. Because the anti-inflammatory properties of AP are likely not reliant on a direct effect on LPS itself, we postulate that other pathways are much more important in explaining the renoprotective properties ascribed to AP. The reevaluation of which properties of the AP enzyme are responsible for the benefit seen in the lab, is an important step to determine where the true potential of AP as a treatment strategy for AKI in the clinic lies. In this review, we will discuss how AP can prevent activation of harmful pro-inflammatory receptors, redirect cell-cell signaling, and protect barrier tissues, which together form the basis for current knowledge of the role of AP in the kidney. With this knowledge in mind and by analyzing currently available clinical evidence, we propose directions for new research that can determine whether AP as a treatment strategy for AKI has a future in the clinical field.
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfae028
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    Zs.A 2198: Show issues Location:
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  2. Article ; Online: Alkaline phosphatase to treat ischaemia-reperfusion injury in living-donor kidney transplantation: APhIRI I feasibility pilot study.

    Steenvoorden, Thei S / van Duin, Robert E / Rood, Janneke A J / Peters-Sengers, Hessel / Nurmohamed, Azam S / Bemelman, Frederike J / Vogt, Liffert / van der Heijden, Joost W

    British journal of clinical pharmacology

    2023  Volume 89, Issue 12, Page(s) 3629–3636

    Abstract: Aims: Ischemia-reperfusion injury (IRI) during kidney transplant procedures is associated with adverse outcome. Alkaline phosphatase (AP) is an enzyme that has the potential to dampen IRI. Prior to this study, it had not been tested in the setting of ... ...

    Abstract Aims: Ischemia-reperfusion injury (IRI) during kidney transplant procedures is associated with adverse outcome. Alkaline phosphatase (AP) is an enzyme that has the potential to dampen IRI. Prior to this study, it had not been tested in the setting of kidney transplantation. This study aimed to evaluate the safety and feasibility of peri-procedural AP administration in living donor kidney transplantation.
    Methods: In this double blind, randomized, placebo-controlled, single-center pilot study, all eligible recipients of living donor kidneys were asked to give informed consent. AP (bRESCAP) or a placebo was administered intravenously over 24 hours after the transplantation procedure. The primary outcome-graft function at 1 year-was represented by iohexol measured glomerular filtration rate (mGFR). Serum and urine biomarkers within seven days after surgery were used as surrogate markers of kidney function and injury.
    Results: Eleven patients were enrolled of whom five were treated with bRESCAP and six with placebo. After 1 year, mGFR was not different between groups. No specific adverse events were observed in the bRESCAP group. Urine expression of injury biomarkers CCL14, NGAL and Cystatin C was lower in the bRESCAP group at day seven. This was statistically significant.
    Conclusion: This study illustrates that bRESCAP treatment is feasible in kidney transplantation, might have a dampening effect on IRI induced renal inflammation, and raises no safety concerns. Future research will evaluate the effects of bRESCAP treatment in donation after circulatory death kidney transplantation where IRI is more pronounced.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Alkaline Phosphatase ; Pilot Projects ; Living Donors ; Feasibility Studies ; Kidney ; Reperfusion Injury/etiology ; Biomarkers
    Chemical Substances Alkaline Phosphatase (EC 3.1.3.1) ; Biomarkers
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15871
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  3. Article ; Online: Reply to: "Discussing sexuality in cancer care: towards personalized information for cancer patients and survivors".

    Eeltink, Corien M / Rood, Janneke A J / Nauta, Irene H / Lissenberg-Witte, Birgit I / Incrocci, Luca / Visser, Otto / Verdonck-de Leeuw, Irma M / Zweegman, Sonja

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2020  Volume 29, Issue 2, Page(s) 535–537

    MeSH term(s) Humans ; Neoplasms/therapy ; Sexual Behavior ; Sexuality ; Survivors
    Language English
    Publishing date 2020-07-15
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-020-05625-4
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    Zs.A 3697: Show issues Location:
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  4. Article ; Online: The need for information among patients with hematological malignancies: Psychometric analyses of the 62-item Hematology Information Needs Questionnaire (HINQ-62).

    Rood, Janneke A J / Lissenberg-Witte, Birgit I / Eeltink, Corien / Stam, Frank / van Zuuren, Florence J / Zweegman, Sonja / Verdonck-de Leeuw, Irma M

    PloS one

    2018  Volume 13, Issue 8, Page(s) e0201699

    Abstract: The purpose of this study was to investigate the psychometric characteristics (content validity, internal consistency, and subscale structure) of the Hematology Information Needs Questionnaire-62 (HINQ-62), a patient reported outcome measure (PROM) for ... ...

    Abstract The purpose of this study was to investigate the psychometric characteristics (content validity, internal consistency, and subscale structure) of the Hematology Information Needs Questionnaire-62 (HINQ-62), a patient reported outcome measure (PROM) for assessing the need for information among patients with hematological malignancies (HM-patients). Baseline data were used from a prospective study on the need for information which 336 newly diagnosed HM-patients had completed. In phase 1 (design phase), data from the first 135 patients were used and in phase 2 (validation phase), data from the remaining 201 HM patients were used. Content validity was analyzed by examining irrelevance of items. Items were considered irrelevant if more than 10% of the patients scored totally disagree on that item. The subscale structure of the HINQ-62 was investigated with Factor analysis (FA) (exploratory FA in phase 1 and confirmatory FA in phase 2). Cronbach's α was computed for the different subscales and >.70 was considered as good internal consistency. None of the 62 HINQ-items were irrelevant. Exploratory FA identified five subscales: "Disease, symptoms, treatment and side-effects", "Etiology, sleep and physical changes", "Self-care", "Medical tests and prognosis", and "Psychosocial". Root Mean Square Error of Approximation (RMSEA) among patients was 0.037 in phase 1 and 0.045 in phase 2. The comparative fit index (CFI)/Tucker-Lewis index -non-normed fit index among patients was 0.984/0.983 and 0.948/0.946, in phase 1 and 2 respectively. The internal consistency of the subscales was good, with Cronbach's α 0.82-0.99. The HINQ is a valid PROM for assessing the need for information among Dutch HM-patients at diagnosis.
    MeSH term(s) Female ; Health Knowledge, Attitudes, Practice ; Hematologic Neoplasms ; Humans ; Male ; Middle Aged ; Patient Reported Outcome Measures ; Psychometrics ; Surveys and Questionnaires
    Language English
    Publishing date 2018-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0201699
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  5. Article ; Online: Perceived need for information of patients with haematological malignancies: a literature review.

    Rood, Janneke A J / Eeltink, Corien M / van Zuuren, Florence J / Verdonck-de Leeuw, Irma M / Huijgens, Peter C

    Journal of clinical nursing

    2015  Volume 24, Issue 3-4, Page(s) 353–369

    Abstract: Aims and objectives: To provide insight into the perceived need for information of patients with haematological malignancies.: Background: Providing timely and accurate information to patients diagnosed with a haematological malignancy is a challenge ...

    Abstract Aims and objectives: To provide insight into the perceived need for information of patients with haematological malignancies.
    Background: Providing timely and accurate information to patients diagnosed with a haematological malignancy is a challenge in clinical practice; treatment often has to start promptly, with little time to inform patients.
    Design: Literature review.
    Methods: A comprehensive literature search was conducted from all available literature to May 2013 in the databases: Cumulative Index to Nursing and Allied Health Literature, PsycINFO and PubMed (Medline). Relevant studies were reviewed regarding the perceived need for information on various topics, sources of information and satisfaction with information provided.
    Results: The initial search revealed 215 articles, fourteen of which were relevant. Patients need basic information on the disease (diagnosis and diagnostics), treatment (various treatment options, side effects and duration), prognosis (curability and prolonging life) and all other topics (recovery, self-care and psychosocial functioning). Need for detailed information varied between studies. Patients expressed a higher need for medical than for psychosocial information. Patients preferred to receive information from their doctors the most, followed by nurses. Most studies described patients' satisfaction with the information provided.
    Conclusion: Based on the limited number of data available, medical information is for patients of higher priority compared to psychosocial information. Patients need basic information on diagnosis, treatment, prognosis and all other topics. Need for detailed information varied between studies. Patients were satisfied with the provided information, preferably offered by doctors and nurses.
    Relevance to clinical practice: The perceived need for information and satisfaction with the information provided differs strongly between patients. In clinical practice, more attention is needed for information tailored to the patient, taking into account important moderating factors such as age, type of cancer, time since diagnosis, treatment modality and coping style.
    MeSH term(s) Adult ; Aged ; Health Services Needs and Demand ; Hematologic Neoplasms/nursing ; Hematologic Neoplasms/psychology ; Humans ; Information Seeking Behavior ; Male ; Middle Aged ; Nursing Process ; Patient Education as Topic ; Patient Satisfaction
    Language English
    Publishing date 2015-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1159483-4
    ISSN 1365-2702 ; 0962-1067 ; 1752-9816
    ISSN (online) 1365-2702
    ISSN 0962-1067 ; 1752-9816
    DOI 10.1111/jocn.12630
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    Zs.A 3764: Show issues Location:
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  6. Article ; Online: Cognitive coping style (monitoring and blunting) and the need for information, information satisfaction and shared decision making among patients with haematological malignancies.

    Rood, Janneke A J / Van Zuuren, Florence J / Stam, Frank / van der Ploeg, Tjeerd / Huijgens, Peter C / Verdonck-de Leeuw, Irma M

    Psycho-oncology

    2015  Volume 24, Issue 5, Page(s) 564–571

    Abstract: Objective: A haematological malignancy is a serious, life-altering disease and may be characterised as an uncontrollable and unpredictable stress situation. In dealing with potentially threatening information, individuals generally utilise two main ... ...

    Abstract Objective: A haematological malignancy is a serious, life-altering disease and may be characterised as an uncontrollable and unpredictable stress situation. In dealing with potentially threatening information, individuals generally utilise two main cognitive coping styles: monitoring (the tendency to seek threat-relevant information) and blunting (avoiding threatening information and seeking distraction). The aim of this study was to obtain insight into the association between cognitive coping style and (a) need for information, (b) satisfaction with information, (c) involvement in decision making, and (d) quality of life (QoL).
    Methods: In this cross-sectional study, coping style was assessed among adult patients diagnosed with a haematological malignancy, using an adapted version of the Threatening Medical Situations Inventory. Information need, information satisfaction, decision-making preference and QoL were measured with validated questionnaires.
    Results: In total, 458 patients returned the questionnaire (66%). A monitoring coping style was positively related to need for both general and specific information. Blunting was positively and QoL was negatively related to need for information. Monitoring was positively related to involvement in decision-making and negatively to information satisfaction. Using multivariate analysis, this relation between monitoring and information satisfaction disappeared, and for blunting, we found a negatively significant relation. QoL was not related to coping style.
    Conclusions: Among patients with haematological malignancies, coping style is related to a need for information, information satisfaction, and involvement in treatment decision-making. Therefore, it is important for health care professionals to be aware of individual differences in cognitive coping style.
    MeSH term(s) Adaptation, Psychological ; Cognition ; Cross-Sectional Studies ; Decision Making ; Female ; Hematologic Neoplasms/psychology ; Humans ; Information Seeking Behavior ; Male ; Middle Aged ; Multivariate Analysis ; Patient Education as Topic ; Patient Participation/psychology ; Patient Satisfaction ; Quality of Life/psychology ; Regression Analysis ; Stress, Psychological/psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1118536-3
    ISSN 1099-1611 ; 1057-9249
    ISSN (online) 1099-1611
    ISSN 1057-9249
    DOI 10.1002/pon.3699
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    Zs.A 3550: Show issues Location:
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  7. Article ; Online: Perceived need for information among patients with a haematological malignancy: associations with information satisfaction and treatment decision-making preferences.

    Rood, Janneke A J / van Zuuren, Florence J / Stam, Frank / van der Ploeg, Tjeerd / Eeltink, Corien / Verdonck-de Leeuw, Irma M / Huijgens, Peter C

    Hematological oncology

    2015  Volume 33, Issue 2, Page(s) 85–98

    Abstract: For patients with haematological malignancies, information on disease, prognosis, treatment and impact on quality of life is of the utmost importance. To gain insight into the perceived need for information in relation to sociodemographic and clinical ... ...

    Abstract For patients with haematological malignancies, information on disease, prognosis, treatment and impact on quality of life is of the utmost importance. To gain insight into the perceived need for information in relation to sociodemographic and clinical parameters, comorbidity, quality of life (QoL) and information satisfaction, we compiled a questionnaire based on existing validated questionnaires. A total of 458 patients diagnosed with a haematological malignancy participated. The perceived need for information was moderate to high (40-70%). Multivariate regression analyses showed that a higher need for information was related to younger age, worse QoL, being member of a patient society and moderate comorbidity. The need for disease and treatment-related information was higher than the need for psychosocial information. A higher need for disease and treatment-related information was associated to being diagnosed with multiple myeloma. A higher need for psychosocial information was related to a lower educational level. The information provision could be improved according to 41% of the patients. Higher satisfaction with provided information was associated with better QoL. Most patients (62%) reported that they wanted to be fully informed about their illness and actively involved in treatment decision-making. The results contribute to improving patient-tailored information provision and shared decision-making in clinical practice.
    MeSH term(s) Age Factors ; Aged ; Attitude to Health ; Comorbidity ; Decision Making ; Educational Status ; Female ; Health Literacy ; Health Services Needs and Demand ; Hematologic Neoplasms/psychology ; Hematologic Neoplasms/therapy ; Humans ; Information Seeking Behavior ; Male ; Middle Aged ; Netherlands ; Patient Participation/psychology ; Patient Satisfaction ; Professional-Patient Relations ; Psychology ; Quality of Life ; Self-Help Groups ; Surveys and Questionnaires
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.2138
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