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Article ; Online: Time-dependent memory transformation in hippocampus and neocortex is semantic in nature.

Krenz, Valentina / Alink, Arjen / Sommer, Tobias / Roozendaal, Benno / Schwabe, Lars

2023 Volume 14, Issue 1, Page(s) 6037

Abstract: Memories undergo a time-dependent neural reorganization, which is assumed to be accompanied by a transformation from detailed to more gist-like memory. However, the nature of this transformation and its underlying neural mechanisms are largely unknown. ... ...

Abstract	Memories undergo a time-dependent neural reorganization, which is assumed to be accompanied by a transformation from detailed to more gist-like memory. However, the nature of this transformation and its underlying neural mechanisms are largely unknown. Here, we report that the time-dependent transformation of memory is semantic in nature, while we find no credible evidence for a perceptual transformation. Model-based MRI analyses reveal time-dependent increases in semantically transformed representations of events in prefrontal and parietal cortices, while specific pattern representations in the anterior hippocampus decline over time. Posterior hippocampal memory reinstatement, in turn, increases over time and is linked to the semantic gist of the original memory, without a statistically significant link to perceptual details. These findings indicate that qualitative changes in memory over time, associated with distinct representational changes in the neocortex and within the hippocampus, reflect a semantic transformation, which may promote the integration of memories into abstract knowledge structures.
MeSH term(s)	Humans ; Hippocampus ; Neocortex/diagnostic imaging ; Parietal Lobe ; Semantics ; Memory
Language	English
Publishing date	2023-09-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41648-1
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Article ; Online: Glucocorticoid effects on working memory impairment require l-type calcium channel activity within prefrontal cortex.

Barsegyan, Areg / McGaugh, James L / Roozendaal, Benno

Neurobiology of learning and memory

2022 Volume 197, Page(s) 107700

Abstract: Previous findings have indicated that glucocorticoid hormones impair working memory via an interaction with the β-adrenoceptor-cAMP signaling cascade to rapidly increase cAMP-dependent protein kinase (PKA) activity within the prefrontal cortex (PFC). ... ...

Abstract	Previous findings have indicated that glucocorticoid hormones impair working memory via an interaction with the β-adrenoceptor-cAMP signaling cascade to rapidly increase cAMP-dependent protein kinase (PKA) activity within the prefrontal cortex (PFC). However, it remains elusive how such activation of PKA can affect downstream cellular mechanisms in regulating PFC cognitive function. PKA is known to activate l-type voltage-gated Ca
MeSH term(s)	Rats ; Animals ; Male ; Memory, Short-Term/physiology ; Glucocorticoids/pharmacology ; Calcium Channels, L-Type/metabolism ; Rats, Sprague-Dawley ; Diltiazem/metabolism ; Diltiazem/pharmacology ; Memory Disorders ; Prefrontal Cortex/physiology
Chemical Substances	Glucocorticoids ; adenosine-3',5'-cyclic phosphorothioate (23645-17-2) ; Calcium Channels, L-Type ; Diltiazem (EE92BBP03H)
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1223366-3
ISSN	1095-9564 ; 1074-7427
ISSN (online)	1095-9564
ISSN	1074-7427
DOI	10.1016/j.nlm.2022.107700
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Article ; Online: Opposite effects of noradrenergic and glucocorticoid activation on accuracy of an episodic-like memory.

Roozendaal, Benno / Mirone, Gabriele

Psychoneuroendocrinology

2020 Volume 114, Page(s) 104588

Abstract: Stressful and emotionally arousing experiences activate hormonal systems that create strong memories. It remains unclear, however, how this strengthening affects the quality of such memories. In the present study, we examined whether the noradrenergic ... ...

Abstract	Stressful and emotionally arousing experiences activate hormonal systems that create strong memories. It remains unclear, however, how this strengthening affects the quality of such memories. In the present study, we examined whether the noradrenergic and glucocorticoid hormonal systems affect accuracy of episodic-like memory. We trained male Sprague-Dawley rats on an episodic-like association task, termed inhibitory avoidance discrimination task, in which they explored two different contexts, but shock was given only in the latter context. Forty-eight hours later, retention latencies were tested in the two training contexts as well as in a novel context. The noradrenergic stimulant yohimbine, administered systemically immediately after the training session, enhanced both accuracy and strength of the memory, as shown by long latencies specific to the shock context. By contrast, the glucocorticoid corticosterone induced a generalized strengthening of memory and enhanced latencies in both the shock and non-shock training contexts. Retention latencies in the novel context were not significantly affected. These findings indicate that the noradrenergic and glucocorticoid systems, while both strengthening memory of the shock experience per se, produce opposite effects on accuracy of the shock-context association.
MeSH term(s)	Adrenergic alpha-2 Receptor Antagonists/pharmacology ; Animals ; Avoidance Learning/drug effects ; Avoidance Learning/physiology ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Conditioning, Classical/drug effects ; Conditioning, Classical/physiology ; Corticosterone/pharmacology ; Discrimination Learning/drug effects ; Discrimination Learning/physiology ; Glucocorticoids/pharmacology ; Glucocorticoids/physiology ; Inhibition, Psychological ; Male ; Memory, Episodic ; Norepinephrine/physiology ; Psychomotor Performance/drug effects ; Psychomotor Performance/physiology ; Rats ; Rats, Sprague-Dawley ; Retention, Psychology/drug effects ; Retention, Psychology/physiology ; Yohimbine/pharmacology
Chemical Substances	Adrenergic alpha-2 Receptor Antagonists ; Glucocorticoids ; Yohimbine (2Y49VWD90Q) ; Corticosterone (W980KJ009P) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2020-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2020.104588
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Article ; Online: Mechanisms of memory under stress.

Schwabe, Lars / Hermans, Erno J / Joëls, Marian / Roozendaal, Benno

Neuron

2022 Volume 110, Issue 9, Page(s) 1450–1467

Abstract: It is well established that stress has a major impact on memory, driven by the concerted action of various stress mediators on the brain. Recent years, however, have seen considerable advances in our understanding of the cellular, neural network, and ... ...

Abstract	It is well established that stress has a major impact on memory, driven by the concerted action of various stress mediators on the brain. Recent years, however, have seen considerable advances in our understanding of the cellular, neural network, and cognitive mechanisms through which stress alters memory. These novel insights highlight the intricate interplay of multiple stress mediators, including-beyond corticosteroids, catecholamines, and peptides-for instance, endocannabinoids, which results in time-dependent shifts in large-scale neural networks. Such stress-induced network shifts enable highly specific memories of the stressful experience in the long run at the cost of transient impairments in mnemonic flexibility during and shortly after a stressful event. Based on these recent discoveries, we provide a new integrative framework that links the cellular, systems, and cognitive mechanisms underlying acute stress effects on memory processes and points to potential targets for treating aberrant memory in stress-related mental disorders.
MeSH term(s)	Brain ; Catecholamines ; Humans ; Memory
Chemical Substances	Catecholamines
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2022.02.020
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Noradrenergic arousal after encoding reverses the course of systems consolidation in humans.

Krenz, Valentina / Sommer, Tobias / Alink, Arjen / Roozendaal, Benno / Schwabe, Lars

Nature communications

2021 Volume 12, Issue 1, Page(s) 6054

Abstract: It is commonly assumed that episodic memories undergo a time-dependent systems consolidation process, during which hippocampus-dependent memories eventually become reliant on neocortical areas. Here we show that systems consolidation dynamics can be ... ...

Abstract	It is commonly assumed that episodic memories undergo a time-dependent systems consolidation process, during which hippocampus-dependent memories eventually become reliant on neocortical areas. Here we show that systems consolidation dynamics can be experimentally manipulated and even reversed. We combined a single pharmacological elevation of post-encoding noradrenergic activity through the α
MeSH term(s)	Adult ; Arousal ; Double-Blind Method ; Female ; Hippocampus/drug effects ; Hippocampus/physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Memory Consolidation/drug effects ; Memory, Episodic ; Memory, Long-Term/drug effects ; Memory, Long-Term/physiology ; Norepinephrine/pharmacology ; Recognition, Psychology/drug effects ; Recognition, Psychology/physiology ; Yohimbine/pharmacology ; Young Adult
Chemical Substances	Yohimbine (2Y49VWD90Q) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2021-10-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-26250-7
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Article ; Online: Glucocorticoid-induced enhancement of extinction-from animal models to clinical trials.

de Quervain, Dominique / Wolf, Oliver T / Roozendaal, Benno

Psychopharmacology

2019 Volume 236, Issue 1, Page(s) 183–199

Abstract: Extensive evidence from both animal model and human research indicates that glucocorticoid hormones are crucially involved in modulating memory performance. Glucocorticoids, which are released during stressful or emotionally arousing experiences, enhance ...

Abstract	Extensive evidence from both animal model and human research indicates that glucocorticoid hormones are crucially involved in modulating memory performance. Glucocorticoids, which are released during stressful or emotionally arousing experiences, enhance the consolidation of new memories, including extinction memory, but reduce the retrieval of previously stored memories. These memory-modulating properties of glucocorticoids have recently received considerable interest for translational purposes because strong aversive memories lie at the core of several fear-related disorders, including post-traumatic stress disorder and phobias. Moreover, exposure-based psychological treatment of these disorders relies on successful fear extinction. In this review, we argue that glucocorticoid-based interventions facilitate fear extinction by reducing the retrieval of aversive memories and enhancing the consolidation of extinction memories. Several clinical trials have already indicated that glucocorticoids might be indeed helpful in the treatment of fear-related disorders.
MeSH term(s)	Animals ; Clinical Trials as Topic/methods ; Disease Models, Animal ; Emotions/drug effects ; Emotions/physiology ; Extinction, Psychological/drug effects ; Extinction, Psychological/physiology ; Fear/drug effects ; Fear/physiology ; Fear/psychology ; Glucocorticoids/pharmacology ; Glucocorticoids/therapeutic use ; Humans ; Memory/drug effects ; Memory/physiology ; Stress Disorders, Post-Traumatic/drug therapy ; Stress Disorders, Post-Traumatic/psychology
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2019-01-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-018-5116-0
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Article: Noradrenergic arousal after encoding reverses the course of systems consolidation in humans

Krenz, Valentina / Sommer, Tobias / Alink, Arjen / Roozendaal, Benno / Schwabe, Lars

Nature Communications

2021 Volume 12, Issue 1, Page(s) No

Title translation	Noradrenerge Erregung nach der Kodierung kehrt den Verlauf der Systemkonsolidierung beim Menschen um (DeepL)
Abstract	It is commonly assumed that episodic memories undergo a time-dependent systems consolidation process, during which hippocampus-dependent memories eventually become reliant on neocortical areas. Here we show that systems consolidation dynamics can be experimentally manipulated and even reversed. We combined a single pharmacological elevation of post-encoding noradrenergic activity through the alpha(2)-adrenoceptor antagonist yohimbine with fMRI scanning both during encoding and recognition testing either 1 or 28 days later. We show that yohimbine administration, in contrast to placebo, leads to a time-dependent increase in hippocampal activity and multivariate encoding-retrieval pattern similarity, an indicator of episodic reinstatement, between 1 and 28 days. This is accompanied by a time-dependent decrease in neocortical activity. Behaviorally, these neural changes are linked to a reduced memory decline over time after yohimbine intake. These findings indicate that noradrenergic activity shortly after encoding may alter and even reverse systems consolidation in humans, thus maintaining vividness of memories over time.
Keywords	Adrenerge Hemmstoffe ; Adrenergic Blocking Drugs ; Episodic Memory ; Episodisches Gedächtnis ; Functional Magnetic Resonance Imaging ; Funktionelle Magnetresonanztomographie ; Gedächtnis ; Gedächtniskonsolidierung ; Human Information Storage ; Informationsspeicherprozesse beim Menschen ; Memory ; Memory Consolidation ; Neuroendocrinology ; Neuroendokrinologie ; Noradrenalin ; Norepinephrine ; Yohimbin ; Yohimbine
Language	English
Document type	Article
ZDB-ID	2553671-0
ISSN	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-26250-7
Database	PSYNDEX

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Article: The inhibitory avoidance discrimination task to investigate accuracy of memory.

Atucha, Erika / Roozendaal, Benno

Frontiers in behavioral neuroscience

2015 Volume 9, Page(s) 60

Abstract: The present study was aimed at developing a new inhibitory avoidance task, based on training and/or testing rats in multiple contexts, to investigate accuracy of memory. In the first experiment, male Sprague-Dawley rats were given footshock in an ... ...

Abstract	The present study was aimed at developing a new inhibitory avoidance task, based on training and/or testing rats in multiple contexts, to investigate accuracy of memory. In the first experiment, male Sprague-Dawley rats were given footshock in an inhibitory avoidance apparatus and, 48 h later, retention latencies of each rat were assessed in the training apparatus (Shock box) as well as in a novel, contextually modified, apparatus. Retention latencies in the Shock box were significantly longer than those in the Novel box, indicating accurate memory of the training context. When the noradrenergic stimulant yohimbine (0.3 mg/kg, sc) was administered after the training, 48-h retention latencies in the Shock box, but not Novel box, were increased, indicating that the noradrenergic activation enhanced memory of the training experience without reducing memory accuracy. In the second experiment, rats were trained on an inhibitory avoidance discrimination task: They were first trained in an inhibitory avoidance apparatus without footshock (Non-Shock box), followed 1 min later by footshock training in a contextually modified apparatus (Shock box). Forty-eight-hour retention latencies in the Shock and Non-Shock boxes did not differ from each other but were both significantly longer than those in a Novel box, indicating that rats remembered the two training contexts but did not have episodic-like memory of the association of footshock with the correct training context. When the interval between the two training episodes was increased to 2 min, rats showed accurate memory of the association of footshock with the training context. Yohimbine administered after the training also enhanced rats' ability to remember in which training context they had received actual footshock. These findings indicate that the inhibitory avoidance discrimination task is a novel variant of the well-established inhibitory avoidance task suitable to investigate accuracy of memory.
Language	English
Publishing date	2015-03-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2015.00060
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Article ; Online: Toward Understanding Developmental Disruption of Default Mode Network Connectivity Due to Early Life Stress.

Wang, Huan / Verkes, Robbert-Jan / Roozendaal, Benno / Hermans, Erno J

Biological psychiatry. Cognitive neuroscience and neuroimaging

2019 Volume 4, Issue 1, Page(s) 5–7

MeSH term(s)	Brain Mapping ; Female ; Humans ; Mothers ; Nerve Net ; Stress, Psychological
Language	English
Publishing date	2019-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2879089-3
ISSN	2451-9030 ; 2451-9022
ISSN (online)	2451-9030
ISSN	2451-9022
DOI	10.1016/j.bpsc.2018.11.008
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Article ; Online: Noradrenergic enhancement of object recognition and object location memory in mice.

Song, Qi / Bolsius, Youri G / Ronzoni, Giacomo / Henckens, Marloes J A G / Roozendaal, Benno

Stress (Amsterdam, Netherlands)

2020 Volume 24, Issue 2, Page(s) 181–188

Abstract: Extensive evidence indicates that noradrenergic activation is essentially involved in mediating the enhancing effects of emotional arousal on memory consolidation. Our current understanding of the neurobiological mechanisms underlying the memory- ... ...

Abstract	Extensive evidence indicates that noradrenergic activation is essentially involved in mediating the enhancing effects of emotional arousal on memory consolidation. Our current understanding of the neurobiological mechanisms underlying the memory-modulatory effects of the noradrenergic system is primarily based on pharmacological studies in rats, employing targeted administration of noradrenergic drugs into specific brain regions. However, the further delineation of the specific neural circuitry involved would benefit from experimental tools that are currently more readily available in mice. Previous studies have not, as yet, investigated the effect of noradrenergic enhancement of memory in mice, which show different cognitive abilities and higher endogenous arousal levels induced by a training experience compared to rats. In the present study, we investigated the effect of posttraining noradrenergic activation in male C57BL/6J mice on the consolidation of object recognition and object location memory. We found that the noradrenergic stimulant yohimbine (0.3 or 1.0 mg/kg) administered systemically immediately after an object training experience dose-dependently enhanced 24-h memory of both the identity and location of the object. Thus, these findings indicate that noradrenergic activation also enhances memory consolidation processes in mice, paving the way for a systematic investigation of the neural circuitry underlying these emotional arousal effects on memory.
MeSH term(s)	Animals ; Male ; Memory ; Memory, Long-Term ; Mice ; Mice, Inbred C57BL ; Norepinephrine ; Rats ; Stress, Psychological
Chemical Substances	Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2020-04-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1387706-9
ISSN	1607-8888 ; 1025-3890
ISSN (online)	1607-8888
ISSN	1025-3890
DOI	10.1080/10253890.2020.1747427
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