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  1. Article: Feasibility of imaging synaptic density in the human spinal cord using [

    Rossano, Samantha / Toyonaga, Takuya / Bini, Jason / Nabulsi, Nabeel / Ropchan, Jim / Cai, Zhengxin / Huang, Yiyun / Carson, Richard E

    EJNMMI physics

    2022  Volume 9, Issue 1, Page(s) 32

    Abstract: Purpose: Neuronal damage and synapse loss in the spinal cord (SC) have been implicated in spinal cord injury (SCI) and neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Current standards of diagnosis for SCI include CT or MRI ... ...

    Abstract Purpose: Neuronal damage and synapse loss in the spinal cord (SC) have been implicated in spinal cord injury (SCI) and neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Current standards of diagnosis for SCI include CT or MRI imaging to evaluate injury severity. The current study explores the use of PET imaging with [
    Results: First, simulations of baseline and blocking [
    Conclusions: The results presented here provide evidence for the feasibility of SV2A PET imaging in the human SC, however, specific binding of [
    Language English
    Publishing date 2022-05-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2768912-8
    ISSN 2197-7364
    ISSN 2197-7364
    DOI 10.1186/s40658-022-00464-0
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  2. Article: In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [

    Smart, Kelly / Zheng, Ming-Qiang / Holden, Daniel / Felchner, Zachary / Zhang, Li / Han, Yanjiang / Ropchan, Jim / Carson, Richard E / Vasdev, Neil / Huang, Yiyun

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: Glycogen synthase kinase 3 (GSK-3) is a potential therapeutic target for a range of neurodegenerative and psychiatric disorders. The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [ ...

    Abstract Glycogen synthase kinase 3 (GSK-3) is a potential therapeutic target for a range of neurodegenerative and psychiatric disorders. The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020194
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  3. Article ; Online: Evaluation of a First PET Tracer Suitable for Imaging the Sigma-2 Receptor in the Brain of Nonhuman Primates.

    Alluri, Santosh Reddy / Zheng, MingQiang / Holden, Daniel / Zhang, Ying / Zhang, Li / Felchner, Zachary / Li, Songye / Ropchan, Jim / Carson, Richard / Jia, Hongmei / Huang, Yiyun

    Molecular pharmaceutics

    2023  Volume 21, Issue 1, Page(s) 194–200

    Abstract: The sigma-2 receptor (σ2R), recently identified as transmembrane protein 97, is expressed in many cell types and mediates important functions in both the peripheral and central nervous systems. Over the years, σ2R has emerged as a potential therapeutic ... ...

    Abstract The sigma-2 receptor (σ2R), recently identified as transmembrane protein 97, is expressed in many cell types and mediates important functions in both the peripheral and central nervous systems. Over the years, σ2R has emerged as a potential therapeutic target for cancer and neurological disorders such as Alzheimer's disease (AD). The currently available σ2R radiotracers have been developed primarily for cancer imaging with limited brain uptake. Here, we report the evaluation of the first brain penetrant
    MeSH term(s) Animals ; Radiopharmaceuticals ; Macaca mulatta ; Positron-Emission Tomography/methods ; Brain/diagnostic imaging ; Neoplasms ; Primates
    Chemical Substances sigma-2 receptor ; Radiopharmaceuticals
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00750
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    Zs.A 6250: Show issues Location:
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  4. Article: Author Correction: Synaptic loss and its association with symptom severity in Parkinson's disease.

    Holmes, Sophie E / Honhar, Praveen / Tinaz, Sule / Naganawa, Mika / Hilmer, Ansel T / Gallezot, Jean-Dominique / Dias, Mark / Yang, Yanghong / Toyonaga, Takuya / Esterlis, Irina / Mecca, Adam / Van Dyck, Christopher / Henry, Shannan / Ropchan, Jim / Nabulsi, Nabeel / Louis, Elan D / Comley, Robert / Finnema, Sjoerd J / Carson, Richard E /
    Matuskey, David

    NPJ Parkinson's disease

    2024  Volume 10, Issue 1, Page(s) 55

    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/s41531-024-00674-6
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  5. Article ; Online: First-in-Human Study of

    Drake, Lindsey R / Wu, Yanjun / Naganawa, Mika / Asch, Ruth / Zheng, Chao / Najafzadeh, Soheila / Pracitto, Richard / Lindemann, Marcel / Li, Songye / Ropchan, Jim / Labaree, David / Emery, Paul R / Dias, Mark / Henry, Shannan / Nabulsi, Nabeel / Matuskey, David / Hillmer, Ansel T / Gallezot, Jean-Dominique / Carson, Richard E /
    Cai, Zhengxin / Huang, Yiyun

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2024  

    Abstract: PET imaging of synaptic vesicle glycoprotein 2A allows for noninvasive quantification of synapses. This first-in-human study aimed to evaluate the kinetics, test-retest reproducibility, and extent of specific binding of a recently developed synaptic ... ...

    Abstract PET imaging of synaptic vesicle glycoprotein 2A allows for noninvasive quantification of synapses. This first-in-human study aimed to evaluate the kinetics, test-retest reproducibility, and extent of specific binding of a recently developed synaptic vesicle glycoprotein 2A PET ligand, (
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.266470
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    Zs.A 114: Show issues Location:
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    Zs.MO 328: Show issues

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  6. Article: Synaptic loss and its association with symptom severity in Parkinson's disease.

    Holmes, Sophie E / Honhar, Praveen / Tinaz, Sule / Naganawa, Mika / Hilmer, Ansel T / Gallezot, Jean-Dominique / Dias, Mark / Yang, Yanghong / Toyonaga, Takuya / Esterlis, Irina / Mecca, Adam / Van Dyck, Christopher / Henry, Shannan / Ropchan, Jim / Nabulsi, Nabeel / Louis, Elan D / Comley, Robert / Finnema, Sjoerd J / Carson, Richard E /
    Matuskey, David

    NPJ Parkinson's disease

    2024  Volume 10, Issue 1, Page(s) 42

    Abstract: Parkinson's disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD and other ... ...

    Abstract Parkinson's disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD and other neurodegenerative disorders. Here, we provide new clinical insights from a cross-sectional, high-resolution positron emission tomography (PET) study of 30 PD individuals and 30 age- and sex-matched healthy controls (HC) with the radiotracer [
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/s41531-024-00655-9
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  7. Article ; Online: A modification to improve the reliability of [

    Labaree, David C / Ropchan, Jim R / Nabulsi, Nabeel / Huang, Yiyun

    Journal of labelled compounds & radiopharmaceuticals

    2017  Volume 60, Issue 12, Page(s) 592–595

    Abstract: We report herein a modification to a component of the GE radiochemistry system that increases the yield and reliability of [ ...

    Abstract We report herein a modification to a component of the GE radiochemistry system that increases the yield and reliability of [
    MeSH term(s) Carbon Radioisotopes/chemistry ; Cyanides/chemical synthesis ; Cyanides/chemistry ; Isotope Labeling ; Radiochemistry/instrumentation
    Chemical Substances Carbon Radioisotopes ; Cyanides
    Language English
    Publishing date 2017-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 196095-7
    ISSN 1099-1344 ; 0362-4803 ; 0022-2135
    ISSN (online) 1099-1344
    ISSN 0362-4803 ; 0022-2135
    DOI 10.1002/jlcr.3540
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    Zs.A 1332: Show issues Location:
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  8. Article ; Online: Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates.

    Chen, Baosheng / Ojha, Devi Prasan / Toyonaga, Takuya / Tong, Jie / Pracitto, Richard / Thomas, Monique A / Liu, Michael / Kapinos, Michael / Zhang, Li / Zheng, Ming-Qiang / Holden, Daniel / Fowles, Krista / Ropchan, Jim / Nabulsi, Nabeel / De Feyter, Henk / Carson, Richard E / Huang, Yiyun / Cai, Zhengxin

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 7, Page(s) 2081–2099

    Abstract: Purpose: Currently, there are multiple active clinical trials involving poly(ADP-ribose) polymerase (PARP) inhibitors in the treatment of glioblastoma. The noninvasive quantification of baseline PARP expression using positron emission tomography (PET) ... ...

    Abstract Purpose: Currently, there are multiple active clinical trials involving poly(ADP-ribose) polymerase (PARP) inhibitors in the treatment of glioblastoma. The noninvasive quantification of baseline PARP expression using positron emission tomography (PET) may provide prognostic information and lead to more precise treatment. Due to the lack of brain-penetrant PARP imaging agents, the reliable and accurate in vivo quantification of PARP in the brain remains elusive. Herein, we report the synthesis of a brain-penetrant PARP PET tracer, (R)-2-(2-methyl-1-(methyl-
    Methods: We synthesized [
    Results: [
    Conclusion: [
    MeSH term(s) Rats ; Animals ; Glioblastoma/diagnostic imaging ; Glioblastoma/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/metabolism ; Tissue Distribution ; Brain/diagnostic imaging ; Brain/metabolism ; Positron-Emission Tomography/methods ; Primates
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors
    Language English
    Publishing date 2023-02-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06162-y
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    Zs.A 1227: Show issues Location:
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  9. Article ; Online: Evaluation of (

    Ahmed, Hazem / Zheng, Ming-Qiang / Smart, Kelly / Fang, Hanyi / Zhang, Li / Emery, Paul R / Gao, Hong / Ropchan, Jim / Haider, Ahmed / Tamagnan, Gilles / Carson, Richard E / Ametamey, Simon M / Huang, Yiyun

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2022  Volume 63, Issue 12, Page(s) 1912–1918

    Abstract: Despite 2 decades of research, ... ...

    Abstract Despite 2 decades of research, no
    MeSH term(s) Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Ligands ; Macaca mulatta/metabolism ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism
    Chemical Substances Ligands ; Radiopharmaceuticals ; Receptors, N-Methyl-D-Aspartate ; Fluorine-18 (GZ5I74KB8G)
    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.263977
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    Zs.MO 328: Show issues

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  10. Article ; Online: Translational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [

    Fang, Hanyi / Rossano, Samantha / Wang, Xingxing / Nabulsi, Nabeel / Kelley, Brian / Fowles, Krista / Ropchan, Jim / Strittmatter, Stephen M / Carson, Richard E / Huang, Yiyun

    Molecular imaging and biology

    2022  Volume 24, Issue 4, Page(s) 560–569

    Abstract: Purpose: The descending raphespinal serotonin (5-HT) system contributes to neural activities required for locomotion. The presynaptic serotonin transporter (SERT) is a marker of 5-HT innervation. In this study, we explored the use of PET imaging with ... ...

    Abstract Purpose: The descending raphespinal serotonin (5-HT) system contributes to neural activities required for locomotion. The presynaptic serotonin transporter (SERT) is a marker of 5-HT innervation. In this study, we explored the use of PET imaging with the SERT radioligand [
    Procedures: PET imaging with [
    Results: Intense uptake in the brain and intact spinal cord was observed at 30-60 min post-injection of [
    Conclusion: [
    MeSH term(s) Animals ; Citalopram ; Humans ; Indicators and Reagents ; Positron-Emission Tomography/methods ; Rats ; Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Spinal Cord/diagnostic imaging ; Spinal Cord Injuries/diagnostic imaging ; Spinal Cord Injuries/metabolism ; Tissue Distribution
    Chemical Substances Indicators and Reagents ; Serotonin Plasma Membrane Transport Proteins ; Citalopram (0DHU5B8D6V) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-021-01698-7
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