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  1. Article: Remarks on the Lunacy Acts (Scotland).

    Rorie, James

    Journal of psychological medicine and mental pathology (London, England : 1875)

    2017  Volume 2, Issue Pt 1, Page(s) 59–69

    Language English
    Publishing date 2017-09-14
    Publishing country England
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Analysis of the Evidence of the Dillwyn Committee.

    Rorie, James

    Journal of psychological medicine and mental pathology (London, England : 1875)

    2017  Volume 4, Issue Pt 1, Page(s) 44–61

    Language English
    Publishing date 2017-09-14
    Publishing country England
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Psyllium is not fermented in the human gut.

    McRorie, J W

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    2015  Volume 27, Issue 11, Page(s) 1681–1682

    MeSH term(s) Cathartics/therapeutic use ; Colon/drug effects ; Female ; Gastrointestinal Transit/drug effects ; Humans ; Male ; Methane/analysis ; Psyllium/therapeutic use
    Chemical Substances Cathartics ; Psyllium (8063-16-9) ; Methane (OP0UW79H66)
    Language English
    Publishing date 2015-11
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.12649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Engaging youth in mHealth: what works and how can we be sure?

    Hightow-Weidman, Lisa B / Horvath, Keith J / Scott, Hyman / Hill-Rorie, Jonathan / Bauermeister, Jose A

    mHealth

    2021  Volume 7, Page(s) 23

    Abstract: Background: Youth participating in mobile health (mHealth) intervention trials often engage with the technologies [e.g., applications (app) or mobile-optimized websites] only partially, often prematurely discontinuing use altogether. Limited engagement ... ...

    Abstract Background: Youth participating in mobile health (mHealth) intervention trials often engage with the technologies [e.g., applications (app) or mobile-optimized websites] only partially, often prematurely discontinuing use altogether. Limited engagement can impact the interventions effect on behavior change and compromise researchers' ability to test and estimate the true efficacy of their interventions. While mHealth interventions have been shown to be feasible and acceptable to youth, across diverse health conditions, strategies to increase engagement have been less well studied. Specifically, within HIV prevention and care mHealth interventions, there is not consensus as to which components represent the "key ingredients" to support maximal engagement of youth. Further, successful intervention evaluation requires the ability to systematically track users' engagement with intervention components (i.e., paradata) to evaluate its effects on behavior change.
    Methods: As part of the Adolescent Medicine Trials Network UNC/Emory Center for Innovative Technology (iTech) portfolio of HIV/AIDS Interventions, we present diverse strategies used across five mHealth protocols seeking to promote youth engagement, track and measure engagement through paradata, and incorporate these components into mHealth intervention evaluations.
    Results: We describe the importance of defining and measuring engagement using case studies from iTech to illustrate how different research teams select mHealth features to promote youth engagement over time, taking into account features embedded in the technology design, key mechanisms of change and trial outcomes (e.g., HIV testing, pre-exposure prophylaxis uptake and adherence, HIV treatment adherence). Finally, we discuss how the research teams plan to evaluate engagement's role on their intervention's outcomes.
    Conclusions: Based on this synthesis, we discuss strategies to enhance mHealth engagement during intervention development and design, ensure its monitoring and reporting throughout the trial, and evaluate its impact on trial outcomes.
    Language English
    Publishing date 2021-04-20
    Publishing country China
    Document type Journal Article
    ISSN 2306-9740
    ISSN 2306-9740
    DOI 10.21037/mhealth-20-48
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinical data support that psyllium is not fermented in the gut.

    McRorie, Johnson

    The American journal of gastroenterology

    2013  Volume 108, Issue 9, Page(s) 1541

    MeSH term(s) Dietary Fiber/metabolism ; Fermentation/physiology ; Gastrointestinal Tract/metabolism ; Humans ; Psyllium/metabolism
    Chemical Substances Dietary Fiber ; Psyllium (8063-16-9)
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Letter
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1038/ajg.2013.211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prunes vs. psyllium for chronic idiopathic constipation.

    McRorie, J W

    Alimentary pharmacology & therapeutics

    2011  Volume 34, Issue 2, Page(s) 258–259

    MeSH term(s) Cathartics/therapeutic use ; Constipation/therapy ; Dietary Fiber/therapeutic use ; Humans ; Laxatives/therapeutic use ; Prunus ; Psyllium/therapeutic use
    Chemical Substances Cathartics ; Dietary Fiber ; Laxatives ; Psyllium (8063-16-9)
    Language English
    Publishing date 2011-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/j.1365-2036.2011.04713.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A qualitative exploration of how to support PrEP adherence among young men who have sex with men.

    Psaros, Christina / Hill-Rorie, Jonathan / Quint, Meg / Horvitz, Casey / Dormitzer, Julian / Biello, Katie B / Krakower, Douglas S / Safren, Steven A / Mimiaga, Matthew J / Sullivan, Patrick / Hightow-Weidman, Lisa B / Mayer, Kenneth H

    AIDS care

    2023  Volume 36, Issue 6, Page(s) 732–743

    Abstract: New HIV infections disproportionately affect young men who have sex with men (YMSM). PrEP is effective in preventing HIV acquisition; however, adherence is critical and is often suboptimal among YMSM. Interventions addressing the unique PrEP adherence ... ...

    Abstract New HIV infections disproportionately affect young men who have sex with men (YMSM). PrEP is effective in preventing HIV acquisition; however, adherence is critical and is often suboptimal among YMSM. Interventions addressing the unique PrEP adherence challenges faced by YMSM are needed. We conducted qualitative interviews with 20 HIV-negative, YMSM (ages 15-24) with a PrEP indication and 11 healthcare professionals to inform adaption of a PrEP adherence intervention (Life-Steps for PrEP) for YMSM. We explored environmental, healthcare, and individual factors influencing uptake, adherence, attitudes, and perspectives (including desired modifications) on the Life-Steps intervention. Interviews were analyzed using content analysis. Of YMSM study participants (mean age 21.6) 55% were White, 15% Hispanic, and 5% Black. Most YMSM were PrEP-experienced (70%). Healthcare professionals (6 prescribers, 1 nurse, 2 health educators, 2 other/unspecified) averaged 6.9 years of experience caring for YMSM. All described stigma as a barrier to PrEP; YMSM expressed concern around being perceived as "risky" and concern about inadvertent PrEP disclosure if family/friends found their medication, or if parental insurance was used. Difficulty with planning for potential adherence challenges were identified by both groups. YMSM highlighted benefits of a nurse-led intervention (i.e., adding "legitimacy"), but stressed need for nonjudgmental, "savvy" interventionists. YMSM expressed a desire for comprehensive YMSM-specific sexual health information. These findings informed modification and expansion of Life-Steps content. Results highlight key potential barriers, many of which center around privacy. Content that addresses PrEP stigma, disclosing PrEP use, navigating insurance, and planning ahead in a nonjudgmental environment by trusted providers emerged as important components of a YMSM-focused delivery of Life-Steps for PrEP.
    MeSH term(s) Humans ; Male ; Homosexuality, Male/psychology ; HIV Infections/prevention & control ; Medication Adherence/psychology ; Pre-Exposure Prophylaxis ; Qualitative Research ; Adolescent ; Young Adult ; Social Stigma ; Anti-HIV Agents/therapeutic use ; Interviews as Topic ; Health Knowledge, Attitudes, Practice ; Adult ; Sexual and Gender Minorities/psychology
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1012651-x
    ISSN 1360-0451 ; 0954-0121
    ISSN (online) 1360-0451
    ISSN 0954-0121
    DOI 10.1080/09540121.2023.2240070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Evaluate the Benefit of the Probiotic Bifidobacterium infantis 35624 in Non-Patients With Symptoms of Abdominal Discomfort and Bloating.

    Ringel-Kulka, Tamar / McRorie, Johnson / Ringel, Yehuda

    The American journal of gastroenterology

    2016  Volume 112, Issue 1, Page(s) 145–151

    Abstract: Objectives: Bifidobacterium infantis 35624 is a probiotic that is used often in patients with irritable bowel syndrome (IBS). Non-patients with bowel symptoms may differ from patients with IBS in the impact of their bowel symptoms on illness severity, ... ...

    Abstract Objectives: Bifidobacterium infantis 35624 is a probiotic that is used often in patients with irritable bowel syndrome (IBS). Non-patients with bowel symptoms may differ from patients with IBS in the impact of their bowel symptoms on illness severity, healthcare and treatment seeking behavior. The aim of this study is to assess the efficacy of B. infantis 35624 (10
    Methods: A double-blind, randomized, placebo-controlled, parallel study with a 2-week placebo run-in phase followed by a 4-week intervention phase was conducted at ten clinical centers (USA). Subjects were recruited from the general population by advertisement. The study randomized 302 subjects who experienced abdominal discomfort and bloating ≥2-times per week for at least three months but have not seen a physician or received prescribed medication for their symptoms in the past 12 months. Subjects were assessed for pre- to post-intervention changes in symptom severity (on a 6-point Likert scale; 0=none, 5=very severe) and frequency (symptoms-free days).
    Results: A total of 275 subjects (mean age 42 years, 79% female, 74% Caucasian) provided evaluable data. Overall mean severity scores at baseline were 2.4 for abdominal discomfort and 2.5 for bloating with no significant differences between the placebo and probiotic groups. Both groups showed significant (P<0.05) improvement in abdominal discomfort and bloating scores over the 4-week intervention period. Mean severity symptom scores at the end of intervention showed no significant differences between the probiotic and the placebo groups in either abdominal discomfort or bloating (P>0.3). The frequency of abdominal bloating-free days was greater in the B. infantis 35624 group compared to the placebo group (P<0.05). Both regimens were well tolerated.
    Conclusions: Unlike previous clinical studies in patients with IBS, B. infantis 35624 did not show a significant improvement in the mean severity of symptoms of abdominal discomfort and bloating in a non-patient population. This may be explained by the high placebo effect and the lower impact of functional bowel symptoms in the non-patient population.
    MeSH term(s) Abdominal Pain/therapy ; Adult ; Bifidobacterium longum subspecies infantis ; Double-Blind Method ; Female ; Flatulence ; Humans ; Male ; Probiotics/therapeutic use ; Severity of Illness Index ; Treatment Outcome
    Language English
    Publishing date 2016-11-15
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1038/ajg.2016.511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Inulin-type fructans have no significant beneficial effects on lipid or glucose metabolism.

    McRorie, J W / Gibb, R D / McKeown, N M

    European journal of clinical nutrition

    2017  Volume 71, Issue 5, Page(s) 677

    Language English
    Publishing date 2017-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/ejcn.2017.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Uptake and Acceptability of MyChoices: Results of a Pilot RCT of a Mobile App Designed to Increase HIV Testing and PrEP Uptake Among Young American MSM.

    Biello, Katie B / Daddario, Salvatore R / Hill-Rorie, Jonathan / Futterman, Donna / Sullivan, Patrick S / Hightow-Weidman, Lisa / Jones, Jeb / Mimiaga, Matthew J / Mayer, Kenneth H

    AIDS and behavior

    2022  Volume 26, Issue 12, Page(s) 3981–3990

    Abstract: Young men who have sex with men (YMSM) remain at disproportionate risk for HIV acquisition in the United States (US), yet use of evidence-based prevention strategies, including routine HIV testing and pre-exposure prophylaxis (PrEP), remain low. ... ...

    Abstract Young men who have sex with men (YMSM) remain at disproportionate risk for HIV acquisition in the United States (US), yet use of evidence-based prevention strategies, including routine HIV testing and pre-exposure prophylaxis (PrEP), remain low. Smartphones and mobile app usage are nearly ubiquitous in this population. Given the potential for scalability, a mobile app to increase HIV testing and PrEP use among YMSM has the potential to make an extraordinary public health impact if efficacious. Based on extensive formative, community-engaged research, we developed a theory-driven mobile app-MyChoices-to increase HIV testing and PrEP uptake among YMSM. In a pilot randomized controlled trial (RCT), participants (n = 60) were randomized 2:1 to receive MyChoices or standard of care (SOC). Data from 3 to 6-month post-baseline assessments demonstrate that the app was highly acceptable (System Usability Score; mean = 75.8, SD = 10.7) and feasible (94% used the MyChoices app at least once; mean = 15.3 sessions, SD = 9.8). While not powered to assess efficacy, those in the MyChoices arm had 22% higher prevalence of HIV testing over follow-up compared to those in the SOC arm (NS). There was no difference in PrEP uptake. A fully-powered efficacy trial is warranted; if efficacy is demonstrated, the MyChoices app could be easily scaled to reach YMSM across the US.
    MeSH term(s) Male ; Humans ; United States/epidemiology ; Homosexuality, Male ; Mobile Applications ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Pre-Exposure Prophylaxis/methods ; HIV Testing ; Sexual and Gender Minorities
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-022-03724-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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