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  1. Article: Corrigendum:

    Montagud-Marrahi, Enrique / Luque, Yosu / Ros, Ruben Rabadan / Ajami, Tarek / Cuadrado-Payan, Elena / Estrella, Hector / Arancibia, Andres / Sánchez-Etayo, Gerard / Bohils, Marc / Marrero, Ramsés / Fundora, Yilliam / Ramírez-Bajo, Maria José / Banon-Maneus, Elisenda / Rovira, Jordi / Larque, Ana-Belén / Campistol, Josep Maria / Diekmann, Fritz / Musquera, Mireia

    Frontiers in bioengineering and biotechnology

    2024  Volume 12, Page(s) 1397979

    Abstract: This corrects the article DOI: 10.3389/fbioe.2023.1330043.]. ...

    Abstract [This corrects the article DOI: 10.3389/fbioe.2023.1330043.].
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2024.1397979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Ex vivo

    Montagud-Marrahi, Enrique / Luque, Yosu / Ros, Ruben Rabadan / Ajami, Tarek / Cuadrado-Payan, Elena / Estrella, Hector / Arancibia, Andres / Sánchez-Etayo, Gerard / Bohils, Marc / Marrero, Ramsés / Fundora, Yilliam / Ramírez-Bajo, Maria José / Banon-Maneus, Elisenda / Rovira, Jordi / Larque, Ana-Belén / Campistol, Josep Maria / Diekmann, Fritz / Musquera, Mireia

    Frontiers in bioengineering and biotechnology

    2024  Volume 11, Page(s) 1330043

    Abstract: The transplant community is focused on prolonging ... ...

    Abstract The transplant community is focused on prolonging the
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1330043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: In vivo partial cellular reprogramming enhances liver plasticity and regeneration.

    Hishida, Tomoaki / Yamamoto, Mako / Hishida-Nozaki, Yuriko / Shao, Changwei / Huang, Ling / Wang, Chao / Shojima, Kensaku / Xue, Yuan / Hang, Yuqing / Shokhirev, Maxim / Memczak, Sebastian / Sahu, Sanjeeb Kumar / Hatanaka, Fumiyuki / Ros, Ruben Rabadan / Maxwell, Matthew B / Chavez, Jasmine / Shao, Yanjiao / Liao, Hsin-Kai / Martinez-Redondo, Paloma /
    Guillen-Guillen, Isabel / Hernandez-Benitez, Reyna / Esteban, Concepcion Rodriguez / Qu, Jing / Holmes, Michael C / Yi, Fei / Hickey, Raymond D / Garcia, Pedro Guillen / Delicado, Estrella Nuñez / Castells, Antoni / Campistol, Josep M / Yu, Yang / Hargreaves, Diana C / Asai, Akihiro / Reddy, Pradeep / Liu, Guang-Hui / Izpisua Belmonte, Juan Carlos

    Cell reports

    2022  Volume 39, Issue 4, Page(s) 110730

    Abstract: Mammals have limited regenerative capacity, whereas some vertebrates, like fish and salamanders, are able to regenerate their organs efficiently. The regeneration in these species depends on cell dedifferentiation followed by proliferation. We generate a ...

    Abstract Mammals have limited regenerative capacity, whereas some vertebrates, like fish and salamanders, are able to regenerate their organs efficiently. The regeneration in these species depends on cell dedifferentiation followed by proliferation. We generate a mouse model that enables the inducible expression of the four Yamanaka factors (Oct-3/4, Sox2, Klf4, and c-Myc, or 4F) specifically in hepatocytes. Transient in vivo 4F expression induces partial reprogramming of adult hepatocytes to a progenitor state and concomitantly increases cell proliferation. This is indicated by reduced expression of differentiated hepatic-lineage markers, an increase in markers of proliferation and chromatin modifiers, global changes in DNA accessibility, and an acquisition of liver stem and progenitor cell markers. Functionally, short-term expression of 4F enhances liver regenerative capacity through topoisomerase2-mediated partial reprogramming. Our results reveal that liver-specific 4F expression in vivo induces cellular plasticity and counteracts liver failure, suggesting that partial reprogramming may represent an avenue for enhancing tissue regeneration.
    MeSH term(s) Animals ; Cell Dedifferentiation ; Cellular Reprogramming ; Hepatocytes/metabolism ; Liver/metabolism ; Liver Regeneration ; Mammals ; Mice
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.110730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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