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  1. Article ; Online: ChatGPT: una novedosa herramienta de escritura para artículos científicos, pero no un autor (por el momento).

    Ros-Arlanzón, P / Pérez-Sempere, A

    Revista de neurologia

    2023  Volume 76, Issue 8, Page(s) 277

    Title translation ChatGPT: a novel tool for writing scientific articles, but not an author (for the time being).
    MeSH term(s) Humans ; Writing ; Authorship
    Language Spanish
    Publishing date 2023-04-13
    Publishing country Spain
    Document type Letter
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    DOI 10.33588/rn.7608.2023066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5003: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Acute tandem occlusion stroke in internal carotid artery and fetal posterior cerebral artery: endovascular management.

    Ros-Arlanzón, P / Elvira-Soler, E / Domínguez-Rodríguez, C

    Revista de neurologia

    2023  Volume 76, Issue 11, Page(s) 371–374

    Abstract: Introduction: When the posterior cerebral artery arises from the internal carotid artery with an absent P1 segment, it is called fetal posterior cerebral artery (FPCA). It is unclear whether FPCA increases the risk of acute ischemic stroke, and the ... ...

    Title translation Ictus isquémico agudo por oclusión en tándem de la arteria carótida interna y la arteria cerebral posterior fetal: tratamiento endovascular.
    Abstract Introduction: When the posterior cerebral artery arises from the internal carotid artery with an absent P1 segment, it is called fetal posterior cerebral artery (FPCA). It is unclear whether FPCA increases the risk of acute ischemic stroke, and the endovascular treatment of acute ischemic stroke due to acute occlusion of FPCA is not well established.
    Case report: We report a case of acute ischemic stroke due to tandem occlusion of internal carotid artery and ipsilateral fetal posterior cerebral artery treated successfully with acute stenting of proximal lesion and mechanical thrombectomy of distal lesion with excellent neurological and functional outcomes.
    Conclusion: Although further investigations are needed to determine the best treatment of these patients, endovascular treatment of fetal posterior cerebral artery occlusion is feasible.
    MeSH term(s) Humans ; Carotid Artery, Internal/diagnostic imaging ; Ischemic Stroke ; Posterior Cerebral Artery/diagnostic imaging ; Endovascular Procedures ; Stroke/etiology ; Treatment Outcome ; Thrombectomy ; Stents ; Retrospective Studies
    Chemical Substances 2-amino-1-(4-chlorophenyl)-3-fluoropropane (76605-09-9)
    Language Spanish
    Publishing date 2023-05-23
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    DOI 10.33588/rn.7611.2022432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5003: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Epidemiology and molecular characterization of adult genetic myopathies in a southeastern region of Spain.

    Ros-Arlanzón, P / Pelegrín-Durá, L / Aledo-Sala, C / Moreno-Navarro, L / Vaamonde-Esteban, Y / Muñoz-Ambit, A / Sánchez-Pérez, R / Díaz-Marín, C

    Revista de neurologia

    2024  Volume 78, Issue 9, Page(s) 239–246

    Abstract: Introduction: Genetic myopathies constitute a collection of rare diseases that significantly impact patient functionality and quality of life. Early diagnosis of genetic myopathies can prevent future complications and provide families with genetic ... ...

    Title translation Epidemiología y caracterización molecular de las miopatías genéticas en adultos en una región del sureste de España.
    Abstract Introduction: Genetic myopathies constitute a collection of rare diseases that significantly impact patient functionality and quality of life. Early diagnosis of genetic myopathies can prevent future complications and provide families with genetic counselling. Despite the substantial impact of genetic myopathies on the adult population, the global epidemiology of these disorders is inadequately addressed in the literature.
    Aims: To enhance understanding of both the epidemiology and genetics of these disorders within the province of Alicante, situated in southeastern Spain.
    Material and methods: Between 2020 and 2022, a prospective observational study was conducted at the Alicante Health Area-General Hospital, enrolling patients aged 16 years or older with suspected genetic myopathies. Sociodemographic, clinical, and genetic data were collected. The reference date for prevalence calculation was established as December 31, 2022. Official demographic data of the health area were used to set the population at risk.
    Results: In total, 83 patients were identified with confirmed genetically related myopathy, resulting in an overall prevalence of 29.59 cases per 100,000 inhabitants. The diagnostic yield for molecular genetic testing was found to be 69.16%. The most prevalent genetic myopathies identified included myotonic dystrophy (27.5%), dystrophinopathies (15.7%), and facioscapulohumeral dystrophy (15.7%).
    Conclusion: The prevalence of GMs can vary considerably depending on the geographical region and the studied population. The analysis of diagnostic yield suggests that genetic studies should be considered useful in the diagnosis of genetic myopathies.
    MeSH term(s) Humans ; Spain/epidemiology ; Male ; Female ; Adult ; Prospective Studies ; Middle Aged ; Prevalence ; Muscular Diseases/epidemiology ; Muscular Diseases/genetics ; Aged ; Young Adult ; Adolescent
    Language English
    Publishing date 2024-05-14
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    DOI 10.33588/rn.7809.2024071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5003: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy.

    Marcotti, Aida / Fernández-Trillo, Jorge / González, Alejandro / Vizcaíno-Escoto, Marta / Ros-Arlanzón, Pablo / Romero, Luz / Vela, José Miguel / Gomis, Ana / Viana, Félix / de la Peña, Elvira

    Brain : a journal of neurology

    2022  Volume 146, Issue 2, Page(s) 475–491

    Abstract: Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced colorectal cancer, often leads to a form of chemotherapy-induced peripheral neuropathy ...

    Abstract Chemotherapy-induced peripheral neuropathy is a frequent, disabling side effect of anticancer drugs. Oxaliplatin, a platinum compound used in the treatment of advanced colorectal cancer, often leads to a form of chemotherapy-induced peripheral neuropathy characterized by mechanical and cold hypersensitivity. Current therapies for chemotherapy-induced peripheral neuropathy are ineffective, often leading to the cessation of treatment. Transient receptor potential ankyrin 1 (TRPA1) is a polymodal, non-selective cation-permeable channel expressed in nociceptors, activated by physical stimuli and cellular stress products. TRPA1 has been linked to the establishment of chemotherapy-induced peripheral neuropathy and other painful neuropathic conditions. Sigma-1 receptor is an endoplasmic reticulum chaperone known to modulate the function of many ion channels and receptors. Sigma-1 receptor antagonist, a highly selective antagonist of Sigma-1 receptor, has shown effectiveness in a phase II clinical trial for oxaliplatin chemotherapy-induced peripheral neuropathy. However, the mechanisms involved in the beneficial effects of Sigma-1 receptor antagonist are little understood. We combined biochemical and biophysical (i.e. intermolecular Förster resonance energy transfer) techniques to demonstrate the interaction between Sigma-1 receptor and human TRPA1. Pharmacological antagonism of Sigma-1R impaired the formation of this molecular complex and the trafficking of functional TRPA1 to the plasma membrane. Using patch-clamp electrophysiological recordings we found that antagonists of Sigma-1 receptor, including Sigma-1 receptor antagonist, exert a marked inhibition on plasma membrane expression and function of human TRPA1 channels. In TRPA1-expressing mouse sensory neurons, Sigma-1 receptor antagonists reduced inward currents and the firing of actions potentials in response to TRPA1 agonists. Finally, in a mouse experimental model of oxaliplatin neuropathy, systemic treatment with a Sigma-1 receptor antagonists prevented the development of painful symptoms by a mechanism involving TRPA1. In summary, the modulation of TRPA1 channels by Sigma-1 receptor antagonists suggests a new strategy for the prevention and treatment of chemotherapy-induced peripheral neuropathy and could inform the development of novel therapeutics for neuropathic pain.
    MeSH term(s) Mice ; Humans ; Animals ; Oxaliplatin/toxicity ; TRPA1 Cation Channel ; Antineoplastic Agents/toxicity ; Transient Receptor Potential Channels ; Neuralgia/chemically induced ; Neuralgia/prevention & control ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Sigma-1 Receptor
    Chemical Substances Oxaliplatin (04ZR38536J) ; TRPA1 Cation Channel ; Antineoplastic Agents ; Transient Receptor Potential Channels ; TRPA1 protein, human ; Trpa1 protein, mouse
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awac273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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