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  1. Article: Osteomalacia.

    Rosa, Jan

    Vnitrni lekarstvi

    2023  Volume 69, Issue 4, Page(s) 254–260

    Abstract: Osteomalacia with characteristic histomorphometric, radiographic, laboratory and clinical features is a prominent syndrome of disturbed bone mineralisation in adulthood. From an etiological point of view, osteomalacia is usually caused by substrate ( ... ...

    Title translation Osteomalacie.
    Abstract Osteomalacia with characteristic histomorphometric, radiographic, laboratory and clinical features is a prominent syndrome of disturbed bone mineralisation in adulthood. From an etiological point of view, osteomalacia is usually caused by substrate (calcium, phosphate) deficiency, presence of excess mineralization inhibitors or deficiency or ineffectivness of mineralization facilitator (vitamin D). In proportion to the high number of congenital and acquired causes of osteomalacia, its clinical and laboratory picture is heterogeneous and rarely fully expressed. The treatment of a particular case is determined by the cause of osteomalacia and may (but does not necessarily) include correction of the underlying disease, administration of calcium and various forms of vitamin D, as well as orthopaedic interventions. For some of the hereditary forms, biological or replacement therapy is prospectively available. The article attempts to cover the whole range of osteomalacia variants, mentioning a fact discussed only in recent years - the occurrence of oligosymptomatic, incompletely expressed forms.
    MeSH term(s) Humans ; Osteomalacia/diagnosis ; Osteomalacia/etiology ; Calcium ; Vitamin D/therapeutic use ; Vitamin D Deficiency ; Syndrome ; Vitamins/therapeutic use
    Chemical Substances Calcium (SY7Q814VUP) ; Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2023-06-09
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 138213-5
    ISSN 1801-7592 ; 0042-773X
    ISSN (online) 1801-7592
    ISSN 0042-773X
    DOI 10.36290/vnl.2023.048
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 327: Show issues Location:
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    Zs.MO 526: Show issues

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  2. Article ; Online: Simultaneous fMRI and metabolic MRS of hyperpolarized [1-

    Hyppönen, Viivi-Elina A / Rosa, Jessica / Kettunen, Mikko I

    NMR in biomedicine

    2024  Volume 37, Issue 5, Page(s) e5108

    Abstract: Functional MRI (fMRI) and MRS (fMRS) can be used to noninvasively map cerebral activation and metabolism. Recently, ... ...

    Abstract Functional MRI (fMRI) and MRS (fMRS) can be used to noninvasively map cerebral activation and metabolism. Recently, hyperpolarized
    MeSH term(s) Rats ; Female ; Animals ; Magnetic Resonance Imaging/methods ; Pyruvic Acid/metabolism ; Nicotine/pharmacology ; Rats, Sprague-Dawley ; Bicarbonates/metabolism ; Carbon Isotopes/metabolism ; Lactic Acid/metabolism
    Chemical Substances Pyruvic Acid (8558G7RUTR) ; Nicotine (6M3C89ZY6R) ; Bicarbonates ; Carbon Isotopes ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.5108
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    Zs.A 2869: Show issues Location:
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  3. Article ; Online: FDA approvals in 2023: biomarker-positive subsets, equipoise and verification of benefit.

    Norsworthy, Kelly J / Lee-Alonzo, Rosa J / Pazdur, Richard

    Nature reviews. Clinical oncology

    2024  Volume 21, Issue 5, Page(s) 333–334

    MeSH term(s) Humans ; United States Food and Drug Administration ; United States ; Drug Approval ; Biomarkers, Tumor/genetics ; Neoplasms/drug therapy ; Neoplasms/genetics
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-024-00871-5
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    Zs.MG 103: Show issues

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  4. Article ; Online: Toll-Like receptor 4 (TLR4) polymorphism rs2149356 and risk of gout in a Spanish cohort.

    Torres, Rosa J

    Nucleosides, nucleotides & nucleic acids

    2020  Volume 39, Issue 10-12, Page(s) 1424–1431

    Abstract: Gout is the most common arthritis and it is associated to urate monosodium crystals deposits in articulations, kidney and soft tissue. The urate monosodium crystals deposit initiates an inflammatory response; mediated by NLRP3 inflammasome, with the ... ...

    Abstract Gout is the most common arthritis and it is associated to urate monosodium crystals deposits in articulations, kidney and soft tissue. The urate monosodium crystals deposit initiates an inflammatory response; mediated by NLRP3 inflammasome, with the release of interleukin 1β. Toll-like receptor 4 (TLR4) is involved in this response. Although serum urate level is a strong predictor of incident gout, only about half of those with serum urate concentrations ≥10mg/dL develop clinically evident gout over 15 years. Therefore, it has been postulated that other factors, including genetic or immunity related factors, seems to be necessary to the apparition of the acute gout flare beside hyperuricemia. The association of TLR4 single nucleotide polymorphism (SNP) rs2149356 and gout risk is controversial with different results according to different populations.
    MeSH term(s) Cohort Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Gout/genetics ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Spain ; Toll-Like Receptor 4/genetics
    Chemical Substances TLR4 protein, human ; Toll-Like Receptor 4
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008956-9
    ISSN 1532-2335 ; 1525-7770
    ISSN (online) 1532-2335
    ISSN 1525-7770
    DOI 10.1080/15257770.2020.1780438
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3870: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Clinical experience with adjustable scleral lenses.

    Lipener, César / Rosa, Juliana

    Arquivos brasileiros de oftalmologia

    2022  Volume 86, Issue 1, Page(s) 38–45

    Abstract: Purpose: The aim of this study was to evaluate the fitting process of a scleral lens that allows several parameter adjustments during trials and after the initial period of use. In addition, we verified which adjustments were needed and used the most, ... ...

    Abstract Purpose: The aim of this study was to evaluate the fitting process of a scleral lens that allows several parameter adjustments during trials and after the initial period of use. In addition, we verified which adjustments were needed and used the most, their indications, and how often these resources were used, and checked the results.
    Methods: Scleral contact lens fittings in a private clinic setting were prospectively analyzed in a sequential, non-randomized, and non-comparative manner. All the patients underwent a complete ophthalmic examination and had an indication for scleral lens use (Zenlens, Alden Optical).
    Results: Scleral fit was analyzed in 80 eyes of 45 patients. Regarding diagnosis, 72% of the patients had keratoconus; 12%, radial keratotomy; 5%, post-refractive surgery ectasia; 5%, dry eye; and 3%, high myopia. In 66 (82.5%) of the 80 eyes studied, parameters were modified when the lenses were ordered. The reasons that led to the modifications were apical touch or decreased sagittal height, increased sagittal height, cylindrical over-refraction, poor visual acuity, lens flexure, peripheral touch, 360° edge compression, horizontal edge compression, and vertical edge compression.
    Conclusion: In this study, the use of Zenlens scleral lenses was shown to be a promising corrective treatment for patients requiring the use of scleral lenses. Although the study suggests a learning curve, as many adjustments were allowed, the lens could be customized according to the patients' needs. This increased the success rates of fitting and wearing, and consequently, use of the lens became a great option for the visual rehabilitation of patients.
    Language English
    Publishing date 2022-02-16
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.20230009
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    Zs.B 503: Show issues Location:
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    Zs.MO 317: Show issues

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  6. Article: Neurodevelopmental Subtypes of Functional Brain Organization in the ABCD Study Using a Rigorous Analytic Framework.

    DeRosa, Jacob / Friedman, Naomi P / Calhoun, Vince / Banich, Marie T

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The current study demonstrates that an individual's resting-state functional connectivity (RSFC) is a dependable biomarker for identifying differential patterns of cognitive and emotional functioning during late childhood. Using baseline RSFC data from ... ...

    Abstract The current study demonstrates that an individual's resting-state functional connectivity (RSFC) is a dependable biomarker for identifying differential patterns of cognitive and emotional functioning during late childhood. Using baseline RSFC data from the Adolescent Brain Cognitive Development (ABCD) study, which includes children aged 9-11, we identified four distinct RSFC subtypes We introduce an integrated methodological pipeline for testing the reliability and importance of these subtypes. In the Identification phase, Leiden Community Detection defined RSFC subtypes, with their reproducibility confirmed through a split-sample technique in the Validation stage. The Evaluation phase showed that distinct cognitive and mental health profiles are associated with each subtype, with the Predictive phase indicating that subtypes better predict various cognitive and mental health characteristics than individual RSFC connections. The Replication stage employed bootstrapping and down-sampling methods to substantiate the reproducibility of these subtypes further. This work allows future explorations of developmental trajectories of these RSFC subtypes.
    Language English
    Publishing date 2024-03-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.16.585343
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  7. Article ; Online: The pristine precursor of Andean-type magmatism preserved in magma mingling zones.

    Gómez-Frutos, Daniel / Castro, Antonio / de la Rosa, Jesús

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5047

    Abstract: Intermediate magma compositions have been postulated to be parental to Andean-type magmatism in the recent years. Geochemical and experimental methods have allowed the modelling of a hypothetical parental composition that accounts for the major element ... ...

    Abstract Intermediate magma compositions have been postulated to be parental to Andean-type magmatism in the recent years. Geochemical and experimental methods have allowed the modelling of a hypothetical parental composition that accounts for the major element trends displayed by Andean-type batholiths. However, natural plutonic examples matching the modelled composition remain lacking, likely due to the predominance of fractionated liquids and cumulates in the batholiths after protracted and large-scale differentiation. Contrary to this, magma mingling zones, a common feature in Andean-type batholiths, are characterised by quenching phenomena, minimising differentiation. In this paper, we present data from intermediate magmatism in the world-class Gerena magma mingling zone in the Seville Sierra Norte batholith (southern Iberia), compositionally equivalent to Andean-type magmatic series. Geochemical data from quenched dark globules of variable scale and the corresponding host granodiorites are contrasted with the bimodal trends displayed by the host batholith. Results suggest that the smaller-scale dark globules have not undergone any significant fractionation. Furthermore, after conducting geochemical modelling we conclude the dark globules represent a composition that could be parental to Andean-type magmas. We propose that magma mingling zones are an optimal place to probe for parental magmas of Andean-type magmatism, particularly those represented in pristine melanocratic, intermediate globules.
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55699-x
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  8. Article ; Online: Breaking barriers for glioblastoma with a path to enhanced drug delivery.

    Noorani, Imran / de la Rosa, Jorge

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 5909

    MeSH term(s) Humans ; Glioblastoma/drug therapy
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-41694-9
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  9. Article ; Online: Dried aquatic macrophytes are floating egg banks and potential dispersal vectors of ostracods (Crustacea) from pleuston communities

    Rosa, Jonathan / Martens, K. / Higuti, Janet

    Hydrobiologia. 2023 Mar., v. 850, no. 6 p.1319-1329

    2023  

    Abstract: In aquatic ecosystems, such as Neotropical floodplains, it is common to find dried aquatic macrophytes along the margins of various environments (e.g. lakes and rivers) during the dry season. Here, we evaluate the potential of dried Eichhornia crassipes ... ...

    Abstract In aquatic ecosystems, such as Neotropical floodplains, it is common to find dried aquatic macrophytes along the margins of various environments (e.g. lakes and rivers) during the dry season. Here, we evaluate the potential of dried Eichhornia crassipes as a dispersal vector of ostracod resting eggs by assessing the abundance, richness and beta diversity of the dormant associated fauna. We test two hypotheses: (1) that the roots of E. crassipes shelter and disperse ostracod resting eggs and (2) that the abundance, richness and beta diversity of dormant assemblages will increase over the incubation time after re-hydration. Dried E. crassipes from floodplain lakes were hydrated with distilled water. The microcosms were kept in germinating chambers with controlled temperature and photoperiod during 147 days. A total of 397 ostracods representing seven species hatched from the resting eggs attached to dried macrophyte roots. An increase in richness and a decrease in abundance were observed over the weeks, although these trends were not significant. However, the beta diversity increased significantly over the incubation time. Our results show that the complex root systems of E. crassipes have the potential for storage and dispersal of ostracod resting eggs.
    Keywords Eichhornia crassipes ; Neotropics ; Ostracoda ; dry season ; eggs ; fauna ; floodplains ; macrophytes ; species diversity ; temperature
    Language English
    Dates of publication 2023-03
    Size p. 1319-1329.
    Publishing place Springer International Publishing
    Document type Article ; Online
    ZDB-ID 214428-1
    ISSN 1573-5117 ; 0018-8158
    ISSN (online) 1573-5117
    ISSN 0018-8158
    DOI 10.1007/s10750-022-04818-8
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Melting Pot or Boiling Pot? Exploring Our Society's Diversity.

    DeLaRosa, Jacob

    The Annals of thoracic surgery

    2021  Volume 114, Issue 1, Page(s) 18–19

    Language English
    Publishing date 2021-07-24
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2021.06.055
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    Zs.A 252: Show issues Location:
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