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Article ; Online: Lateral ventricle differences between first-episode schizophrenia and first-episode psychotic bipolar disorder: A population-based morphometric MRI study.

Rosa, Pedro G P / Schaufelberger, Maristela S / Uchida, Ricardo R / Duran, Fabio L S / Lappin, Julia M / Menezes, Paulo R / Scazufca, Márcia / McGuire, Philip K / Murray, Robin M / Busatto, Geraldo F

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

2010 Volume 11, Issue 7, Page(s) 873–887

Abstract: Objectives: The extent to which psychotic disorders fall into distinct diagnostic categories or can be regarded as lying on a single continuum is controversial. We compared lateral ventricle volumes between a large sample of patients with first-episode ... ...

Abstract	Objectives: The extent to which psychotic disorders fall into distinct diagnostic categories or can be regarded as lying on a single continuum is controversial. We compared lateral ventricle volumes between a large sample of patients with first-episode schizophrenia or bipolar disorder and a healthy control group from the same neighbourhood. Methods: Population-based MRI study with 88 first-episode psychosis (FEP) patients, grouped into those with schizophrenia/schizophreniform disorder (N=62), bipolar disorder (N=26) and 94 controls. Results: Right and left lateral ventricular and right temporal horn volumes were larger in FEP subjects than controls. Within the FEP sample, post-hoc tests revealed larger left lateral ventricles and larger right and left temporal horns in schizophrenia subjects relative to controls, while there was no difference between patients with bipolar disorder and controls. None of the findings was attributable to effects of antipsychotics. Conclusions: This large-sample population-based MRI study showed that neuroanatomical abnormalities in subjects with schizophrenia relative to controls from the same neighbourhood are evident at the first episode of illness, but are not detectable in bipolar disorder patients. These data are consistent with a model of psychosis in which early brain insults of neurodevelopmental origin are more relevant to schizophrenia than to bipolar disorder.
MeSH term(s)	Adult ; Bipolar Disorder/diagnosis ; Bipolar Disorder/pathology ; Brain/pathology ; Dominance, Cerebral/physiology ; Female ; Humans ; Image Processing, Computer-Assisted ; Lateral Ventricles/pathology ; Magnetic Resonance Imaging ; Male ; Organ Size/physiology ; Psychotic Disorders/diagnosis ; Psychotic Disorders/pathology ; Psychotic Disorders/psychology ; Recurrence ; Reference Values ; Schizophrenia/diagnosis ; Schizophrenia/pathology ; Schizophrenic Psychology ; Young Adult
Language	English
Publishing date	2010-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2051402-5
ISSN	1814-1412 ; 1562-2975
ISSN (online)	1814-1412
ISSN	1562-2975
DOI	10.3109/15622975.2010.486042
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Article ; Online: A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.

Gutman, Boris A / van Erp, Theo G M / Alpert, Kathryn / Ching, Christopher R K / Isaev, Dmitry / Ragothaman, Anjani / Jahanshad, Neda / Saremi, Arvin / Zavaliangos-Petropulu, Artemis / Glahn, David C / Shen, Li / Cong, Shan / Alnaes, Dag / Andreassen, Ole Andreas / Doan, Nhat Trung / Westlye, Lars T / Kochunov, Peter / Satterthwaite, Theodore D / Wolf, Daniel H /

Huang, Alexander J / Kessler, Charles / Weideman, Andrea / Nguyen, Dana / Mueller, Bryon A / Faziola, Lawrence / Potkin, Steven G / Preda, Adrian / Mathalon, Daniel H / Bustillo, Juan / Calhoun, Vince / Ford, Judith M / Walton, Esther / Ehrlich, Stefan / Ducci, Giuseppe / Banaj, Nerisa / Piras, Fabrizio / Piras, Federica / Spalletta, Gianfranco / Canales-Rodríguez, Erick J / Fuentes-Claramonte, Paola / Pomarol-Clotet, Edith / Radua, Joaquim / Salvador, Raymond / Sarró, Salvador / Dickie, Erin W / Voineskos, Aristotle / Tordesillas-Gutiérrez, Diana / Crespo-Facorro, Benedicto / Setién-Suero, Esther / van Son, Jacqueline Mayoral / Borgwardt, Stefan / Schönborn-Harrisberger, Fabienne / Morris, Derek / Donohoe, Gary / Holleran, Laurena / Cannon, Dara / McDonald, Colm / Corvin, Aiden / Gill, Michael / Filho, Geraldo Busatto / Rosa, Pedro G P / Serpa, Mauricio H / Zanetti, Marcus V / Lebedeva, Irina / Kaleda, Vasily / Tomyshev, Alexander / Crow, Tim / James, Anthony / Cervenka, Simon / Sellgren, Carl M / Fatouros-Bergman, Helena / Agartz, Ingrid / Howells, Fleur / Stein, Dan J / Temmingh, Henk / Uhlmann, Anne / de Zubicaray, Greig I / McMahon, Katie L / Wright, Margie / Cobia, Derin / Csernansky, John G / Thompson, Paul M / Turner, Jessica A / Wang, Lei

Human brain mapping

2021 Volume 43, Issue 1, Page(s) 352–372

Abstract: Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ... ...

Abstract	Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.
MeSH term(s)	Amygdala/diagnostic imaging ; Amygdala/pathology ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/pathology ; Hippocampus/diagnostic imaging ; Hippocampus/pathology ; Humans ; Multicenter Studies as Topic ; Neuroimaging ; Schizophrenia/diagnostic imaging ; Schizophrenia/pathology ; Thalamus/diagnostic imaging ; Thalamus/pathology
Language	English
Publishing date	2021-09-08
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.25625
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Article ; Online: Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals.

Favre, Pauline / Pauling, Melissa / Stout, Jacques / Hozer, Franz / Sarrazin, Samuel / Abé, Christoph / Alda, Martin / Alloza, Clara / Alonso-Lana, Silvia / Andreassen, Ole A / Baune, Bernhard T / Benedetti, Francesco / Busatto, Geraldo F / Canales-Rodríguez, Erick J / Caseras, Xavier / Chaim-Avancini, Tiffany Moukbel / Ching, Christopher R K / Dannlowski, Udo / Deppe, Michael /

Eyler, Lisa T / Fatjo-Vilas, Mar / Foley, Sonya F / Grotegerd, Dominik / Hajek, Tomas / Haukvik, Unn K / Howells, Fleur M / Jahanshad, Neda / Kugel, Harald / Lagerberg, Trine V / Lawrie, Stephen M / Linke, Julia O / McIntosh, Andrew / Melloni, Elisa M T / Mitchell, Philip B / Polosan, Mircea / Pomarol-Clotet, Edith / Repple, Jonathan / Roberts, Gloria / Roos, Annerine / Rosa, Pedro G P / Salvador, Raymond / Sarró, Salvador / Schofield, Peter R / Serpa, Mauricio H / Sim, Kang / Stein, Dan J / Sussmann, Jess E / Temmingh, Henk S / Thompson, Paul M / Verdolini, Norma / Vieta, Eduard / Wessa, Michele / Whalley, Heather C / Zanetti, Marcus V / Leboyer, Marion / Mangin, Jean-François / Henry, Chantal / Duchesnay, Edouard / Houenou, Josselin

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2019 Volume 44, Issue 13, Page(s) 2298

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Language	English
Publishing date	2019-09-16
Publishing country	England
Document type	Published Erratum
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-019-0521-6
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Article ; Online: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2019 Volume 44, Issue 13, Page(s) 2285–2293

Abstract: Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical ... ...

Abstract	Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R
MeSH term(s)	Adult ; Bipolar Disorder/diagnostic imaging ; Bipolar Disorder/pathology ; Brain/diagnostic imaging ; Brain/pathology ; Corpus Callosum/diagnostic imaging ; Corpus Callosum/pathology ; Diffusion Tensor Imaging ; Female ; Humans ; Male ; Neural Pathways/diagnostic imaging ; Neural Pathways/pathology ; White Matter/diagnostic imaging ; White Matter/pathology
Language	English
Publishing date	2019-08-21
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-019-0485-6
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Article ; Online: Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.

Hoogman, Martine / van Rooij, Daan / Klein, Marieke / Boedhoe, Premika / Ilioska, Iva / Li, Ting / Patel, Yash / Postema, Merel C / Zhang-James, Yanli / Anagnostou, Evdokia / Arango, Celso / Auzias, Guillaume / Banaschewski, Tobias / Bau, Claiton H D / Behrmann, Marlene / Bellgrove, Mark A / Brandeis, Daniel / Brem, Silvia / Busatto, Geraldo F /

Calderoni, Sara / Calvo, Rosa / Castellanos, Francisco X / Coghill, David / Conzelmann, Annette / Daly, Eileen / Deruelle, Christine / Dinstein, Ilan / Durston, Sarah / Ecker, Christine / Ehrlich, Stefan / Epstein, Jeffery N / Fair, Damien A / Fitzgerald, Jacqueline / Freitag, Christine M / Frodl, Thomas / Gallagher, Louise / Grevet, Eugenio H / Haavik, Jan / Hoekstra, Pieter J / Janssen, Joost / Karkashadze, Georgii / King, Joseph A / Konrad, Kerstin / Kuntsi, Jonna / Lazaro, Luisa / Lerch, Jason P / Lesch, Klaus-Peter / Louza, Mario R / Luna, Beatriz / Mattos, Paulo / McGrath, Jane / Muratori, Filippo / Murphy, Clodagh / Nigg, Joel T / Oberwelland-Weiss, Eileen / O'Gorman Tuura, Ruth L / O'Hearn, Kirsten / Oosterlaan, Jaap / Parellada, Mara / Pauli, Paul / Plessen, Kerstin J / Ramos-Quiroga, J Antoni / Reif, Andreas / Reneman, Liesbeth / Retico, Alessandra / Rosa, Pedro G P / Rubia, Katya / Shaw, Philip / Silk, Tim J / Tamm, Leanne / Vilarroya, Oscar / Walitza, Susanne / Jahanshad, Neda / Faraone, Stephen V / Francks, Clyde / van den Heuvel, Odile A / Paus, Tomas / Thompson, Paul M / Buitelaar, Jan K / Franke, Barbara

Human brain mapping

2020 Volume 43, Issue 1, Page(s) 37–55

Abstract: Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging ... ...

Abstract	Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case-control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case-control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.
MeSH term(s)	Attention Deficit Disorder with Hyperactivity/diagnostic imaging ; Attention Deficit Disorder with Hyperactivity/pathology ; Autism Spectrum Disorder/diagnostic imaging ; Autism Spectrum Disorder/pathology ; Brain/diagnostic imaging ; Brain/pathology ; Humans ; Multicenter Studies as Topic ; Neuroimaging ; Neurosciences
Language	English
Publishing date	2020-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.25029
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Article ; Online: Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets.

Postema, Merel C / Hoogman, Martine / Ambrosino, Sara / Asherson, Philip / Banaschewski, Tobias / Bandeira, Cibele E / Baranov, Alexandr / Bau, Claiton H D / Baumeister, Sarah / Baur-Streubel, Ramona / Bellgrove, Mark A / Biederman, Joseph / Bralten, Janita / Brandeis, Daniel / Brem, Silvia / Buitelaar, Jan K / Busatto, Geraldo F / Castellanos, Francisco X / Cercignani, Mara /

Chaim-Avancini, Tiffany M / Chantiluke, Kaylita C / Christakou, Anastasia / Coghill, David / Conzelmann, Annette / Cubillo, Ana I / Cupertino, Renata B / de Zeeuw, Patrick / Doyle, Alysa E / Durston, Sarah / Earl, Eric A / Epstein, Jeffery N / Ethofer, Thomas / Fair, Damien A / Fallgatter, Andreas J / Faraone, Stephen V / Frodl, Thomas / Gabel, Matt C / Gogberashvili, Tinatin / Grevet, Eugenio H / Haavik, Jan / Harrison, Neil A / Hartman, Catharina A / Heslenfeld, Dirk J / Hoekstra, Pieter J / Hohmann, Sarah / Høvik, Marie F / Jernigan, Terry L / Kardatzki, Bernd / Karkashadze, Georgii / Kelly, Clare / Kohls, Gregor / Konrad, Kerstin / Kuntsi, Jonna / Lazaro, Luisa / Lera-Miguel, Sara / Lesch, Klaus-Peter / Louza, Mario R / Lundervold, Astri J / Malpas, Charles B / Mattos, Paulo / McCarthy, Hazel / Namazova-Baranova, Leyla / Nicolau, Rosa / Nigg, Joel T / Novotny, Stephanie E / Oberwelland Weiss, Eileen / O'Gorman Tuura, Ruth L / Oosterlaan, Jaap / Oranje, Bob / Paloyelis, Yannis / Pauli, Paul / Picon, Felipe A / Plessen, Kerstin J / Ramos-Quiroga, J Antoni / Reif, Andreas / Reneman, Liesbeth / Rosa, Pedro G P / Rubia, Katya / Schrantee, Anouk / Schweren, Lizanne J S / Seitz, Jochen / Shaw, Philip / Silk, Tim J / Skokauskas, Norbert / Soliva Vila, Juan C / Stevens, Michael C / Sudre, Gustavo / Tamm, Leanne / Tovar-Moll, Fernanda / van Erp, Theo G M / Vance, Alasdair / Vilarroya, Oscar / Vives-Gilabert, Yolanda / von Polier, Georg G / Walitza, Susanne / Yoncheva, Yuliya N / Zanetti, Marcus V / Ziegler, Georg C / Glahn, David C / Jahanshad, Neda / Medland, Sarah E / Thompson, Paul M / Fisher, Simon E / Franke, Barbara / Francks, Clyde

Journal of child psychology and psychiatry, and allied disciplines

2021 Volume 62, Issue 10, Page(s) 1202–1219

Abstract: Objective: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain ... ...

Abstract	Objective: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. Methods: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries. Results: There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing. Conclusion: Prior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.
MeSH term(s)	Adolescent ; Adult ; Attention Deficit Disorder with Hyperactivity ; Autism Spectrum Disorder ; Brain/diagnostic imaging ; Caudate Nucleus ; Child ; Humans ; Magnetic Resonance Imaging
Language	English
Publishing date	2021-03-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218136-8
ISSN	1469-7610 ; 0021-9630 ; 0373-8086
ISSN (online)	1469-7610
ISSN	0021-9630 ; 0373-8086
DOI	10.1111/jcpp.13396
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Article ; Online: No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis.

de Kovel, Carolien G F / Aftanas, Lyubomir / Aleman, André / Alexander-Bloch, Aaron F / Baune, Bernhard T / Brack, Ivan / Bülow, Robin / Busatto Filho, Geraldo / Carballedo, Angela / Connolly, Colm G / Cullen, Kathryn R / Dannlowski, Udo / Davey, Christopher G / Dima, Danai / Dohm, Katharina / Erwin-Grabner, Tracy / Frodl, Thomas / Fu, Cynthia H Y / Hall, Geoffrey B /

Glahn, David C / Godlewska, Beata / Gotlib, Ian H / Goya-Maldonado, Roberto / Grabe, Hans Jörgen / Groenewold, Nynke A / Grotegerd, Dominik / Gruber, Oliver / Harris, Mathew A / Harrison, Ben J / Hatton, Sean N / Hickie, Ian B / Ho, Tiffany C / Jahanshad, Neda / Kircher, Tilo / Krämer, Bernd / Krug, Axel / Lagopoulos, Jim / Leehr, Elisabeth J / Li, Meng / MacMaster, Frank P / MacQueen, Glenda / McIntosh, Andrew M / McLellan, Quinn / Medland, Sarah E / Mueller, Bryon A / Nenadic, Igor / Osipov, Evgeny / Papmeyer, Martina / Portella, Maria J / Reneman, Liesbeth / Rosa, Pedro G P / Sacchet, Matthew D / Schnell, Knut / Schrantee, Anouk / Sim, Kang / Simulionyte, Egle / Sindermann, Lisa / Singh, Aditya / Stein, Dan J / Ubani, Benjamin N / Van der Wee, Nic J A / Van der Werff, Steven J A / Veer, Ilya M / Vives-Gilabert, Yolanda / Völzke, Henry / Walter, Henrik / Walter, Martin / Schreiner, Melinda Westlund / Whalley, Heather / Winter, Nils / Wittfeld, Katharina / Yang, Tony T / Yüksel, Dilara / Zaremba, Dario / Thompson, Paul M / Veltman, Dick J / Schmaal, Lianne / Francks, Clyde

The American journal of psychiatry

2019 Volume 176, Issue 12, Page(s) 1039–1049

Abstract: Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy ... ...

Abstract	Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.
MeSH term(s)	Adult ; Brain/anatomy & histology ; Case-Control Studies ; Databases, Factual/statistics & numerical data ; Depressive Disorder, Major/pathology ; Dominance, Cerebral ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Meta-Analysis as Topic ; Neuroimaging ; Young Adult
Language	English
Publishing date	2019-07-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	280045-7
ISSN	1535-7228 ; 0002-953X
ISSN (online)	1535-7228
ISSN	0002-953X
DOI	10.1176/appi.ajp.2019.18101144
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Article ; Online: Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples.

Hoogman, Martine / Muetzel, Ryan / Guimaraes, Joao P / Shumskaya, Elena / Mennes, Maarten / Zwiers, Marcel P / Jahanshad, Neda / Sudre, Gustavo / Wolfers, Thomas / Earl, Eric A / Soliva Vila, Juan Carlos / Vives-Gilabert, Yolanda / Khadka, Sabin / Novotny, Stephanie E / Hartman, Catharina A / Heslenfeld, Dirk J / Schweren, Lizanne J S / Ambrosino, Sara / Oranje, Bob /

de Zeeuw, Patrick / Chaim-Avancini, Tiffany M / Rosa, Pedro G P / Zanetti, Marcus V / Malpas, Charles B / Kohls, Gregor / von Polier, Georg G / Seitz, Jochen / Biederman, Joseph / Doyle, Alysa E / Dale, Anders M / van Erp, Theo G M / Epstein, Jeffery N / Jernigan, Terry L / Baur-Streubel, Ramona / Ziegler, Georg C / Zierhut, Kathrin C / Schrantee, Anouk / Høvik, Marie F / Lundervold, Astri J / Kelly, Clare / McCarthy, Hazel / Skokauskas, Norbert / O'Gorman Tuura, Ruth L / Calvo, Anna / Lera-Miguel, Sara / Nicolau, Rosa / Chantiluke, Kaylita C / Christakou, Anastasia / Vance, Alasdair / Cercignani, Mara / Gabel, Matt C / Asherson, Philip / Baumeister, Sarah / Brandeis, Daniel / Hohmann, Sarah / Bramati, Ivanei E / Tovar-Moll, Fernanda / Fallgatter, Andreas J / Kardatzki, Bernd / Schwarz, Lena / Anikin, Anatoly / Baranov, Alexandr / Gogberashvili, Tinatin / Kapilushniy, Dmitry / Solovieva, Anastasia / El Marroun, Hanan / White, Tonya / Karkashadze, Georgii / Namazova-Baranova, Leyla / Ethofer, Thomas / Mattos, Paulo / Banaschewski, Tobias / Coghill, David / Plessen, Kerstin J / Kuntsi, Jonna / Mehta, Mitul A / Paloyelis, Yannis / Harrison, Neil A / Bellgrove, Mark A / Silk, Tim J / Cubillo, Ana I / Rubia, Katya / Lazaro, Luisa / Brem, Silvia / Walitza, Susanne / Frodl, Thomas / Zentis, Mariam / Castellanos, Francisco X / Yoncheva, Yuliya N / Haavik, Jan / Reneman, Liesbeth / Conzelmann, Annette / Lesch, Klaus-Peter / Pauli, Paul / Reif, Andreas / Tamm, Leanne / Konrad, Kerstin / Oberwelland Weiss, Eileen / Busatto, Geraldo F / Louza, Mario R / Durston, Sarah / Hoekstra, Pieter J / Oosterlaan, Jaap / Stevens, Michael C / Ramos-Quiroga, J Antoni / Vilarroya, Oscar / Fair, Damien A / Nigg, Joel T / Thompson, Paul M / Buitelaar, Jan K / Faraone, Stephen V / Shaw, Philip / Tiemeier, Henning / Bralten, Janita / Franke, Barbara

The American journal of psychiatry

2019 Volume 176, Issue 7, Page(s) 531–542

Abstract: Objective: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical ... ...

Abstract	Objective: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical characteristics related to ADHD using large-scale studies. Methods: Cortical thickness and surface area (based on the Desikan-Killiany atlas) were compared between case subjects with ADHD (N=2,246) and control subjects (N=1,934) for children, adolescents, and adults separately in ENIGMA-ADHD, a consortium of 36 centers. To assess familial effects on cortical measures, case subjects, unaffected siblings, and control subjects in the NeuroIMAGE study (N=506) were compared. Associations of the attention scale from the Child Behavior Checklist with cortical measures were determined in a pediatric population sample (Generation-R, N=2,707). Results: In the ENIGMA-ADHD sample, lower surface area values were found in children with ADHD, mainly in frontal, cingulate, and temporal regions; the largest significant effect was for total surface area (Cohen's d=-0.21). Fusiform gyrus and temporal pole cortical thickness was also lower in children with ADHD. Neither surface area nor thickness differences were found in the adolescent or adult groups. Familial effects were seen for surface area in several regions. In an overlapping set of regions, surface area, but not thickness, was associated with attention problems in the Generation-R sample. Conclusions: Subtle differences in cortical surface area are widespread in children but not adolescents and adults with ADHD, confirming involvement of the frontal cortex and highlighting regions deserving further attention. Notably, the alterations behave like endophenotypes in families and are linked to ADHD symptoms in the population, extending evidence that ADHD behaves as a continuous trait in the population. Future longitudinal studies should clarify individual lifespan trajectories that lead to nonsignificant findings in adolescent and adult groups despite the presence of an ADHD diagnosis.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Attention Deficit Disorder with Hyperactivity/diagnostic imaging ; Attention Deficit Disorder with Hyperactivity/pathology ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Case-Control Studies ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Cerebral Cortex/physiopathology ; Child ; Child, Preschool ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Psychiatric Status Rating Scales ; Sex Factors ; Young Adult
Language	English
Publishing date	2019-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	280045-7
ISSN	1535-7228 ; 0002-953X
ISSN (online)	1535-7228
ISSN	0002-953X
DOI	10.1176/appi.ajp.2019.18091033
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.

Dima, Danai / Modabbernia, Amirhossein / Papachristou, Efstathios / Doucet, Gaelle E / Agartz, Ingrid / Aghajani, Moji / Akudjedu, Theophilus N / Albajes-Eizagirre, Anton / Alnaes, Dag / Alpert, Kathryn I / Andersson, Micael / Andreasen, Nancy C / Andreassen, Ole A / Asherson, Philip / Banaschewski, Tobias / Bargallo, Nuria / Baumeister, Sarah / Baur-Streubel, Ramona / Bertolino, Alessandro /

Bonvino, Aurora / Boomsma, Dorret I / Borgwardt, Stefan / Bourque, Josiane / Brandeis, Daniel / Breier, Alan / Brodaty, Henry / Brouwer, Rachel M / Buitelaar, Jan K / Busatto, Geraldo F / Buckner, Randy L / Calhoun, Vincent / Canales-Rodríguez, Erick J / Cannon, Dara M / Caseras, Xavier / Castellanos, Francisco X / Cervenka, Simon / Chaim-Avancini, Tiffany M / Ching, Christopher R K / Chubar, Victoria / Clark, Vincent P / Conrod, Patricia / Conzelmann, Annette / Crespo-Facorro, Benedicto / Crivello, Fabrice / Crone, Eveline A / Dannlowski, Udo / Dale, Anders M / Davey, Christopher / de Geus, Eco J C / de Haan, Lieuwe / de Zubicaray, Greig I / den Braber, Anouk / Dickie, Erin W / Di Giorgio, Annabella / Doan, Nhat Trung / Dørum, Erlend S / Ehrlich, Stefan / Erk, Susanne / Espeseth, Thomas / Fatouros-Bergman, Helena / Fisher, Simon E / Fouche, Jean-Paul / Franke, Barbara / Frodl, Thomas / Fuentes-Claramonte, Paola / Glahn, David C / Gotlib, Ian H / Grabe, Hans-Jörgen / Grimm, Oliver / Groenewold, Nynke A / Grotegerd, Dominik / Gruber, Oliver / Gruner, Patricia / Gur, Rachel E / Gur, Ruben C / Hahn, Tim / Harrison, Ben J / Hartman, Catharine A / Hatton, Sean N / Heinz, Andreas / Heslenfeld, Dirk J / Hibar, Derrek P / Hickie, Ian B / Ho, Beng-Choon / Hoekstra, Pieter J / Hohmann, Sarah / Holmes, Avram J / Hoogman, Martine / Hosten, Norbert / Howells, Fleur M / Hulshoff Pol, Hilleke E / Huyser, Chaim / Jahanshad, Neda / James, Anthony / Jernigan, Terry L / Jiang, Jiyang / Jönsson, Erik G / Joska, John A / Kahn, Rene / Kalnin, Andrew / Kanai, Ryota / Klein, Marieke / Klyushnik, Tatyana P / Koenders, Laura / Koops, Sanne / Krämer, Bernd / Kuntsi, Jonna / Lagopoulos, Jim / Lázaro, Luisa / Lebedeva, Irina / Lee, Won Hee / Lesch, Klaus-Peter / Lochner, Christine / Machielsen, Marise W J / Maingault, Sophie / Martin, Nicholas G / Martínez-Zalacaín, Ignacio / Mataix-Cols, David / Mazoyer, Bernard / McDonald, Colm / McDonald, Brenna C / McIntosh, Andrew M / McMahon, Katie L / McPhilemy, Genevieve / Meinert, Susanne / Menchón, José M / Medland, Sarah E / Meyer-Lindenberg, Andreas / Naaijen, Jilly / Najt, Pablo / Nakao, Tomohiro / Nordvik, Jan E / Nyberg, Lars / Oosterlaan, Jaap / de la Foz, Víctor Ortiz-García / Paloyelis, Yannis / Pauli, Paul / Pergola, Giulio / Pomarol-Clotet, Edith / Portella, Maria J / Potkin, Steven G / Radua, Joaquim / Reif, Andreas / Rinker, Daniel A / Roffman, Joshua L / Rosa, Pedro G P / Sacchet, Matthew D / Sachdev, Perminder S / Salvador, Raymond / Sánchez-Juan, Pascual / Sarró, Salvador / Satterthwaite, Theodore D / Saykin, Andrew J / Serpa, Mauricio H / Schmaal, Lianne / Schnell, Knut / Schumann, Gunter / Sim, Kang / Smoller, Jordan W / Sommer, Iris / Soriano-Mas, Carles / Stein, Dan J / Strike, Lachlan T / Swagerman, Suzanne C / Tamnes, Christian K / Temmingh, Henk S / Thomopoulos, Sophia I / Tomyshev, Alexander S / Tordesillas-Gutiérrez, Diana / Trollor, Julian N / Turner, Jessica A / Uhlmann, Anne / van den Heuvel, Odile A / van den Meer, Dennis / van der Wee, Nic J A / van Haren, Neeltje E M / Van't Ent, Dennis / van Erp, Theo G M / Veer, Ilya M / Veltman, Dick J / Voineskos, Aristotle / Völzke, Henry / Walter, Henrik / Walton, Esther / Wang, Lei / Wang, Yang / Wassink, Thomas H / Weber, Bernd / Wen, Wei / West, John D / Westlye, Lars T / Whalley, Heather / Wierenga, Lara M / Williams, Steven C R / Wittfeld, Katharina / Wolf, Daniel H / Worker, Amanda / Wright, Margaret J / Yang, Kun / Yoncheva, Yulyia / Zanetti, Marcus V / Ziegler, Georg C / Thompson, Paul M / Frangou, Sophia

Human brain mapping

2021 Volume 43, Issue 1, Page(s) 452–469

Abstract: Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or ... ...

Abstract	Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Amygdala/anatomy & histology ; Amygdala/diagnostic imaging ; Corpus Striatum/anatomy & histology ; Corpus Striatum/diagnostic imaging ; Hippocampus/anatomy & histology ; Hippocampus/diagnostic imaging ; Human Development/physiology ; Neuroimaging ; Thalamus/anatomy & histology ; Thalamus/diagnostic imaging
Language	English
Publishing date	2021-02-11
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.25320
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.

Frangou, Sophia / Modabbernia, Amirhossein / Williams, Steven C R / Papachristou, Efstathios / Doucet, Gaelle E / Agartz, Ingrid / Aghajani, Moji / Akudjedu, Theophilus N / Albajes-Eizagirre, Anton / Alnaes, Dag / Alpert, Kathryn I / Andersson, Micael / Andreasen, Nancy C / Andreassen, Ole A / Asherson, Philip / Banaschewski, Tobias / Bargallo, Nuria / Baumeister, Sarah / Baur-Streubel, Ramona /

Bertolino, Alessandro / Bonvino, Aurora / Boomsma, Dorret I / Borgwardt, Stefan / Bourque, Josiane / Brandeis, Daniel / Breier, Alan / Brodaty, Henry / Brouwer, Rachel M / Buitelaar, Jan K / Busatto, Geraldo F / Buckner, Randy L / Calhoun, Vincent / Canales-Rodríguez, Erick J / Cannon, Dara M / Caseras, Xavier / Castellanos, Francisco X / Cervenka, Simon / Chaim-Avancini, Tiffany M / Ching, Christopher R K / Chubar, Victoria / Clark, Vincent P / Conrod, Patricia / Conzelmann, Annette / Crespo-Facorro, Benedicto / Crivello, Fabrice / Crone, Eveline A / Dale, Anders M / Dannlowski, Udo / Davey, Christopher / de Geus, Eco J C / de Haan, Lieuwe / de Zubicaray, Greig I / den Braber, Anouk / Dickie, Erin W / Di Giorgio, Annabella / Doan, Nhat Trung / Dørum, Erlend S / Ehrlich, Stefan / Erk, Susanne / Espeseth, Thomas / Fatouros-Bergman, Helena / Fisher, Simon E / Fouche, Jean-Paul / Franke, Barbara / Frodl, Thomas / Fuentes-Claramonte, Paola / Glahn, David C / Gotlib, Ian H / Grabe, Hans-Jörgen / Grimm, Oliver / Groenewold, Nynke A / Grotegerd, Dominik / Gruber, Oliver / Gruner, Patricia / Gur, Rachel E / Gur, Ruben C / Hahn, Tim / Harrison, Ben J / Hartman, Catharine A / Hatton, Sean N / Heinz, Andreas / Heslenfeld, Dirk J / Hibar, Derrek P / Hickie, Ian B / Ho, Beng-Choon / Hoekstra, Pieter J / Hohmann, Sarah / Holmes, Avram J / Hoogman, Martine / Hosten, Norbert / Howells, Fleur M / Hulshoff Pol, Hilleke E / Huyser, Chaim / Jahanshad, Neda / James, Anthony / Jernigan, Terry L / Jiang, Jiyang / Jönsson, Erik G / Joska, John A / Kahn, Rene / Kalnin, Andrew / Kanai, Ryota / Klein, Marieke / Klyushnik, Tatyana P / Koenders, Laura / Koops, Sanne / Krämer, Bernd / Kuntsi, Jonna / Lagopoulos, Jim / Lázaro, Luisa / Lebedeva, Irina / Lee, Won Hee / Lesch, Klaus-Peter / Lochner, Christine / Machielsen, Marise W J / Maingault, Sophie / Martin, Nicholas G / Martínez-Zalacaín, Ignacio / Mataix-Cols, David / Mazoyer, Bernard / McDonald, Colm / McDonald, Brenna C / McIntosh, Andrew M / McMahon, Katie L / McPhilemy, Genevieve / Meinert, Susanne / Menchón, José M / Medland, Sarah E / Meyer-Lindenberg, Andreas / Naaijen, Jilly / Najt, Pablo / Nakao, Tomohiro / Nordvik, Jan E / Nyberg, Lars / Oosterlaan, Jaap / de la Foz, Víctor Ortiz-García / Paloyelis, Yannis / Pauli, Paul / Pergola, Giulio / Pomarol-Clotet, Edith / Portella, Maria J / Potkin, Steven G / Radua, Joaquim / Reif, Andreas / Rinker, Daniel A / Roffman, Joshua L / Rosa, Pedro G P / Sacchet, Matthew D / Sachdev, Perminder S / Salvador, Raymond / Sánchez-Juan, Pascual / Sarró, Salvador / Satterthwaite, Theodore D / Saykin, Andrew J / Serpa, Mauricio H / Schmaal, Lianne / Schnell, Knut / Schumann, Gunter / Sim, Kang / Smoller, Jordan W / Sommer, Iris / Soriano-Mas, Carles / Stein, Dan J / Strike, Lachlan T / Swagerman, Suzanne C / Tamnes, Christian K / Temmingh, Henk S / Thomopoulos, Sophia I / Tomyshev, Alexander S / Tordesillas-Gutiérrez, Diana / Trollor, Julian N / Turner, Jessica A / Uhlmann, Anne / van den Heuvel, Odile A / van den Meer, Dennis / van der Wee, Nic J A / van Haren, Neeltje E M / van 't Ent, Dennis / van Erp, Theo G M / Veer, Ilya M / Veltman, Dick J / Voineskos, Aristotle / Völzke, Henry / Walter, Henrik / Walton, Esther / Wang, Lei / Wang, Yang / Wassink, Thomas H / Weber, Bernd / Wen, Wei / West, John D / Westlye, Lars T / Whalley, Heather / Wierenga, Lara M / Wittfeld, Katharina / Wolf, Daniel H / Worker, Amanda / Wright, Margaret J / Yang, Kun / Yoncheva, Yulyia / Zanetti, Marcus V / Ziegler, Georg C / Thompson, Paul M / Dima, Danai

Human brain mapping

2021 Volume 43, Issue 1, Page(s) 431–451

Abstract: Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and ... ...

Abstract	Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Cerebral Cortex/anatomy & histology ; Cerebral Cortex/diagnostic imaging ; Cross-Sectional Studies ; Human Development/physiology ; Neuroimaging
Language	English
Publishing date	2021-02-17
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.25364
Database	MEDical Literature Analysis and Retrieval System OnLINE

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