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Article ; Online: Applications of Alzheimer's disease staging to clinical trials.

Therriault, Joseph / Gauthier, Serge / Rosa-Neto, Pedro

Aging

2023 Volume 15, Issue 1, Page(s) 4–5

MeSH term(s)	Humans ; Alzheimer Disease ; tau Proteins ; Amyloid beta-Peptides ; Biomarkers
Chemical Substances	tau Proteins ; Amyloid beta-Peptides ; Biomarkers
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Editorial
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204482
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Article ; Online: Advanced brain imaging for the diagnosis of Alzheimer disease.

Wang, Yi-Ting Tina / Rosa-Neto, Pedro / Gauthier, Serge

Current opinion in neurology

2023 Volume 36, Issue 5, Page(s) 481–490

Abstract: Purpose of review: The purpose is to review the latest advances of brain imaging for the diagnosis of Alzheimer disease (AD).: Recent findings: Brain imaging techniques provide valuable and complementary information to support the diagnosis of ... ...

Abstract	Purpose of review: The purpose is to review the latest advances of brain imaging for the diagnosis of Alzheimer disease (AD). Recent findings: Brain imaging techniques provide valuable and complementary information to support the diagnosis of Alzheimer disease in clinical and research settings. The recent FDA accelerated approvals of aducanumab, lecanemab and donanemab made amyloid-PET critical in helping determine the optimal window for anti-amyloid therapeutic interventions. Tau-PET, on the other hand, is considered of key importance for the tracking of disease progression and for monitoring therapeutic interventions in clinical trials. PET imaging for microglial activation, astrocyte reactivity and synaptic degeneration are still new techniques only used in the research field, and more studies are needed to validate their use in the clinical diagnosis of AD. Finally, artificial intelligence has opened new prospective in the early detection of AD using MRI modalities. Summary: Brain imaging techniques using PET improve our understanding of the different AD-related pathologies and their relationship with each other along the course of disease. With more robust validation, machine learning and deep learning algorithms could be integrated with neuroimaging modalities to serve as valuable tools for clinicians to make early diagnosis and prognosis of AD.
MeSH term(s)	Humans ; Alzheimer Disease/diagnostic imaging ; Artificial Intelligence ; Prospective Studies ; Brain/diagnostic imaging ; Neuroimaging
Language	English
Publishing date	2023-08-03
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1182686-1
ISSN	1473-6551 ; 1350-7540
ISSN (online)	1473-6551
ISSN	1350-7540
DOI	10.1097/WCO.0000000000001198
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Article ; Online: <i>In vivo</i> tau staging in Alzheimer's disease.

Therriault, Joseph / Gauthier, Serge / Rosa-Neto, Pedro

Aging

2022 Volume 14, Issue 17, Page(s) 6842–6843

MeSH term(s)	Alzheimer Disease ; Amyloid beta-Peptides ; Biomarkers ; Humans ; tau Proteins
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; tau Proteins
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204293
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Article ; Online: Author Response: Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex,

Therriault, Joseph / Pascoal, Tharick / Gauthier, Serge / Rosa-Neto, Pedro

Neurology

2022 Volume 97, Issue 12, Page(s) 609

MeSH term(s)	Alzheimer Disease/genetics ; Apolipoprotein E4/genetics ; Cognitive Dysfunction/genetics ; Humans ; tau Proteins
Chemical Substances	Apolipoprotein E4 ; tau Proteins
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000012586
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Article ; Online: Mesocorticolimbic function in cocaine polydrug users: A multimodal study of drug cue reactivity and cognitive regulation.

Scala, Stephanie G / Kang, Min Su / Cox, Sylvia M L / Rosa-Neto, Pedro / Massarweh, Gassan / Leyton, Marco

Addiction biology

2024 Volume 29, Issue 1, Page(s) e13358

Abstract: Addictions are thought to be fostered by the emergence of poorly regulated mesocorticolimbic responses to drug-related cues. The development and persistence of these responses might be promoted by altered glutamate transmission, including changes to type ...

Abstract	Addictions are thought to be fostered by the emergence of poorly regulated mesocorticolimbic responses to drug-related cues. The development and persistence of these responses might be promoted by altered glutamate transmission, including changes to type 5 metabotropic glutamate receptors (mGluR5s). Unknown, however, is when these changes arise and whether the mGluR5 and mesocorticolimbic alterations are related. To investigate, non-dependent cocaine polydrug users and cocaine-naïve healthy controls underwent a positron emission tomography scan (15 cocaine users and 14 healthy controls) with [
MeSH term(s)	Humans ; Cues ; Brain ; Cocaine-Related Disorders ; Cocaine/adverse effects ; Cocaine/metabolism ; Cognition ; Oximes ; Pyridines
Chemical Substances	3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime ; Cocaine (I5Y540LHVR) ; Oximes ; Pyridines
Language	English
Publishing date	2024-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1324314-7
ISSN	1369-1600 ; 1355-6215
ISSN (online)	1369-1600
ISSN	1355-6215
DOI	10.1111/adb.13358
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Article ; Online: Contactin 5 and Apolipoproteins Interplay in Alzheimer's Disease.

Dauar, Marina Tedeschi / Picard, Cynthia / Labonté, Anne / Breitner, John / Rosa-Neto, Pedro / Villeneuve, Sylvia / Poirier, Judes

Journal of Alzheimer's disease : JAD

2024 Volume 98, Issue 4, Page(s) 1361–1375

Abstract: Background: Apolipoproteins and contactin 5 are proteins associated with Alzheimer's disease (AD) pathophysiology. Apolipoproteins act on transport and clearance of cholesterol and phospholipids during synaptic turnover and terminal proliferation. ... ...

Abstract	Background: Apolipoproteins and contactin 5 are proteins associated with Alzheimer's disease (AD) pathophysiology. Apolipoproteins act on transport and clearance of cholesterol and phospholipids during synaptic turnover and terminal proliferation. Contactin 5 is a neuronal membrane protein involved in key processes of neurodevelopment. Objective: To investigate the interactions between contactin 5 and apolipoproteins in AD, and the role of these proteins in response to neuronal damage. Methods: Apolipoproteins (measured by Luminex), contactin 5 (measured by Olink's proximity extension assay), and cholesterol (measured by liquid chromatography mass spectrometry) were assessed in the cerebrospinal fluid (CSF) and plasma of cognitively unimpaired participants (n = 93). Gene expression was measured using polymerase chain reaction in the frontal cortex of autopsied-confirmed AD (n = 57) and control subjects (n = 31) and in the hippocampi of mice following entorhinal cortex lesions. Results: Contactin 5 positively correlated with apolipoproteins B (p = 5.4×10-8), D (p = 1.86×10-4), E (p = 2.92×10-9), J (p = 2.65×10-9), and with cholesterol (p = 0.0096) in the CSF, and with cholesterol (p = 0.02), HDL (p = 0.0143), and LDL (p = 0.0121) in the plasma. Negative correlations were seen between CNTN5, APOB (p = 0.034) and APOE (p = 0.015) mRNA levels in the brains of control subjects. In the mouse model, apoe and apoj gene expression increased during the reinnervation phase (p < 0.05), while apob (p = 0.023) and apod (p = 0.006) increased in the deafferentation stage. Conclusions: Extensive interactions were observed between contactin 5 and apolipoproteins and cholesterol, possibly due to neuronal damage. The alterations in gene expression of apolipoproteins suggest a role in axonal, terminal, and synaptic remodeling in response to entorhinal cortex damage.
MeSH term(s)	Humans ; Mice ; Animals ; Alzheimer Disease/metabolism ; Apolipoproteins/genetics ; Apolipoproteins E/metabolism ; Apolipoproteins B ; Cholesterol ; Contactins
Chemical Substances	Apolipoproteins ; Apolipoproteins E ; Apolipoproteins B ; Cholesterol (97C5T2UQ7J) ; Contactins
Language	English
Publishing date	2024-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-231003
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Article ; Online: Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice.

Lee, Karen Ka Yan / Chattopadhyaya, Bidisha / do Nascimento, Antônia Samia Fernandes / Moquin, Luc / Rosa-Neto, Pedro / Amilhon, Bénédicte / Di Cristo, Graziella

Neurobiology of disease

2024 Volume 193, Page(s) 106465

Abstract: Children who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive ... ...

Abstract	Children who experienced moderate perinatal asphyxia (MPA) are at risk of developing long lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional problems. The prefrontal cortex (PFC) regulates cognitive flexibility and emotional behavior. Neurons that release serotonin (5-HT) project to the PFC, and compounds modulating 5-HT activity influence emotion and cognition. Whether 5-HT dysregulations contribute to MPA-induced cognitive problems is unknown. We established a MPA mouse model, which displays recognition and spatial memory impairments and dysfunctional cognitive flexibility. We found that 5-HT expression levels, quantified by immunohistochemistry, and 5-HT release, quantified by in vivo microdialysis in awake mice, are reduced in PFC of adult MPA mice. MPA mice also show impaired body temperature regulation following injection of the 5-HT
MeSH term(s)	Humans ; Child ; Mice ; Animals ; Serotonin/metabolism ; Selective Serotonin Reuptake Inhibitors ; Receptor, Serotonin, 5-HT1A ; Asphyxia ; Fluoxetine/pharmacology ; Serotonin Receptor Agonists/pharmacology ; Receptors, Serotonin ; Cognition ; 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology ; Hypoxia
Chemical Substances	Serotonin (333DO1RDJY) ; Selective Serotonin Reuptake Inhibitors ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; Fluoxetine (01K63SUP8D) ; Serotonin Receptor Agonists ; Receptors, Serotonin ; 8-Hydroxy-2-(di-n-propylamino)tetralin (78950-78-4)
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2024.106465
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Zs.A 4444: Show issues

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Article ; Online: Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases".

Zimmer, Eduardo R / Pascoal, Tharick A / Rosa-Neto, Pedro / Nordberg, Agneta / Pellerin, Luc

Science translational medicine

2022 Volume 14, Issue 659, Page(s) eabm8302

Abstract: Astrocytes might be the major contributor to the radioactive signal captured by PET in the microglia-dependent modulation of FDG-PET. ...

Abstract	Astrocytes might be the major contributor to the radioactive signal captured by PET in the microglia-dependent modulation of FDG-PET.
MeSH term(s)	Fluorodeoxyglucose F18 ; Glucose ; Humans ; Microglia ; Neurodegenerative Diseases/diagnostic imaging ; Positron-Emission Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.abm8302
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Article ; Online: Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia.

Chu, Min / Jiang, Deming / Liu, Li / Nie, Binbin / Rosa-Neto, Pedro / Chen, Kewei / Wu, Liyong

Neurobiology of aging

2023 Volume 124, Page(s) 29–38

Abstract: Graph theory is a novel approach used to examine the balance of brain connectomes. However, the clinical relevance of white matter (WM) connectome changes in the behavioral variant frontotemporal dementia (bvFTD) is not well understood. We aimed to ... ...

Abstract	Graph theory is a novel approach used to examine the balance of brain connectomes. However, the clinical relevance of white matter (WM) connectome changes in the behavioral variant frontotemporal dementia (bvFTD) is not well understood. We aimed to investigate the clinical relevance of WM topological alterations in bvFTD. Thirty patients with probable bvFTD and 30 healthy controls underwent diffusion tensor imaging, structural MRI, and neuropsychological assessment. WM connectivity between 90 brain regions was calculated and the graph approach was applied to capture the individual characteristics of the anatomical network. Voxel-based morphometry and tract-based spatial statistics were used to present the gray matter atrophy and disrupted WM integrity. The topological organization was disrupted in patients with bvFTD both globally and locally. Compared to controls, bvFTD data showed a different pattern of hub region distributions. Notably, the nodal efficiency of the right superior orbital frontal gyrus was associated with apathy and disinhibition. Topological measures may be potential image markers for early diagnosis and disease severity monitoring of bvFTD.
MeSH term(s)	Humans ; Frontotemporal Dementia/psychology ; Diffusion Tensor Imaging/methods ; Clinical Relevance ; Brain/diagnostic imaging ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2023.01.004
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Article ; Online: Altered Anterior Insular Metabolic Connectivity in Asymptomatic MAPT P301L Carriers.

Chu, Min / Jiang, Deming / Liu, Li / Nie, Binbin / Cui, Bo / Wang, Yihao / Rosa-Neto, Pedro / Wu, Liyong

Journal of Alzheimer's disease : JAD

2023 Volume 93, Issue 4, Page(s) 1369–1380

Abstract: Background: The insula is the predominant brain region impaired in behavioral variant frontotemporal dementia (bvFTD). However, structural and functional changes in the sub-insula in the asymptomatic stage of bvFTD are unknown.: Objective: To ... ...

Abstract	Background: The insula is the predominant brain region impaired in behavioral variant frontotemporal dementia (bvFTD). However, structural and functional changes in the sub-insula in the asymptomatic stage of bvFTD are unknown. Objective: To describe structural and functional changes in insula subregions in asymptomatic carriers of the P301L mutation of the microtubule-associated protein tau (MAPT) gene and patients with bvFTD. Methods: Six asymptomatic MAPT P301L mutation carriers and 12 MAPT negative control subjects of the same pedigree were enrolled, along with 30 patients with a clinical diagnosis of bvFTD and 30 matched controls. All subjects underwent hybrid positron emission tomography/magnetic resonance imaging. Atlas-based parcellation using a fine-grained Brainnetome Atlas was conducted to assess gray matter (GM) volume, metabolism, and metabolic connectivity in the sub-insula (region of interest). Results: There was no significant GM atrophy or hypometabolism in insula subregions in asymptomatic MAPT P301L carriers, although decreased metabolic connectivity between vIa-middle temporal gyrus, vIa-temporal poles, dIa-middle temporal gyrus and dIa-temporal poles; and increased connectivity between vIa-orbitofrontal, vIa-dorsal lateral superior frontal gyrus, and dIa-orbitofrontal and dIa-dorsal lateral superior frontal gyrus were observed. Patients with bvFTD had significant atrophy and hypometabolism in all insula subregions and decreased metabolic connectivity in the whole brain, including vIa/dIa-middle temporal and vIa/dIa-temporal poles. The standardized uptake value ratios of vIa and dIa were negatively associated with Frontal behavior inventory disinhibition scale scores. Conclusion: Metabolic connectivity is altered in vIa and dIa subregions of the sub-insula in MAPT P301L mutation carriers before the occurrence of atrophy, hypometabolism, and clinical symptoms.
MeSH term(s)	Humans ; Brain/pathology ; Frontotemporal Dementia/diagnostic imaging ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism ; Cerebral Cortex/pathology ; Temporal Lobe/pathology ; Magnetic Resonance Imaging ; Atrophy/pathology
Chemical Substances	tau Proteins ; MAPT protein, human
Language	English
Publishing date	2023-05-12
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-221035
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