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  1. Article ; Online: Description of a Novel Technique to Address Both External Nasal Valve Collapse and the Aesthetic of the Nasal Tip.

    Rosario, Eleanor May / Ferguson, Mark / Machado, Poliana Batista / Saleh, Hesham

    Facial plastic surgery : FPS

    2022  Volume 39, Issue 3, Page(s) 307–310

    Abstract: Severe concavity of the lateral crura can lead to an unsightly aesthetic deformity of the nasal tip and narrowing of the external nasal valve. Concurrently, if the lateral crura are structurally weak, this can lead to a functional issue. We report a ... ...

    Abstract Severe concavity of the lateral crura can lead to an unsightly aesthetic deformity of the nasal tip and narrowing of the external nasal valve. Concurrently, if the lateral crura are structurally weak, this can lead to a functional issue. We report a previously undescribed technique of combining a lateral crural reversal with a turn-in flap. This achieves dual goals of aesthetic improvement and structural reinforcement, without the need for grafting.
    MeSH term(s) Humans ; Rhinoplasty/methods ; Esthetics, Dental ; Nose/surgery ; Surgical Flaps
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/a-1967-8477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Use of tranexamic acid-soaked NasoPore® in the emergency department, to reduce epistaxis admissions.

    Rosario, Eleanor / Sharma, Ekta / Patel, Ankit / Guvensen, Gabrielle / Ashroff, Rizal / McClenaghan, Fiona / Hariri, Ahmad / Joseph, Jonathan

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2023  Volume 48, Issue 6, Page(s) 909–914

    Abstract: Objectives: The aim of this study was to assess the efficacy of a new emergency department (ED) intervention for the management of non-traumatic, anterior epistaxis in adult patients, aiming to reduce epistaxis admissions.: Design: A new epistaxis ... ...

    Abstract Objectives: The aim of this study was to assess the efficacy of a new emergency department (ED) intervention for the management of non-traumatic, anterior epistaxis in adult patients, aiming to reduce epistaxis admissions.
    Design: A new epistaxis pathway was introduced for use by ED practitioners. This was disseminated in ED through an educational campaign by the ear, nose and throat team. A tranexamic acid (500 mg/5 mL)-soaked NasoPore® packing step was introduced for epistaxis which did not terminate following 10 min of simple first aid. The pathway was utilised for adult patients presenting with non-traumatic, anterior epistaxis. Pre- and post-implementation periods were defined, and all adults attending ED with non-traumatic, anterior epistaxis were included. Pre- and post-implementation epistaxis treatment interventions, admission rates and re-attendance rates were recorded by retrospective audit and compared.
    Results: In the post-implementation group, epistaxis admissions were 51.7% (p < .05) lower than in the pre-implementation group, as a proportion of the total number attending ED with epistaxis during these periods.
    Conclusions: The significant reduction in epistaxis admissions demonstrates that this ED intervention is beneficial for patient outcomes.
    MeSH term(s) Adult ; Humans ; Emergency Service, Hospital/statistics & numerical data ; Epistaxis/drug therapy ; Epistaxis/epidemiology ; Epistaxis/therapy ; Hospitalization/statistics & numerical data ; Retrospective Studies ; Tranexamic Acid/therapeutic use ; Bandages ; United Kingdom
    Chemical Substances Tranexamic Acid (6T84R30KC1)
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.14093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Description of a Novel Technique to Address Both External Nasal Valve Collapse and the Aesthetic of the Nasal Tip

    Rosario, Eleanor May / Ferguson, Mark / Machado, Poliana Batista / Saleh, Hesham

    Facial Plastic Surgery

    (Evidence Based Medicine in Facial Plastic Surgery)

    2022  Volume 39, Issue 03, Page(s) 307–310

    Abstract: Severe concavity of the lateral crura can lead to an unsightly aesthetic deformity of the nasal tip and narrowing of the external nasal valve. Concurrently, if the lateral crura are structurally weak, this can lead to a functional issue. We report a ... ...

    Series title Evidence Based Medicine in Facial Plastic Surgery
    Abstract Severe concavity of the lateral crura can lead to an unsightly aesthetic deformity of the nasal tip and narrowing of the external nasal valve. Concurrently, if the lateral crura are structurally weak, this can lead to a functional issue. We report a previously undescribed technique of combining a lateral crural reversal with a turn-in flap. This achieves dual goals of aesthetic improvement and structural reinforcement, without the need for grafting.
    Keywords lateral crural reversal ; turn-in flap ; external nasal valve collapse
    Language English
    Publishing date 2022-10-25
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 630090-x
    ISSN 1098-8793 ; 0736-6825
    ISSN (online) 1098-8793
    ISSN 0736-6825
    DOI 10.1055/a-1967-8477
    Database Thieme publisher's database

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  4. Article ; Online: Clinical and Immunologic Features of Ultra-Short Celiac Disease.

    Mooney, Peter D / Kurien, Matthew / Evans, Kate E / Rosario, Eleanor / Cross, Simon S / Vergani, Patricia / Hadjivassiliou, Marios / Murray, Joseph A / Sanders, David S

    Gastroenterology

    2016  Volume 150, Issue 5, Page(s) 1125–1134

    Abstract: Background & aims: The clinical effects of gluten-sensitive enteropathy with villous atrophy limited to the duodenal bulb (D1) have not been delineated in adults with celiac disease. We investigated the sensitivity of D1 biopsy analysis in the detection ...

    Abstract Background & aims: The clinical effects of gluten-sensitive enteropathy with villous atrophy limited to the duodenal bulb (D1) have not been delineated in adults with celiac disease. We investigated the sensitivity of D1 biopsy analysis in the detection of celiac disease, the number and sites of biopsies required to detect ultra-short celiac disease (USCD, villous atrophy limited to D1), and the clinical phenotype of USCD.
    Methods: We performed a prospective study of 1378 patients (mean age, 50.3 y; 62% female) who underwent endoscopy at a tertiary medical center in the United Kingdom from 2008 through 2014; routine duodenal biopsy specimens were collected from D1 and the second part of the duodenum (D2). Quadrantic D1 biopsy specimens were collected from 171 consecutive patients with a high suspicion of celiac disease (mean age, 46.5 y; 64% female). Clinical data from patients diagnosed with USCD, based on biopsy analysis, were compared with those from patients with conventional celiac disease (CCD) (villous atrophy beyond D1) and individuals without celiac disease (controls). The number of intraepithelial lymphocytes (IELs) and immune phenotypes were compared between D1 vs D2 in patients with celiac disease.
    Results: Of the 1378 patients assessed, 268 (19.4%) were diagnosed with celiac disease; 9.7% of these patients had villous atrophy confined to D1 (USCD; P < .0001). Collection of a single additional biopsy specimen from any D1 site increased the sensitivity of celiac disease detection by 9.3%-10.8% (P < .0001). Patients with USCD were younger (P = .03), had lower titers of tissue transglutaminase antibody (P = .001), and less frequently presented with diarrhea (P = .001) than patients with CCD. Higher proportions of patients with CCD had ferritin deficiency (P = .007) or folate deficiency (P = .003) than patients with USCD or controls. Patients with celiac disease had a median of 50 IELs/100 enterocytes in D1 and a median of 48 IELs/100 enterocytes (P = .7) in D2. The phenotype of IELs from patients with D1 celiac disease was indistinguishable from those of patients with D2 celiac disease.
    Conclusions: Collection of a single additional biopsy specimen from any site in the D1 intestine increases the sensitivity of detection for celiac disease. Patients with USCD may have early stage or limited celiac disease, with a mild clinical phenotype and infrequent nutritional deficiencies.
    MeSH term(s) Atrophy ; Autoantibodies/blood ; Biopsy ; Case-Control Studies ; Celiac Disease/diagnosis ; Celiac Disease/epidemiology ; Celiac Disease/immunology ; Celiac Disease/pathology ; Decision Support Techniques ; Decision Trees ; Diarrhea/epidemiology ; Duodenum/pathology ; England/epidemiology ; Enterocytes/pathology ; Female ; Ferritins/blood ; Ferritins/deficiency ; Folic Acid Deficiency/blood ; Folic Acid Deficiency/epidemiology ; GTP-Binding Proteins/immunology ; Gastroscopy ; Humans ; Lymphocytes/immunology ; Male ; Microvilli/pathology ; Middle Aged ; Predictive Value of Tests ; Prevalence ; Prognosis ; Prospective Studies ; Reproducibility of Results ; Severity of Illness Index ; Tertiary Care Centers ; Transglutaminases/immunology
    Chemical Substances Autoantibodies ; Ferritins (9007-73-2) ; transglutaminase 2 (EC 2.3.2.-) ; Transglutaminases (EC 2.3.2.13) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2016.01.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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