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Article ; Online: A Etnomatemática nos cursos de formação continuada de professores

Adriana Breda / Valderez Marina do Rosário Lim / Gleny Terezinha Duro Guimarães

Revista Latinoamericana de Etnomatemática, Vol 5, Iss 1, Pp 116-

implicações das regularidades discursivas e das relações de poder na produção de subjetividades

2012 Volume 148

Abstract: This work aims to present a discussion, consequential from a masters degree research, of how the use of Ethnomathematics in continuing education programs for mathematics' teachers implies inthe production osubjectivities. Therefore, two Masters ... ...

Abstract	This work aims to present a discussion, consequential from a masters degree research, of how the use of Ethnomathematics in continuing education programs for mathematics' teachers implies inthe production osubjectivities. Therefore, two Masters dissertations that studied the Ethnomathematics in teachers educationline were analyzed: one from a private institution and one produced at a publicinstitution,disclosed in theyears 2006 and 2009, respectively, in Porto Alegre-RS. The analysis has focused on investigating, according to Foucault's discourse theories, through the discursive regularities and power/knowledgerelations, how different modes of subjectivity are produced in the researching subjects. By using twoguiding principles of visibility: Ethnomathematics as art and technique to explain and understand within thedifferent cultures andthe relation of it with the teacher`s training and the Ethnomathematics as a mechanism of government, itfollows that the discussions of the analyzed papers operate as governance mechanisms able to qualify and lead conducts, producing this way, unique modes of subjectivity.
Keywords	Special aspects of education ; LC8-6691 ; Science ; Q ; Mathematics ; QA1-939
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Universidad de Nariño
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Supramolecular design of self-assembling nanofibers for cartilage regeneration.

Shah, Ramille N / Shah, Nirav A / Del Rosario Lim, Marc M / Hsieh, Caleb / Nuber, Gordon / Stupp, Samuel I

Proceedings of the National Academy of Sciences of the United States of America

2010 Volume 107, Issue 8, Page(s) 3293–3298

Abstract: Molecular and supramolecular design of bioactive biomaterials could have a significant impact on regenerative medicine. Ideal regenerative therapies should be minimally invasive, and thus the notion of self-assembling biomaterials programmed to transform ...

Abstract	Molecular and supramolecular design of bioactive biomaterials could have a significant impact on regenerative medicine. Ideal regenerative therapies should be minimally invasive, and thus the notion of self-assembling biomaterials programmed to transform from injectable liquids to solid bioactive structures in tissue is highly attractive for clinical translation. We report here on a coassembly system of peptide amphiphile (PA) molecules designed to form nanofibers for cartilage regeneration by displaying a high density of binding epitopes to transforming growth factor beta-1 (TGFbeta-1). Growth factor release studies showed that passive release of TGFbeta-1 was slower from PA gels containing the growth factor binding sites. In vitro experiments indicate these materials support the survival and promote the chondrogenic differentiation of human mesenchymal stem cells. We also show that these materials can promote regeneration of articular cartilage in a full thickness chondral defect treated with microfracture in a rabbit model with or even without the addition of exogenous growth factor. These results demonstrate the potential of a completely synthetic bioactive biomaterial as a therapy to promote cartilage regeneration.
MeSH term(s)	Animals ; Cartilage, Articular/injuries ; Cartilage, Articular/physiology ; Gels ; Humans ; Nanofibers ; Peptides/chemistry ; Peptides/metabolism ; Rabbits ; Regeneration ; Regenerative Medicine/methods ; Surface-Active Agents ; Transforming Growth Factor beta1/chemistry ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Gels ; Peptides ; Surface-Active Agents ; Transforming Growth Factor beta1
Language	English
Publishing date	2010-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0906501107
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Article: Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice.

Masternak, Michal M / Al-Regaiey, Khalid A / Del Rosario Lim, Marc Michael / Bonkowski, Michael S / Panici, Jacob A / Przybylski, Grzegorz K / Bartke, Andrzej

The journals of gerontology. Series A, Biological sciences and medical sciences

2005 Volume 60, Issue 10, Page(s) 1238–1245

Abstract: Resistance to growth hormone, reduced insulin-like growth factor 1 (IGF1) action, and enhanced insulin sensitivity are likely mediators of extended life span and delayed aging process in growth hormone receptor/binding protein knockout (GHR-KO) mice. Fat ...

Abstract	Resistance to growth hormone, reduced insulin-like growth factor 1 (IGF1) action, and enhanced insulin sensitivity are likely mediators of extended life span and delayed aging process in growth hormone receptor/binding protein knockout (GHR-KO) mice. Fat metabolism and genes involved in fatty acid oxidation are strongly involved in insulin action. Using real-time polymerase chain reaction and western blot we have examined expression of peroxisome proliferator-activated receptors (PPARs) and retinoid X receptor (RXR) genes in the skeletal muscle of normal and GHR-KO mice subjected to 30% caloric restriction. The results indicate that caloric restriction decreased the expression of PPARgamma, PPARalpha, and PPARbeta/delta which would lead to down-regulation of fat metabolism. This suggested metabolic change clearly does not affect whole-body insulin action. These findings suggest that whole-animal insulin sensitivity is not regulated through skeletal muscle insulin action.
MeSH term(s)	Animals ; Blotting, Western ; Caloric Restriction ; Cholesterol/analysis ; Fats/metabolism ; Fatty Acids, Nonesterified/analysis ; Insulin/physiology ; Insulin Resistance/physiology ; Mice ; Mice, Knockout ; Muscle, Skeletal/chemistry ; PPAR alpha/genetics ; PPAR gamma/genetics ; PPAR-beta/genetics ; Peroxisome Proliferator-Activated Receptors/analysis ; Peroxisome Proliferator-Activated Receptors/genetics ; Polymerase Chain Reaction ; Receptors, Somatotropin/genetics ; Retinoid X Receptors/genetics ; Triglycerides/analysis
Chemical Substances	Fats ; Fatty Acids, Nonesterified ; Insulin ; PPAR alpha ; PPAR gamma ; PPAR-beta ; Peroxisome Proliferator-Activated Receptors ; Receptors, Somatotropin ; Retinoid X Receptors ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2005-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/60.10.1238
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Article: Supramolecular design of self-assembling nanofibers for cartilage regeneration

Shah, Ramille N / Shah, Nirav A / Del Rosario Lim, Marc M / Hsieh, Caleb / Nuber, Gordon / Stupp, Samuel I

Proceedings of the National Academy of Sciences of the United States of America. 2010 Feb. 23, v. 107, no. 8

2010

Abstract	Molecular and supramolecular design of bioactive biomaterials could have a significant impact on regenerative medicine. Ideal regenerative therapies should be minimally invasive, and thus the notion of self-assembling biomaterials programmed to transform from injectable liquids to solid bioactive structures in tissue is highly attractive for clinical translation. We report here on a coassembly system of peptide amphiphile (PA) molecules designed to form nanofibers for cartilage regeneration by displaying a high density of binding epitopes to transforming growth factor Î²-1 (TGFÎ²-1). Growth factor release studies showed that passive release of TGFÎ²-1 was slower from PA gels containing the growth factor binding sites. In vitro experiments indicate these materials support the survival and promote the chondrogenic differentiation of human mesenchymal stem cells. We also show that these materials can promote regeneration of articular cartilage in a full thickness chondral defect treated with microfracture in a rabbit model with or even without the addition of exogenous growth factor. These results demonstrate the potential of a completely synthetic bioactive biomaterial as a therapy to promote cartilage regeneration.
Keywords	binding sites ; biocompatible materials ; cartilage ; epitopes ; gels ; humans ; in vitro studies ; medicine ; models ; nanofibers ; rabbits ; stem cells ; therapeutics ; transforming growth factors
Language	English
Dates of publication	2010-0223
Size	p. 3293-3298.
Publishing place	National Academy of Sciences
Document type	Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0906501107
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Article: Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart.

Masternak, Michal M / Al-Regaiey, Khalid A / Del Rosario Lim, Marc Michael / Jimenez-Ortega, Vanesa / Panici, Jacob A / Bonkowski, Michael S / Kopchick, John J / Wang, Zhihui / Bartke, Andrzej

Experimental gerontology

2006 Volume 41, Issue 4, Page(s) 417–429

Abstract: Blockade of growth hormone (GH), decreased insulin-like growth factor-1 (IGF1) action and increased insulin sensitivity are associated with life extension and an apparent slowing of the aging process. We examined expression of genes involved in insulin ... ...

Abstract	Blockade of growth hormone (GH), decreased insulin-like growth factor-1 (IGF1) action and increased insulin sensitivity are associated with life extension and an apparent slowing of the aging process. We examined expression of genes involved in insulin action, IR, IRS1, IRS2, IGF1, IGF1R, GLUT4, PPARs and RXRs in the hearts of normal and GHR-/- (KO) mice fed ad libitum or subjected to 30% caloric restriction (CR). CR increased the cardiac expression of IR, IRS1, IGF1, IGF1R and GLUT4 in normal mice and IRS1, GLUT4, PPARalpha and PPARbeta/delta in GHR-KO animals. Expression of IR, IRS1, IRS2, IGF1, GLUT4, PPARgamma and PPARalpha did not differ between GHR-KO and normal mice. These unexpected results suggest that CR may lead to major modifications of insulin action in the heart, but high insulin sensitivity of GHR-KO mice is not associated with alterations in the levels of most of the examined molecules related to intracellular insulin signaling.
MeSH term(s)	Aging/metabolism ; Animals ; Blotting, Western ; Caloric Restriction ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Gene Expression ; Glucose Transporter Type 4/genetics ; Glucose Transporter Type 4/metabolism ; Growth Hormone/genetics ; Growth Hormone/metabolism ; Insulin/metabolism ; Insulin Resistance ; Insulin-Like Growth Factor I/genetics ; Insulin-Like Growth Factor I/metabolism ; Male ; Mice ; Mice, Knockout ; Mice, Transgenic ; Myocardium/metabolism ; PPAR alpha/genetics ; PPAR alpha/metabolism ; PPAR delta/genetics ; PPAR delta/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism ; PPAR-beta/genetics ; PPAR-beta/metabolism ; RNA, Messenger/analysis ; Receptor, IGF Type 1/genetics ; Receptor, IGF Type 1/metabolism ; Receptor, Insulin/genetics ; Receptor, Insulin/metabolism ; Receptors, Somatotropin/genetics ; Receptors, Somatotropin/metabolism ; Retinoid X Receptors/genetics ; Retinoid X Receptors/metabolism ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Signal Transduction/physiology
Chemical Substances	Carrier Proteins ; Glucose Transporter Type 4 ; Insulin ; PPAR alpha ; PPAR delta ; PPAR gamma ; PPAR-beta ; RNA, Messenger ; Receptors, Somatotropin ; Retinoid X Receptors ; somatotropin-binding protein ; Insulin-Like Growth Factor I (67763-96-6) ; Growth Hormone (9002-72-6) ; Receptor, IGF Type 1 (EC 2.7.10.1) ; Receptor, Insulin (EC 2.7.10.1)
Language	English
Publishing date	2006-04
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	390992-x
ISSN	0531-5565
ISSN	0531-5565
DOI	10.1016/j.exger.2006.01.009
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Article: Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice.

Masternak, Michal M / Al-Regaiey, Khalid A / Del Rosario Lim, Marc Michael / Jimenez-Ortega, Vanesa / Panici, Jacob A / Bonkowski, Michael S / Kopchick, John J / Bartke, Andrzej

The journals of gerontology. Series A, Biological sciences and medical sciences

2005 Volume 60, Issue 11, Page(s) 1394–1398

Abstract: Growth hormone receptor/binding protein knockout (GHR-KO) mice live approximately 40% longer than their normal siblings do. These mice have dramatically reduced plasma levels of insulin-like growth factor 1 (IGF1) and enhanced insulin sensitivity. We ... ...

Abstract	Growth hormone receptor/binding protein knockout (GHR-KO) mice live approximately 40% longer than their normal siblings do. These mice have dramatically reduced plasma levels of insulin-like growth factor 1 (IGF1) and enhanced insulin sensitivity. We examined the expression level of peroxisome proliferator-activated receptors (PPARs) and retinoid X receptors family genes in the livers of normal and GHR-KO mice fed ad libitum or subjected to long-term 30% caloric restriction (CR). The levels of PPARgamma and PPARalpha messenger RNA and proteins and the levels of retinoid X receptors messenger RNA were elevated in long-lived GHR-KO mice as compared to normal mice with no major effect of CR in either genotype. These findings suggest that enhanced insulin sensitivity of GHR-KO mice may be related to the altered actions of PPARs family members in the liver. The results also indicate that CR may increase insulin sensitivity through a different mechanism.
MeSH term(s)	Animals ; Blotting, Western ; Caloric Restriction ; Insulin Resistance ; Liver/metabolism ; Mice ; Mice, Knockout ; Peroxisome Proliferator-Activated Receptors/genetics ; Peroxisome Proliferator-Activated Receptors/metabolism ; Phenotype ; Receptors, Somatotropin/genetics ; Receptors, Somatotropin/physiology ; Retinoid X Receptors/genetics ; Retinoid X Receptors/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Chemical Substances	Peroxisome Proliferator-Activated Receptors ; Receptors, Somatotropin ; Retinoid X Receptors
Language	English
Publishing date	2005-10-07
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/60.11.1394
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Article: Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice.

Masternak, Michal M / Al-Regaiey, Khalid A / Del Rosario Lim, Marc Michael / Jimenez-Ortega, Vanesa / Panici, Jacob A / Bonkowski, Michael S / Bartke, Andrzej

Experimental gerontology

2005 Volume 40, Issue 8-9, Page(s) 679–684

Abstract: Growth hormone receptor/binding protein knockout (GHR-KO) mice are characterized by resistance to growth hormone (GH), reduced insulin like growth factor 1 (IGF1) levels and enhanced insulin sensitivity and markedly increased lifespan. Findings in these ... ...

Abstract	Growth hormone receptor/binding protein knockout (GHR-KO) mice are characterized by resistance to growth hormone (GH), reduced insulin like growth factor 1 (IGF1) levels and enhanced insulin sensitivity and markedly increased lifespan. Findings in these and other long-lived mutant mice, and in normal animals subjected to caloric restriction (CR) indicate that insulin signaling is importantly involved in the control of longevity. We have examined the mRNA expression level of genes involved in insulin/IGF1 action in the skeletal muscle and liver of normal and GHR-KO mice fed ad libitum or subjected to long term 30% CR. The levels of IR, IRS1, IRS2, GLUT4 and IGF1 message in the skeletal muscle were reduced by CR in both normal and GHR-KO mice. In the liver, the results indicate that in GHR-KO mice mRNA expression of genes related to early steps of insulin signaling is up-regulated in the liver but not in the muscle. The results also show that improved insulin sensitivity in response to CR is not due to increased mRNA expression of the above genes in either normal or GHR-KO animals.
MeSH term(s)	Animals ; Caloric Restriction ; Genotype ; Glucose Transporter Type 4/genetics ; Insulin/metabolism ; Insulin Receptor Substrate Proteins ; Insulin Resistance ; Insulin-Like Growth Factor I/genetics ; Intracellular Signaling Peptides and Proteins ; Liver/metabolism ; Longevity/physiology ; Mice ; Mice, Knockout ; Muscle, Skeletal/metabolism ; Phenotype ; Phosphoproteins/genetics ; RNA, Messenger/analysis ; Receptor, IGF Type 1/genetics ; Receptor, Insulin/genetics ; Receptors, Somatotropin/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics
Chemical Substances	Glucose Transporter Type 4 ; Insulin ; Insulin Receptor Substrate Proteins ; Intracellular Signaling Peptides and Proteins ; Irs1 protein, mouse ; Irs2 protein, mouse ; Phosphoproteins ; RNA, Messenger ; Receptors, Somatotropin ; Insulin-Like Growth Factor I (67763-96-6) ; Receptor, IGF Type 1 (EC 2.7.10.1) ; Receptor, Insulin (EC 2.7.10.1)
Language	English
Publishing date	2005-08
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	390992-x
ISSN	0531-5565
ISSN	0531-5565
DOI	10.1016/j.exger.2005.06.003
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Article ; Online: Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial)

Joachim Gerss / Javier Ripollés-Melchor / Emmanuel Futier / Melanie Meersch / Carola Wempe / Detlef Kindgen-Milles / Alexander Zarbock / Markus W Hollmann / Sigismond Lasocki / Thomas Rimmele / Tim Rahmel / Michael Adamzik / Hartmuth Nowak / Ingeborg Welters / Brian Johnston / Ane Abad-motos / Alfredo Abad-gurumeta / Marc Moritz Berger / Davide Ricci /

Maurizio Cecconi / Gudrun Kunst / Christian Stoppe / Christian Putensen / Marlies Ostermann / Sascha Ott / Brijesh Patel / Gabriele Baldini / Antoine Lamblin / Karen Williams / Elena Mancini / Christian Arndt / Hinnerk Wulf / Marc Irqsusi / Wim Vandenberghe / John Kellum / Raphael Weiss / Jackie Donovan / Lui G Forni / Giacomo Monti / Céline Monard / Markus A Weigand / Thorsten Brenner / Ulrich Jaschinski / Carlos Lopez / Maxime Leger / Emmanuel Rineau / Philipp Simon / María Gómez-Rojo / Lars Bergmann / Alicia Waite / Savino Spadaro / Alexander Wolf / Andrew Spence / Simon Dubler / Alexander PJ Vlaar / Patrick Schober / Ben C Creagh-Brown / Nandor Marczin / Emilio Maseda / Christian Strauss / Stefano Romagnoli / Christian Nusshag / Ulrich Gobel / Ángel Candela-Toha / Jon Silversides / Nuttha Lumlertgul / Khaschayar Saadat-Gilani / Vincent Legros / Timo Brandenburger / Thomas Dimski / Laura Huthmann / Claude Pelletier / Manon Schleß / Peter Rosenberger / Helene Häberle / Jan Gerrit Haaker / Matthias Gründel / Lucia Cattin / Laura Villarino Villa / Juan Victor Lorente / Christine Martin / Jan Larmann / Wolfgang Bauer / Giovanni Borghi / Benjamin O’Brien / Thilo von Groote / Antoine Guillaume Schneider / Silvia De Rosa / Diego Parise / Alice Bernard / Paula Fernández-Valdes-Bango / Irene Romero Bhathal / A Suarez-de-la-Rica / Gianluca Villa / Raquel García-Álvarez / Antonio Siniscalchi / Richard Ellerkmann / Florian Espeter / Christian Porschen / Mahan Sadjadi / Michael Storck / Tobias Brix / Dana Meschede / Wida Amini / Carina Stenger / Julius Freytag / Jens Brands / Matthias Unterberg / Britta Marko / Fabian Dusse / Wolfgang A Wetsch / Sandra E Stoll / Hendrik Drinhaus / Bernd W Böttiger / Onnen Mörer / Lars-Olav Harnisch / Roswitha Lubjuhn / Daniel Heise / Christian Bode / Andrea Sauer / Konrad Peukert / Lennart Wild / Philippe Kruse / Jan Menzenbach / Valbona Mirakaj / Sabine Hermann / Stefanie Decker / Mona Jung-König / Tobias Hölle / Sarah Dehne / Jörg Reutershan / Thomas Prüfer / Stefan Pielmeier / Indra Wimmelmeier / Michaela Scholz / Andrea Paris / Isabel Christina Gallego Zapata / Holger Pohl / Nirmeen Fayed / Kai Dielmann / Evelyn Martin / Tilo Koch / Alexander Mück / Philipp Deetjen / Ngoc Bich Mehlmann / Peter M Spieth / Andreas Güldner / Axel Rand / Maximillian Ragaller / Martin Mirus / Rebecca Bockholt / Marc Herzog / Maren Kleine-Brüggeney / Ant Isabelle Cristiani / Marion Ohl / Monica Vieira Da Silva / Gilda Filipe de Castro Reblo / Matthias Hilty / Katharina Spanaus / Benedetta Mura / Eleonora Terreni / Francesco Magiotti / Lorenzo Turi / Cristiana Laici / Chiara Capozzi / Andrea Castelli / Massimiliano Greco / Antonio Messina / Gianluca Castellani / Romina Aceto / Vinicio Danzi / Alessandro Rigobello / Massimo De Cal / Monica Zanella / Gaetano Scaramuzzo / Riccardo La Rosa / Paolo Priani / Alberto Volta Carlo / Stefano Turi / Martina Baiardo Redaelli / Marilena Marmiere / Kittisak Weerapolchai / Shelley Lorah / Fabiola D’Amato / Aneta Bociek / Rosario Lim / Benjie Cendreda / Reynaldo Dela Cuesta / Eirini Kosifidou / Zoka Milan / Juliana Fernanda / Emma Clarey / Daveena Meeks / Nicholas J Lees / Marco Scaramuzzi / Orinta Kviatkovske / Adam Glass / Christine Turley / Charlotte Quinn / Syeda Haider / Adam Rossiter / Syed Nasser / Ned Gilbert-Kawai / Tatjana Besse-Hammer / Eric Hoste / Hannah Schaubroeck / Jan De Waele / Jenni Breel / Eline de Klerk / Harm-Jan de Grooth / Lothar Schwarte / Alexander Loer / Alicia Ruiz-Escobar / Diana Fernández-García / Nerea Gómez-Pérez / Pascual Crespo-Aliseda / Cristina Cerro-Zaballos / Cristina Fernández-Martín / Eduardo Martín-Montero / Alejandro Suarez de la Rica / Héctor Berges Gutiérrez / Maria del Pino Heredia Pérez / Maria de los Reyes Bellido Fernández / Liena Izquierdo López / Javier Valiente Lourtau / Ma Angeles Ferre Colomer / Ma Azucena Pajares Moncho / Maria Jesús Montero Hernández / Esther Pérez Sancho / Silvia Polo Matínez / Pedro Rivera Soria / Maider Puyada Jáuregui / Hugo Rivera Ramos / Marta Antelo Adrán / Ramón Adalia Bartolomé / Patricia Galán Menéndez / Laura Llinares Espin / Yuri Santiago Loaiza Aldean / Víctor MoralesAriza / Rosalía Navarro-Perez / Luis Santé-Serna / Pedro de la Calle-Elguezabal / Rubén Sánchez-Martín / Inés De Soto / Pau Vallhonrat Alcántara / Laura Perelló Cerdà / Gal·la Rouras Hurtado / Paula Rodriguez Nieto / John Narros Sicluna / Angel Molero Molinero / Juan Pablo Nocete / Elena Murcia Sánchez / Stanislas Abrard / Marie-Luce Parrouffe / Frank Bidar / Lucie Aupetitgendre / Ugo Schiff / Bertille Paquette / Gaëlle Sellier / Nathalie Borgnetta / Benjamin Brochet / Thierry Floch / Julien Coffinet / Marion Leclercq-Rouget

BMJ Open, Vol 13, Iss

study protocol for an international, prospective, randomised controlled multicentre trial

2023 Volume 3

Abstract: Introduction Previous studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury (AKI), might ... ...

Abstract	Introduction Previous studies demonstrated that the implementation of the Kidney Disease Improving Global Outcomes (KDIGO) guideline-based bundle, consisting of different supportive measures in patients at high risk for acute kidney injury (AKI), might reduce rate and severity of AKI after surgery. However, the effects of the care bundle in broader population of patients undergoing surgery require confirmation.Methods and analysis The BigpAK-2 trial is an international, randomised, controlled, multicentre trial. The trial aims to enrol 1302 patients undergoing major surgery who are subsequently admitted to the intensive care or high dependency unit and are at high-risk for postoperative AKI as identified by urinary biomarkers (tissue inhibitor of metalloproteinases 2insulin like growth factor binding protein 7 (TIMP-2)IGFBP7)). Eligible patients will be randomised to receive either standard of care (control) or a KDIGO-based AKI care bundle (intervention). The primary endpoint is the incidence of moderate or severe AKI (stage 2 or 3) within 72 hours after surgery, according to the KDIGO 2012 criteria. Secondary endpoints include adherence to the KDIGO care bundle, occurrence and severity of any stage of AKI, change in biomarker values during 12 hours after initial measurement of (TIMP-2)*(IGFBP7), number of free days of mechanical ventilation and vasopressors, need for renal replacement therapy (RRT), duration of RRT, renal recovery, 30-day and 60-day mortality, intensive care unit length-of-stay and hospital length-of-stay and major adverse kidney events. An add-on study will investigate blood and urine samples from recruited patients for immunological functions and kidney damage.Ethics and dissemination The BigpAK-2 trial was approved by the Ethics Committee of the Medical Faculty of the University of Münster and subsequently by the corresponding Ethics Committee of the participating sites. A study amendment was approved subsequently. In the UK, the trial was adopted as an NIHR portfolio study. Results will ...
Keywords	Medicine ; R
Subject code	616 ; 610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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