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  1. Article ; Online: Impact of surgery for endometriosis on the outcomes of in vitro fertilization.

    Ferrero, Simone / Gazzo, Irene / Crosa, Marco / Rosato, Francesco Paolo / Barra, Fabio / Leone Roberti Maggiore, Umberto

    Best practice & research. Clinical obstetrics & gynaecology

    2024  , Page(s) 102496

    Abstract: This narrative review aims to summarize available evidence on the IVF-associated outcomes after surgery for endometriosis. Only one retrospective study investigated if surgical treatment of superficial/peritoneal endometriosis may modify the outcomes of ... ...

    Abstract This narrative review aims to summarize available evidence on the IVF-associated outcomes after surgery for endometriosis. Only one retrospective study investigated if surgical treatment of superficial/peritoneal endometriosis may modify the outcomes of IVF; therefore, more data are needed to confirm the benefit of surgery for this type of disease for improving ART outcomes, and to be able to support it in routine practice. Solid evidence from several meta-analyses demonstrates that surgical treatment of endometriomas does not enhance the outcomes of IVF. In contrast, surgical treatment of ovarian endometriosis may lead to a reduction in ovarian reserve, especially in cases involving bilateral endometriomas or repeated surgical procedures. Some non-randomized studies have examined if surgical treatment on deep endometriosis may influence IVF outcomes. A systematic review with meta-analysis revealed that patients who underwent surgery before IVF exhibited significantly higher pregnancy rates per patient, pregnancy rates per cycle, and live birth rates per patient compared to those without prior surgery. However, the available data are insufficient to recommend surgical excision of deep endometriosis as the first-line treatment for asymptomatic patients to enhance IVF outcomes.
    Language English
    Publishing date 2024-04-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2024.102496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The role of surgical procedures on discriminative performance of the updated euroSCORE II.

    Barili, Fabio / Pacini, Davide / Rosato, Francesco / Parolari, Alessandro

    The Journal of thoracic and cardiovascular surgery

    2013  Volume 146, Issue 4, Page(s) 986–987

    MeSH term(s) Aged ; Algorithms ; Cardiac Surgical Procedures/adverse effects ; Cardiac Surgical Procedures/mortality ; Decision Support Techniques ; Female ; Humans ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; ROC Curve ; Risk Assessment ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2013.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lo studio PRIORITY - PRedictIng long term Outcomes afteR Isolated coronary arTery bypass surgerY.

    Barili, Fabio / D'Errigo, Paola / Rosato, Stefano / Pagano, Eva / Forti, Marco / Biancari, Fausto / Evangelista, Andrea / D'Ovidio, Mariangela / Gellini, Mara / Borsellino, Lucia / Grossi, Claudio / Rosato, Francesco / Parolari, Alessandro / Seccareccia, Fulvia

    Giornale italiano di cardiologia (2006)

    2021  Volume 22, Issue 4, Page(s) 327–331

    Abstract: The allocation of clinical and economic resources is an emerging issue in health management. A useful update necessarily depends on the evaluation of long-term outcomes of clinical and surgical resources that can permit emphasis on all amendable fields, ... ...

    Title translation The PRIORITY study - PRedictIng long term Outcomes afteR Isolated coronary arTery bypass surgerY.
    Abstract The allocation of clinical and economic resources is an emerging issue in health management. A useful update necessarily depends on the evaluation of long-term outcomes of clinical and surgical resources that can permit emphasis on all amendable fields, improve quality of care, and reduce health costs. The PRIORITY (PRedictIng long term Outcomes afteR Isolated coronary arTery bypass surgerY) study represents the first innovative step toward the updating of health management in a selected field, surgery for coronary artery disease, which is one of the most prevalent diseases and requires allocation of high-cost resources, although information on long-term outcomes is limited. The aims of the PRIORITY study are the identification of preoperative risk factors for long-term outcomes and the development of clinical and administrative preoperative scores that can guide clinicians and the national health system to more appropriate actions for increasing quality of care and reducing costs.
    MeSH term(s) Coronary Artery Bypass ; Coronary Artery Disease/surgery ; Humans ; Risk Factors ; Treatment Outcome
    Language Italian
    Publishing date 2021-03-30
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3574.35579
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  4. Article ; Online: An unusual complication of transapical aortic valve implantation: a left ventricular pseudoaneurysm infiltrating the thoracic wall.

    Rosato, Francesco / Grossi, Claudio / Barili, Fabio

    Heart (British Cardiac Society)

    2012  Volume 98, Issue 24, Page(s) 1837

    MeSH term(s) Aged, 80 and over ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aortic Valve Stenosis/surgery ; Cardiac Catheterization/adverse effects ; Diagnosis, Differential ; Heart Aneurysm/diagnostic imaging ; Heart Aneurysm/etiology ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/methods ; Heart Ventricles ; Humans ; Male ; Multidetector Computed Tomography ; Thoracic Wall
    Language English
    Publishing date 2012-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2012-302737
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  5. Article ; Online: In-hospital mortality risk assessment in elective and non-elective cardiac surgery: a comparison between EuroSCORE II and age, creatinine, ejection fraction score.

    Barili, Fabio / Pacini, Davide / Rosato, Francesco / Roberto, Maurizio / Battisti, Alberto / Grossi, Claudio / Alamanni, Francesco / Di Bartolomeo, Roberto / Parolari, Alessandro

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2014  Volume 46, Issue 1, Page(s) 44–48

    Abstract: Objectives: Age, creatinine, ejection fraction (ACEF) score is a simplified algorithm for prediction of mortality after elective cardiac surgery. Although mainly conceived for elective cardiac surgery, no information is available on its performance in ... ...

    Abstract Objectives: Age, creatinine, ejection fraction (ACEF) score is a simplified algorithm for prediction of mortality after elective cardiac surgery. Although mainly conceived for elective cardiac surgery, no information is available on its performance in non-elective surgery and on comparison with the new EuroSCORE II. This study was undertaken to compare the performance of ACEF score and EuroSCORE II within classes of urgency.
    Methods: Complete data on 13 871 consecutive patients who underwent major cardiac surgery in a 6-year period were retrieved from three prospective institutional databases. Discriminatory power was assessed using the c-index and h with Delong, bootstrap and Venkatraman methods. Calibration was evaluated with calibration curves and associated statistics.
    Results: The in-hospital mortality rate was 2.5%. The discriminatory power of ACEF score within elective and non-elective surgery was similar (area under the curve (AUC) 0.71, 95% confidence interval (CI) 0.67-0.74 and AUC 0.68, 95% CI 0.62-0.73, respectively) but significantly lower than that of EuroSCORE II (AUC 0.80, 95% CI 0.77-0.83 for elective surgery; AUC 0.82, 95% CI 0.78-0.85 for non-elective surgery). The calibration patterns were different in the two subgroups, but the summary statistics underscored a miscalibration in both of them (U-statistic and Spiegelhalter Z-test P-values <0.05). Even the calibration of EuroSCORE II was insufficient, although it was demonstrated to be well calibrated in the first tertile of predicted risk.
    Conclusions: This study demonstrated that the performance of ACEF score in predicting in-hospital mortality in elective and non-elective cardiac surgery is comparable. Nonetheless, it is not as satisfactory as the new EuroSCORE II, as its discrimination is significantly lower and it is also miscalibrated.
    MeSH term(s) Age Factors ; Aged ; Cardiovascular Surgical Procedures/mortality ; Creatinine/analysis ; Data Interpretation, Statistical ; Elective Surgical Procedures ; Female ; Hospital Mortality ; Humans ; Male ; ROC Curve ; Risk Assessment/methods ; Risk Factors ; Stroke Volume
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2014-07
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Validation Studies
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezt581
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  6. Article: Survival and Recurrence of Endocarditis following Mechanical vs. Biological Aortic Valve Replacement for Endocarditis in Patients Aged 40 to 65 Years: Data from the INFECT-Registry.

    Salsano, Antonio / Di Mauro, Michele / Labate, Laura / Della Corte, Alessandro / Lo Presti, Federica / De Bonis, Michele / Trumello, Cinzia / Rinaldi, Mauro / Cura Stura, Erik / Actis Dato, Guglielmo / Punta, Giuseppe / Nicolini, Francesco / Carino, Davide / De Vincentiis, Carlo / Garatti, Andrea / Cappabianca, Giangiuseppe / Musazzi, Andrea / Cugola, Diego / Merlo, Maurizio /
    Pacini, Davide / Folesani, Gianluca / Sponga, Sandro / Vendramin, Igor / Pilozzi Casado, Alberto / Rosato, Francesco / Mikus, Elisa / Savini, Carlo / Onorati, Francesco / Luciani, Giovanni Battista / Scrofani, Roberto / Epifani, Francesco / Musumeci, Francesco / Lio, Antonio / Colli, Andrea / Falcetta, Giosuè / Nicolardi, Salvatore / Zaccaria, Salvatore / Vizzardi, Enrico / Pantaleo, Antonio / Minniti, Giuseppe / Villa, Emmanuel / Dalla Tomba, Margherita / Pollari, Francesco / Barili, Fabio / Parolari, Alessandro / Lorusso, Roberto / Santini, Francesco

    Journal of clinical medicine

    2023  Volume 13, Issue 1

    Abstract: Background: Infective endocarditis (IE) is a serious disease, and in many cases, surgery is necessary. Whether the type of prosthesis implanted for aortic valve replacement (AVR) for IE impacts patient survival is a matter of debate. The aim of the ... ...

    Abstract Background: Infective endocarditis (IE) is a serious disease, and in many cases, surgery is necessary. Whether the type of prosthesis implanted for aortic valve replacement (AVR) for IE impacts patient survival is a matter of debate. The aim of the present study is to quantify differences in long-term survival and recurrence of endocarditis AVR for IE according to prosthesis type among patients aged 40 to 65 years.
    Methods: This was an analysis of the INFECT-REGISTRY. Trends in proportion to the use of mechanical prostheses versus biological ones over time were tested by applying the sieve bootstrapped t-test. Confounders were adjusted using the optimal full-matching propensity score. The difference in overall survival was compared using the Cox model, whereas the differences in recurrence of endocarditis were evaluated using the Gray test.
    Results: Overall, 4365 patients were diagnosed and operated on for IE from 2000 to 2021. Of these, 549, aged between 40 and 65 years, underwent AVR. A total of 268 (48.8%) received mechanical prostheses, and 281 (51.2%) received biological ones. A significant trend in the reduction of implantation of mechanical vs. biological prostheses was observed during the study period (
    Conclusions: The present analysis of the INFECT-REGISTRY shows increased survival and reduced recurrence of endocarditis after a mechanical aortic valve prosthesis implant for IE in middle-aged patients.
    Language English
    Publishing date 2023-12-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13010153
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  7. Article ; Online: Hemoglobin trends in isolated coronary artery bypass grafting performed off-pump and with standard and mini circuits.

    Rosato, Francesco / Bruzzone, Dario / Cheema, Faisal H / Capo, Antonio / Ardemagni, Enrico / Verna, Anna / Rosano, Silvia / Grossi, Claudio / Barili, Fabio

    Artificial organs

    2012  Volume 36, Issue 10, Page(s) 868–874

    Abstract: The comparison of hemodilution at the end of surgery is of limited use as it represents only a snapshot of a dynamic phenomenon. This study was undertaken to compare the perioperative hemoglobin curves of isolated coronary artery bypass grafting ... ...

    Abstract The comparison of hemodilution at the end of surgery is of limited use as it represents only a snapshot of a dynamic phenomenon. This study was undertaken to compare the perioperative hemoglobin curves of isolated coronary artery bypass grafting performed with minimized extracorporeal circulation, traditional cardiopulmonary bypass, and off-pump technique. The propensity score method was used to select three groups of patients, homogenous regarding preoperative and operative data, who underwent isolated coronary artery bypass grafting. A generalized linear mixed model was used for estimating differences in perioperative hemoglobin trends among groups. The three groups were each composed of 50 patients with no differences in demographic data, preoperative risk profile, preoperative hemoglobin, or type of surgery. There was no significant difference in major postoperative complications. The pattern of the hemodilution curves was similar in patients operated with mini-circuit and off-pump technique (P > 005). Mini-circuit led to a 3.1 ± 11.9% hemoglobin reduction, which was similar to the off-pump group (1.6 ± 8.9%, P = 0.99 at ANOVA) and significantly different from the standard extracorporeal circuit group (16.0 ± 10.3%, P < 0.001 at ANOVA). The generalized linear mixed model determined that the standard circuit was the only independent predictor for increased hemodilution. Its effect on hemodilution was time-dependent and the slope of the hemoglobin curve was more pronounced between systemic heparinization and the end of surgery. Perioperative hemoglobin trends of patients who underwent myocardial revascularization with mini-circuit were similar to those of off-pump surgery and significantly less pronounced than those of standard extracorporeal circulation.
    MeSH term(s) Aged ; Cardiopulmonary Bypass/methods ; Coronary Artery Bypass, Off-Pump/methods ; Extracorporeal Circulation/methods ; Female ; Hemodilution ; Hemoglobins/analysis ; Humans ; Male ; Middle Aged ; Prospective Studies
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2012-10
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/j.1525-1594.2012.01481.x
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  8. Article ; Online: Aortic valve replacement: reliability of EuroSCORE in predicting early outcomes.

    Barili, Fabio / Di Gregorio, Omar / Capo, Antonio / Ardemagni, Enrico / Rosato, Francesco / Argenziano, Michael / Grossi, Claudio

    International journal of cardiology

    2010  Volume 144, Issue 2, Page(s) 343–345

    Abstract: EuroSCORE algorithms were developed to predict perioperative mortality in cardiac surgery. This study was designed to evaluate the reliability of EuroSCORE algorithms and to analyze the predicting role of the scoring system's factors on patients that ... ...

    Abstract EuroSCORE algorithms were developed to predict perioperative mortality in cardiac surgery. This study was designed to evaluate the reliability of EuroSCORE algorithms and to analyze the predicting role of the scoring system's factors on patients that undergo isolate AVR. 339 patients underwent aortic valve replacement. Data collection was prospective and the logistic and additive EuroSCORE algorithms were calculated according to published guidelines. The observed-over-expected mortality ratio was 0.096. In the ROC curve analysis, the asymptotic significance was greater than 0.05. On multivariate analysis, only critical preoperative state remained significant independent predictor of in-hospital mortality (Odds Ratio 1.6, CI 1.2-2.1). These outcomes suggest that EuroSCORE models may fail in predicting hospital mortality in subsets of cardiac surgery patients and dedicated risk models for isolate aortic valvular surgery may be useful to provide more precise estimates of hospital mortality.
    MeSH term(s) Aged ; Algorithms ; Aortic Valve/surgery ; Female ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis ; Humans ; Male ; Prognosis ; Prospective Studies ; Time Factors
    Language English
    Publishing date 2010-10-08
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2009.03.026
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  9. Article ; Online: Relation of Prolonged Pacemaker Dependency After Cardiac Surgery to Mortality.

    Lorusso, Roberto / Ravaux, Justine M / Barili, Fabio / Bidar, Elham / Vernooy, Kevin / Mauro, Michele Di / Miceli, Antonio / Parolari, Alessandro / Daprati, Andrea / Myasoedova, Veronika / Alamanni, Francesco / De Vincentiis, Carlo / Aime', Ezio / Nicolini, Francesco / Gonzi, GianLuca / Colli, Andrea / Gerosa, Gino / De Bonis, Michele / Paglino, Gabriele /
    Bella, Paolo Della / Dato, Guglielmo Actis / Varone, Egidio / Sponga, Sandro / Toniolo, Mauro / Proclemer, Alessandro / Livi, Ugolino / Mariscalco, Giovanni / Cottini, Marzia / Beghi, Cesare / Scrofani, Roberto / Foresti, Davide / Tritto, Francesco Paolo / Gregorio, Rosario / Villa, Emmanuel / Troise, Giovanni / Pecora, Domenico / Serraino, Filiberto / Jiritano, Federica / Rosato, Francesco / Grasso, Elena / Paparella, Domenico / Amorese, Lilla / Vizzardi, Enrico / Solinas, Marco / Arena, Giuseppe / Maselli, Daniele / Simon, Caterina / Glauber, Mattia / Merlo, Maurizio

    The American journal of cardiology

    2020  Volume 138, Page(s) 66–71

    Abstract: Permanent pacemaker implantation (PPI) represents a rare complication after cardiac surgery, with no uniform agreement on timing and no information on follow-up. A multicenter retrospective study was designed to assess pacemaker dependency (PMD) and long- ...

    Abstract Permanent pacemaker implantation (PPI) represents a rare complication after cardiac surgery, with no uniform agreement on timing and no information on follow-up. A multicenter retrospective study was designed to assess pacemaker dependency (PMD) and long-term mortality after cardiac surgery procedures. Between 2004 and 2016, PPI-patients from 18 centers were followed. Time-to-event data were evaluated with semiparametric regression Cox models and semiparametric Fine and Gray model for competing risk framework. Of 859 (0.90%) PPI-patients, 30% were pacemaker independent (PMI) at 6 months. PMD showed higher mortality compared with PMI (10-year survival 80.1% ± 2.6% and 92.2% +2.4%, respectively, log-rank p-value < 0.001) with an unadjusted hazard ratio for death of 0.36 (95% CI 0.20 to 0.65, p< 0.001 favoring PMI) and an adjusted hazard ratio of 0.19 (95% CI 0.08 to 0.45, p< 0.001 with PMD as reference). Crude cumulative incidence function of restored PMI rhythm at follow-up at 6 months, 1 year and 12 years were 30.5% (95% CI 27.3% to 33.7%), 33.7% (95% CI 30.4% to 36.9%) and 37.2% (95% CI 33.8% to 40.6%) respectively. PMI was favored by preoperative sinus rhythm with normal conduction (SR) (HR 2.37, 95% CI 1.65 to 3.40, p< 0.001), whereas coronary artery bypass grafting and aortic valve replacement were independently associated with PMD (HR 0.63, 95% CI 0.45 to 0.88, p = 0.006 and HR 0.807, 95% CI 0.65 to 0.99, p = 0.047 respectively). Time-to-implantation was not associated with increased rate of PMI. Although 30% of PPI-patients are PMI after 6 months, PMD is associated with higher mortality at long term.
    MeSH term(s) Aged ; Aged, 80 and over ; Atrioventricular Block/epidemiology ; Atrioventricular Block/therapy ; Bradycardia/epidemiology ; Bradycardia/therapy ; Cardiac Pacing, Artificial ; Cardiac Surgical Procedures ; Coronary Artery Bypass ; Female ; Heart Valve Prosthesis Implantation ; Humans ; Male ; Middle Aged ; Mortality ; Pacemaker, Artificial ; Postoperative Complications/epidemiology ; Postoperative Complications/therapy ; Proportional Hazards Models ; Retrospective Studies
    Language English
    Publishing date 2020-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2020.10.010
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  10. Article ; Online: Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation.

    Mangner, Norman / del Val, David / Abdel-Wahab, Mohamed / Crusius, Lisa / Durand, Eric / Ihlemann, Nikolaj / Urena, Marina / Pellegrini, Costanza / Giannini, Francesco / Gasior, Tomasz / Wojakowski, Wojtek / Landt, Martin / Auffret, Vincent / Sinning, Jan Malte / Cheema, Asim N / Nombela-Franco, Luis / Chamandi, Chekrallah / Campelo-Parada, Francisco / Munoz-Garcia, Erika /
    Herrmann, Howard C / Testa, Luca / Kim, Won-Keun / Castillo, Juan Carlos / Alperi, Alberto / Tchetche, Didier / Bartorelli, Antonio L / Kapadia, Samir / Stortecky, Stefan / Amat-Santos, Ignacio / Wijeysundera, Harindra C / Lisko, John / Gutiérrez-Ibanes, Enrique / Serra, Vicenç / Salido, Luisa / Alkhodair, Abdullah / Livi, Ugolino / Chakravarty, Tarun / Lerakis, Stamatios / Vilalta, Victoria / Regueiro, Ander / Romaguera, Rafael / Kappert, Utz / Barbanti, Marco / Masson, Jean-Bernard / Maes, Frédéric / Fiorina, Claudia / Miceli, Antonio / Kodali, Susheel / Ribeiro, Henrique B / Mangione, Jose Armando / Sandoli de Brito, Fabio / Actis Dato, Guglielmo Mario / Rosato, Francesco / Ferreira, Maria-Cristina / Correia de Lima, Valter / Colafranceschi, Alexandre Siciliano / Abizaid, Alexandre / Marino, Marcos Antonio / Esteves, Vinicius / Andrea, Julio / Godinho, Roger R / Alfonso, Fernando / Eltchaninoff, Helene / Søndergaard, Lars / Himbert, Dominique / Husser, Oliver / Latib, Azeem / Le Breton, Hervé / Servoz, Clement / Pascual, Isaac / Siddiqui, Saif / Olivares, Paolo / Hernandez-Antolin, Rosana / Webb, John G / Sponga, Sandro / Makkar, Raj / Kini, Annapoorna S / Boukhris, Marouane / Gervais, Philippe / Côté, Mélanie / Holzhey, David / Linke, Axel / Rodés-Cabau, Josep

    Journal of the American College of Cardiology

    2022  Volume 79, Issue 8, Page(s) 772–785

    Abstract: Background: The optimal treatment of patients developing infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is uncertain.: Objectives: The goal of this study was to investigate the clinical characteristics and outcomes ... ...

    Abstract Background: The optimal treatment of patients developing infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is uncertain.
    Objectives: The goal of this study was to investigate the clinical characteristics and outcomes of patients with TAVI-IE treated with cardiac surgery and antibiotics (IE-CS) compared with patients treated with antibiotics alone (IE-AB).
    Methods: Crude and inverse probability of treatment weighting analyses were applied for the treatment effect of cardiac surgery vs medical therapy on 1-year all-cause mortality in patients with definite TAVI-IE. The study used data from the Infectious Endocarditis after TAVI International Registry.
    Results: Among 584 patients, 111 patients (19%) were treated with IE-CS and 473 patients (81%) with IE-AB. Compared with IE-AB, IE-CS was not associated with a lower in-hospital mortality (HR
    Conclusions: In this registry, the majority of patients with TAVI-IE were treated with antibiotics alone. Cardiac surgery was not associated with an improved all-cause in-hospital or 1-year mortality. The high mortality of patients with TAVI-IE was strongly linked to patients' characteristics, pathogen, and IE-related complications.
    MeSH term(s) Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Cardiac Surgical Procedures ; Combined Modality Therapy ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/etiology ; Endocarditis, Bacterial/surgery ; Female ; Humans ; Male ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/surgery ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/etiology ; Staphylococcal Infections/surgery ; Transcatheter Aortic Valve Replacement/adverse effects
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2021.11.056
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