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  1. Article ; Online: The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in rheumatoid arthritis patients tapering tumour necrosis factor inhibitor.

    Rosato, Edoardo

    Rheumatology (Oxford, England)

    2021  Volume 61, Issue SI, Page(s) SI1–SI3

    MeSH term(s) Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/drug therapy ; Fluorodeoxyglucose F18 ; Humans ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Tumor Necrosis Factor Inhibitors
    Chemical Substances Radiopharmaceuticals ; Tumor Necrosis Factor Inhibitors ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-12-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keab932
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  2. Article ; Online: Reduced glomerular filtrate rate, end-stage renal disease, scleroderma renal crisis, and risk of mortality in patients with systemic sclerosis.

    Gigante, A / Rosato, E

    Scandinavian journal of rheumatology

    2021  Volume 51, Issue 3, Page(s) 246–247

    MeSH term(s) Acute Kidney Injury ; Female ; Humans ; Kidney Failure, Chronic ; Male ; Scleroderma, Localized ; Scleroderma, Systemic/complications
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 121265-5
    ISSN 1502-7732 ; 0300-9742
    ISSN (online) 1502-7732
    ISSN 0300-9742
    DOI 10.1080/03009742.2021.1995983
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    Zs.A 832: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Genetic analysis of cryptochrome in insect magnetosensitivity.

    Kyriacou, Charalambos P / Rosato, Ezio

    Frontiers in physiology

    2022  Volume 13, Page(s) 928416

    Abstract: The earth's magnetic field plays an important role in the spectacular migrations and navigational abilities of many higher animals, particularly birds. However, these organisms are not amenable to genetic analysis, unlike the model fruitfly, ...

    Abstract The earth's magnetic field plays an important role in the spectacular migrations and navigational abilities of many higher animals, particularly birds. However, these organisms are not amenable to genetic analysis, unlike the model fruitfly,
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.928416
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  4. Article: Phimosis in Adults: Narrative Review of the New Available Devices and the Standard Treatments.

    Rosato, Eleonora / Miano, Roberto / Germani, Stefano / Asimakopoulos, Anastasios D

    Clinics and practice

    2024  Volume 14, Issue 1, Page(s) 361–376

    Abstract: Background: Phimosis is the inability to completely retract the foreskin and expose the glans. The treatment of phimosis varies depending on the age of the patient and the severity of the disease; a great number of conservative or surgical treatments ... ...

    Abstract Background: Phimosis is the inability to completely retract the foreskin and expose the glans. The treatment of phimosis varies depending on the age of the patient and the severity of the disease; a great number of conservative or surgical treatments are currently available.
    Aim: To provide the first review summarizing the available options for the treatment of adult phimosis.
    Methods: A PubMed, Cochrane and Embase search for peer-reviewed studies, published between January 2001 and December 2022 was performed using the search terms "phimosis AND treatment".
    Results: A total of 288 publications were initially identified through database searching. Thirty manuscripts were ultimately eligible for inclusion in this review. Conservative treatment is an option. and it includes topical steroid application and the new medical silicon tubes (Phimostop™) application for gentle prepuce dilation. Concerning the surgical approach, the gold-standard treatment is represented by circumcision in which tissue synthesis after prepuce removal can be also obtained with barbed sutures, fibrin glues or staples. Laser circumcision seems to be providing superior outcomes in terms of operative time and postoperative complication rate when compared to the traditional one. Several techniques of preputioplasty and use of in situ devices (which crush the foreskin and simultaneously create haemostasis) have been also described. These in situ devices seem feasible, safe and effective in treating phimosis while they also reduce the operative time when compared to traditional circumcision. Patient satisfaction rates, complications and impact on sexual function of the main surgical treatments are presented.
    Conclusion: Many conservative and surgical treatments are available for the treatment of adult phimosis. The choice of the right treatment depends on the grade of phimosis, results, complications, and cost-effectiveness.
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2605724-4
    ISSN 2039-7283 ; 2039-7275
    ISSN (online) 2039-7283
    ISSN 2039-7275
    DOI 10.3390/clinpract14010028
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  5. Article ; Online: Serum kynurenic acid is lower in systemic sclerosis patients with microvascular damage of hands.

    Pellicano, Chiara / Colalillo, Amalia / Rosato, Edoardo

    Microvascular research

    2023  Volume 148, Page(s) 104537

    Abstract: Background: Endothelial dysfunction occurs early in systemic sclerosis (SSc), leading to tissue hypoxia, vasoconstriction and fibrosis. It has been demonstrated that endothelial cells (ECs) are able to produce kynurenic acid (KYNA) in response to ... ...

    Abstract Background: Endothelial dysfunction occurs early in systemic sclerosis (SSc), leading to tissue hypoxia, vasoconstriction and fibrosis. It has been demonstrated that endothelial cells (ECs) are able to produce kynurenic acid (KYNA) in response to vascular inflammation, due to its anti-inflammatory and anti-oxidants activity. In SSc patients, blood perfusion of hands, assessed by laser speckle contrast analysis (LASCA), correlated negatively with the extent of the nailfold microvascular damage, scored according to nailfold videocapillaroscopy (NVC) classification. Aim of this study was to evaluate the difference of serum KYNA in SSc patients with different stages of microvascular damage.
    Methods: Serum KYNA was assessed in 40 SSc patients at the enrolment. NVC was performed to evaluate capillaroscopic patterns (early, active and late). LASCA was performed to evaluate mean peripheral blood perfusion (PBP) of both hands and to evaluate the proximal-distal gradient (PDG).
    Results: Median PDG was significantly lower in SSc patients with late NVC pattern compared to SSc patients with early and active NVC pattern [3.79 pU (IQR -8.55-18.16) vs 23.55 pU (IQR 14.92-43.80), p < 0.01]. Serum KYNA was significantly lower in SSc patients with late NVC pattern compared to SSc patient with early and active NVC pattern [45.19 ng/mL (IQR 42.70-54.74) vs 52.65 ng/mL (IQR 49.99-60.29), p < 0.05]. Moreover, SSc patients without PDG had significantly lower serum KYNA than in SSc patients with PDG [48.03 ng/mL (IQR 43.87-53.68) vs 59.27 ng/mL (IQR 49.15-71.00), p < 0.05].
    Conclusion: KYNA is lower in SSc patients with late NCV pattern and without PDG. KYNA may be associated with early endothelial dysfunction.
    MeSH term(s) Humans ; Kynurenic Acid ; Nails/blood supply ; Endothelial Cells ; Scleroderma, Systemic ; Hand ; Vascular Diseases ; Microscopic Angioscopy
    Chemical Substances Kynurenic Acid (H030S2S85J)
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/j.mvr.2023.104537
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    Zs.A 746: Show issues Location:
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  6. Article ; Online: Body composition and microvascular damage in systemic sclerosis patients.

    Gigante, A / Rosato, E / Muscaritoli, M

    Journal of endocrinological investigation

    2020  Volume 44, Issue 1, Page(s) 205–206

    MeSH term(s) Body Composition ; Humans ; Microcirculation ; Scleroderma, Systemic/complications ; Vascular Diseases/etiology ; Vascular Diseases/pathology
    Language English
    Publishing date 2020-07-18
    Publishing country Italy
    Document type Letter
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-020-01364-9
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    Zs.A 1480: Show issues Location:
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  7. Article ; Online: Human genital tracts microbiota: dysbiosis crucial for infertility.

    Venneri, M A / Franceschini, E / Sciarra, F / Rosato, E / D'Ettorre, G / Lenzi, A

    Journal of endocrinological investigation

    2022  Volume 45, Issue 6, Page(s) 1151–1160

    Abstract: Human body is colonized by trillions of microbes, influenced by several factors, both endogenous, as hormones and circadian regulation, and exogenous as, life-style habits and nutrition. The alteration of such factors can lead to microbial dysbiosis, a ... ...

    Abstract Human body is colonized by trillions of microbes, influenced by several factors, both endogenous, as hormones and circadian regulation, and exogenous as, life-style habits and nutrition. The alteration of such factors can lead to microbial dysbiosis, a phenomenon which, in turn, represents a risk factor in many different pathologies including cancer, diabetes, autoimmune and cardiovascular disease, and infertility. Female microbiota dysbiosis (vaginal, endometrial, placental) and male microbiota dysbiosis (seminal fluid) can influence the fertility, determining a detrimental impact on various conditions, as pre-term birth, neonatal illnesses, and macroscopic sperm parameters impairments. Furthermore, unprotected sexual intercourse creates a bacterial exchange between partners, and, in addition, each partner can influence the microbiota composition of partner's reproductive tracts. This comprehensive overview of the effects of bacterial dysbiosis in both sexes and how partners might influence each other will allow for better personalization of infertility management.
    MeSH term(s) Dysbiosis/microbiology ; Female ; Humans ; Infant, Newborn ; Infertility/etiology ; Male ; Microbiota ; Placenta ; Pregnancy ; Vagina
    Language English
    Publishing date 2022-02-03
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-022-01752-3
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  8. Article ; Online: Clinical management of androgen excess and defect in women.

    Rosato, Elena / Sciarra, Francesca / Minnetti, Marianna / Degjoni, Anisa / Venneri, Mary Anna

    Expert review of endocrinology & metabolism

    2024  Volume 19, Issue 1, Page(s) 21–35

    Abstract: Introduction: Hyperandrogenism and hypoandrogenism are complex disorders involving multiple-organ systems. While androgen excess is a well-characterized condition, androgen deficiency still needs diagnostic criteria, as there are no specific cutoffs.: ...

    Abstract Introduction: Hyperandrogenism and hypoandrogenism are complex disorders involving multiple-organ systems. While androgen excess is a well-characterized condition, androgen deficiency still needs diagnostic criteria, as there are no specific cutoffs.
    Areas covered: We highlight the most recent findings on the role of androgens in female pathophysiology, investigating clinically relevant conditions of androgen insufficiency or excess throughout a woman's life, and their possible therapeutic management.
    Expert opinion: Combined oral contraceptives (COCs) should be considered as first-line therapy for the management of menstrual irregularity and/or clinical hyperandrogenism in adolescents with a clear diagnosis of polycystic ovary syndrome (PCOS). There are limited evidence-based data regarding specific types or doses of COCs for management of PCOS in women; however, the lowest effective estrogen dose should be considered for treatment. Despite evidence regarding safety, efficacy, and clinical use, testosterone therapy has not been approved for women by most regulatory agencies for treatment of hypoactive sexual desire disorder (HSDD). The long-term safety for treatments with testosterone is still to be evaluated, and this review highlights the need for more research in this area.
    MeSH term(s) Adolescent ; Female ; Humans ; Hyperandrogenism/drug therapy ; Androgens/therapeutic use ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/diagnosis ; Testosterone/therapeutic use ; Estrogens
    Chemical Substances Androgens ; Testosterone (3XMK78S47O) ; Estrogens
    Language English
    Publishing date 2024-01-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1080/17446651.2023.2279537
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  9. Article: Urodynamic Parameters and Continence Outcomes in Asymptomatic Patients with Ileal Orthotopic Neobladder: A Systematic Review and Metanalysis.

    Asimakopoulos, Anastasios D / Finazzi Agrò, Enrico / Piechaud, Thierry / Gakis, Georgios / Gaston, Richard / Rosato, Eleonora

    Cancers

    2024  Volume 16, Issue 7

    Abstract: Introduction: The orthotopic neobladder is the type of urinary diversion (UD) that most closely resembles the original bladder. However, in the literature the urodynamic aspects are scarcely analysed.: Objective: To provide the first systematic ... ...

    Abstract Introduction: The orthotopic neobladder is the type of urinary diversion (UD) that most closely resembles the original bladder. However, in the literature the urodynamic aspects are scarcely analysed.
    Objective: To provide the first systematic review (SR) on the urodynamic (UDS) outcomes of the ileal orthotopic neobladders (ONB). Continence outcomes are also presented.
    Methods: A PubMed, Embase and Cochrane CENTRAL search for peer-reviewed studies on ONB published between January 2001-December 2022 was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement.
    Results and conclusion: Fifty-nine manuscripts were eligible for inclusion in this SR. A great heterogeneity of data was encountered. Concerning UDS parameters, the pooled mean was 406.2 mL (95% CI: 378.9-433.4 mL) for maximal (entero)cystometric capacity (MCC) and 21.4 cmH
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071253
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  10. Article ; Online: When pulmonary arterial hypertension complicates connective tissue diseases: we still have not found what we are looking for.

    Gigante, Antonietta / Papa, Silvia / Rosato, Edoardo / Badagliacca, Roberto / Marra, Alberto Maria

    Internal and emergency medicine

    2024  

    Language English
    Publishing date 2024-04-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-024-03598-4
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