Article ; Online: Comparison of Aerosol Deposition Between a Cynomolgus Macaque and a 3D Printed Cast Model of the Animal.
2023 Volume 40, Issue 3, Page(s) 765–775
Abstract: Purpose: Preclinical aerosol studies using animals are essential for evaluating toxic or therapeutic effects on human respiratory tract. Macaques are relevant animal models for respiratory studies, but they are sensitive, expensive and difficult-to- ... ...
| Abstract | Purpose: Preclinical aerosol studies using animals are essential for evaluating toxic or therapeutic effects on human respiratory tract. Macaques are relevant animal models for respiratory studies, but they are sensitive, expensive and difficult-to-access. Methods: In the context of preliminary studies before animal experiments, we set up an alternative in vitro anatomical model of macaque airways to reduce, refine and replace (3Rs) the animals. We printed an in vitro anatomical cast until the third bronchial division from X-ray computed tomography data of a healthy cynomolgus macaque. This in vitro model was then connected to a respiratory pump to mimic macaque's breathing. We assessed the relevance of this in vitro model, by comparing aerosol deposition patterns obtained with the anatomical model and in three macaques using planar gamma camera imaging. DTPA- Results: The data showed no statistical differences between the animal and anatomical in vitro models in terms of total aerosol deposited in the airways. However, the distribution of the deposition in the airways showed a higher deposited fraction in the upper respiratory tract in the animals than the in vitro model for all particle sizes. Conclusions: The anatomical printed model appears to be a relevant in vitro tool to predict total aerosol deposition in macaque airways. |
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| MeSH term(s) | Animals ; Humans ; Administration, Inhalation ; Lung ; Aerosols ; Nebulizers and Vaporizers ; Macaca ; Printing, Three-Dimensional ; Particle Size |
| Chemical Substances | Aerosols |
| Language | English |
| Publishing date | 2023-01-18 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 843063-9 |
| ISSN | 1573-904X ; 0724-8741 ; 0739-0742 |
| ISSN (online) | 1573-904X |
| ISSN | 0724-8741 ; 0739-0742 |
| DOI | 10.1007/s11095-022-03466-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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