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Book ; Conference proceedings: Neurohumoral changes in hypertensive heart disease

Rosei, Enrico Agabiti

proceedings of the satellite symposium to the 7th meeting of the European Society of Hypertension ; Gardone Riviera, Italy, June 14, 1995

1996

Institution	European Society of Hypertension
Author's details	ed. by Enrico Agabiti Rosei
Keywords	Hypertension / physiopathology / congresses ; Heart Diseases / physiopathology / congresses ; Neurotransmitters / physiology / congresses
Language	English
Publishing country	Italy
Document type	Book ; Conference proceedings
Note	In: High blood pressure & cardiovasular prevention. - ISSN 1120-9879. - 5 (1996),2, S. 91 - 123; 3, S. 164 - 189
HBZ-ID	HT007366673
Database	Catalogue ZB MED Medicine, Health

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Zs A 4289 -5-	not available for loan	Zeitschriften-Lesesaal

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Article ; Online: The fixed-dose combination of lercanidipine and enalapril: more than mere blood pressure reduction.

Rosei, Enrico Agabiti

Current medical research and opinion

2016 Volume 32, Issue sup2, Page(s) 1–2

Language	English
Publishing date	2016
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1080/03007995.2016.1247687
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Zs.A 955: Show issues

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Article: How important is blood pressure variability?

Rosei, Enrico Agabiti / Chiarini, Giulia / Rizzoni, Damiano

European heart journal supplements : journal of the European Society of Cardiology

2020 Volume 22, Issue Suppl E, Page(s) E1–E6

Abstract: Arterial blood pressure (BP) is a continuous variable, with a physiology characterized by significant variability stemming from the complex interaction among haemodynamic factors, neuronal reflexes, as well as hormonal, behavioural, and environmental ... ...

Abstract	Arterial blood pressure (BP) is a continuous variable, with a physiology characterized by significant variability stemming from the complex interaction among haemodynamic factors, neuronal reflexes, as well as hormonal, behavioural, and environmental stimuli. The homoeostatic response accounts for the physiologic variability in BP in normotensive individuals, which is more evident in hypertensive patients. Blood pressure variability is a complex phenomenon, which could be classified in various types:
Language	English
Publishing date	2020-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1463769-8
ISSN	1554-2815 ; 1520-765X
ISSN (online)	1554-2815
ISSN	1520-765X
DOI	10.1093/eurheartj/suaa061
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Zs.A 1563 -Suppl.-: Show issues

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Article: Reduction of Cardiovascular Risk through Angiotensin II Type 1 Receptor Antagonism : Focus on Olmesartan Medoxomil.

Rosei, Enrico Agabiti

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

2013 Volume 15, Issue 4, Page(s) 231–243

Abstract: It is well recognized that angiotensin II is involved in the pathogenesis of hypertension. Less well recognized - until recently, at least - is its involvement in the pathogenesis of atherosclerosis. However, it is now evident that angiotensin II ... ...

Abstract	It is well recognized that angiotensin II is involved in the pathogenesis of hypertension. Less well recognized - until recently, at least - is its involvement in the pathogenesis of atherosclerosis. However, it is now evident that angiotensin II promotes oxidative stress, vascular remodelling, inflammation, and the formation of atherosclerotic lesions. These actions, which are mediated almost exclusively by the angiotensin II type 1 (AT(1)) receptor, can be blocked by administration of angiotensin II type 1 receptor antagonists (angiotensin receptor blockers [ARBs]). Of the seven ARBs currently in clinical use, olmesartan is one of the most effective. The rapid and consistent antihypertensive efficacy of this drug, which allows a high proportion of patients to achieve their target blood pressure (BP), is associated with beneficial effects on oxidative stress, vascular remodelling, inflammation, and atherosclerotic lesion formation. These effects appear to be independent of the BP-lowering activity of olmesartan. In clinical trials, olmesartan has been shown to control microinflammation in hypertensive patients, to reduce oxidative stress in patients with type 2 diabetes mellitus, and to normalize the wall: lumen ratio of small resistance arteries (a measure of vascular remodelling) in patients with hypertension. Moreover, in a 2-year study involving hypertensive patients with carotid atherosclerosis (the MORE [Multicentre Olmesartan atherosclerosis Regression Evaluation] trial), olmesartan reduced the intima-media thickness of the carotid artery and significantly reduced the volume of large atherosclerotic plaques. These data suggest that olmesartan may reduce cardiovascular risk by simultaneously normalizing BP and reversing the proatherogenic effects of angiotensin II.
Language	English
Publishing date	2013-01-22
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	1236337-6
ISSN	1179-1985 ; 1120-9879
ISSN (online)	1179-1985
ISSN	1120-9879
DOI	10.2165/0151642-200815040-00003
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Article ; Online: Prognostic significance of the wall to lumen ratio of retinal arterioles evaluated by adaptive optics.

De Ciuceis, Carolina / Rosei, Claudia Agabiti / Malerba, Paolo / Rossini, Claudia / Nardin, Matteo / Chiarini, Giulia / Famà, Francesca / Lemoli, Matteo / Baresi, Mattia / Petelca, Alina / Bortoluzzi, Chiara / Porteri, Enzo / Salvetti, Massimo / Muiesan, Maria Lorenza / Rosei, Enrico Agabiti / Rizzoni, Damiano

European journal of internal medicine

2023 Volume 122, Page(s) 86–92

Abstract: Objective: Microvascular structural alterations may be considered an important form of hypertension-mediated organ damage. An increased media-to-lumen ratio of subcutaneous small arteries evaluated with locally invasive techniques (micromyography) ... ...

Abstract	Objective: Microvascular structural alterations may be considered an important form of hypertension-mediated organ damage. An increased media-to-lumen ratio of subcutaneous small arteries evaluated with locally invasive techniques (micromyography) predicts the development of cardiovascular (CV) events. However, it is not known whether retinal arteriole structural alterations evaluated with a noninvasive approach (Adaptive Optics) may have a prognostic significance. Design and methods: Two-hundred and thirty-seven subjects (mean age 58.7 ± 16.1 years, age range 13-89 years; 116 males) were included in the study: 65 normotensive subjects (27.4 %) and 172 patients with essential hypertension or primary aldosteronism (72.6 %). All subjects underwent a non-invasive evaluation of retinal arteriolar wall-to-lumen ratio (WLR) by Adaptive Optics. Subjects were re-evaluated after an average follow-up time of 4.55 years in order to assess the occurrence of clinical events (non CV and/or CV death or events). Results: Fifty-four events occurred in the study population:26 were cardio-cerebrovascular events (ischemic or hemorragic stroke, atrial fibrillation, heart failure, coronary artery disease, peripheral artery disease, cardiac valvular disease) while the remaining were deaths for any cause, or neoplastic diseases. Subjects with events were older and had a WLR of retinal arterioles significantly greater than those without events. The event-free survival was significantly worse in those with a baseline WLR above the median value of the population (0.28) according to Kaplan-Mayer survival curves and multivariate analysis (Cox's proportional hazard model). The evidence was confirmed after restricting the analysis to CV events. Conclusions: Structural alterations of retinal arterioles evaluated by Adaptive Optics may predict total and CV events.
MeSH term(s)	Male ; Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Arterioles/diagnostic imaging ; Prognosis ; Retinal Vessels/diagnostic imaging ; Hypertension ; Blood Pressure
Language	English
Publishing date	2023-10-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2023.10.035
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Zs.A 2608: Show issues

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Article ; Online: Dronedarone: an emerging therapy for atrial fibrillation.

Rosei, Enrico Agabiti / Salvetti, Massimo

Therapeutic advances in cardiovascular disease

2010 Volume 4, Issue 3, Page(s) 155–164

Abstract: Atrial fibrillation (AF) is a common arrhythmia, with a prevalence ranging from 0.1% to 9.0% at different ages, and is associated with increased cardiovascular events and mortality. A significant increase in the prevalence of the disease is expected to ... ...

Abstract	Atrial fibrillation (AF) is a common arrhythmia, with a prevalence ranging from 0.1% to 9.0% at different ages, and is associated with increased cardiovascular events and mortality. A significant increase in the prevalence of the disease is expected to occur in the coming years as a consequence of the aging of the population and advances in the management of coronary artery disease and heart failure. Effective rhythm control may be difficult to obtain in a significant proportion of patients with AF. The limited efficacy and the possible adverse effects of antiarrhythmic drugs has led researchers to focus their attention on new molecules, in a search of compounds with antiarrhythmic efficacy and a more favourable safety profile. Among several new drugs developed for the management of AF, dronedarone, a benzofuran derivative that shares many of the antiarrhythmic properties of amiodarone, but with a more favourable safety profile, seems particularly promising. The drug is noniodinated, has less lipophilicity, reaches therapeutic concentrations over a shorter period of time and has lower tissue accumulation. Dronedarone, similarly to amiodarone, exhibits electrophysiologic characteristics of all 4 Vaughan Williams classes. Clinical studies have shown that dronedarone effectively reduces ventricular rate, may prevent or delay the recurrence of AF, and may reduce cardiovascular morbidity and mortality in patients with AF or atrial flutter. The drug has an overall good safety profile, in particular with low pulmonary and thyroid toxicity. An important exception is represented by patients with unstable haemodynamic conditions, in which the use of dronedarone has been found to be associated with an increase in mortality. Dronedarone has been recently approved for clinical use by the Food and Drug Administration and by the European Medicines Agency. Further results from trials and clinical use will better define the efficacy and safety profile of dronedarone in AF compared with other antiarrhythmic drugs and its role in the management of patients with AF.
MeSH term(s)	Amiodarone/adverse effects ; Amiodarone/analogs & derivatives ; Amiodarone/therapeutic use ; Animals ; Anti-Arrhythmia Agents/adverse effects ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/physiopathology ; Drug Approval ; Heart Rate/drug effects ; Heart Ventricles/physiopathology ; Humans ; Secondary Prevention ; Treatment Outcome
Chemical Substances	Anti-Arrhythmia Agents ; dronedarone (JQZ1L091Y2) ; Amiodarone (N3RQ532IUT)
Language	English
Publishing date	2010-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2485062-7
ISSN	1753-9455 ; 1753-9447
ISSN (online)	1753-9455
ISSN	1753-9447
DOI	10.1177/1753944710366266
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Zs.A 6798: Show issues

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Article ; Online: Small artery remodelling in diabetes.

Rosei, Enrico Agabiti / Rizzoni, Damiano

Journal of cellular and molecular medicine

2010 Volume 14, Issue 5, Page(s) 1030–1036

Abstract: The aim of this article is to briefly review available data regarding changes in the structure of microvessels observed in patients with diabetes mellitus, and possible correction by effective treatment. The development of structural changes in the ... ...

Abstract	The aim of this article is to briefly review available data regarding changes in the structure of microvessels observed in patients with diabetes mellitus, and possible correction by effective treatment. The development of structural changes in the systemic vasculature is the end result of established hypertension. In essential hypertension, small arteries of smooth muscle cells are restructured around a smaller lumen and there is no net growth of the vascular wall, although in some secondary forms of hypertension, a hypertrophic remodelling may be detected. Moreover, in non-insulin-dependent diabetes mellitus a hypertrophic remodelling of subcutaneous small arteries is present. Indices of small resistance artery structure, such as the tunica media to internal lumen ratio, may have a strong prognostic significance in hypertensive and diabetic patients, over and above all other known cardiovascular risk factors. Therefore, regression of vascular alterations is an appealing goal of antihypertensive treatment. Different antihypertensive drugs seem to have different effect on vascular structure. In diabetic hypertensive patients, a significant regression of structural alterations of small resistance arteries with drugs blocking the renin-angiotensin system (angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers) was demonstrated. Alterations in the microcirculation represent a common pathological finding, and microangiopathy is one of the most important mechanisms involved in the development of organ damage as well as of clinical events in patients with diabetes mellitus. Renin-angiotensin system blockade seems to be effective in preventing/regressing alterations in microvascular structure.
MeSH term(s)	Arteries/physiopathology ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/physiopathology ; Diabetes Complications/physiopathology ; Diabetes Mellitus/physiopathology ; Diabetes Mellitus/therapy ; Endothelium/physiopathology ; Humans
Language	English
Publishing date	2010-07-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/j.1582-4934.2010.01075.x
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Zs.A 5752: Show issues

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Article: Clinical value of diastolic dysfunction in hypertension.

Rosei, Enrico Agabiti

Journal of hypertension

2002 Volume 20, Issue 6, Page(s) 1083–1084

MeSH term(s)	Blood Pressure ; Diastole ; Humans ; Hypertension/physiopathology
Language	English
Publishing date	2002-08-16
Publishing country	England
Document type	Comment ; Editorial ; Review
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/00004872-200206000-00017
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 614: Show issues

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Article: Lo studio I-PRESERVE.

Trimarco, Bruno / Rosei, Enrico Agabiti

Giornale italiano di cardiologia (2006)

2009 Volume 10, Issue 8, Page(s) 495–498

Title translation	The I-PRESERVE study.
MeSH term(s)	Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Biphenyl Compounds/therapeutic use ; Follow-Up Studies ; Heart Failure/drug therapy ; Heart Failure/mortality ; Heart Failure/physiopathology ; Humans ; Quality of Life ; Randomized Controlled Trials as Topic ; Research Design ; Stroke Volume/drug effects ; Survival Analysis ; Tetrazoles/therapeutic use ; Treatment Outcome
Chemical Substances	Angiotensin II Type 1 Receptor Blockers ; Biphenyl Compounds ; Tetrazoles ; irbesartan (J0E2756Z7N)
Language	Italian
Publishing date	2009-08
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
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Zs.A 6738: Show issues

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Article ; Online: The UrgeRe (Urgenze Ipertensive: Un Progetto Educazionale Fondato Sulla Vita Reale, Hypertensive Urgencies: A Project in the Real World) Project.

Muiesan, Maria Lorenza / Rosei, Enrico Agabiti / Borghi, Claudio / De Luca, Nicola / Ghiadoni, Lorenzo / Grassi, Guido / Perlini, Stefano / Pucci, Giacomo / Salvetti, Massimo / Volpe, Massimo / Ferri, Claudio

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

2021 Volume 28, Issue 2, Page(s) 151–157

Abstract: The approach to hypertensive emergiencies (HE) and urgencies (HU) may be different according to local clinical practice, despite recent guidelines and position papers recommendations. The Italian Society of Hypertension (Società Italiana della ... ...

Abstract	The approach to hypertensive emergiencies (HE) and urgencies (HU) may be different according to local clinical practice, despite recent guidelines and position papers recommendations. The Italian Society of Hypertension (Società Italiana della Ipertensione Arteriosa, SIIA) developed an online survey, in order to explore the awareness, management and treatment of HU in Italy, sending by e mail a 12 items questionnaire to the members of the SIIA. The results show that the definition of HU was correctly identified by 62% of the responders. Most physicians identified the role of pharmacological therapy or legal/illegal substances abuse as possible cause of BP elevation; the use of a benzodiazepine drugs was considered worthwhile by 65% of responders. The prescription of diagnostic test and drug administration significantly differed from guidelines recommendations and only 57% of the physicians reported to treat HU with oral drug administration. Sub-lingual nifedipine was prescribed by 13% or responders. This survey shows the need to further spread the updated scientific information on the management and treatment of HE and HU, along with the improvement of the interrelationship with the general practitioner health system in Italy.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Drug Utilization/trends ; Emergencies ; Female ; General Practice/trends ; Guideline Adherence/trends ; Health Care Surveys ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/physiopathology ; Italy/epidemiology ; Male ; Middle Aged ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/trends ; Risk Factors ; Treatment Outcome ; Young Adult
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2021-02-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	1236337-6
ISSN	1179-1985 ; 1120-9879
ISSN (online)	1179-1985
ISSN	1120-9879
DOI	10.1007/s40292-021-00433-1
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