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  1. Article ; Online: Short Photoperiod-Dependent Enrichment of

    Kissmann, Ann-Kathrin / Rosenau, Frank / Herwig, Annika / Diedrich, Victoria

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: The Djungarian hamster ( ...

    Abstract The Djungarian hamster (
    MeSH term(s) Cricetinae ; Animals ; Humans ; Phodopus/physiology ; Photoperiod ; Gastrointestinal Microbiome ; Akkermansia ; Body Weight/physiology ; Seasons
    Language English
    Publishing date 2023-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically Important

    Rodríguez-Castaño, Gina P / Rosenau, Frank / Ständker, Ludger / Firacative, Carolina

    Pharmaceutics

    2023  Volume 15, Issue 3

    Abstract: Expanding the antifungal drug arsenal for ... ...

    Abstract Expanding the antifungal drug arsenal for treating
    Language English
    Publishing date 2023-02-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15030789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Heterologous Rhamnolipid Biosynthesis: Advantages, Challenges, and the Opportunity to Produce Tailor-Made Rhamnolipids.

    Wittgens, Andreas / Rosenau, Frank

    Frontiers in bioengineering and biotechnology

    2020  Volume 8, Page(s) 594010

    Abstract: The first heterologous expression of genes responsible for the production of rhamnolipids was already implemented in the mid-1990s during the functional identification of ... ...

    Abstract The first heterologous expression of genes responsible for the production of rhamnolipids was already implemented in the mid-1990s during the functional identification of the
    Language English
    Publishing date 2020-10-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2020.594010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Insights into the Adsorption Mechanisms of the Antimicrobial Peptide CIDEM-501 on Membrane Models.

    Alpízar-Pedraza, Daniel / Roque-Diaz, Yessica / Garay-Pérez, Hilda / Rosenau, Frank / Ständker, Ludger / Montero-Alejo, Vivian

    Antibiotics (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: CIDEM-501 is a hybrid antimicrobial peptide rationally designed based on the structure of panusin and panulirin template peptides. The new peptide exhibits significant antibacterial activity against multidrug-resistant pathogens (MIC = 2-4 μM) while ... ...

    Abstract CIDEM-501 is a hybrid antimicrobial peptide rationally designed based on the structure of panusin and panulirin template peptides. The new peptide exhibits significant antibacterial activity against multidrug-resistant pathogens (MIC = 2-4 μM) while conserving no toxicity in human cell lines. We conducted molecular dynamics (MD) simulations using the CHARMM-36 force field to explore the CIDEM-501 adsorption mechanism with different membrane compositions. Several parameters that characterize these interactions were analyzed to elucidate individual residues' structural and thermodynamic contributions. The membrane models were constructed using CHARMM-GUI, mimicking the bacterial and eukaryotic phospholipid compositions. Molecular dynamics simulations were conducted over 500 ns, showing rapid and highly stable peptide adsorption to bacterial lipids components rather than the zwitterionic eucaryotic model membrane. A predominant peptide orientation was observed in all models dominated by an electric dipole. The peptide remained parallel to the membrane surface with the center loop oriented to the lipids. Our findings shed light on the antibacterial activity of CIDEM-501 on bacterial membranes and yield insights valuable for designing potent antimicrobial peptides targeting multi- and extreme drug-resistant bacteria.
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13020167
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  5. Article ; Online: Pore-forming peptide C14R exhibits potent antifungal activity against clinical isolates of

    Vélez, Norida / Argel, Andreys / Kissmann, Ann-Kathrin / Alpízar-Pedraza, Daniel / Escandón, Patricia / Rosenau, Frank / Ständker, Ludger / Firacative, Carolina

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1389020

    Abstract: Introduction: Invasive candidiasis is a global public health problem as it poses a significant threat in hospital-settings. The aim of this study was to evaluate C14R, an analog derived from peptide BP100, as a potential antimicrobial peptide against ... ...

    Abstract Introduction: Invasive candidiasis is a global public health problem as it poses a significant threat in hospital-settings. The aim of this study was to evaluate C14R, an analog derived from peptide BP100, as a potential antimicrobial peptide against the prevalent opportunistic yeast
    Methods: Antifungal susceptibility testing of C14R against 99 C
    Results: C. albicans
    Discussion: C14R has a potent antifungal activity against a large set of clinical isolates of both
    MeSH term(s) Humans ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida albicans ; Fluconazole/pharmacology ; Fluconazole/therapeutic use ; Candida auris ; Candidiasis, Invasive ; Peptides/pharmacology ; Microbial Sensitivity Tests ; Drug Resistance, Fungal ; Candidiasis
    Chemical Substances Antifungal Agents ; Fluconazole (8VZV102JFY) ; Peptides
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1389020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: On the road towards tailor-made rhamnolipids: current state and perspectives.

    Wittgens, Andreas / Rosenau, Frank

    Applied microbiology and biotechnology

    2018  Volume 102, Issue 19, Page(s) 8175–8185

    Abstract: Rhamnolipids are biosurfactants with an enormous potential to replace or complement classic surfactants in industrial applications. They consist of one or two L-rhamnose residues linked to one or two 3-hydroxyfatty acids of various chain lengths, which ... ...

    Abstract Rhamnolipids are biosurfactants with an enormous potential to replace or complement classic surfactants in industrial applications. They consist of one or two L-rhamnose residues linked to one or two 3-hydroxyfatty acids of various chain lengths, which can also contain unsaturated carbon-carbon bonds, yielding a wide variety of different structures each with its specific physicochemical properties. Since different applications of surfactants require specific tenside characteristics related to surface tension reduction, emulsification, and foaming etc., rhamnolipids represent a platform molecule which harbors an enormous potential to adopt tailor-made properties to meet a huge variety of demands of surfactants for food-, healthcare-, and biotechnological applications. We are here giving an overview on current technology to synthesize tailor-made rhamnolipids based on the biotechnological use of different enzymes responsible for rhamnolipid biosynthesis originating from different naturally rhamnolipid-producing microorganism. Furthermore, we present future strategies to determine the number of L-rhamnose and 3-hydroxyfatty acids as well as their specific chain lengths and unsaturations to produce customized rhamnolipids perfectly tuned for every application.
    MeSH term(s) Animals ; Biotechnology/methods ; Fatty Acids/chemistry ; Glycolipids/chemistry ; Humans ; Rhamnose/chemistry ; Surface-Active Agents/chemistry
    Chemical Substances Fatty Acids ; Glycolipids ; Surface-Active Agents ; rhamnolipid ; Rhamnose (QN34XC755A)
    Language English
    Publishing date 2018-07-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-018-9240-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2229: Show issues Location:
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  7. Article: The Potential of Sequential Fermentations in Converting C1 Substrates to Higher-Value Products.

    Stark, Christina / Münßinger, Sini / Rosenau, Frank / Eikmanns, Bernhard J / Schwentner, Andreas

    Frontiers in microbiology

    2022  Volume 13, Page(s) 907577

    Abstract: Today production of (bulk) chemicals and fuels almost exclusively relies on petroleum-based sources, which are connected to greenhouse gas release, fueling climate change. This increases the urgence to develop alternative bio-based technologies and ... ...

    Abstract Today production of (bulk) chemicals and fuels almost exclusively relies on petroleum-based sources, which are connected to greenhouse gas release, fueling climate change. This increases the urgence to develop alternative bio-based technologies and processes. Gaseous and liquid C1 compounds are available at low cost and often occur as waste streams. Acetogenic bacteria can directly use C1 compounds like CO, CO
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.907577
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  8. Article: Enriched Aptamer Libraries in Fluorescence-Based Assays for

    Zhang, Yiting / Xing, Hu / Bolotnikov, Grigory / Krämer, Markus / Gotzmann, Nina / Knippschild, Uwe / Kissmann, Ann-Kathrin / Rosenau, Frank

    Microorganisms

    2023  Volume 11, Issue 9

    Abstract: Rikenella ... ...

    Abstract Rikenella microfusus
    Language English
    Publishing date 2023-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11092266
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  9. Article ; Online: Robust Protocol for the Synthesis of BSA Nanohydrogels by Inverse Nanoemulsion for Drug Delivery.

    Sihler, Susanne / Krämer, Markus / Schmitt, Felicitas / Favella, Patrizia / Mützel, Laura / Baatz, Jennifer / Rosenau, Frank / Ziener, Ulrich

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 23, Page(s) 8176–8185

    Abstract: In a highly efficient and reproducible process, bovine serum albumin (BSA) nanogels are prepared from inverse nanoemulsions. The concept of independent nanoreactors of the individual droplets in the nanoemulsions allows high protein concentrations of up ... ...

    Abstract In a highly efficient and reproducible process, bovine serum albumin (BSA) nanogels are prepared from inverse nanoemulsions. The concept of independent nanoreactors of the individual droplets in the nanoemulsions allows high protein concentrations of up to 0.6% in the inverse total system. The BSA gel networks are generated by the 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride coupling strategy widely used in protein chemistry. In a robust work-up protocol, the hydrophobic continuous phase of the inverse emulsion is stepwise replaced by water without compromising the colloidal stability and non-toxicity of the nanogel particles. Further, the simple process allows the loading of the nanogels with various cargos like a dye (Dy-495), a drug (ibuprofen), another protein [FMN-binding fluorescent protein (EcFbFP)], and oligonucleotides [plasmid DNA for enhanced GFP expression in mammalian cells (pEGFP c3) and a synthetic anti-
    MeSH term(s) Rats ; Animals ; Humans ; Nanogels ; Serum Albumin, Bovine/chemistry ; Drug Delivery Systems ; Ibuprofen ; Cell Line ; Drug Carriers/chemistry ; Mammals
    Chemical Substances Nanogels ; Serum Albumin, Bovine (27432CM55Q) ; Ibuprofen (WK2XYI10QM) ; Drug Carriers
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c00635
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  10. Article ; Online: IMPATIENT-qPCR: monitoring SELEX success during in vitro aptamer evolution.

    Kissmann, Ann-Kathrin / Bolotnikov, Grigory / Li, Runliu / Müller, Franziska / Xing, Hu / Krämer, Markus / Gottschalk, Kay-E / Andersson, Jakob / Weil, Tanja / Rosenau, Frank

    Applied microbiology and biotechnology

    2024  Volume 108, Issue 1, Page(s) 284

    Abstract: SELEX (Systematic Evolution of Ligands by Exponential enrichment) processes aim on the evolution of high-affinity aptamers as binding entities in diagnostics and biosensing. Aptamers can represent game-changers as constituents of diagnostic assays for ... ...

    Abstract SELEX (Systematic Evolution of Ligands by Exponential enrichment) processes aim on the evolution of high-affinity aptamers as binding entities in diagnostics and biosensing. Aptamers can represent game-changers as constituents of diagnostic assays for the management of instantly occurring infectious diseases or other health threats. Without in-process quality control measures SELEX suffers from low overall success rates. We present a quantitative PCR method for fast and easy quantification of aptamers bound to their targets. Simultaneous determination of melting temperatures (T
    MeSH term(s) Biological Assay ; Oligonucleotides ; Quality Control ; Temperature
    Chemical Substances Oligonucleotides
    Language English
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-024-13085-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2229: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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