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Article: Trends in Incidence Rates during 1999-2008 and Prevalence in 2008 of Childhood Type 1 Diabetes Mellitus in GERMANY – Model-Based National Estimates

Stahl-Pehe, Anna / Rosenbauer, Joachim

PLOS ONE, 10(7):e0132716

2015

Abstract: AIMS: To estimate the national incidence rate and trend of type 1 diabetes (T1DM) in Germany from 1999 to 2008 and the national prevalence in 2008 in the age group 0–14 years. METHODS: Data were taken from a nationwide registry for incident cases of T1DM ...

Institution	Deutsches Diabetes-Zentrum
Abstract	AIMS: To estimate the national incidence rate and trend of type 1 diabetes (T1DM) in Germany from 1999 to 2008 and the national prevalence in 2008 in the age group 0–14 years. METHODS: Data were taken from a nationwide registry for incident cases of T1DM in the ages 0–4 years and 3 regional registries (North-Rhine-Westphalia, Baden-Wuerttemberg and Saxony) for incident cases of T1DM in the ages 0–14 years covering 41% of the child population in Germany. The degree of ascertainment was ≥ 97% in all registries. Incident and prevalent cases were grouped by region, sex, age (0–4, 5–9, 10–14 years), and, for incident data, additionally by two 5-year periods (1999–2003, 2004–2008). Poisson regression models were fitted to the data to derive national estimates of incidence rate trends and prevalence in the age groups 5–9, 10–14 and 0–14 years. We used direct age-standardization. RESULTS: The estimated national incidence rate in 0-14-year-olds increased significantly by 18.1% (95%CI: 11.6–25.0%, p<0.001) from 1999–2003 to 2004–2008, independent of sex, corresponding to an average annual increase of 3.4% (95%-CI: 2.2–4.6%). The overall incidence rate was estimated at 22.9 per 100,000 person-years and we identified a within-country west-east-gradient previously unknown. The national prevalence in the ages 0–14 years on 31/12/2008 was estimated to be 148.1 per 100,000 persons. CONCLUSIONS: The national incidence rate of childhood T1DM in Germany is higher than in many other countries around the world. Importantly, the estimated trend of the incidence rate confirms the international data of a global increase of T1DM incidences.
Keywords	Age groups ; German people ; Germany ; Diabetes mellitus ; Europe ; Medicine and health sciences ; Surveys ; Pediatrics
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype

Rosenbauer, Joachim / Baechle, Christina / Roden, Michael

Genes, 8(5):146

2017

Abstract: INTRODUCTION: Major histocompatibility complex class II genes are considered major genetic risk factors for autoimmune diabetes. We analysed Human Leukocyte Antigen (HLA) DR and DQ haplotypes in a cohort with early-onset (age < 5 years), long term type 1 ...

Institution	Deutsches Diabetes-Zentrum
Abstract	INTRODUCTION: Major histocompatibility complex class II genes are considered major genetic risk factors for autoimmune diabetes. We analysed Human Leukocyte Antigen (HLA) DR and DQ haplotypes in a cohort with early-onset (age < 5 years), long term type 1 diabetes (T1D) and explored their influence on clinical and laboratory parameters. METHODS: Intermediate resolution HLA-DRB1, DQA1 and DQB1 typing was performed in 233 samples from the German Paediatric Diabetes Biobank and compared with a local control cohort of 19,544 cases. Clinical follow-up data of 195 patients (diabetes duration 14.2 ± 2.9 years) and residual C-peptide levels were compared between three HLA risk groups using multiple linear regression analysis. RESULTS: Genetic variability was low, 44.6% (104/233) of early-onset T1D patients carried the highest-risk genotype HLA-DRB103:01-DQA105:01-DQB102:01/DRB104-DQA103:01-DQB103:02 (HLA-DRB1*04 denoting 04:01/02/04/05), and 231 of 233 individuals carried at least one of six risk haplotypes. Comparing clinical data between the highest (n = 83), moderate (n = 106) and low risk (n = 6) genotypes, we found no difference in age at diagnosis (mean age 2.8 ± 1.1 vs. 2.8 ± 1.2 vs. 3.2 ± 1.5 years), metabolic control, or frequency of associated autoimmune diseases between HLA risk groups (each p > 0.05). Residual C-peptide was detectable in 23.5% and C-peptide levels in the highest-risk group were comparable to levels in moderate to high risk genotypes. CONCLUSION: In this study, we saw no evidence for a different clinical course of early-onset T1D based on the HLA genotype within the first ten years after manifestation.
Keywords	C-peptide ; MHC II ; autoimmunity ; diabetes mellitus ; human leukocyte antigen
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: Impact of Maternal Country of Birth on Type-1-Diabetes Therapy and Outcome in 27,643 Children and Adolescents from the DPV Registry

Baechle, Christina / Icks, Andrea / Rosenbauer, Joachim

PLOS ONE, 10(8):e0135178

2015

Abstract: OBJECTIVE: To study the impact of maternal country of birth on type-1-diabetes (T1D) therapy and outcome. STUDY DESIGN AND METHODS: 27,643 T1D patients aged ≤20 years with documented maternal country of birth from the multicenter German/Austrian diabetes ...

Institution	Deutsches Diabetes-Zentrum
Abstract	OBJECTIVE: To study the impact of maternal country of birth on type-1-diabetes (T1D) therapy and outcome. STUDY DESIGN AND METHODS: 27,643 T1D patients aged ≤20 years with documented maternal country of birth from the multicenter German/Austrian diabetes patient registry (DPV) were analyzed. Patients were categorized based on their mother’s origin: Germany/Austria (reference), Turkey, Southern Europe, and Eastern Europe. To compare BMI standard deviation score (BMI-SDS), diabetes therapy and outcome between groups, multivariable regression was applied with adjustments for age, sex and duration of diabetes. Based on observed marginal frequencies, adjusted estimates were calculated. Linear regression was used for continuous data, logistic regression for binary data and Poisson regression for count data. All statistical analyses were performed using SAS 9.4. Significance was set at a two-tailed p<0.05. RESULTS: 83.3% of patients were offspring of native mothers. A Turkish, Southern or Eastern European background was documented in 2.4%, 1.7% and 4.3% of individuals. After demographic adjustment, patients with migration background had a higher mean BMI-SDS (Turkey, Southern Europe or Eastern Europe vs. Germany/Austria: 0.58±0.03, 0.40±0.04, or 0.37±0.02 vs. 0.31±0.01; ±SE) and a lower use of insulin pumps (26.8%, 27.9%, or 32.6% vs. 37.9%) compared to offspring of native mothers. Mean HbA1c was worst in individuals of Turkish mothers (Turkey vs. Germany/Austria: 69.7±0.7 vs. 66.6±0.1 mmol/mol; ±SE). Patients of Eastern European descent had an increased rate of severe hypoglycemia (22.09±0.13 vs. 16.13±0.02 events per 100 patient-years) and ketoacidosis was more prevalent in offspring of Turkish or Southern European mothers (7.50±0.10, or 7.13±0.11 vs. 6.54±0.02 events per 100 patient-years). Patients of Turkish descent were more often hospitalized (57.2±2.7 vs. 48.5±0.4 per 100 patient-years). All differences were significant. CONCLUSION: The differences in diabetes therapy and outcome among patients with distinct migration background suggest that specific challenges have to be considered in clinical care.
Keywords	Germany ; Diabetes mellitus ; Dyslipidemia ; Europe ; HbA1c ; Hypoglycemia ; Insulin ; Turkey (country)
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: Symptoms of Eating Disorders and Depression in Emerging Adults with Early-Onset, Long-Duration Type 1 Diabetes and Their Association with Metabolic Control

Baechle, Christina / Stahl-Pehe, Anna / Rosenbauer, Joachim

PLOS ONE, 10(6):e0131027

2015

Abstract: BACKGROUND: This study analyzed the prevalence of and association between symptoms of eating disorders and depression in female and male emerging adults with early-onset, long-duration type 1 diabetes and investigated how these symptoms are associated ... ...

Institution	Deutsches Diabetes-Zentrum
Abstract	BACKGROUND: This study analyzed the prevalence of and association between symptoms of eating disorders and depression in female and male emerging adults with early-onset, long-duration type 1 diabetes and investigated how these symptoms are associated with metabolic control. METHODS: In a nationwide population-based survey, 211 type 1 diabetes patients aged 18-21 years completed standardized questionnaires, including the SCOFF questionnaire for eating disorder symptoms and the Patient Health Questionnaire (PHQ-9) for symptoms of depression and severity of depressive symptoms (PHQ-9 score). Multiple linear and logistic regression models were used to analyze the association between eating disorder and depressive symptoms and their associations with HbA1c. RESULTS: A total of 30.2% of the women and 9.5% of the men were screening positive for eating disorders. The mean PHQ-9 score (standard deviation) was 5.3 (4.4) among women and 3.9 (3.6) among men. Screening positive for an eating disorder was associated with more severe depressive symptoms among women (βwomen 3.8, p<0.001). However, neither eating disorder symptoms nor severity of depressive symptoms were associated with HbA1c among women, while HbA1c increased with the severity of depressive symptoms among men (βmen 0.14, p=0.006). CONCLUSIONS: Because of the high prevalence of eating disorder and depressive symptoms, their interrelationship, and their associations with metabolic control, particularly among men, regular mental health screening is recommended for young adults with type 1 diabetes.
Keywords	Adolescents ; Depression ; Diabetes mellitus ; Eating ; Eating disorders ; HbA1c ; Mental health and psychiatry ; Young adults
Language	English
Document type	Article
Database	Repository for Life Sciences

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Book ; Audio / Video ; Thesis: Prävalenz, Risikofaktoren und Früherkennung peripherer Venenerkrankungen mit Hilfe einer nichtinvasiven, rechnergesteuerten Methode (CLRR)

Rosenbauer, Joachim

Aachener Venenstudie

(Berichte aus der Medizin)

1999

Author's details	Joachim Rosenbauer
Series title	Berichte aus der Medizin
Keywords	Bein ; Venenkrankheit ; Frühdiagnostik ; Risikofaktor
Subject	Risikofaktoren ; Vene ; Venenkrankheiten ; Untere Extremität ; Beine ; Früherkennung ; Frühdiagnose
Language	German
Size	II, 270 S. : Ill., graph. Darst.
Edition	Als Ms. gedr.
Publisher	Shaker
Publishing place	Aachen
Document type	Book ; Audio / Video ; Thesis
Thesis / German Habilitation thesis	Aachen, Techn. Hochsch., Diss., 1998
HBZ-ID	HT009814996
ISBN	3-8265-4603-2 ; 978-3-8265-4603-7
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Elucidating the Underlying Mechanisms of the Marked Increase in Childhood Type 1 Diabetes During the COVID-19 Pandemic-The Diabetes Pandemic.

Kamrath, Clemens / Holl, Reinhard W / Rosenbauer, Joachim

JAMA network open

2023 Volume 6, Issue 6, Page(s) e2321231

MeSH term(s)	Humans ; Diabetes Mellitus, Type 1/epidemiology ; Pandemics ; COVID-19
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.21231
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Spatiotemporal association between COVID-19 incidence and type 1 diabetes incidence among children and adolescents: a register-based ecological study in Germany.

Rosenbauer, Joachim / Stahl-Pehe, Anna / Baechle, Christina / Lanzinger, Stefanie / Kamrath, Clemens / Kuß, Oliver / Holl, Reinhard W

Frontiers in endocrinology

2024 Volume 14, Page(s) 1287354

Abstract: Objective: Studies have shown an increased incidence of pediatric type 1 diabetes during the COVID-19 pandemic, but the detailed role of SARS-CoV-2 infection in the incidence increase in type 1 diabetes remains unclear. We investigated the ... ...

Abstract	Objective: Studies have shown an increased incidence of pediatric type 1 diabetes during the COVID-19 pandemic, but the detailed role of SARS-CoV-2 infection in the incidence increase in type 1 diabetes remains unclear. We investigated the spatiotemporal association of pediatric type 1 diabetes and COVID-19 incidence at the district level in Germany. Methods: For the period from March 2020 to June 2022, nationwide data on incident type 1 diabetes among children and adolescents aged <20 years and daily documented COVID-19 infections in the total population were obtained from the German Diabetes Prospective Follow-up Registry and the Robert Koch Institute, respectively. Data were aggregated at district level and seven time periods related to COVID-19 pandemic waves. Spatiotemporal associations between indirectly standardized incidence rates of type 1 diabetes and COVID-19 were analyzed by Spearman correlation and Bayesian spatiotemporal conditional autoregressive Poisson models. Results: Standardized incidence ratios of type 1 diabetes and COVID-19 in the pandemic period were not significantly correlated across districts and time periods. A doubling of the COVID-19 incidence rate was not associated with a significant increase in the incidence rate of type 1 diabetes (relative risk 1.006, 95% CI 0.987; 1.019). Conclusion: Our findings based on data from the pandemic period indirectly indicate that a causal relationship between SARS-COV-2 infection and type 1 diabetes among children and adolescents is unlikely.
MeSH term(s)	Humans ; Adolescent ; Child ; Diabetes Mellitus, Type 1/epidemiology ; Incidence ; Bayes Theorem ; Pandemics ; Prospective Studies ; COVID-19/epidemiology ; SARS-CoV-2 ; Germany/epidemiology ; Phenols ; Thiazoles
Chemical Substances	CI 987 ; Phenols ; Thiazoles
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1287354
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comments on Rahmati et al., The global impact of COVID-19 pandemic on the incidence of pediatric new-onset type 1 diabetes and ketoacidosis: A systematic review and meta-analysis. J Med Virol. 2022; 1-16 (doi: 10.1002/jmv.27996).

Rosenbauer, Joachim / Stahl-Pehe, Anna / Schlesinger, Sabrina / Kuß, Oliver

Journal of medical virology

2022 Volume 95, Issue 1, Page(s) e28272

MeSH term(s)	Humans ; Child ; COVID-19/epidemiology ; Diabetes Mellitus, Type 1/epidemiology ; Incidence ; Pandemics ; Ketosis
Language	English
Publishing date	2022-11-14
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28272
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Article: Referat – Glykämische Kontrolle verhindert Übersterblichkeit nicht völlig

Rosenbauer, Joachim

Diabetologie und Stoffwechsel

2015 Volume 10, Issue 02, Page(s) 71–72

Language	German
Publishing date	2015-04-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2222993-0
ISSN	1861-9010 ; 1861-9002
ISSN (online)	1861-9010
ISSN	1861-9002
DOI	10.1055/s-0034-1397710
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Article: Increased risk of impaired treatment satisfaction among girls/women and young people with suboptimal HbA1c: Results of a nationwide type 1 diabetes study.

Stahl-Pehe, Anna / Selinski, Silvia / Bächle, Christina / Rosenbauer, Joachim

Diabetology & metabolic syndrome

2021 Volume 13, Issue 1, Page(s) 55

Abstract: Background: This study aims to analyze the patient-reported outcome (PRO) of treatment satisfaction in a sample of children, adolescents and young adults with long-duration type 1 diabetes and to determine potential risk factors for poor treatment ... ...

Abstract	Background: This study aims to analyze the patient-reported outcome (PRO) of treatment satisfaction in a sample of children, adolescents and young adults with long-duration type 1 diabetes and to determine potential risk factors for poor treatment satisfaction and the intraindividual changes over a 3-year period. Methods: This study used data from two population-based questionnaire surveys conducted in 2015-2016 and 2018-2019. The participants were 11 to 27 years old and had a type 1 diabetes duration of 10 years or longer in 2015-2016 (n = 575). Factors that were potentially associated with poor treatment satisfaction (moderate, poor or very poor) compared to the reference group (very good or good treatment satisfaction) were analyzed by log binomial regression adjusted for sex and age group. Results: In 2015-2016 (2018-2019), 26% (33%) of the respondents rated their diabetes treatment/consultation as "very good", 53% (46%) as "good", and 20% (21%) as "poor". Based on the 2018-2019 data, girls/women had an increased risk of poor treatment satisfaction (RR Conclusions: Most study participants were satisfied with their diabetes treatment. However, we identified risk groups that would benefit from targeted interventions to improve this important PRO.
Language	English
Publishing date	2021-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-021-00673-0
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