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  1. Book ; Online ; E-Book: Pathological specimens and genomic medicine

    Tangrea, Michael A. / Rosenberg, Avi Z. / Emmert-Buck, Michael R.

    emerging issues

    2019  

    Author's details editors Michael A Tangrea, Avi Z Rosenberg, Michael R Emmert-Buck
    Keywords Pathology, Molecular / methods ; Genomics / methods
    Language English
    Size 1 Online-Ressource (ix, 370 Seiten), Illustrationen
    Publisher World Scientific
    Publishing place New Jersey
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020116647
    ISBN 9789813276239 ; 9789813276222 ; 9813276231 ; 9813276223
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Peeling and Plummeting.

    Connolly, Caoilfhionn M / Meeks, Monica / Rosenberg, Avi Z / Birkness-Gartman, Jacqueline E / Gelber, Allan C

    The New England journal of medicine

    2024  Volume 390, Issue 10, Page(s) 935–942

    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcps2306879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Krüppel-like Factor 5 Plays an Important Role in the Pathogenesis of Chronic Pancreatitis.

    Alavi, Maryam / Mejia-Bautista, Ana / Tang, Meiyi / Bandovic, Jela / Rosenberg, Avi Z / Bialkowska, Agnieszka B

    Cancers

    2023  Volume 15, Issue 22

    Abstract: Chronic pancreatitis results in the formation of pancreatic intraepithelial neoplasia (PanIN) and poses a risk of developing pancreatic cancer. Our previous study demonstrated that Krüppel-like factor 5 (KLF5) is necessary for forming acinar-to-ductal ... ...

    Abstract Chronic pancreatitis results in the formation of pancreatic intraepithelial neoplasia (PanIN) and poses a risk of developing pancreatic cancer. Our previous study demonstrated that Krüppel-like factor 5 (KLF5) is necessary for forming acinar-to-ductal metaplasia (ADM) in acute pancreatitis. Here, we investigated the role of KLF5 in response to chronic injury in the pancreas. Human tissues originating from chronic pancreatitis patients showed increased levels of epithelial KLF5. An inducible genetic model combining the deletion of
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15225427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Biomarkers of Chronic Renal Tubulointerstitial Injury.

    Bagnasco, Serena M / Rosenberg, Avi Z

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2019  Volume 67, Issue 9, Page(s) 633–641

    Abstract: Progression of renal parenchyma injury is characterized by increasing interstitial fibrosis and tubular atrophy, irrespective of the cause. Histopathologic assessment of renal tissue obtained by biopsy remains the gold standard for determining the ... ...

    Abstract Progression of renal parenchyma injury is characterized by increasing interstitial fibrosis and tubular atrophy, irrespective of the cause. Histopathologic assessment of renal tissue obtained by biopsy remains the gold standard for determining the presence and extent of tubulointerstitial scarring. Discovery of robust non-invasive means for capturing a snapshot and for longitudinal monitoring of parenchymal deterioration has been the focus of intense multimodal effort by investigators within the renal community and beyond. Research in this field has included the use of in vitro and in vivo experimental models and has fostered the development and evaluation of tissue and biofluid assays for novel analytes with potential translation to the diagnosis and prognosis of kidney disease. Here, we examine recent advances in the search of "biomarkers" for detection of renal tubulointerstitial scarring and prediction of renal outcome in human renal disease.
    MeSH term(s) Animals ; Biomarkers/analysis ; Biomarkers/blood ; Biomarkers/urine ; Biopsy ; Disease Progression ; Exosomes/pathology ; Extracellular Matrix/pathology ; Fibrosis ; Humans ; Kidney Tubules/pathology ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/urine
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/0022155419861092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.321: Show issues Location:
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  5. Article ; Online: Podocytopathy in Obesity: Challenges of Living Large.

    Giannini, Gabriel / Kopp, Jeffrey B / Rosenberg, Avi Z

    Seminars in nephrology

    2021  Volume 41, Issue 4, Page(s) 307–317

    Abstract: Renal injury resulting from obesity is a growing concern caused by the global obesity epidemic. We discuss the glomerular structure, obesity-related glomerular changes, and diagnostic pathologic criteria for obesity-related glomerulopathy. The three main ...

    Abstract Renal injury resulting from obesity is a growing concern caused by the global obesity epidemic. We discuss the glomerular structure, obesity-related glomerular changes, and diagnostic pathologic criteria for obesity-related glomerulopathy. The three main hypothesized mechanisms of podocyte injury are mechanical stress on the podocytes, metabolic derangement, and genetic/molecular factors. Weight loss, renin-angiotensin-aldosterone system inhibitors, and improved insulin resistance may slow the progression. A more comprehensive understanding of obesity-related glomerulopathy will help in developing more effective therapies.
    MeSH term(s) Humans ; Insulin Resistance ; Kidney Diseases ; Kidney Glomerulus ; Obesity/complications ; Podocytes
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2021.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Introduction: Obesity and the kidney.

    Kopp, Jeffrey B / Rosenberg, Avi Z / Levi, Moshe

    Seminars in nephrology

    2021  Volume 41, Issue 4, Page(s) 295

    MeSH term(s) Body Mass Index ; Humans ; Kidney ; Obesity/complications
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2021.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Artificial intelligence driven next-generation renal histomorphometry.

    Santo, Briana A / Rosenberg, Avi Z / Sarder, Pinaki

    Current opinion in nephrology and hypertension

    2021  Volume 29, Issue 3, Page(s) 265–272

    Abstract: Purpose of review: Successful integration of artificial intelligence into extant clinical workflows is contingent upon a number of factors including clinician comprehension and interpretation of computer vision. This article discusses how image analysis ...

    Abstract Purpose of review: Successful integration of artificial intelligence into extant clinical workflows is contingent upon a number of factors including clinician comprehension and interpretation of computer vision. This article discusses how image analysis and machine learning have enabled comprehensive characterization of kidney morphology for development of automated diagnostic and prognostic renal pathology applications.
    Recent findings: The primordial digital pathology informatics work employed classical image analysis and machine learning to prognosticate renal disease. Although this classical approach demonstrated tremendous potential, subsequent advancements in hardware technology rendered artificial neural networks '(ANNs) the method of choice for machine vision in computational pathology'. Offering rapid and reproducible detection, characterization and classification of kidney morphology, ANNs have facilitated the development of diagnostic and prognostic applications. In addition, modern machine learning with ANNs has revealed novel biomarkers in kidney disease, demonstrating the potential for machine vision to elucidate novel pathologic mechanisms beyond extant clinical knowledge.
    Summary: Despite the revolutionary developments potentiated by modern machine learning, several challenges remain, including data quality control and curation, image annotation and ontology, integration of multimodal data and interpretation of machine vision or 'opening the black box'. Resolution of these challenges will not only revolutionize diagnostic pathology but also pave the way for precision medicine and integration of artificial intelligence in the process of care.
    MeSH term(s) Artificial Intelligence ; Humans ; Image Processing, Computer-Assisted/methods ; Kidney/pathology ; Machine Learning ; Neural Networks, Computer ; Prognosis
    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  8. Article ; Online: The Role of Exposomes in the Pathophysiology of Autoimmune Diseases II: Pathogens.

    Vojdani, Aristo / Vojdani, Elroy / Rosenberg, Avi Z / Shoenfeld, Yehuda

    Pathophysiology : the official journal of the International Society for Pathophysiology

    2022  Volume 29, Issue 2, Page(s) 243–280

    Abstract: In our continuing examination of the role of exposomes in autoimmune disease, we use this review to focus on pathogens. Infections are major contributors to the pathophysiology of autoimmune diseases through various mechanisms, foremost being molecular ... ...

    Abstract In our continuing examination of the role of exposomes in autoimmune disease, we use this review to focus on pathogens. Infections are major contributors to the pathophysiology of autoimmune diseases through various mechanisms, foremost being molecular mimicry, when the structural similarity between the pathogen and a human tissue antigen leads to autoimmune reactivity and even autoimmune disease. The three best examples of this are oral pathogens, SARS-CoV-2, and the herpesviruses. Oral pathogens reach the gut, disturb the microbiota, increase gut permeability, cause local inflammation, and generate autoantigens, leading to systemic inflammation, multiple autoimmune reactivities, and systemic autoimmunity. The COVID-19 pandemic put the spotlight on SARS-CoV-2, which has been called "the autoimmune virus." We explore in detail the evidence supporting this. We also describe how viruses, in particular herpesviruses, have a role in the induction of many different autoimmune diseases, detailing the various mechanisms involved. Lastly, we discuss the microbiome and the beneficial microbiota that populate it. We look at the role of the gut microbiome in autoimmune disorders, because of its role in regulating the immune system. Dysbiosis of the microbiota in the gut microbiome can lead to multiple autoimmune disorders. We conclude that understanding the precise roles and relationships shared by all these factors that comprise the exposome and identifying early events and root causes of these disorders can help us to develop more targeted therapeutic protocols for the management of this worldwide epidemic of autoimmunity.
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1212740-1
    ISSN 1873-149X ; 0928-4680
    ISSN (online) 1873-149X
    ISSN 0928-4680
    DOI 10.3390/pathophysiology29020020
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    Zs.A 4137: Show issues Location:
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  9. Article ; Online: The evolving story of apolipoprotein L1 nephropathy: the end of the beginning.

    Daneshpajouhnejad, Parnaz / Kopp, Jeffrey B / Winkler, Cheryl A / Rosenberg, Avi Z

    Nature reviews. Nephrology

    2022  Volume 18, Issue 5, Page(s) 307–320

    Abstract: Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were identified in 2010 and are relatively common among individuals of sub-Saharan African ancestry. Approximately 13% of African Americans carry two APOL1 risk alleles. These ... ...

    Abstract Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were identified in 2010 and are relatively common among individuals of sub-Saharan African ancestry. Approximately 13% of African Americans carry two APOL1 risk alleles. These variants, termed G1 and G2, are a frequent cause of kidney disease - termed APOL1 nephropathy - that typically manifests as focal segmental glomerulosclerosis and the clinical syndrome of hypertension and arterionephrosclerosis. Cell culture studies suggest that APOL1 variants cause cell dysfunction through several processes, including alterations in cation channel activity, inflammasome activation, increased endoplasmic reticulum stress, activation of protein kinase R, mitochondrial dysfunction and disruption of APOL1 ubiquitinylation. Risk of APOL1 nephropathy is mostly confined to individuals with two APOL1 risk variants. However, only a minority of individuals with two APOL1 risk alleles develop kidney disease, suggesting the need for a 'second hit'. The best recognized factor responsible for this 'second hit' is a chronic viral infection, particularly HIV-1, resulting in interferon-mediated activation of the APOL1 promoter, although most individuals with APOL1 nephropathy do not have an obvious cofactor. Current therapies for APOL1 nephropathies are not adequate to halt progression of chronic kidney disease, and new targeted molecular therapies are in clinical trials.
    MeSH term(s) African Americans/genetics ; Apolipoprotein L1/genetics ; Apolipoprotein L1/metabolism ; Apolipoproteins/genetics ; Female ; Genetic Predisposition to Disease ; Glomerulosclerosis, Focal Segmental/genetics ; Humans ; Male ; Renal Insufficiency, Chronic/genetics ; Risk Factors
    Chemical Substances APOL1 protein, human ; Apolipoprotein L1 ; Apolipoproteins
    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00538-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 107: Show issues

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  10. Article ; Online: Hydroxychloroquine-induced mimic of renal Fabry disease.

    Sperati, C John / Rosenberg, Avi Z

    Kidney international

    2018  Volume 94, Issue 3, Page(s) 634

    MeSH term(s) Adult ; Antirheumatic Agents/adverse effects ; Biopsy ; Diagnosis, Differential ; Fabry Disease/diagnosis ; Female ; Humans ; Hydroxychloroquine/adverse effects ; Kidney/diagnostic imaging ; Kidney/drug effects ; Kidney/pathology ; Kidney/ultrastructure ; Kidney Diseases/chemically induced ; Kidney Diseases/diagnosis ; Kidney Diseases/pathology ; Lupus Erythematosus, Systemic/drug therapy ; Microscopy, Electron
    Chemical Substances Antirheumatic Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2018-08-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2018.02.003
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