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  1. Book ; Online ; E-Book: The Dynamics of Cultural Evolution

    Rosenberg, Michael

    The Central Role of Purposive Behaviors

    (Studies in Human Ecology and Adaptation ; 12)

    2022  

    Abstract: This book explores the nature of cultural and culturally structured social and behavioral entities, their evolutionary interactions, and the central role purposive behaviors play in those interactions. It, first, makes the case for cultural and cultural ... ...

    Author's details by Michael Rosenberg
    Series title Studies in Human Ecology and Adaptation ; 12
    Abstract This book explores the nature of cultural and culturally structured social and behavioral entities, their evolutionary interactions, and the central role purposive behaviors play in those interactions. It, first, makes the case for cultural and cultural structured systems being considered as true entities bounded in time and space, and not ephemera in a constant state of becoming another system. Second, it examines how these entities interact to produce evolutionary culture change. It then argues that the intent of purposive behaviors is reliably knowable in the aggregate, at least when dealing with expressions of behavioral tendencies in the animal kingdom, humans included. Finally, the book references well documented behavioral tendencies for examples of proximate causation in the evolution of settled village societies and, following that, socially complex societies. Through these efforts, the book synthesizes the various approaches to the evolution of culture and provides a complete and comprehensive picture of the process. It provides a corrective to the tendency to view cultural systems as entirely open ended and as capable of changing in any direction; and also to treating cultural evolution as solely a result of selective forces, that is, in terms of only ultimate causation. This book provides an engaging and critical counterview to established theories of cultural evolution and is of interest to scholars and students of different disciplines, from anthropology and archeology, to evolutionary biology and epigenetics.
    Keywords Human evolution ; Anthropology ; Archaeology ; Social evolution ; Evolution (Biology) ; Paleontology ; Evolutionary Anthropology ; Cultural Evolution ; Social Evolution ; Evolutionary Biology
    Subject code 303.4
    Language English
    Size 1 online resource (207 pages)
    Edition 1st ed. 2022.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9783031048630 ; 9783031048623 ; 3031048636 ; 3031048628
    DOI 10.1007/978-3-031-04863-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: MetaWin 3: open-source software for meta-analysis.

    Rosenberg, Michael S

    Frontiers in bioinformatics

    2024  Volume 4, Page(s) 1305969

    Abstract: The rise of research synthesis and systematic reviews over the last 25 years has been aided by a series of software packages providing simple and accessible GUI interfaces which are intuitively easy to use by novice analysts and users. Development of ... ...

    Abstract The rise of research synthesis and systematic reviews over the last 25 years has been aided by a series of software packages providing simple and accessible GUI interfaces which are intuitively easy to use by novice analysts and users. Development of many of these packages has been abandoned over time due to a variety of factors, leaving a gap in the software infrastructure available for meta-analysis. To fulfill the continued demand for a GUI-based meta-analytic system, we have now released MetaWin 3 as free, open-source, multi-platform software. MetaWin3 is written in Python and developed from scratch relative to earlier versions. The codebase is available on Github, with pre-compiled executables for both Windows and macOS available from the MetaWin website. MetaWin includes standardized effect size calculations, exploratory and publication bias analyses, and allows for both simple and complex explanatory models of variation within a meta-analytic framework, including meta-regression, using traditional least-squares/moments estimation.
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-7647
    ISSN (online) 2673-7647
    DOI 10.3389/fbinf.2024.1305969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Refixation Induced Pendular Vertical Oscillations and Pupillary Oculomotor Synkinesis: 2 Signs of Pontine Hemorrhage.

    Rosenberg, Michael L

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2023  

    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Deep Learning and Biased Prediction: More Questions Than Answers?

    Rosenberg, Michael A

    Circulation. Heart failure

    2023  Volume 17, Issue 1, Page(s) e011368

    MeSH term(s) Humans ; Deep Learning ; Heart Failure ; Machine Learning
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.123.011368
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  5. Article ; Online: Trusting Magic: Interpretability of Predictions From Machine Learning Algorithms.

    Rosenberg, Michael A

    Circulation

    2021  Volume 143, Issue 13, Page(s) 1299–1301

    MeSH term(s) Algorithms ; Humans ; Long QT Syndrome ; Machine Learning ; Torsades de Pointes
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.053733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: The agile approach to adaptive research

    Rosenberg, Michael J.

    optimizing eficiency in clinical development

    (Wiley series on technologies for the pharmaceutical industry)

    2010  

    Author's details Michael J. Rosenberg
    Series title Wiley series on technologies for the pharmaceutical industry
    Keywords Drug Discovery / organization & administration ; Drug Discovery / methods ; Efficiency, Organizational
    Language English
    Size XIX, 274 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT016366455
    ISBN 978-0-470-24751-8 ; 0-470-24751-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 2598 order for loan Magazin

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  7. Article ; Online: Quantifying changes in individual-specific template-based representations of center-of-mass dynamics during walking with ankle exoskeletons using Hybrid-SINDy.

    Rosenberg, Michael C / Proctor, Joshua L / Steele, Katherine M

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1031

    Abstract: Ankle exoskeletons alter whole-body walking mechanics, energetics, and stability by altering center-of-mass (CoM) motion. Controlling the dynamics governing CoM motion is, therefore, critical for maintaining efficient and stable gait. However, how CoM ... ...

    Abstract Ankle exoskeletons alter whole-body walking mechanics, energetics, and stability by altering center-of-mass (CoM) motion. Controlling the dynamics governing CoM motion is, therefore, critical for maintaining efficient and stable gait. However, how CoM dynamics change with ankle exoskeletons is unknown, and how to optimally model individual-specific CoM dynamics, especially in individuals with neurological injuries, remains a challenge. Here, we evaluated individual-specific changes in CoM dynamics in unimpaired adults and one individual with post-stroke hemiparesis while walking in shoes-only and with zero-stiffness and high-stiffness passive ankle exoskeletons. To identify optimal sets of physically interpretable mechanisms describing CoM dynamics, termed template signatures, we leveraged hybrid sparse identification of nonlinear dynamics (Hybrid-SINDy), an equation-free data-driven method for inferring sparse hybrid dynamics from a library of candidate functional forms. In unimpaired adults, Hybrid-SINDy automatically identified spring-loaded inverted pendulum-like template signatures, which did not change with exoskeletons (p > 0.16), except for small changes in leg resting length (p < 0.001). Conversely, post-stroke paretic-leg rotary stiffness mechanisms increased by 37-50% with zero-stiffness exoskeletons. While unimpaired CoM dynamics appear robust to passive ankle exoskeletons, how neurological injuries alter exoskeleton impacts on CoM dynamics merits further investigation. Our findings support Hybrid-SINDy's potential to discover mechanisms describing individual-specific CoM dynamics with assistive devices.
    MeSH term(s) Adult ; Humans ; Ankle ; Exoskeleton Device ; Nonlinear Dynamics ; Ankle Joint ; Gene Library ; Stroke
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50999-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reader response: Mystery Case: Bilateral temporal crescent sparing after cardiac arrest.

    Rosenberg, Michael

    Neurology

    2019  Volume 92, Issue 18, Page(s) 870

    MeSH term(s) Heart Arrest ; Humans
    Language English
    Publishing date 2019-04-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000007414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficient DNA-based data storage using shortmer combinatorial encoding.

    Preuss, Inbal / Rosenberg, Michael / Yakhini, Zohar / Anavy, Leon

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7731

    Abstract: Data storage in DNA has recently emerged as a promising archival solution, offering space-efficient and long-lasting digital storage solutions. Recent studies suggest leveraging the inherent redundancy of synthesis and sequencing technologies by using ... ...

    Abstract Data storage in DNA has recently emerged as a promising archival solution, offering space-efficient and long-lasting digital storage solutions. Recent studies suggest leveraging the inherent redundancy of synthesis and sequencing technologies by using composite DNA alphabets. A major challenge of this approach involves the noisy inference process, obstructing large composite alphabets. This paper introduces a novel approach for DNA-based data storage, offering, in some implementations, a 6.5-fold increase in logical density over standard DNA-based storage systems, with near-zero reconstruction error. Combinatorial DNA encoding uses a set of clearly distinguishable DNA shortmers to construct large combinatorial alphabets, where each letter consists of a subset of shortmers. We formally define various combinatorial encoding schemes and investigate their theoretical properties. These include information density and reconstruction probabilities, as well as required synthesis and sequencing multiplicities. We then propose an end-to-end design for a combinatorial DNA-based data storage system, including encoding schemes, two-dimensional (2D) error correction codes, and reconstruction algorithms, under different error regimes. We performed simulations and show, for example, that the use of 2D Reed-Solomon error correction has significantly improved reconstruction rates. We validated our approach by constructing two combinatorial sequences using Gibson assembly, imitating a 4-cycle combinatorial synthesis process. We confirmed the successful reconstruction, and established the robustness of our approach for different error types. Subsampling experiments supported the important role of sampling rate and its effect on the overall performance. Our work demonstrates the potential of combinatorial shortmer encoding for DNA-based data storage and describes some theoretical research questions and technical challenges. Combining combinatorial principles with error-correcting strategies, and investing in the development of DNA synthesis technologies that efficiently support combinatorial synthesis, can pave the way to efficient, error-resilient DNA-based storage solutions.
    MeSH term(s) Sequence Analysis, DNA/methods ; DNA/genetics ; DNA Replication ; Algorithms ; Information Storage and Retrieval
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58386-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Involuntary "Voluntary" Nystagmus.

    Rosenberg, Michael L

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2020  Volume 41, Issue 4, Page(s) e688–e691

    Abstract: Background: Voluntary nystagmus is a common phenomenon in the general population and is believed to be under voluntary control. Some patients have an eye movement disorder indistinguishable from voluntary nystagmus and yet have no control over these ... ...

    Abstract Background: Voluntary nystagmus is a common phenomenon in the general population and is believed to be under voluntary control. Some patients have an eye movement disorder indistinguishable from voluntary nystagmus and yet have no control over these movements.
    Methods: Four patients with involuntary eye movements consisting of spontaneous or induced bursts of saccadic eye movements with no intersaccadic interval are described. All eye movements were typical of "voluntary nystagmus," yet they denied any control over the movements. In none of the patients was there any evidence of psychopathology or secondary gain.
    Results: Two types of patients with involuntary eye movements that were indistinguishable from voluntary nystagmus are presented. One group of 2 patients had clear neurological disease, whereas another 2 had no evidence of any neurological pathology.
    Conclusions: The patterns seen in these patients suggest that there is a spectrum of oculomotor saccadic instabilities that includes voluntary nystagmus on one extreme and ocular flutter on the other. In between these 2 are both normal and abnormal patients with eye movements indistinguishable from ocular flutter/voluntary nystagmus that may or may not be induced by convergence. It is suggested that involuntary "voluntary nystagmus" is a real condition and that psychopathology should be ruled in rather than simply assumed.
    MeSH term(s) Eye Movements ; Humans ; Nystagmus, Pathologic/diagnosis ; Ocular Motility Disorders/diagnosis ; Saccades
    Language English
    Publishing date 2020-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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