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  1. AU="Rosenbloom, E Scott"
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Artikel ; Online: Diagnosis of mast cell activation syndrome: a global "consensus-2".

Afrin, Lawrence B / Ackerley, Mary B / Bluestein, Linda S / Brewer, Joseph H / Brook, Jill B / Buchanan, Ariana D / Cuni, Jill R / Davey, William P / Dempsey, Tania T / Dorff, Shanda R / Dubravec, Martin S / Guggenheim, Alena G / Hindman, Kimberly J / Hoffman, Bruce / Kaufman, David L / Kratzer, Stephanie J / Lee, Theodore M / Marantz, Mindy S / Maxwell, Andrew J /
McCann, Kelly K / McKee, Dwight L / Menk Otto, Laurie / Pace, Laura A / Perkins, Dahra D / Radovsky, Laurie / Raleigh, Mary S / Rapaport, Sonia A / Reinhold, Emma J / Renneker, Mark L / Robinson, William A / Roland, Aaron M / Rosenbloom, E Scott / Rowe, Peter C / Ruhoy, Ilene S / Saperstein, David S / Schlosser, David A / Schofield, Jill R / Settle, Janet E / Weinstock, Leonard B / Wengenroth, Martina / Westaway, Mark / Xi, Shijun Cindy / Molderings, Gerhard J

Diagnosis (Berlin, Germany)

2020  Band 8, Heft 2, Seite(n) 137–152

Abstract: The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast ... ...

Abstract The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast cell activation syndrome" (MCAS) grown significantly. Two principal proposals for diagnostic criteria have emerged. One, originally published in 2012, is labeled by its authors as a "consensus" (re-termed here as "consensus-1"). Another sizable contingent of investigators and practitioners favor a different approach (originally published in 2011, newly termed here as "consensus-2"), resembling "consensus-1" in some respects but differing in others, leading to substantial differences between these proposals in the numbers of patients qualifying for diagnosis (and thus treatment). Overdiagnosis by "consensus-2" criteria has potential to be problematic, but underdiagnosis by "consensus-1" criteria seems the far larger problem given (1) increasing appreciation that MCAS is prevalent (up to 17% of the general population), and (2) most MCAS patients, regardless of illness duration prior to diagnosis, can eventually identify treatment yielding sustained improvement. We analyze these proposals (and others) and suggest that, until careful research provides more definitive answers, diagnosis by either proposal is valid, reasonable, and helpful.
Mesh-Begriff(e) Consensus ; Humans ; Mast Cells ; Mastocytosis/diagnosis
Sprache Englisch
Erscheinungsdatum 2020-04-22
Erscheinungsland Germany
Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
ISSN 2194-802X
ISSN (online) 2194-802X
DOI 10.1515/dx-2020-0005
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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