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  1. AU="Rosenblum, Shira T"
  2. AU=Kavousi Javid
  3. AU="Mukram, Mohd Azeemuddin"
  4. AU="Farzana Yasmin"
  5. AU=Epel Elissa S
  6. AU="Voet, W"
  7. AU="Jay Patel"
  8. AU="Iacob, Nicusor"
  9. AU="Guo, Dengyang"
  10. AU="Galacho-Harriero, Ana María"
  11. AU="Awoyelu, E H"
  12. AU="Tinajero, Jose"
  13. AU=Vashishtha Vipin M AU=Vashishtha Vipin M
  14. AU="D'Agostino, Nicole"
  15. AU="Lunetta, Kathryn L"
  16. AU="Tirschmann, Felix"
  17. AU="Adetuyi, B.O."

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  1. Artikel ; Online: Bilateral renal descensus and intravesicular ureteroneocystostomy for treatment of bilateral ureteral ligation and transection that occurred during ovariohysterectomy in two cats.

    Rosenblum, Shira T / Aronson, Lillian R

    Journal of the American Veterinary Medical Association

    2021  Band 260, Heft 1, Seite(n) 100–109

    Abstract: Case description: 6-month-old and 7-month-old spayed female domestic shorthair cats were referred because of complications associated with inadvertent bilateral ureteral ligation and transection during ovariohysterectomy.: Clinical findings: Both ... ...

    Abstract Case description: 6-month-old and 7-month-old spayed female domestic shorthair cats were referred because of complications associated with inadvertent bilateral ureteral ligation and transection during ovariohysterectomy.
    Clinical findings: Both cats had a 1- to 2-day history of lethargy, inappetence, and vomiting. Initial exam findings included lethargy, signs of abdominal pain, anuria, and dehydration. Clinicopathologic testing revealed azotemia and hyperkalemia. Abdominal ultrasonography revealed peritoneal effusion and bilateral pyelectasia in both cats and retroperitoneal effusion in one. Fluid analysis in both cats supported a diagnosis of uroabdomen.
    Treatment and outcome: Exploratory celiotomy was performed in both cats, and bilateral ureteral ligation and transection was confirmed. Bilateral renal descensus and ureteroneocystostomy with an intravesicular mucosal apposition technique was successfully performed in both cats. Clinicopathologic evaluation performed 1 day after surgery in one cat and 5 days after surgery in the other revealed complete resolution of azotemia. Ultrasonographic examination of the urogenital tract performed approximately 4 months after surgery in the first cat and 1 month after surgery in the second cat revealed complete resolution of renal pelvic dilation bilaterally.
    Clinical relevance: Bilateral intravesicular ureteroneocystostomy in conjunction with bilateral renal descensus was used successfully to treat bilateral ureteral transection that occurred in 2 cats during routine ovariohysterectomy. Limited treatment options currently exist for this serious complication, and euthanasia is often considered. This technique, which relies on the use of the natural surrounding tissues for successful treatment, can offer a potential treatment option to correct this uncommon but devastating complication.
    Mesh-Begriff(e) Animals ; Cat Diseases/surgery ; Cats ; Female ; Hysterectomy/veterinary ; Kidney ; Ureter/surgery ; Ureteral Obstruction/surgery ; Ureteral Obstruction/veterinary
    Sprache Englisch
    Erscheinungsdatum 2021-11-12
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.20.10.0596
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Use of a colorimeter is a viable method to measure melanin and erythema content in the context of laser beam attenuation by use of a class IV laser in different tissues in dogs.

    Rosenblum, Shira T / McCarthy, Daniel A / Millis, Darryl L / Odoi, Agricola

    Journal of the American Veterinary Medical Association

    2023  Band 261, Heft 7, Seite(n) 1–8

    Abstract: Objective: Patient factors may alter laser photon attenuation, but these factors have not been adequately evaluated in live dogs. Our objective was to evaluate class IV laser beam attenuation (LBA) by canine tissues using a colorimeter to evaluate ... ...

    Abstract Objective: Patient factors may alter laser photon attenuation, but these factors have not been adequately evaluated in live dogs. Our objective was to evaluate class IV laser beam attenuation (LBA) by canine tissues using a colorimeter to evaluate melanin and erythema indices. We hypothesized that greater melanin and erythema indices and unclipped hair would increase LBA, and these properties would vary among tissues.
    Animals: 20 client-owned dogs.
    Procedures: Between October 1 and December 1, 2017, colorimeter measurements and LBA in various tissues before and after clipping overlying hair were evaluated. Data were analyzed using generalized linear mixed models. Statistical significance was set at P < .05.
    Results: LBA was greater in unclipped (98.6 ± 0.4%) than clipped hair (94.6 ± 0.4%). The least LBA occurred in the pinna (93%) while the greatest occurred in the caudal vertebra (100%) and caudal semitendinosis muscles (100%). Each mm of tissue thickness resulted in LBA of 11.6%. Each unit increase in melanin index resulted in a 3.3% increase in LBA. There was no association of LBA with erythema index.
    Clinical relevance: To our knowledge, this is the first study that evaluated LBA by different tissues in live dogs using a colorimeter to evaluate melanin and erythema indices. We recommend clipping hair prior to photobiomodulation to decrease laser beam attenuation and using increased laser doses in thicker tissues and dogs with high melanin content. The colorimeter may be helpful in customizing patient treatment dosimetry. Future studies are necessary to determine therapeutic laser doses for adequate photobiomodulation effects.
    Mesh-Begriff(e) Dogs ; Animals ; Melanins ; Erythema/veterinary ; Lasers ; Dog Diseases/radiotherapy ; Dog Diseases/surgery
    Chemische Substanzen Melanins
    Sprache Englisch
    Erscheinungsdatum 2023-03-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.22.11.0493
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 423: Hefte anzeigen Standort:
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  3. Artikel ; Online: Suite of clinically relevant functional assays to address therapeutic efficacy and disease mechanism in the dystrophic

    Song, Yafeng / Rosenblum, Shira T / Morales, Leon / Petrov, Mihail / Greer, Christopher / Globerman, Samantha / Stedman, Hansell H

    Journal of applied physiology (Bethesda, Md. : 1985)

    2016  Band 122, Heft 3, Seite(n) 593–602

    Abstract: Duchenne muscular dystrophy (DMD) is a progressive primary myodegenerative disease caused by a genetic deficiency of the 427-kDa cytoskeletal protein dystrophin. Despite its single-gene etiology, DMD's complex pathogenesis remains poorly understood, ... ...

    Abstract Duchenne muscular dystrophy (DMD) is a progressive primary myodegenerative disease caused by a genetic deficiency of the 427-kDa cytoskeletal protein dystrophin. Despite its single-gene etiology, DMD's complex pathogenesis remains poorly understood, complicating the extrapolation from results of preclinical studies in genetic homologs to the design of informative clinical trials. Here we describe novel phenotypic assays which when applied to the
    Mesh-Begriff(e) Animals ; Endpoint Determination/methods ; Exercise Test/methods ; Mice ; Mice, Inbred mdx ; Muscular Dystrophies/diagnosis ; Muscular Dystrophies/physiopathology ; Muscular Dystrophies/therapy ; Outcome Assessment, Health Care/methods ; Reproducibility of Results ; Respiratory Function Tests/methods ; Sensitivity and Specificity ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2016-12-08
    Erscheinungsland United States
    Dokumenttyp Evaluation Study ; Journal Article
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00776.2016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models.

    Song, Yafeng / Morales, Leon / Malik, Alock S / Mead, Andrew F / Greer, Christopher D / Mitchell, Marilyn A / Petrov, Mihail T / Su, Leonard T / Choi, Margaret E / Rosenblum, Shira T / Lu, Xiangping / VanBelzen, Daniel J / Krishnankutty, Ranjith K / Balzer, Frederick J / Loro, Emanuele / French, Robert / Propert, Kathleen J / Zhou, Shangzhen / Kozyak, Benjamin W /
    Nghiem, Peter P / Khurana, Tejvir S / Kornegay, Joe N / Stedman, Hansell H

    Nature medicine

    2019  Band 25, Heft 10, Seite(n) 1505–1511

    Abstract: The essential product of the Duchenne muscular dystrophy (DMD) gene is ... ...

    Abstract The essential product of the Duchenne muscular dystrophy (DMD) gene is dystrophin
    Mesh-Begriff(e) Animals ; Dependovirus/genetics ; Disease Models, Animal ; Dogs ; Dystrophin/genetics ; Genetic Therapy ; Humans ; Mice ; Mice, Inbred mdx ; Muscle Contraction/genetics ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Dystrophies/genetics ; Muscular Dystrophies/pathology ; Muscular Dystrophies/therapy ; Muscular Dystrophy, Animal/genetics ; Muscular Dystrophy, Animal/pathology ; Muscular Dystrophy, Animal/therapy ; Muscular Dystrophy, Duchenne/genetics ; Muscular Dystrophy, Duchenne/pathology ; Muscular Dystrophy, Duchenne/therapy ; Transgenes/genetics ; Utrophin/genetics ; Utrophin/therapeutic use
    Chemische Substanzen Dystrophin ; Utrophin
    Sprache Englisch
    Erscheinungsdatum 2019-10-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-019-0594-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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