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  1. Book ; Thesis: Etablierung eines Großtiermodells zur frühen zielgerichteten hämodynamischen Therapie in der Postreanimationsphase

    Rosenthal, Peter

    2016  

    Author's details vorgelegt von Peter Rosenthal
    Language German
    Size 81 Seiten, Diagramme, 21 cm
    Publishing place Kiel
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Christian-Albrechts-Universität zu Kiel, 2016
    HBZ-ID HT019317829
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 D 451 order for loan Magazin

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  2. Article ; Online: Advances in Pediatric Liver Diseases.

    Rosenthal, Philip

    Clinics in liver disease

    2022  Volume 26, Issue 3, Page(s) xiii

    MeSH term(s) Child ; Humans ; Liver Diseases/therapy
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2022.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnosis and management of Alagille and progressive familial intrahepatic cholestasis.

    Cheng, Katherine / Rosenthal, Philip

    Hepatology communications

    2023  Volume 7, Issue 12

    Abstract: Alagille syndrome and progressive familial intrahepatic cholestasis are conditions that can affect multiple organs. Advancements in molecular testing have aided in the diagnosis of both. The impairment of normal bile flow and secretion leads to the ... ...

    Abstract Alagille syndrome and progressive familial intrahepatic cholestasis are conditions that can affect multiple organs. Advancements in molecular testing have aided in the diagnosis of both. The impairment of normal bile flow and secretion leads to the various hepatic manifestations of these diseases. Medical management of Alagille syndrome and progressive familial intrahepatic cholestasis remains mostly targeted on supportive care focusing on quality of life, cholestasis, and fat-soluble vitamin deficiency. The most difficult therapeutic issue is typically related to pruritus, which can be managed by various medications such as ursodeoxycholic acid, rifampin, cholestyramine, and antihistamines. Surgical operations were previously used to disrupt enterohepatic recirculation, but recent medical advancements in the use of ileal bile acid transport inhibitors have shown great efficacy for the treatment of pruritus in both Alagille syndrome and progressive familial intrahepatic cholestasis.
    MeSH term(s) Humans ; Alagille Syndrome/diagnosis ; Alagille Syndrome/genetics ; Alagille Syndrome/therapy ; Quality of Life ; Cholestasis ; Pruritus/diagnosis ; Pruritus/surgery
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1097/HC9.0000000000000314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Advances in Pediatric Hepatology.

    Rosenthal, Philip

    Clinics in liver disease

    2018  Volume 22, Issue 4, Page(s) xi

    Language English
    Publishing date 2018-08-22
    Publishing country United States
    Document type Editorial
    ZDB-ID 1472315-3
    ISSN 1557-8224 ; 1089-3261
    ISSN (online) 1557-8224
    ISSN 1089-3261
    DOI 10.1016/j.cld.2018.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Dry Eye Disease and the Oculofacial Pain Syndrome.

    Rosenthal, Perry

    International ophthalmology clinics

    2017  Volume 57, Issue 2, Page(s) 41–45

    MeSH term(s) Dry Eye Syndromes/complications ; Eye Pain/etiology ; Facial Pain/etiology ; Humans
    Language English
    Publishing date 2017-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207382-1
    ISSN 1536-9617 ; 0020-8167
    ISSN (online) 1536-9617
    ISSN 0020-8167
    DOI 10.1097/IIO.0000000000000165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Particle-Wise Higher-Order SPH Field Approximation for DVR

    Fischer, Jonathan / Schulze, Martin / Rosenthal, Paul / Linsen, Lars

    2024  

    Abstract: When employing Direct Volume Rendering (DVR) for visualizing volumetric scalar fields, classification is generally performed on a piecewise constant or piecewise linear approximation of the field on a viewing ray. Smoothed Particle Hydrodynamics (SPH) ... ...

    Abstract When employing Direct Volume Rendering (DVR) for visualizing volumetric scalar fields, classification is generally performed on a piecewise constant or piecewise linear approximation of the field on a viewing ray. Smoothed Particle Hydrodynamics (SPH) data sets define volumetric scalar fields as the sum of individual particle contributions, at highly varying spatial resolution. We present an approach for approximating SPH scalar fields along viewing rays with piece-wise polynomial functions of higher order. This is done by approximating each particle contribution individually and then efficiently summing the results, thus generating a higher-order representation of the field with a resolution adapting to the data resolution in the volume.
    Keywords Computer Science - Graphics
    Publishing date 2024-01-05
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Editorial: an expert consensus for the management of chronic hepatitis B in Asian Americans.

    Ebel, N H / Rosenthal, P

    Alimentary pharmacology & therapeutics

    2018  Volume 47, Issue 11, Page(s) 1541–1542

    MeSH term(s) Asian Americans ; Carcinoma, Hepatocellular ; Consensus ; Hepatitis B virus ; Hepatitis B, Chronic ; Humans ; Liver Neoplasms
    Language English
    Publishing date 2018-06-07
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.14620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Real-world experience of maralixibat in Alagille syndrome: Novel findings outside of clinical trials.

    Himes, Ryan / Rosenthal, Philip / Dilwali, Natasha / Smith, Kathryn / Venick, Robert / Gonzalez-Peralta, Regino P

    Journal of pediatric gastroenterology and nutrition

    2024  Volume 78, Issue 3, Page(s) 506–513

    Abstract: Objective: Maralixibat, an ileal bile acid transporter inhibitor, is the first drug approved by the U.S. Food and Drug Administration for the treatment of cholestatic pruritus in patients aged ≥3 months with Alagille syndrome (ALGS). Approval was based ... ...

    Abstract Objective: Maralixibat, an ileal bile acid transporter inhibitor, is the first drug approved by the U.S. Food and Drug Administration for the treatment of cholestatic pruritus in patients aged ≥3 months with Alagille syndrome (ALGS). Approval was based on reductions in pruritus from the pivotal ICONIC trial, information from two additional trials (ITCH and IMAGO), and long-term extension studies. Although participants in these trials met strict inclusion and exclusion criteria, patients have received maralixibat under broader circumstances as part of an expanded access program or commercially. The expanded access and postapproval settings inform a real-world understanding of effectiveness and safety. The objective was to report on the use of maralixibat in the real-world setting in eight patients who otherwise would not have met entrance criteria for the clinical trials, providing unique insights into its effectiveness in the management of ALGS.
    Methods: We reviewed records of patients with ALGS who received maralixibat but would have been excluded from trials due to surgical biliary diversion, reduction of antipruritic/cholestatic concomitant medications, administration of medication through a gastrostomy or nasogastric tube, or use in patients under consideration for transplantation.
    Results: Maralixibat appeared to be effective with reductions in pruritus compared to baseline. Consistent with clinical trials, maralixibat was well tolerated without appreciable gastrointestinal complications. Liver enzyme elevations were observed but were interpreted as consistent with normal fluctuations observed in ALGS, with no increases in bilirubin.
    Conclusion: Maralixibat may be effective and well tolerated in patients with ALGS in broader clinical contexts than previously reported.
    MeSH term(s) Humans ; Alagille Syndrome/complications ; Alagille Syndrome/drug therapy ; Alagille Syndrome/surgery ; Benzothiepins ; Cholestasis/drug therapy ; Cholestasis/complications ; Longitudinal Studies ; Pruritus/drug therapy ; Pruritus/etiology ; Clinical Trials as Topic ; Infant
    Chemical Substances Benzothiepins ; maralixibat
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1002/jpn3.12101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1728: Show issues Location:
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  9. Article ; Online: Food insecurity is a risk factor for metabolic dysfunction-associated steatotic liver disease in Latinx children.

    Maxwell, Sarah L / Price, Jennifer C / Perito, Emily R / Rosenthal, Philip / Wojcicki, Janet M

    Pediatric obesity

    2024  Volume 19, Issue 6, Page(s) e13109

    Abstract: Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease among US children. Studies have associated food insecurity with MASLD in adults, but there are few studies of pediatric MASLD, ... ...

    Abstract Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease among US children. Studies have associated food insecurity with MASLD in adults, but there are few studies of pediatric MASLD, particularly in high-risk populations. We assessed the impact of household food insecurity at 4 years of age on MASLD in Latinx children.
    Methods: Using a prospective cohort design, Latina mothers were recruited during pregnancy and followed with their children until early to mid-childhood. Our primary exposure was household food insecurity at 4 years of age measured using the validated US Household Food Security Food Module. Our primary outcome, MASLD, was defined as alanine transaminase (ALT) ≥95th% for age/gender plus body mass index (BMI) ≥85% at time of ALT measurement (assessed between ages 5-12). We used multivariable logistic regression models to test for independent associations between household food insecurity and pediatric MASLD.
    Results: Among 136 children, 28.7% reported household food insecurity at 4 years of age and 27.2% had MASLD in early to middle childhood. Approximately 49% of children with MASLD and 21% of children without MASLD were food insecure (p < 0.01). Exposure to household food insecurity at age 4 was independently associated with a 3.7-fold higher odds of MASLD later in childhood (95% CI: 1.5-9.0, p < 0.01).
    Conclusions: Exposure to household food insecurity at 4 years of age was associated with increased risk for MASLD later in childhood. Further studies are needed to explore mechanism(s) and impact of reducing food insecurity on risk for MASLD.
    MeSH term(s) Humans ; Hispanic or Latino/statistics & numerical data ; Female ; Food Insecurity ; Child, Preschool ; Male ; Risk Factors ; Prospective Studies ; Child ; Body Mass Index ; Non-alcoholic Fatty Liver Disease/epidemiology ; Alanine Transaminase/blood
    Chemical Substances Alanine Transaminase (EC 2.6.1.2)
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2655527-X
    ISSN 2047-6310 ; 2047-6302
    ISSN (online) 2047-6310
    ISSN 2047-6302
    DOI 10.1111/ijpo.13109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6619: Show issues Location:
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  10. Article ; Online: Editorial commentary: the conundrum of Lamivudine and tenofovir disoproxil fumarate for hepatitis B: fetus versus infant.

    Rosenthal, Philip

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2015  Volume 60, Issue 2, Page(s) 279–280

    MeSH term(s) Adenine/analogs & derivatives ; Anti-HIV Agents/therapeutic use ; Breast Feeding ; Disease Transmission, Infectious/prevention & control ; Female ; Hepatitis B/drug therapy ; Hepatitis B/prevention & control ; Humans ; Lamivudine/therapeutic use ; Organophosphonates/therapeutic use ; Pregnancy
    Chemical Substances Anti-HIV Agents ; Organophosphonates ; Lamivudine (2T8Q726O95) ; Adenine (JAC85A2161)
    Language English
    Publishing date 2015-01-15
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciu801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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