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Book: Win win ecology

Rosenzweig, Michael L.

how the earth's species can survive in the midst of human enterprise

2003

Title variant	Win-win ecology
Author's details	Michael L. Rosenzweig
Keywords	Nature conservation/Economic aspects ; Biological diversity conservation/Economic aspects ; Human ecology ; Humanökologie ; Biodiversität ; Naturschutz ; Umweltökonomie
Subject	Green ecology ; Umweltökonomik ; Umweltschutz ; Ökologische Ökonomie ; Biologische Vielfalt ; Vielfalt ; Mensch
Subject code	333.9516
Language	English
Size	211 S. : Ill., graph. Darst.
Publisher	Oxford Univ. Press
Publishing place	Oxford u.a.
Publishing country	United States
Document type	Book
Note	Includes bibliographical references
HBZ-ID	HT013692444
ISBN	0-19-515604-8 ; 978-0-19-515604-1
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Article ; Online: Amyloidosis with Cardiac Involvement: Identification, Characterization, and Management.

Jamal, Faizi / Rosenzweig, Michael

Current hematologic malignancy reports

2021 Volume 16, Issue 4, Page(s) 357–366

Abstract: Purpose of review: Amyloidosis is a protein deposition disease whereby a variety of precursor proteins form insoluble fibrils that deposit in tissues, causing organ dysfunction and, many times, death. Accurate characterization of the disease based on ... ...

Abstract	Purpose of review: Amyloidosis is a protein deposition disease whereby a variety of precursor proteins form insoluble fibrils that deposit in tissues, causing organ dysfunction and, many times, death. Accurate characterization of the disease based on the nature of the precursor protein, organ involvement, and extent of disease is paramount to guide management. Cardiac amyloidosis is critical to understand because of its impact on prognosis and new treatment options available. Recent findings: New imaging methods have proven to be considerably valuable in the identification of cardiac amyloid infiltration. For treating clinicians, a diagnostic algorithm for patients with suspected amyloidosis with or without cardiomyopathy is shown to help classify disease and to direct appropriate genetic testing and management. For patients with light chain disease, recently introduced treatments adopted from multiple myeloma therapies have significantly extended progression-free and overall survival as well as organ response. In addition, new medical interventions are now available for those with transthyretin amyloidosis. Although cardiac amyloidosis contributes significantly to the morbidity and mortality associated with systemic disease, new tools are available to assist with diagnosis, prognosis, and management.
MeSH term(s)	Amyloidosis/complications ; Amyloidosis/pathology ; Cardiomyopathies/etiology ; Cardiomyopathies/pathology ; Humans
Language	English
Publishing date	2021-06-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2229765-0
ISSN	1558-822X ; 1558-8211
ISSN (online)	1558-822X
ISSN	1558-8211
DOI	10.1007/s11899-021-00626-4
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Article ; Online: Liver and Gastrointestinal Involvement.

Rosenzweig, Michael / Comenzo, Raymond L

Hematology/oncology clinics of North America

2020 Volume 34, Issue 6, Page(s) 1081–1090

Abstract: Early diagnosis of AL amyloidosis and appreciation of the nutritional and coagulation abnormalities associated with liver and gastrointestinal involvement are critically important in the treatment and management. In cases of severe malabsorption total ... ...

Abstract	Early diagnosis of AL amyloidosis and appreciation of the nutritional and coagulation abnormalities associated with liver and gastrointestinal involvement are critically important in the treatment and management. In cases of severe malabsorption total parenteral nutrition can be extremely helpful as a bridge to organ improvement. Rarely the use of antifibrinolytic agents such as oral aminocaproic acid with transfusion support may control severe bleeding in patients with coagulation abnormalities. It is important to keep in mind that organ improvement should follow in lag phase after the reduction in the pathologic free light chain with treatment. Closely following light chain levels may permit brief holidays from treatment and enable periods of recovery before resuming therapy in patients with prompt early and deep hematologic responses.
MeSH term(s)	Adult ; Female ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/metabolism ; Gastrointestinal Diseases/therapy ; Humans ; Immunoglobulin Light Chains/metabolism ; Immunoglobulin Light-chain Amyloidosis/complications ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Immunoglobulin Light-chain Amyloidosis/metabolism ; Immunoglobulin Light-chain Amyloidosis/therapy ; Liver Diseases/diagnosis ; Liver Diseases/etiology ; Liver Diseases/metabolism ; Liver Diseases/therapy ; Male ; Middle Aged
Chemical Substances	Immunoglobulin Light Chains
Language	English
Publishing date	2020-10-01
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	93115-9
ISSN	1558-1977 ; 0889-8588
ISSN (online)	1558-1977
ISSN	0889-8588
DOI	10.1016/j.hoc.2020.09.001
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Article ; Online: Liver and Gastrointestinal Involvement: Update.

Rosenzweig, Michael / Kastritis, Efstathios

Hematology/oncology clinics of North America

2020 Volume 34, Issue 6S, Page(s) e1–e13

Abstract: The organs affected most commonly by AL amyloidosis are the kidneys and heart, however, liver and gastrointestinal (GI) tract are also commonly affected. Symptoms of GI amyloidosis often mimic those of other GI disorders; having a keen awareness of the ... ...

Abstract	The organs affected most commonly by AL amyloidosis are the kidneys and heart, however, liver and gastrointestinal (GI) tract are also commonly affected. Symptoms of GI amyloidosis often mimic those of other GI disorders; having a keen awareness of the need to evaluate for amyloidosis is critical in avoiding delay in diagnosis and intervention. GI and liver involvement is associated with significant complications, and challenges in symptomatic management. As with all AL-related organ disease, early systemic treatment can prevent progression of tissue damage and improve outcomes.
MeSH term(s)	Animals ; Diagnostic Imaging ; Disease Management ; Disease Susceptibility ; Gastrointestinal Tract/diagnostic imaging ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/pathology ; Humans ; Immunoglobulin Light-chain Amyloidosis/epidemiology ; Immunoglobulin Light-chain Amyloidosis/etiology ; Immunoglobulin Light-chain Amyloidosis/pathology ; Immunoglobulin Light-chain Amyloidosis/therapy ; Incidence ; Liver/diagnostic imaging ; Liver/metabolism ; Liver/pathology ; Organ Specificity ; Prognosis ; Symptom Assessment
Language	English
Publishing date	2020-12-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	93115-9
ISSN	1558-1977 ; 0889-8588
ISSN (online)	1558-1977
ISSN	0889-8588
DOI	10.1016/j.hoc.2020.11.001
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Article: Green roofs: new ecosystems to defend species diversity

Rosenzweig, Michael L

Israel journal of ecology & evolution. 2016 Aug. 29, v. 62, no. 1-2

2016

Abstract: Many contributions to the symposium seek to expand the role of green roofs in the conservation of biodiversity. Indeed, if green roofs can be harnessed for biodiversity, they will add area to that now available to nature. That would have the mass effect ... ...

Abstract	Many contributions to the symposium seek to expand the role of green roofs in the conservation of biodiversity. Indeed, if green roofs can be harnessed for biodiversity, they will add area to that now available to nature. That would have the mass effect of increasing the sustainable number of species in simple conformity with the species--area relationship. Because all green roofs are novel ecosystems, all represent instances of reconciliation ecology, i.e., re-engineering human uses to permit simultaneous beneficial use by people and nature. Green roofs can provide a large number of experiments that might teach us how to improve their design. But those experiments, like any in science, must be overtly designed so that their hypotheses are clear and explicit, their methods repeatable, and their data appropriate for rigorous analysis. I present an embryonic example using native plant species growing at ground level in the urban environments of Tucson, AZ, USA. Steps include: (1) formulating a hypothesis; (2) developing a database of species' attributes to allow intelligent selection for hypothesis testing; (3) developing software to allow winnowing the list of species to sets with a good chance, according to the hypothesis, of growing together; (4) installing the sets of plants and measuring the results; (5) defining a continuous measure of conformity with the hypothesis; and (6) comparing results to hypothesis. If ecologists can successfully design reconciled ecosystems in urban settings â green roofs included â city people will be able to re-establish their everyday connection to nature.
Keywords	computer software ; databases ; ecologists ; ecosystems ; green roofs ; humans ; indigenous species ; plants (botany) ; species diversity ; urban areas ; Arizona
Language	English
Dates of publication	2016-0829
Size	p. 7-14.
Publishing place	Taylor & Francis
Document type	Article
ISSN	2224-4662
DOI	10.1080/15659801.2015.1121600
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Phase 1 Study of Bortezomib, Fludarabine, and Melphalan, With or Without Total Marrow Irradiation, as Allogeneic Hematopoietic Stem Cell Transplant Conditioning for High-risk or Relapsed/Refractory Multiple Myeloma.

Ladbury, Colton / Sanchez, James / Chowdhury, Arnab / Palmer, Joycelynne / Liu, An / Stein, Anthony / Htut, Myo / Farol, Leonardo / Cai, Ji-Lian / Somlo, George / Rosenzweig, Michael / Wong, Jeffrey C / Sahebi, Firoozeh

American journal of clinical oncology

2024

Abstract: Objectives: We conducted a phase 1 study of a conditioning regimen with or without total marrow irradiation (TMI) before allogeneic hematopoietic stem cell transplantation for patients with high-risk or refractory multiple myeloma.: Methods: Eighteen ...

Abstract	Objectives: We conducted a phase 1 study of a conditioning regimen with or without total marrow irradiation (TMI) before allogeneic hematopoietic stem cell transplantation for patients with high-risk or refractory multiple myeloma. Methods: Eighteen patients were enrolled on one of 2 strata. Patients with no prior radiation received TMI (900 cGy), fludarabine (FLU), and melphalan (MEL) conditioning, with bortezomib added in the second cohort (stratum I). Patients with prior radiation received FLU, MEL, and bortezomib, without TMI (stratum II). Results: Eight patients were enrolled in the TMI arm (stratum I). One of 3 patients in cohort 1 experienced dose-limiting toxicity (DLT), which led to the expansion to 3 more patients with no DLT. Cohort 2 enrolled only 2 patients due to low accrual, with bortezomib, added at 0.5 mg/m2; neither experienced DLT. Nine patients were enrolled in the non-TMI arm (stratum II). Three patients were enrolled in cohort 1 (bortezomib 0.5 mg/m2) and none experienced DLT. Three were enrolled in cohort 2 (bortezomib 0.7 mg/m2), and 1 experienced DLT; therefore, the cohort expanded to 3 more patients. One more patient experienced DLT. Median overall survival on strata I and II was 44.5 months (95% CI: 1.73-not reached) and 21.6 months (95% CI: 4.1-72.7), respectively. Median progression-free survival on strata I and II was 18.1 months (95% CI: 1.73-not reached) and 8.9 months (95% CI: 2.7-24.4), respectively. Conclusions: TMI 900 cGy, FLU, and MEL are considered feasible as conditioning for allogeneic stem cell transplantation and may warrant further investigation due to favorable response rates and survival.
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	604536-4
ISSN	1537-453X ; 0277-3732
ISSN (online)	1537-453X
ISSN	0277-3732
DOI	10.1097/COC.0000000000001095
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Article: Treatment of Multiple Myeloma: Finding the Right Combination.

Rosenzweig, Michael A / Krishnan, Amrita

Oncology (Williston Park, N.Y.)

2016 Volume 30, Issue 5, Page(s) 466–467

MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Multiple Myeloma/drug therapy
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	1067950-9
ISSN	0890-9091
ISSN	0890-9091
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Article: Too much of a good thing? A landscape-of-fear analysis for collared peccaries (Pecaritajacu) reveals hikers act as a greater deterrent than thorny or bitter food

Bleicher, Sonny S / Rosenzweig, Michael L

Canadian journal of zoology. 2018, v. 96, no. 4

2018

Abstract: To study how wildlife perceive recreating humans, we studied the habitat selection of a human commensalist, the collared peccary (Pecari tajacu (Linnaeus, 1758)). We measured peccary activity patterns in an area of high human activity (Tumamoc Hill ... ...

Abstract	To study how wildlife perceive recreating humans, we studied the habitat selection of a human commensalist, the collared peccary (Pecari tajacu (Linnaeus, 1758)). We measured peccary activity patterns in an area of high human activity (Tumamoc Hill Desert Laboratory in Tucson, Arizona, USA) using a landscape-of-fear analysis. We examined whether the perception of risk from human activity interacted with the chemical (tannin) and mechanical (thorns) antipredator mechanisms of local plant species. The peccaries avoided food stations near a hiking trail. The population foraged less near houses, i.e., moderate human activity, than in the perceived safety of a small wadi. Plant defence treatments impacted the harvesting of food only in the safe zone, suggesting that risk trumps food selectivity. The strong effect of the hiking trail on habitat selection in this disturbance-loving species is an indicator of a much larger impact on sensitive species in conservation areas.
Keywords	anthropogenic activities ; antipredatory behavior ; avoidance behavior ; conservation areas ; foraging ; habitat preferences ; harvesting ; hiking ; humans ; man-made trails ; Pecari tajacu ; plant spines ; risk ; tannins ; wildlife ; Arizona
Language	English
Size	p. 317-324.
Publishing place	NRC Research Press
Document type	Article
ZDB-ID	241716-9
ISSN	1480-3283 ; 0008-4301
ISSN (online)	1480-3283
ISSN	0008-4301
DOI	10.1139/cjz-2017-0158
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Light chain (AL) amyloidosis

Rosenzweig Michael / Landau Heather

Journal of Hematology & Oncology, Vol 4, Iss 1, p

update on diagnosis and management

2011 Volume 47

Abstract: Abstract Light chain (AL) amyloidosis is a plasma cell dyscrasia characterized by the pathologic production of fibrillar proteins comprised of monoclonal light chains which deposit in tissues and cause organ dysfunction. The diagnosis can be challenging, ...

Abstract	Abstract Light chain (AL) amyloidosis is a plasma cell dyscrasia characterized by the pathologic production of fibrillar proteins comprised of monoclonal light chains which deposit in tissues and cause organ dysfunction. The diagnosis can be challenging, requiring a biopsy and often specialized testing to confirm the subtype of systemic disease. The goal of treatment is eradication of the monoclonal plasma cell population and suppression of the pathologic light chains which can result in organ improvement and extend patient survival. Standard treatment approaches include high dose melphalan (HDM) followed by autologous hematopoietic stem cell transplantation (SCT) or oral melphalan with dexamethasone (MDex). The use of novel agents (thalidomide, lenalidomide and bortezomib) alone and in combination with steroids and alkylating agents has shown efficacy and continues to be explored. A risk adapted approach to SCT followed by novel agents as consolidation reduces treatment related mortality with promising outcomes. Immunotherapeutic approaches targeting pathologic plasma cells and amyloid precursor proteins or fibrils are being developed. Referral of patients to specialized centers focusing on AL amyloidosis and conducting clinical trials is essential to improving patient outcomes.
Keywords	Diseases of the blood and blood-forming organs ; RC633-647.5 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; DOAJ:Oncology
Subject code	610
Language	English
Publishing date	2011-11-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Leflunomide Confers Rapid Recovery from COVID-19 and is Coupled with Temporal Immunologic Changes.

Dona, Ada Alice / Sanchez, James F / Palmer, Joycelynne M / Synold, Timothy W / Chiuppesi, Flavia / Thomas, Sandra / Caserta, Enrico / Singer, Mahmoud / Tandoh, Theophilus / Chowdhury, Arnab / Krishnan, Amrita / Rosenzweig, Michael / Diamond, Don J / Rosen, Steven / Pichiorri, Flavia / Dadwal, Sanjeet

Journal of immunological sciences

2023 Volume 7, Issue 1, Page(s) 9–27

Abstract: Background: Vaccines for SARS-CoV-2 have been considerably effective in reducing rates of infection and severe COVID-19. However, many patients, especially those who are immunocompromised due to cancer or other factors, as well as individuals who are ... ...

Abstract	Background: Vaccines for SARS-CoV-2 have been considerably effective in reducing rates of infection and severe COVID-19. However, many patients, especially those who are immunocompromised due to cancer or other factors, as well as individuals who are unable to receive vaccines or are in resource-poor countries, will continue to be at risk for COVID-19. We describe clinical, therapeutic, and immunologic correlatives in two patients with cancer and severe COVID-19 who were treated with leflunomide after failing to respond to standard-of-care comprising remdesivir and dexamethasone. Both patients had breast cancer and were on therapy for the malignancy. Methods: The protocol is designed with the primary objective to assess the safety and tolerability of leflunomide in treating severe COVID-19 in patients with cancer. Leflunomide dosing consisted of a loading dose of 100 mg daily for the first three days, followed by daily dosing, at the assigned dose level (Dose Level 1: 40 mg, Dose Level -1, 20 mg; Dose Level 2, 60 mg), for an additional 11 days. At defined intervals, serial monitoring of blood samples for toxicity, pharmacokinetics, and immunologic correlative studies were performed, as well as nasopharyngeal swabs for PCR analysis of SARS-CoV-2. Results: Preclinically, leflunomide impaired viral RNA replication, and clinically, it led to a rapid improvement in the two patients discussed herein. Both patients completely recovered, with minimal toxicities; all adverse events experienced were considered unrelated to leflunomide. Single-cell mass-cytometry analysis showed that leflunomide increased levels of CD8+ cytotoxic and terminal effector T cells and decreased naïve and memory B cells. Conclusions: With ongoing COVID-19 transmission and occurrence of breakthrough infections in vaccinated individuals, including patients with cancer, therapeutic agents that target both the virus and host inflammatory response would be helpful despite the availability of currently approved anti-viral agents. Furthermore, from an access to care perspective, especially in resource-limited areas, an inexpensive, readily available, effective drug with existing safety data in humans is relevant in the real-world setting.
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article
DOI	10.29245/2578-3009/2023/1.1241
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