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Article ; Online: Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.

Yamashita, Akihiro / Ignatenko, Olesia / Nguyen, Mai / Lambert, Raphaëlle / Watt, Kathleen / Daneault, Caroline / Robillard-Frayne, Isabelle / Topisirovic, Ivan / Rosiers, Christine Des / McBride, Heidi M

Biology direct

2023 Volume 18, Issue 1, Page(s) 60

Abstract: Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated into cellular signaling pathways are not yet ... ...

Abstract	Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated into cellular signaling pathways are not yet understood. Herein, we report the cellular responses to peroxisomal proteotoxic stress upon silencing the peroxisomal protease/chaperone LONP2. Depletion of LONP2 triggered the accumulation of its substrate TYSND1 protease, while the overall expression of peroxisomal proteins, as well as TYSND1-dependent ACOX1 processing appeared normal, reflecting early stages of peroxisomal proteotoxic stress. Consequently, the alteration of peroxisome size and numbers, and luminal protein import failure was coupled with induction of cell-specific cellular stress responses. Specific to COS-7 cells was a strong activation of the integrated stress response (ISR) and upregulation of ribosomal biogenesis gene expression levels. Common changes between COS-7 and U2OS cell lines included repression of the retinoic acid signaling pathway and upregulation of sphingolipids. Cholesterol accumulated in the endomembrane compartments in both cell lines, consistent with evidence that peroxisomes are required for cholesterol flux out of late endosomes. These unexpected consequences of peroxisomal stress provide an important insight into our understanding of the tissue-specific responses seen in peroxisomal disorders.
MeSH term(s)	Signal Transduction ; Endosomes ; Ribosomes ; Peptide Hydrolases ; Up-Regulation
Chemical Substances	Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2221028-3
ISSN	1745-6150 ; 1745-6150
ISSN (online)	1745-6150
ISSN	1745-6150
DOI	10.1186/s13062-023-00416-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results.

Baron, Cantin / Cherkaoui, Sarah / Therrien-Laperriere, Sandra / Ilboudo, Yann / Poujol, Raphaël / Mehanna, Pamela / Garrett, Melanie E / Telen, Marilyn J / Ashley-Koch, Allison E / Bartolucci, Pablo / Rioux, John D / Lettre, Guillaume / Rosiers, Christine Des / Ruiz, Matthieu / Hussin, Julie G

iScience

2023 Volume 26, Issue 12, Page(s) 108473

Abstract: Metabolite genome-wide association studies (mGWAS) have advanced our understanding of the genetic control of metabolite levels. However, interpreting these associations remains challenging due to a lack of tools to annotate gene-metabolite pairs beyond ... ...

Abstract	Metabolite genome-wide association studies (mGWAS) have advanced our understanding of the genetic control of metabolite levels. However, interpreting these associations remains challenging due to a lack of tools to annotate gene-metabolite pairs beyond the use of conservative statistical significance threshold. Here, we introduce the shortest reactional distance (SRD) metric, drawing from the comprehensive KEGG database, to enhance the biological interpretation of mGWAS results. We applied this approach to three independent mGWAS, including a case study on sickle cell disease patients. Our analysis reveals an enrichment of small SRD values in reported mGWAS pairs, with SRD values significantly correlating with mGWAS p values, even beyond the standard conservative thresholds. We demonstrate the utility of SRD annotation in identifying potential false negatives and inaccuracies within current metabolic pathway databases. Our findings highlight the SRD metric as an objective, quantitative and easy-to-compute annotation for gene-metabolite pairs, suitable to integrate statistical evidence to biological networks.
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.108473
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Article: The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults

Lamantia, Valérie / Bissonnette, Simon / Provost, Viviane / Devaux, Marie / Cyr, Yannick / Daneault, Caroline / Rosiers, Christine Des / Faraj, May

Journal of nutrition. 2019 Jan. 01, v. 149, no. 1

2019

Abstract: δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear ... ...

Abstract	δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n–3 PUFA intake, promote T2D risk factors. The aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB. This is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m2): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m2, 66% fat) and white adipose tissue (WAT) function (storage of 3H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations. While both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = −0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = −0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC6h) of plasma chylomicrons (apoB48, r = −0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = −0.36, P = 0.004) and AUC6h chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = −0.45, P < 0.001 in women; D6D: r = −0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment. Association of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults.
Keywords	adiposity ; adults ; antagonists ; body mass index ; chylomicrons ; eicosapentaenoic acid ; enzyme activity ; enzymes ; high fat foods ; insulin resistance ; insulin secretion ; lipid content ; metabolic studies ; noninsulin-dependent diabetes mellitus ; omega-3 fatty acids ; overweight ; phospholipid fatty acids ; postmenopause ; risk factors ; white adipose tissue ; women
Language	English
Dates of publication	2019-0101
Size	p. 57-67.
Publishing place	Oxford University Press
Document type	Article
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1093/jn/nxy238
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults.

Lamantia, Valérie / Bissonnette, Simon / Provost, Viviane / Devaux, Marie / Cyr, Yannick / Daneault, Caroline / Rosiers, Christine Des / Faraj, May

The Journal of nutrition

2018 Volume 149, Issue 1, Page(s) 57–67

Abstract: Background: δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n-3 (ω-3) and n-6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by ... ...

Abstract	Background: δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n-3 (ω-3) and n-6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n-3 PUFA intake, promote T2D risk factors. Objective: The aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB. Methods: This is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m2): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m2, 66% fat) and white adipose tissue (WAT) function (storage of 3H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations. Results: While both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = -0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = -0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC6h) of plasma chylomicrons (apoB48, r = -0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = -0.36, P = 0.004) and AUC6h chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = -0.45, P < 0.001 in women; D6D: r = -0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment. Conclusions: Association of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults.
MeSH term(s)	Apolipoproteins B/blood ; Delta-5 Fatty Acid Desaturase ; Diabetes Mellitus, Type 2/metabolism ; Fatty Acid Desaturases/genetics ; Fatty Acid Desaturases/metabolism ; Female ; Gene Expression Regulation, Enzymologic ; Humans ; Male ; Middle Aged ; Overweight/metabolism ; Risk Factors
Chemical Substances	Apolipoproteins B ; Delta-5 Fatty Acid Desaturase ; Fatty Acid Desaturases (EC 1.14.19.-)
Language	English
Publishing date	2018-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1093/jn/nxy238
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Article ; Online: Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice.

Demers, Geneviève / Roy, Jerome / Machuca-Parra, Arturo Israel / Dashtehei Pour, Zahra / Bairamian, Diane / Daneault, Caroline / Rosiers, Christine Des / Ferreira, Guillaume / Alquier, Thierry / Fulton, Stephanie

International journal of obesity (2005)

2020 Volume 44, Issue 9, Page(s) 1936–1945

Abstract: Objective: Obesity significantly elevates the odds of developing mood disorders. Chronic consumption of a saturated high-fat diet (HFD) elicits anxiodepressive behavior in a manner linked to metabolic dysfunction and neuroinflammation in mice. Dietary ... ...

Abstract	Objective: Obesity significantly elevates the odds of developing mood disorders. Chronic consumption of a saturated high-fat diet (HFD) elicits anxiodepressive behavior in a manner linked to metabolic dysfunction and neuroinflammation in mice. Dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) can improve both metabolic and mood impairments by relieving inflammation. Despite these findings, the effects of n-3 PUFA supplementation on energy homeostasis, anxiodepressive behavior, brain lipid composition, and gliosis in the diet-induced obese state are unclear. Methods: Male C57Bl/6J mice were fed a saturated high-fat diet (HFD) or chow for 20 weeks. During the last 5 weeks mice received daily gavage ("supplementation") of fish oil (FO) enriched with equal amounts of docosahexaenoic (DHA) and eicosapentaenoic acid (EPA) or control corn oil. Food intake and body weight were measured throughout while additional metabolic parameters and anxiety- and despair-like behavior (elevated-plus maze, light-dark box, and forced swim tasks) were evaluated during the final week of supplementation. Forebrain lipid composition and markers of microglia activation and astrogliosis were assessed by gas chromatography-mass spectrometry and real-time PCR, respectively. Results: Five weeks of FO supplementation corrected glucose intolerance and attenuated hyperphagia in HFD-induced obese mice without affecting adipose mass. FO supplementation also defended against the anxiogenic and depressive-like effects of HFD. Brain lipids, particularly anti-inflammatory PUFA, were diminished by HFD, whereas FO restored levels beyond control values. Gene expression markers of brain reactive gliosis were supressed by FO. Conclusions: Supplementing a saturated HFD with FO rich in EPA and DHA corrects glucose intolerance, inhibits food intake, suppresses anxiodepressive behaviors, enhances anti-inflammatory brain lipids, and dampens indices of brain gliosis in obese mice. Together, these findings support increasing dietary n-3 PUFA for the treatment of metabolic and mood disturbances associated with excess fat intake and obesity.
MeSH term(s)	Adipose Tissue/drug effects ; Animals ; Anxiety ; Behavior, Animal/drug effects ; Brain/drug effects ; Brain/metabolism ; Brain Chemistry/drug effects ; Depression ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Fish Oils/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Obesity/psychology
Chemical Substances	Fish Oils
Language	English
Publishing date	2020-06-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-020-0623-6
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Article ; Online: Branched chain amino acids selectively promote cardiac growth at the end of the awake period.

Latimer, Mary N / Sonkar, Ravi / Mia, Sobuj / Frayne, Isabelle Robillard / Carter, Karen J / Johnson, Christopher A / Rana, Samir / Xie, Min / Rowe, Glenn C / Wende, Adam R / Prabhu, Sumanth D / Frank, Stuart J / Rosiers, Christine Des / Chatham, John C / Young, Martin E

Journal of molecular and cellular cardiology

2021 Volume 157, Page(s) 31–44

Abstract: Essentially all biological processes fluctuate over the course of the day, manifesting as time-of-day-dependent variations with regards to the way in which organ systems respond to normal behaviors. For example, basic, translational, and epidemiologic ... ...

Abstract	Essentially all biological processes fluctuate over the course of the day, manifesting as time-of-day-dependent variations with regards to the way in which organ systems respond to normal behaviors. For example, basic, translational, and epidemiologic studies indicate that temporal partitioning of metabolic processes governs the fate of dietary nutrients, in a manner in which concentrating caloric intake towards the end of the day is detrimental to both cardiometabolic and cardiovascular parameters. Despite appreciation that branched chain amino acids impact risk for obesity, diabetes mellitus, and heart failure, it is currently unknown whether the time-of-day at which dietary BCAAs are consumed influence cardiometabolic/cardiovascular outcomes. Here, we report that feeding mice a BCAA-enriched meal at the end of the active period (i.e., last 4 h of the dark phase) rapidly increases cardiac protein synthesis and mass, as well as cardiomyocyte size; consumption of the same meal at the beginning of the active period (i.e., first 4 h of the dark phase) is without effect. This was associated with a greater BCAA-induced activation of mTOR signaling in the heart at the end of the active period; pharmacological inhibition of mTOR (through rapamycin) blocked BCAA-induced augmentation of cardiac mass and cardiomyocyte size. Moreover, genetic disruption of the cardiomyocyte circadian clock abolished time-of-day-dependent fluctuations in BCAA-responsiveness. Finally, we report that repetitive consumption of BCAA-enriched meals at the end of the active period accelerated adverse cardiac remodeling and contractile dysfunction in mice subjected to transverse aortic constriction. Thus, our data demonstrate that the timing of BCAA consumption has significant implications for cardiac health and disease.
MeSH term(s)	ARNTL Transcription Factors/deficiency ; Amino Acids, Branched-Chain/metabolism ; Animals ; Biomarkers ; Circadian Clocks ; Disease Susceptibility ; Eating ; Energy Metabolism ; Mice ; Mice, Knockout ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Protein Biosynthesis ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Ventricular Remodeling/genetics ; Wakefulness
Chemical Substances	ARNTL Transcription Factors ; Amino Acids, Branched-Chain ; Bmal1 protein, mouse ; Biomarkers ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-04-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2021.04.005
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Article ; Online: Saturated high-fat feeding independent of obesity alters hypothalamus-pituitary-adrenal axis function but not anxiety-like behaviour.

Hryhorczuk, Cecile / Décarie-Spain, Léa / Sharma, Sandeep / Daneault, Caroline / Rosiers, Christine Des / Alquier, Thierry / Fulton, Stephanie

Psychoneuroendocrinology

2017 Volume 83, Page(s) 142–149

Abstract: Overconsumption of dietary fat can elicit impairments in emotional processes and the response to stress. While excess dietary lipids have been shown to alter hypothalamus-pituitary-adrenal (HPA) axis function and promote anxiety-like behaviour, it is not ...

Abstract	Overconsumption of dietary fat can elicit impairments in emotional processes and the response to stress. While excess dietary lipids have been shown to alter hypothalamus-pituitary-adrenal (HPA) axis function and promote anxiety-like behaviour, it is not known if such changes rely on elevated body weight and if these effects are specific to the type of dietary fat. The objective of this study was to investigate the effect of a saturated and a monounsaturated high-fat diet (HFD) on HPA axis function and anxiety-like behaviour in rats. Biochemical, metabolic and behavioural responses were evaluated following eight weeks on one of three diets: (1) a monounsaturated HFD (50%kcal olive oil), (2) a saturated HFD (50%kcal palm oil), or (3) a control low-fat diet. Weight gain was similar across the three diets while visceral fat mass was elevated by the two HFDs. The saturated HFD had specific actions to increase peak plasma levels of corticosterone and tumour-necrosis-factor-alpha and suppress mRNA expression of glucocorticoid and mineralocorticoid receptors, corticotropin-releasing hormone and 11β-hydroxysteroid dehydrogenase-1 in the paraventricular nucleus of the hypothalamus. Both HFDs enhanced the corticosterone-suppressing response to dexamethasone administration without affecting the physiological response to a restraint stress and failed to increase anxiety-like behaviour as measured in the elevated-plus maze and open field tests. These findings demonstrate that prolonged intake of saturated fat, without added weight gain, increases CORT and modulates central HPA feedback processes. That saturated HFD failed to affect anxiety-like behaviour can suggest that the anxiogenic effects of prolonged high-fat feeding may rely on more pronounced metabolic dysfunction.
Language	English
Publishing date	2017-09
Publishing country	England
Document type	Journal Article
ZDB-ID	197636-9
ISSN	1873-3360 ; 0306-4530
ISSN (online)	1873-3360
ISSN	0306-4530
DOI	10.1016/j.psyneuen.2017.06.002
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Article ; Online: The role of oxidative stress in postprandial endothelial dysfunction.

Lacroix, Sébastien / Rosiers, Christine Des / Tardif, Jean-Claude / Nigam, Anil

Nutrition research reviews

2012 Volume 25, Issue 2, Page(s) 288–301

Abstract: Endothelial dysfunction is a turning point in the initiation and development of atherosclerosis and its complications and is predictive of future cardiovascular events. Ingestion of high-carbohydrate or high-fat meals often results in postprandial ... ...

Abstract	Endothelial dysfunction is a turning point in the initiation and development of atherosclerosis and its complications and is predictive of future cardiovascular events. Ingestion of high-carbohydrate or high-fat meals often results in postprandial hyperglycaemia and/or hypertriacylglycerolaemia that may lead to a transient impairment in endothelial function. The present review will discuss human studies evaluating the impact of high-carbohydrate and high-fat challenges on postprandial endothelial function as well as the potential role of oxidative stress in such postprandial metabolic alterations. Moreover, the present review will differentiate the postprandial endothelial and oxidative impact of meals rich in varying fatty acid types.
MeSH term(s)	Atherosclerosis ; Diet, High-Fat/adverse effects ; Dietary Carbohydrates/administration & dosage ; Dietary Carbohydrates/adverse effects ; Endothelium, Vascular/physiopathology ; Fatty Acids/administration & dosage ; Fatty Acids, Monounsaturated/administration & dosage ; Fatty Acids, Unsaturated/administration & dosage ; Glucose Tolerance Test ; Humans ; Hyperglycemia/etiology ; Hyperglycemia/physiopathology ; Hypertriglyceridemia/etiology ; Hypertriglyceridemia/physiopathology ; Lipid Peroxidation ; Oxidative Stress/physiology ; Trans Fatty Acids/administration & dosage
Chemical Substances	Dietary Carbohydrates ; Fatty Acids ; Fatty Acids, Monounsaturated ; Fatty Acids, Unsaturated ; Trans Fatty Acids
Language	English
Publishing date	2012-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1003534-5
ISSN	1475-2700 ; 0954-4224
ISSN (online)	1475-2700
ISSN	0954-4224
DOI	10.1017/S0954422412000182
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Article ; Online: Association between fat-soluble nutrient status and auditory and visual related potentials in newly diagnosed non-screened infants with cystic fibrosis: A case-control study.

Léveillé, Pauline / Knoth, Inga-Sophia / Denis, Marie-Hélène / Morin, Geneviève / Barlaam, Fanny / Nyalendo, Carine / Daneault, Caroline / Marcotte, Jacques-Edouard / Rosiers, Christine Des / Ferland, Guylaine / Lippé, Sarah / Mailhot, Geneviève

Prostaglandins, leukotrienes, and essential fatty acids

2019 Volume 150, Page(s) 21–30

Abstract: Nutritional deficiencies often precede the diagnosis of cystic fibrosis (CF) in infants, and occur at a stage where the rapidly developing brain is more vulnerable to insult. We aim to compare fat-soluble nutrient status of newly diagnosed non-screened ... ...

Abstract	Nutritional deficiencies often precede the diagnosis of cystic fibrosis (CF) in infants, and occur at a stage where the rapidly developing brain is more vulnerable to insult. We aim to compare fat-soluble nutrient status of newly diagnosed non-screened infants with CF to that of healthy infants, and explore the association with neurodevelopment evaluated by electroencephalography (EEG). Our results show that CF infants had lower levels of all fat-soluble vitamins and docosahexaenoic acid (DHA) compared to controls. The auditory evoked potential responses were higher in CF compared to controls whereas the visual components did not differ between groups. DHA levels were correlated with auditory evoked potential responses. Although resting state frequency power was similar between groups, we observed a negative correlation between DHA levels and low frequencies. This study emphasizes the need for long-term neurodevelopmental follow-up of CF infants and pursuing intervention strategies in the future.
MeSH term(s)	Case-Control Studies ; Cystic Fibrosis/metabolism ; Cystic Fibrosis/physiopathology ; Docosahexaenoic Acids/analysis ; Electroencephalography ; Evoked Potentials, Auditory ; Evoked Potentials, Visual ; Female ; Humans ; Infant ; Male ; Pilot Projects ; Rest ; Vitamins/analysis
Chemical Substances	Vitamins ; Docosahexaenoic Acids (25167-62-8)
Language	English
Publishing date	2019-09-05
Publishing country	Scotland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	286714-x
ISSN	1532-2823 ; 0952-3278
ISSN (online)	1532-2823
ISSN	0952-3278
DOI	10.1016/j.plefa.2019.09.003
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Article: The role of oxidative stress in postprandial endothelial dysfunction

Lacroix, Sébastien / Rosiers, Christine Des / Tardif, Jean-Claude / Nigam, Anil

Nutrition research reviews. 2012 Dec., v. 25, no. 2

2012

Abstract	Endothelial dysfunction is a turning point in the initiation and development of atherosclerosis and its complications and is predictive of future cardiovascular events. Ingestion of high-carbohydrate or high-fat meals often results in postprandial hyperglycaemia and/or hypertriacylglycerolaemia that may lead to a transient impairment in endothelial function. The present review will discuss human studies evaluating the impact of high-carbohydrate and high-fat challenges on postprandial endothelial function as well as the potential role of oxidative stress in such postprandial metabolic alterations. Moreover, the present review will differentiate the postprandial endothelial and oxidative impact of meals rich in varying fatty acid types.
Keywords	atherosclerosis ; fatty acids ; high carbohydrate diet ; high fat diet ; humans ; hyperglycemia ; ingestion ; oxidative stress
Language	English
Dates of publication	2012-12
Size	p. 288-301.
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	1003534-5
ISSN	1475-2700 ; 0954-4224
ISSN (online)	1475-2700
ISSN	0954-4224
DOI	10.1017/S0954422412000182
Database	NAL-Catalogue (AGRICOLA)

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