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  1. Article ; Online: Hereditary hemochromatosis with homozygous C282Y HFE mutation: possible clinical model to assess effects of elevated reactive oxygen species on the development of cardiovascular disease.

    Shizukuda, Yukitaka / Rosing, Douglas R

    Molecular and cellular biochemistry

    2023  Volume 479, Issue 3, Page(s) 617–627

    Abstract: Hereditary hemochromatosis with the homozygous C282Y HFE mutation (HH-282H) is a genetic condition which causes iron overload (IO) and elevated reactive oxygen species (ROS) secondary to the IO. Interestingly, even after successful iron removal therapy, ... ...

    Abstract Hereditary hemochromatosis with the homozygous C282Y HFE mutation (HH-282H) is a genetic condition which causes iron overload (IO) and elevated reactive oxygen species (ROS) secondary to the IO. Interestingly, even after successful iron removal therapy, HH-282H subjects demonstrate chronically elevated ROS. Raised ROS are also associated with the development of multiple cardiovascular diseases and HH-282H subjects may be at risk to develop these complications. In this narrative review, we consider HH-282H subjects as a clinical model for assessing the contribution of elevated ROS to the development of cardiovascular diseases in subjects with fewer confounding clinical risk factors as compared to other disease conditions with high ROS. We identify HH-282H subjects as a potentially unique clinical model to assess the impact of chronically elevated ROS on the development of cardiovascular disease and to serve as a clinical model to detect effective interventions for anti-ROS therapy.
    MeSH term(s) Humans ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/genetics ; Hemochromatosis/complications ; Hemochromatosis/diagnosis ; Hemochromatosis/genetics ; Hemochromatosis Protein/genetics ; Histocompatibility Antigens Class I/genetics ; Iron Overload/genetics ; Iron Overload/diagnosis ; Membrane Proteins/genetics ; Mutation ; Reactive Oxygen Species
    Chemical Substances Hemochromatosis Protein ; HFE protein, human ; Histocompatibility Antigens Class I ; Membrane Proteins ; Reactive Oxygen Species
    Language English
    Publishing date 2023-05-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-023-04726-y
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  2. Article ; Online: Left Ventricular Global Longitudinal Strain to Assess Left Ventricular Systolic Dysfunction in Chronically Treated Cardiac Asymptomatic Hereditary Hemochromatosis With HFE C282Y Homozygosity.

    Shizukuda, Yukitaka / Sidenko, Stanislav / Nguyen, My-Le / Rosing, Douglas R

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2024  Volume 37, Issue 5, Page(s) 568–570

    MeSH term(s) Humans ; Hemochromatosis/complications ; Hemochromatosis/genetics ; Hemochromatosis/diagnosis ; Hemochromatosis/physiopathology ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/diagnosis ; Male ; Female ; Middle Aged ; Hemochromatosis Protein/genetics ; Homozygote ; Echocardiography/methods ; Global Longitudinal Strain
    Chemical Substances Hemochromatosis Protein ; HFE protein, human
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Letter ; Journal Article
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2024.01.014
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  3. Article ; Online: Delaying aging by improved hydration.

    Dmitrieva, Natalia I / Rosing, Douglas R / Boehm, Manfred

    EBioMedicine

    2023  Volume 92, Page(s) 104638

    MeSH term(s) Humans ; Aging ; Drinking
    Language English
    Publishing date 2023-05-26
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104638
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  4. Article ; Online: Effect of standard phlebotomy on myocardial and hepatic iron levels in newly diagnosed cardiac asymptomatic hereditary hemochromatosis subjects with C282Y homozygosity.

    Shizukuda, Yukitaka / Patricia Bandettini, W / Rosing, Douglas R

    EJHaem

    2023  Volume 4, Issue 2, Page(s) 544–547

    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.662
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  5. Article ; Online: Making decision about fluid intake: increase or not increase.

    Dmitrieva, Natalia I / Rosing, Douglas R / Boehm, Manfred

    European heart journal

    2022  Volume 43, Issue 41, Page(s) 4438–4439

    MeSH term(s) Humans ; Hypernatremia ; Decision Making ; Renal Insufficiency, Chronic
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac368
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  6. Article ; Online: Letter to the Editor: Comments Regarding Recent Paper by Chetrit et al.

    Shizukuda, Yukitaka / Rosing, Douglas R

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2019  Volume 32, Issue 9, Page(s) 1249–1250

    MeSH term(s) Heart Ventricles
    Language English
    Publishing date 2019-07-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2019.06.001
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  7. Article: Iron overload and arrhythmias: Influence of confounding factors.

    Shizukuda, Yukitaka / Rosing, Douglas R

    Journal of arrhythmia

    2019  Volume 35, Issue 4, Page(s) 575–583

    Abstract: Arrhythmias as a cardiac complication of iron overload (IO) have been well described for decades in the clinical literature. They are assumed to be directly associated with the myocardial accumulation of iron. However, the influence of heart failure and ... ...

    Abstract Arrhythmias as a cardiac complication of iron overload (IO) have been well described for decades in the clinical literature. They are assumed to be directly associated with the myocardial accumulation of iron. However, the influence of heart failure and elevated oxidative stress, which are major arrhythmogenic confounding factors associated with IO on arrhythmias, has not been critically reviewed in the published literature. A comprehensive narrative review of published articles in PubMed was conducted to address the influence of confounding factors of IO on arrhythmias. The previous data may have been largely confounded by the other cardiac complications of IO, particularly heart failure. The previous studies on IO-related arrhythmias lack proper age-gender-matched control subjects and/or comparison groups with properly controlled confounding factors to assess accurately their etiology and clinical significance. Given the above considerations, further mechanistic investigations to clarify the etiology and clinical relevance of IO-induced arrhythmias are needed. In addition, investigations to develop arrhythmia management strategy specific to IO, are warranted.
    Language English
    Publishing date 2019-06-20
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2696593-8
    ISSN 1883-2148 ; 1880-4276
    ISSN (online) 1883-2148
    ISSN 1880-4276
    DOI 10.1002/joa3.12208
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  8. Article ; Online: Incidence of Symptomatic Arrhythmias and Utilization of Arrhythmia Testing in 10-year Follow up of Cardiac Asymptomatic Hereditary Hemochromatosis Subjects.

    Shizukuda, Yuktiaka / Lingamaneni, Prasanth / Rosing, Douglas R

    The American journal of cardiology

    2021  Volume 157, Page(s) 153–154

    MeSH term(s) Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/physiopathology ; Asymptomatic Diseases ; Electrocardiography, Ambulatory ; Follow-Up Studies ; Forecasting ; Hemochromatosis/complications ; Hemochromatosis/diagnosis ; Hemochromatosis/genetics ; Humans ; Incidence ; Magnetic Resonance Imaging, Cine/methods
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Intramural
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2021.07.031
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  9. Article ; Online: Advancement of echocardiography for surveillance of iron overload cardiomyopathy: comparison to cardiac magnetic resonance imaging.

    Zimmerman, M Jason / Rosing, Douglas R / Shizukuda, Yukitaka

    Journal of echocardiography

    2021  Volume 19, Issue 3, Page(s) 141–149

    Abstract: The prevalence of iron overload cardiomyopathy (IOC) is increasing. Patients with transfusion-dependent anemias or conditions associated with increased iron absorption over time are at a significant risk for the development of iron-overloaded states such ...

    Abstract The prevalence of iron overload cardiomyopathy (IOC) is increasing. Patients with transfusion-dependent anemias or conditions associated with increased iron absorption over time are at a significant risk for the development of iron-overloaded states such as IOC. Current guidelines regarding the diagnostic evaluation and follow-up of patients at risk for IOC exist, and are composed of multiple components, including such as echocardiography, genetic testing, magnetic resonance imaging of liver, and cardiac magnetic resonance imaging (CMR). While these are considered reliable for the evaluation of patients at risk for an iron-overloaded state, there is an access challenge associated with initial and serial CMR scanning in this patient population. Furthermore, there are other limiting factors, such as patient characteristics that may preclude the use of CMR as a viable diagnostic imaging modality for these patients. On the other hand, recent evidence in the literature suggests that transthoracic echocardiography, which has had significant technological advances, can equal or even outperform CMR to identify cardiac functional abnormalities such as subclinical left ventricular strain and left atrial functional abnormalities in iron overload conditions. Therefore, there is a potential role of more frequent use of echocardiography for surveillance of the development of IOC. Our purpose with this narrative review is to describe recent advances in echocardiography and propose a potential increased use of echocardiography in the surveillance of the development of IOC.
    MeSH term(s) Cardiomyopathies/diagnostic imaging ; Echocardiography ; Heart ; Humans ; Iron Overload/diagnostic imaging ; Magnetic Resonance Imaging
    Language English
    Publishing date 2021-03-26
    Publishing country Japan
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2209473-8
    ISSN 1880-344X ; 1349-0222
    ISSN (online) 1880-344X
    ISSN 1349-0222
    DOI 10.1007/s12574-021-00524-x
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  10. Article ; Online: Cardiovascular complications of sickle cell disease.

    Sachdev, Vandana / Rosing, Douglas R / Thein, Swee Lay

    Trends in cardiovascular medicine

    2020  Volume 31, Issue 3, Page(s) 187–193

    Abstract: Sickle cell disease (SCD) is the most common inherited blood disorder in the United States, and a global health problem. Pathological features of the abnormal hemoglobin (HbS) result in 2 hallmarks of the disease - recurrent episodes of acute ... ...

    Abstract Sickle cell disease (SCD) is the most common inherited blood disorder in the United States, and a global health problem. Pathological features of the abnormal hemoglobin (HbS) result in 2 hallmarks of the disease - recurrent episodes of acute microvascular occlusion and chronic hemolytic anemia - that inflict continuous and insidious damage to multiple organs. With improved childhood survival, SCD in adults has evolved into a chronic degenerative disease with underlying damage to multiple organs including the heart and lungs. Cardiopulmonary complications, including cardiomyopathy, diastolic dysfunction, pulmonary hypertension (PH), and sudden cardiac death are the most common causes of morbidity and mortality. Awareness of the sickle-related cardiovascular phenotypes is important for screening, early diagnosis, and intervention of cardiac complications in this disorder.
    MeSH term(s) Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/mortality ; Anemia, Sickle Cell/physiopathology ; Anemia, Sickle Cell/therapy ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/therapy ; Cardiovascular System/physiopathology ; Death, Sudden, Cardiac/epidemiology ; Humans ; Phenotype ; Prognosis ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2020-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2020.02.002
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