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  1. Article: Az anyák és az újszülöttek megmentője, akire mindig büszkék leszünk: Semmelweis Ignác (1818–1865). Aki legyőzte a kórt, de nem győzte meg a kort, az orvostudományok és a sebészet doktora, szülészmester, a Pesti Királyi Magyar Tudományegyetemen az elméleti és gyakorlati szülészet nyilvános, rendes tanára.

    Rosivall, László

    Orvosi hetilap

    2018  Volume 159, Issue 26, Page(s) 1041–1054

    Abstract: Semmelweis finally achieved results from his persistent research work. Those being the scientific analysis of clinical statistical data and his animal experiments, which recognized the dreadful disease of puerperal fever and its prevention. "He not only ... ...

    Title translation The savior of mothers and newborns, whom we shall always be proud of: Ignác Semmelweis (1818-1865). One who defeated the disease, yet could not convince the people, Doctor of Medical Sciences and Surgery, Master of Obstetrics, Professor of Theoretical and Practical Obstetrics at the Pest Royal Hungarian University of Sciences.
    Abstract Semmelweis finally achieved results from his persistent research work. Those being the scientific analysis of clinical statistical data and his animal experiments, which recognized the dreadful disease of puerperal fever and its prevention. "He not only discovered the real cause of puerperal fever but he also created antiseptic prophylaxis, which he introduced in obstetrics and laid the foundations of modern surgery (asepsis). The theory and practice of asepsis stemmed from the discovery of the etiology of puerperal fever and therefore originating from the genius idea of Semmelweis. The discoveries of bacteriology by Lister, Pasteur and Koch only provided a scientific proof of the intuitive statements of Semmelweis." Semmelweis was a pioneer of clinical etiological research whose findings were aggressively disapproved by his colleagues due to earlier medical misunderstandings. Semmelweis is given due respect by posterity as a remuneration, to all the bitterness that he had suffered throughout his life. Semmelweis is considered the savior of mothers and infants. The Hungarian nation is very proud of him as he is one of our models whose oeuvre is acknowledged not only in Hungary but throughout the world. The message of his short, tragic yet effective life is eternal. The figure of Ignác Semmelweis is depicted as a statue and is placed in Chicago among the statues of the most innovative doctors and health care professionals of the world. The statue of Semmelweis is next to the statues of Louis Pasteur and Wilhelm Conrad Röntgen. "Semmelweis reflex" is a new expression which appeared and spread in English speaking countries. The word does not relate to a medical phenomenon but describes a social phenomenon when experts or the whole society automatically rejects discoveries and new recognitions without examination or justification. This phenomenon frequently occurs, even in our times. Orv Hetil. 2018; 159(26): 1041-1054.
    MeSH term(s) Faculty, Medical/history ; Female ; History, 19th Century ; Humans ; Obstetrics/history ; Physicians/history ; Pregnancy ; Puerperal Infection/history
    Language Hungarian
    Publishing date 2018-07
    Publishing country Hungary
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2018.31153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Renovascular effects of angiotensin II

    Rosivall, László

    [Budapest, Hungary, July 16 - 19, 1989]

    (Kidney international : Supplement ; 30)

    1990  

    Author's details guest ed.: L. Rosivall
    Series title Kidney international : Supplement ; 30
    Kidney international
    Kidney international ; Supplement
    Collection Kidney international
    Kidney international ; Supplement
    Keywords Angiotensin II / congresses ; Hemodynamics / drug effects / congresses ; Kidney / drug effects / congresses ; Angiotensin II
    Size S-126 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003655829
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Ignác Fülöp Semmelweis, pioneer of clinical pathophysiology.

    Rosivall, László

    Acta physiologica Hungarica

    2015  Volume 102, Issue 4, Page(s) 343–350

    MeSH term(s) History, 20th Century ; Humans ; Physiology/history
    Language English
    Publishing date 2015-12-21
    Publishing country Hungary
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 802801-1
    ISSN 1588-2683 ; 0231-424X ; 0001-6756
    ISSN (online) 1588-2683
    ISSN 0231-424X ; 0001-6756
    DOI 10.1556/036.102.2015.4.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Greetings to the Reader.

    Rosivall, Laszlo

    Acta physiologica Hungarica

    2015  Volume 102, Issue 3, Page(s) 239–240

    MeSH term(s) Animals ; Biomedical Research ; Editorial Policies ; Humans ; Journal Impact Factor ; Periodicals as Topic ; Physiology
    Language English
    Publishing date 2015-09
    Publishing country Hungary
    Document type Editorial
    ZDB-ID 802801-1
    ISSN 1588-2683 ; 0231-424X ; 0001-6756
    ISSN (online) 1588-2683
    ISSN 0231-424X ; 0001-6756
    DOI 10.1556/036.102.2015.3.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: "A vese képes csodát is tenni!" Interjú Dr. Rosivall Lászlóval.

    Rosivall, László

    Orvosi hetilap

    2010  Volume 151, Issue 38, Page(s) 1556–1559

    Title translation "The kidney can work miracles . . ." Interview with László Rosivall.
    MeSH term(s) Academies and Institutes/organization & administration ; Awards and Prizes ; Biomedical Research ; Charities/organization & administration ; Congresses as Topic/organization & administration ; Diuresis ; Education, Medical, Continuing/organization & administration ; Education, Medical, Continuing/trends ; Europe ; Faculty, Medical ; History, 20th Century ; History, 21st Century ; Humans ; Hungary ; International Cooperation ; Journalism, Medical ; Nephrology/education ; Nephrology/history ; Nephrology/trends ; Physiology/education ; Societies, Medical
    Language Hungarian
    Publishing date 2010-09-08
    Publishing country Hungary
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/OH.2010.38M
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition-An Outstanding Challenge.

    Fintha, Attila / Gasparics, Ákos / Rosivall, László / Sebe, Attila

    Frontiers in pharmacology

    2019  Volume 10, Page(s) 388

    Abstract: Back in 1995, a landmark paper was published, which shaped the fibrosis literature for many years to come. During the characterization of a fibroblast-specific marker (FSP1) in the kidneys, an observation was made, which gave rise to the hypothesis that " ...

    Abstract Back in 1995, a landmark paper was published, which shaped the fibrosis literature for many years to come. During the characterization of a fibroblast-specific marker (FSP1) in the kidneys, an observation was made, which gave rise to the hypothesis that "fibroblasts in some cases arise from the local conversion of epithelium." In the following years, epithelial-mesenchymal transition was in the spotlight of fibrosis research, especially in the kidney. However, the hypothesis came under scrutiny following some discouraging findings from lineage tracing experiments and clinical observations. In this review, we provide a timely overview of the current position of the epithelial-mesenchymal transition hypothesis in the context of fibrosis (with a certain focus on renal fibrosis) and highlight some of the potential hurdles and pitfalls preventing therapeutic breakthroughs targeting fibrotic epithelial-mesenchymal transition.
    Language English
    Publishing date 2019-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2019.00388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intrarenal renin-angiotensin system.

    Rosivall, László

    Molecular and cellular endocrinology

    2009  Volume 302, Issue 2, Page(s) 185–192

    Abstract: Phylogenetically the renin-angiotensin system (RAS) is an ancient regulatory system which has attracted the attention of researchers for about a century. As a result of their efforts, different types of RAS inhibitors are now widely used as therapeutic ... ...

    Abstract Phylogenetically the renin-angiotensin system (RAS) is an ancient regulatory system which has attracted the attention of researchers for about a century. As a result of their efforts, different types of RAS inhibitors are now widely used as therapeutic medicines. The scientific enthusiasm toward RAS remains undiminished and new findings and discoveries are to be expected. Early investigators described the role of RAS in the local control of renal hemodynamics. This correlated well with the morphology of juxtaglomerular apparatus (JGA). Recently developed imaging techniques has allowed for in vivo visualization of cellular functions and the use of molecular biological tools have shed new light on the morphology and physiology of renal RAS, especially in connection with the tubular system. RAS has gained recognition to be more than just an endocrine regulatory system for regulating hemodynamics and water/salt metabolism. RAS is a local tissue and/or cellular regulator with a wide range of effects exerted via various receptors. Local RAS is crucially involved in basic physiological processes like ontogenesis and cell proliferation as well as pathophysiological conditions such as inflammation and tissue fibrosis. These findings may open new frontiers for novel therapeutic approaches. This review focuses only on some specific - less discussed and recently described or hypothesized - morphological and functional aspects of intrarenal RAS, including in vivo imaging of RAS, its effects on juxtaglomerular apparatus and possible cooperative mechanisms among various local renal RAS systems.
    MeSH term(s) Animals ; Cell Communication ; Humans ; Juxtaglomerular Apparatus/metabolism ; Kidney/metabolism ; Kidney/physiology ; Renin/metabolism ; Renin/physiology ; Renin-Angiotensin System
    Chemical Substances Renin (EC 3.4.23.15)
    Language English
    Publishing date 2009-04-29
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2008.09.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus.

    Denicolò, Sara / Reinstadler, Vera / Keller, Felix / Thöni, Stefanie / Eder, Susanne / Heerspink, Hiddo J L / Rosivall, László / Wiecek, Andrzej / Mark, Patrick B / Perco, Paul / Leierer, Johannes / Kronbichler, Andreas / Oberacher, Herbert / Mayer, Gert

    Diabetologia

    2024  

    Abstract: Aims/hypothesis: Non-adherence to medication is a frequent barrier in the treatment of patients with type 2 diabetes mellitus, potentially limiting the effectiveness of evidence-based treatments. Previous studies have mostly relied on indirect adherence ...

    Abstract Aims/hypothesis: Non-adherence to medication is a frequent barrier in the treatment of patients with type 2 diabetes mellitus, potentially limiting the effectiveness of evidence-based treatments. Previous studies have mostly relied on indirect adherence measures to analyse outcomes based on adherence. The aim of this study was to use LC-MS/MS in urine-a non-invasive, direct and objective measure-to assess non-adherence to cardiometabolic drugs and analyse its association with kidney and cardiovascular outcomes.
    Methods: This cohort study includes 1125 participants from the PROVALID study, which follows patients with type 2 diabetes mellitus at the primary care level. Baseline urine samples were tested for 79 cardiometabolic drugs and metabolites thereof via LC-MS/MS. An individual was classified as totally adherent if markers for all drugs were detected, partially non-adherent when at least one marker for one drug was detected, and totally non-adherent if no markers for any drugs were detected. Non-adherence was then analysed in the context of cardiovascular (composite of myocardial infarction, stroke and cardiovascular death) and kidney (composite of sustained 40% decline in eGFR, sustained progression of albuminuria, kidney replacement therapy and death from kidney failure) outcomes.
    Results: Of the participants, 56.3% were totally adherent, 42.0% were partially non-adherent, and 1.7% were totally non-adherent to screened cardiometabolic drugs. Adherence was highest to antiplatelet and glucose-lowering agents and lowest to lipid-lowering agents. Over a median (IQR) follow-up time of 5.10 (4.12-6.12) years, worse cardiovascular outcomes were observed with non-adherence to antiplatelet drugs (HR 10.13 [95% CI 3.06, 33.56]) and worse kidney outcomes were observed with non-adherence to antihypertensive drugs (HR 1.98 [95% CI 1.37, 2.86]).
    Conclusions/interpretation: This analysis shows that non-adherence to cardiometabolic drug regimens is common in type 2 diabetes mellitus and negatively affects kidney and cardiovascular outcomes.
    Language English
    Publishing date 2024-04-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-024-06149-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Can chlorine dioxide prevent the spreading of coronavirus or other viral infections? Medical hypotheses.

    Kály-Kullai, K / Wittmann, M / Noszticzius, Z / Rosivall, László

    Physiology international

    2020  Volume 107, Issue 1, Page(s) 1–11

    Abstract: Motivation: Viruses have caused many epidemics throughout human history. The novel coronavirus [10] is just the latest example. A new viral outbreak can be unpredictable, and development of specific defense tools and countermeasures against the new ... ...

    Abstract Motivation: Viruses have caused many epidemics throughout human history. The novel coronavirus [10] is just the latest example. A new viral outbreak can be unpredictable, and development of specific defense tools and countermeasures against the new virus remains time-consuming even in today's era of modern medical science and technology. In the lack of effective and specific medication or vaccination, it would be desirable to have a nonspecific protocol or substance to render the virus inactive, a substance/protocol, which could be applied whenever a new viral outbreak occurs. This is especially important in cases when the emerging new virus is as infectious as SARS-CoV-2 [4].
    Aims and structure of the present communication: In this editorial, we propose to consider the possibility of developing and implementing antiviral protocols by applying high purity aqueous chlorine dioxide (ClO2) solutions. The aim of this proposal is to initiate research that could lead to the introduction of practical and effective antiviral protocols. To this end, we first discuss some important properties of the ClO2 molecule, which make it an advantageous antiviral agent, then some earlier results of ClO2 gas application against viruses will be reviewed. Finally, we hypothesize on methods to control the spread of viral infections using aqueous ClO2 solutions.
    MeSH term(s) Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; COVID-19 ; Chlorine Compounds/pharmacology ; Clinical Protocols ; Communicable Diseases, Emerging/prevention & control ; Communicable Diseases, Emerging/virology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Disease Transmission, Infectious/prevention & control ; Disinfectants/pharmacology ; Humans ; Oxides/pharmacology ; Pandemics/prevention & control ; Pharmaceutical Solutions/pharmacology ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Research Design ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Chlorine Compounds ; Disinfectants ; Oxides ; Pharmaceutical Solutions ; chlorine dioxide (8061YMS4RM)
    Keywords covid19
    Language English
    Publishing date 2020-03-01
    Publishing country Hungary
    Document type Editorial
    ZDB-ID 2896288-6
    ISSN 2498-602X
    ISSN 2498-602X
    DOI 10.1556/2060.2020.00015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Impact of the first wave of COVID-19 pandemic on the Hungarian university students' social and health behaviour.

    Csépe, Péter / Dinya, Elek / Balázs, Péter / Hosseini, Shahrokh Mirza / Küzdy, Gábor / Rosivall, László

    Zeitschrift fur Gesundheitswissenschaften = Journal of public health

    2021  , Page(s) 1–7

    Abstract: Background: The COVID-19 pandemic brought quick, severe and unexpected changes to our everyday life and also changed the traditional education pattern of Semmelweis University in the middle of academic year 2019-2020. We explored adaptive changes in ... ...

    Abstract Background: The COVID-19 pandemic brought quick, severe and unexpected changes to our everyday life and also changed the traditional education pattern of Semmelweis University in the middle of academic year 2019-2020. We explored adaptive changes in Hungarian students' behaviour and their time-budget in order to determine whether quarantine and/or fear of infection were responsible for these changes.
    Methods: A self-administered online questionnaire was distributed to all students in the Hungarian language program (
    Results: The overall response rate was 11% (
    Conclusion: Social and health-related behaviour of medical students changed basically during the first wave of the pandemic and some changes remained after it in tobacco smoking, nutrition and sleeping habits. Time-budget of students changed significantly during the pandemic and did not return to the baseline values. Results of this study justify future multiple systematic research to analyse and better understand the short- and long-term effects of the current crisis.
    Language English
    Publishing date 2021-10-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1149070-6
    ISSN 2198-1833 ; 0943-1853
    ISSN 2198-1833 ; 0943-1853
    DOI 10.1007/s10389-021-01660-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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