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  1. AU="Ross, Ashley E"
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  1. Article ; Online: Editors' Choice-Review-The Future of Carbon-Based Neurochemical Sensing: A Critical Perspective.

    Ostertag, Blaise J / Ross, Ashley E

    ECS sensors plus

    2023  Volume 2, Issue 4, Page(s) 43601

    Abstract: Carbon-based sensors have remained critical materials for electrochemical detection of neurochemicals, rooted in their inherent biocompatibility and broad potential window. Real-time monitoring using fast-scan cyclic voltammetry has resulted in the rise ... ...

    Abstract Carbon-based sensors have remained critical materials for electrochemical detection of neurochemicals, rooted in their inherent biocompatibility and broad potential window. Real-time monitoring using fast-scan cyclic voltammetry has resulted in the rise of minimally invasive carbon fiber microelectrodes as the material of choice for making measurements in tissue, but challenges with carbon fiber's innate properties have limited its applicability to understudied neurochemicals. Here, we provide a critical review of the state of carbon-based real-time neurochemical detection and offer insight into ways we envision addressing these limitations in the future. This piece focuses on three main hinderances of traditional carbon fiber based materials: diminished temporal resolution due to geometric properties and adsorption/desorption properties of the material, poor selectivity/specificity to most neurochemicals, and the inability to tune amorphous carbon surfaces for specific interfacial interactions. Routes to addressing these challenges could lie in methods like computational modeling of single-molecule interfacial interactions, expansion to tunable carbon-based materials, and novel approaches to synthesizing these materials. We hope this critical piece does justice to describing the novel carbon-based materials that have preceded this work, and we hope this review provides useful solutions to innovate carbon-based material development in the future for individualized neurochemical structures.
    Language English
    Publishing date 2023-12-27
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2754-2726
    ISSN (online) 2754-2726
    DOI 10.1149/2754-2726/ad15a2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Open multi-organ communication device for easy interrogation of tissue slices.

    Delong, Lauren M / Ross, Ashley E

    Lab on a chip

    2023  Volume 23, Issue 13, Page(s) 3034–3049

    Abstract: Here, we have developed an open multi-organ communication device that facilitates cellular and molecular communication ... ...

    Abstract Here, we have developed an open multi-organ communication device that facilitates cellular and molecular communication between
    MeSH term(s) Peyer's Patches ; Lymph Nodes ; Signal Transduction
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d3lc00115f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Wet-Spun Porous Carbon Microfibers for Enhanced Electrochemical Detection.

    Ostertag, Blaise / Ross, Ashley E

    ACS applied materials & interfaces

    2023  Volume 15, Issue 14, Page(s) 17601–17611

    Abstract: We present a novel copolymer-based, uniform porous carbon microfiber (PCMF) formed via wet-spinning for significantly improved electrochemical detection. Carbon fiber (CF), fabricated from a polyacrylonitrile (PAN) precursor, is commonly used in ... ...

    Abstract We present a novel copolymer-based, uniform porous carbon microfiber (PCMF) formed via wet-spinning for significantly improved electrochemical detection. Carbon fiber (CF), fabricated from a polyacrylonitrile (PAN) precursor, is commonly used in batteries or for electrochemical detection of neurochemicals due to its biplanar geometry and desirable edge plane sites with high surface free energy and defects for enhanced analyte interactions. Recently, the presence of pores within carbon materials has presented interesting electrochemistry leading to detection improvements; however, there is currently no method to uniformly create pores on a carbon microfiber surface impacting a broad range of electrochemical applications. Here, we synthesized controllable porous carbon fibers from a spinning dope of the copolymers PAN and poly(methyl methacrylate) (PMMA) in dimethylformamide via wet spinning for the first time. PMMA serves as a sacrificial block introducing macropores of increased edge-plane character on the fiber. Methods were optimized to produce porous CFs at similar dimensions to traditional CF. We prove that an increase in porosity enhances the degree of disorder on the surface, resulting in significantly improved detection capabilities with fast-scan cyclic voltammetry. Local trapping of analytes at porous geometries enables electrochemical reversibility with improved sensitivity, linear range of detection, and measurement temporal resolution. Overall, we demonstrate the utility of a copolymer synthetic method for PCMF fabrication, providing a stable, controlled macroporous fiber framework with enhanced edge plane character. This work will significantly advance fundamental investigations of how pores and edge plane sites influence electrochemical detection.
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c00423
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  4. Article ; Online: Editorial Comment.

    Ross, Ashley E

    The Journal of urology

    2019  Volume 202, Issue 4, Page(s) 708–709

    MeSH term(s) Genomics ; Humans ; Male ; Prostate
    Language English
    Publishing date 2019-09-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/01.JU.0000578516.91582.20
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    Ui VI Zs.91: Show issues Location:
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  5. Article ; Online: A microfluidic chip for sustained oxygen gradient formation in the intestine

    Delong, Lauren M / Witt, Colby E / Pennell, Madison / Ross, Ashley E

    Lab on a chip

    2024  Volume 24, Issue 7, Page(s) 1918–1929

    Abstract: The oxygen gradient across the intestine influences intestinal physiology and the microbial environment of the microbiome. The microbiome releases metabolites that communicate with enterochromaffin cells, neuronal cells, and resident immune cells to ... ...

    Abstract The oxygen gradient across the intestine influences intestinal physiology and the microbial environment of the microbiome. The microbiome releases metabolites that communicate with enterochromaffin cells, neuronal cells, and resident immune cells to facilitate the bidirectional communication across the gut-brain axis. Measuring communication between various cell types within the intestine could provide essential information about key regulators of gut and brain health; however, the microbial environment of the intestine is heavily dependent on the physiological oxygen gradient that exists across the intestinal wall. Likewise, there exist a need for methods which enable real-time monitoring of intestinal signaling
    MeSH term(s) Mice ; Animals ; Oxygen/metabolism ; Microfluidics ; Brain/metabolism
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d3lc00793f
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  6. Article ; Online: Risk Stratification of Low-risk Prostate Cancer: Individualizing Care in the Era of Active Surveillance.

    Ho, Matthew D / Ross, Ashley E / Eggener, Scott E

    The Journal of urology

    2023  Volume 210, Issue 1, Page(s) 38–45

    Abstract: Purpose: While active surveillance is the preferred management for most men with low-risk prostate cancer, a subset may harbor more aggressive disease. In this review we examine the evidence underlying an accurate and nuanced assessment of oncologic ... ...

    Abstract Purpose: While active surveillance is the preferred management for most men with low-risk prostate cancer, a subset may harbor more aggressive disease. In this review we examine the evidence underlying an accurate and nuanced assessment of oncologic risk in these men.
    Materials and methods: We performed a nonsystematic literature review current to January 2023 on PubMed for articles relating to clinical, pathological, molecular, and imaging-based modalities available for risk assessment in men with low-risk prostate cancer. Relevant articles were reviewed by the authors and evidence was summarized.
    Results: Many tools are available to personalize clinical decision-making for men with low-risk prostate cancer. Total volume of cancer, PSA density, and presence of ductal components have been consistently and strongly associated with current or future evidence of higher-grade disease. PSA kinetics, Prostate Imaging Reporting & Data System 4/5 lesions on MRI, perineural invasion, germline mutations, and genomic classifiers all appear to be associated with an increased risk, although are not as extensively validated. Race, percent free PSA, and other serum biomarkers such as Prostate Health Index and 4Kscore do not appear to be associated with long-term elevated risk.
    Conclusions: Long-term prognosis for men diagnosed with low-risk prostate cancer is excellent. There are many factors which should be routinely integrated into the initial management decision as well as determining intensity and frequency of active surveillance. Development of comprehensive multivariable instruments to guide clinical decisions is encouraged.
    MeSH term(s) Male ; Humans ; Prostate-Specific Antigen ; Watchful Waiting ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/therapy ; Prostatic Neoplasms/genetics ; Prostate/pathology ; Risk Assessment
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000003454
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  7. Article ; Online: Graphene oxide fiber microelectrodes with controlled sheet alignment for sensitive neurotransmitter detection.

    Jarosova, Romana / Ostertag, Blaise J / Ross, Ashley E

    Nanoscale

    2023  Volume 15, Issue 37, Page(s) 15249–15258

    Abstract: Here, we synthesized and characterized graphene oxide (GO) fiber microelectrodes with controllable nanosheet orientation to study the extent to which sheet alignment and orientation impacts electrochemical detection of neurochemicals. The alignment of ... ...

    Abstract Here, we synthesized and characterized graphene oxide (GO) fiber microelectrodes with controllable nanosheet orientation to study the extent to which sheet alignment and orientation impacts electrochemical detection of neurochemicals. The alignment of the GO nanosheets was characterized by scanning electron microscopy, Raman spectroscopy, and cyclic voltammetry. The electrochemical performance of GO microelectrodes and its suitability for subsecond detection of neurotransmitters was further evaluated by fast-scan cyclic voltammetry (FSCV). We have shown that the GO sheet alignment has a considerable effect on the electron transfer kinetics, frequency independent behavior, and detection suitability for specific neurotransmitters. Therefore, this fine-tuning aspect of the electrode surface for specific electrochemical detection should be taken into consideration for any future utilization of GO-based biological sensors.
    MeSH term(s) Microelectrodes ; Graphite/chemistry ; Neurotransmitter Agents ; Microscopy, Electron, Scanning ; Electrochemical Techniques
    Chemical Substances graphene oxide ; Graphite (7782-42-5) ; Neurotransmitter Agents
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr02879h
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  8. Article ; Online: Subsecond Codetection of Dopamine and Estradiol at a Modified Sharkfin Waveform.

    Weese-Myers, Moriah E / Ross, Ashley E

    Analytical chemistry

    2023  Volume 96, Issue 1, Page(s) 76–84

    Abstract: 17β-Estradiol (E2) is a ubiquitously expressed hormone that is active in a wide range of neuroprotective and regenerative roles throughout the brain. In particular, it is a well-known dopamine (DA) regulator and is responsible for modulating the ... ...

    Abstract 17β-Estradiol (E2) is a ubiquitously expressed hormone that is active in a wide range of neuroprotective and regenerative roles throughout the brain. In particular, it is a well-known dopamine (DA) regulator and is responsible for modulating the expression of dopaminergic receptors and transporters. Recent studies point to E2 release occurring on a rapid time scale and having impacts on DA activity within seconds to minutes. As such, tools capable of monitoring the release of both E2 and DA in real time are essential for developing an accurate understanding of their interactive roles in neurotransmission and regulation. Currently, no analytical techniques capable of codetection of both analytes with high sensitivity, spatiotemporal resolution, extended monitoring, and minimal tissue damage exist. We describe a modified waveform using fast-scan cyclic voltammetry that is capable of low nanomolar detection of both DA and E2 on a subsecond time scale. Both analytes have limits of detection at or below 30 nM and high sensitivity: 11.31 ± 0.55 nA/μM for DA and 9.47 ± 0.36 nA/μM for E2. The waveform is validated in a tissue matrix, confirming its viability for measurement in a biologically relevant setting. This is the first method capable of codetection of fluctuations in DA and E2 with the temporal, spatial, and sensitivity requirements necessary for studying real-time neurochemical signaling.
    MeSH term(s) Dopamine/metabolism ; Estradiol ; Brain/metabolism ; Signal Transduction
    Chemical Substances Dopamine (VTD58H1Z2X) ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c02967
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  9. Article ; Online: Electrochemistry for neurochemical analysis.

    Ross, Ashley E / Zestos, Alexander G

    Analytical and bioanalytical chemistry

    2021  Volume 413, Issue 27, Page(s) 6687–6688

    MeSH term(s) Animals ; Brain Chemistry ; Electrochemical Techniques/methods ; Humans
    Language English
    Publishing date 2021-10-12
    Publishing country Germany
    Document type Editorial
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-021-03689-7
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  10. Article ; Online: Development of an Electrochemical, Aptamer-Based Sensor for Dynamic Detection of Neuropeptide Y.

    Seibold, Jordan M / Abeykoon, Sanduni W / Ross, Ashley E / White, Ryan J

    ACS sensors

    2023  Volume 8, Issue 12, Page(s) 4504–4511

    Abstract: The ability to monitor dynamic changes in neuropeptide Y (NPY) levels in complex environments can have an impact on many fields, including neuroscience and immunology. Here, we describe the development of an electrochemical, aptamer-based (E-AB) sensor ... ...

    Abstract The ability to monitor dynamic changes in neuropeptide Y (NPY) levels in complex environments can have an impact on many fields, including neuroscience and immunology. Here, we describe the development of an electrochemical, aptamer-based (E-AB) sensor for the dynamic (reversible) measurement of physiologically relevant (nanomolar) concentrations of neuropeptide Y. The E-AB sensors are fabricated using a previously described 80 nucleotide aptamer
    MeSH term(s) Neuropeptide Y/metabolism ; Aptamers, Nucleotide/chemistry ; Biosensing Techniques/methods ; Oxidation-Reduction
    Chemical Substances Neuropeptide Y ; Aptamers, Nucleotide
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.3c00855
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