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Article ; Online: Cognitive profile and neuropsychiatric disorders in Becker muscular dystrophy: A systematic review of literature.

Ferrero, Amanda / Rossi, Marta

2022 Volume 137, Page(s) 104648

Abstract: Background: Brain co-morbidities in DMD are well-documented, less is known about the cognitive, behavioral and psychosocial functioning of patients with BMD.: Methods: The systematic review was carried out on two databases (Pubmed and Scopus) ... ...

Abstract	Background: Brain co-morbidities in DMD are well-documented, less is known about the cognitive, behavioral and psychosocial functioning of patients with BMD. Methods: The systematic review was carried out on two databases (Pubmed and Scopus) according to the PRISMA guidelines. We included all research articles specific to BMD written after 1995. Results: Studies examining neuropsychological and neurobehavioral functioning in BMD are few and have several methods limitations. BMD population is characterized by high rates of cognitive impairment, with specific involvement of different cognitive areas. Unlike DMD, verbal skills are better preserved. Neurodevelopmental and emotional/behavioral disorders have great importance in BMD, due to their high prevalence. Lack of Dp140 or Dp71 can cause intellectual disability, these isoforms are probably responsible for the other brain-related comorbidities as well. Discussion: The results suggest that cognitive and neuropsychiatric comorbid symptoms may affect a significant proportion of BMD patients therefore it is important to mental health and neuropsychological screening. Finding tools for an adequate assessment is a priority in order to include brain outcome measures in clinical trials.
MeSH term(s)	Brain/metabolism ; Cognition ; Dystrophin/metabolism ; Humans ; Muscular Dystrophy, Duchenne/complications ; Muscular Dystrophy, Duchenne/epidemiology ; Protein Isoforms
Chemical Substances	Dystrophin ; Protein Isoforms
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2022.104648
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Article: Evaluating the environmental sustainability of durable products through life cycle assessment. The case of domestic refrigerators

Cappelletti, Federica / Manes, Francesca / Rossi, Marta / Germani, Michele

Sustainable Production and Consumption. 2022 Nov., v. 34

2022

Abstract: Sustainability and durability are not always interchangeable concepts, especially for products that require many resources during their long use phases, like energy related products. In addition, the literature either focuses on how the product ... ...

Abstract	Sustainability and durability are not always interchangeable concepts, especially for products that require many resources during their long use phases, like energy related products. In addition, the literature either focuses on how the product performances change over time or evaluates the convenience of durable goods. In this context, the present work presents a durability assessment from an environmental perspective. Unlikely the existing literature, it simultaneously compares the different methods that describe how the product performances may vary with time, specifically how the foam aging influences the yearly energy consumption of refrigerators and assess the durability from the environmental point of view under different circumstances. The primary outcomes highlight the need to introduce a more accurate description of product performances during their lifetime (i.e. aging of components) to obtain realistic results. Furthermore, this work enlightens the need to align the analytical report on the deterioration of refrigerators' components and provides alternative exemplifications to assess the environmental sustainability of durability. As far as the latter case is concerned, multiple products can take advantage of it and have durability considered from the environmental point of view.
Keywords	durability ; energy ; foams ; life cycle assessment
Language	English
Dates of publication	2022-11
Size	p. 177-189.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2352-5509
DOI	10.1016/j.spc.2022.09.008
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Article: A comparison of different waste collection methods: Environmental impacts and occupational risks

Rossi, Marta / Papetti, Alessandra / Germani, Michele

Journal of cleaner production. 2022 July 12,

2022

Abstract: Municipal waste management, especially in developed countries, has a significant impact on the environment and humans that need to be quantified and mitigated. This study aims to investigate and compare the environmental impact and occupational risks of ... ...

Abstract	Municipal waste management, especially in developed countries, has a significant impact on the environment and humans that need to be quantified and mitigated. This study aims to investigate and compare the environmental impact and occupational risks of the following three municipal waste collection methods in Italy: street bins, door-to-door collection, and a smart bins system. Six waste categories (paper, plastics, glass, metal, organic materials, and residual waste) are analysed. Environmental performances are calculated by the life cycle assessment (LCA) and material and flow analysis (MFA) methodologies. The ergonomic analysis is based on direct observation of municipal waste collectors and the application of standard assessment methods as RULA, NIOSH, and Snook Ciriello. show that the smart bins collection method is environmentally more effective in all the impact categories considered, thanks to the better quality of collected waste. The residual waste flow directed to landfills has a lower value in the case of smart bins (36.63%) in comparison with door-to-door (52.90%) and street bins (89.56%). The use of smart bins allows higher environmental benefits, passing for the Climate Change impact category from −2.80E+01 kg of CO2eq. of the door-to-door system and −2.74E+01 kg of CO2eq. of street bins to −7.13E+01 kg of CO2eq. of smart bins. Regarding the transport phase, the smart bins system determines a reduction of the impact of about 60% if compared with the door-to-door system for all the impact categories considered. On the other hand, acceptable occupational risks result in street and smart waste collection methods, while poor ergonomics conditions are observed during the door-to-door collection. Containers lifting and emptying are the most critical tasks.
Keywords	climate change ; environmental impact ; ergonomics ; glass ; life cycle assessment ; paper ; waste management ; wastes ; Italy
Language	English
Dates of publication	2022-0712
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.133145
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Article ; Online: Diabetes Risk Reduction Diet and Colorectal Cancer Risk.

Natale, Arianna / Turati, Federica / Taborelli, Martina / Giacosa, Attilio / Augustin, Livia S A / Crispo, Anna / Negri, Eva / Rossi, Marta / La Vecchia, Carlo

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2024 Volume 33, Issue 5, Page(s) 731–738

Abstract: Background: Diabetes has been associated with colorectal cancer. We evaluated whether adherence to a diabetes risk reduction diet (DRRD) can favorably influence the risk of colorectal cancer.: Methods: Data came from a multicentric Italian case- ... ...

Abstract	Background: Diabetes has been associated with colorectal cancer. We evaluated whether adherence to a diabetes risk reduction diet (DRRD) can favorably influence the risk of colorectal cancer. Methods: Data came from a multicentric Italian case-control study including 1,953 histologically confirmed colorectal cancer cases and 4,154 hospital controls admitted for acute nonneoplastic diseases. Diet was assessed through a validated and reproducible food frequency questionnaire. The DRRD score was computed assigning higher values for higher consumption of cereal fiber, fruit, coffee, nuts and a higher polyunsaturated/saturated fats ratio and for lower glycemic index and lower consumption of red/processed meat and sweetened beverages and fruit juices. The ORs and the corresponding 95% confidence intervals (CI) of colorectal cancer according to the DRRD score were obtained using logistic regression models adjusting for total energy intake and other major confounders. Results: The DRRD was inversely related to colorectal cancer risk. The ORs of colorectal cancer were 0.77 (95% CI, 0.67-0.89) for the third versus first score tertile (Ptrend < 0.001) and 0.92 (95% CI, 0.87-0.96) for a 3-point increment in the score. Inverse associations were observed for colon and rectal cancers and were consistent in strata of sex, age, and other major covariates. Conclusions: A higher adherence to a DRRD was inversely associated with colorectal cancer risk. Impact: Given the high incidence and mortality rates of colorectal cancer, adherence to a DRRD can have relevant prevention and public health implications.
MeSH term(s)	Humans ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/prevention & control ; Colorectal Neoplasms/etiology ; Male ; Female ; Case-Control Studies ; Middle Aged ; Aged ; Risk Factors ; Risk Reduction Behavior ; Italy/epidemiology ; Diet/statistics & numerical data ; Diet/adverse effects ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/prevention & control
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-23-1400
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Article ; Online: Larval nutrition impacts survival to adulthood, body size and the allometric scaling of metabolic rate in adult honeybees.

Nicholls, Elizabeth / Rossi, Marta / Niven, Jeremy E

The Journal of experimental biology

2021 Volume 224, Issue 14

Abstract: Resting metabolic rate (RMR) is a fundamental physiological measure linked to numerous aspects of organismal function, including lifespan. Although dietary restriction in insects during larval growth/development affects adult RMR, the impact of the ... ...

Abstract	Resting metabolic rate (RMR) is a fundamental physiological measure linked to numerous aspects of organismal function, including lifespan. Although dietary restriction in insects during larval growth/development affects adult RMR, the impact of the nutritional composition of larval diets (i.e. diet quality) on adult RMR has not been studied. Using in vitro rearing to control larval diet quality, we determined the effect of dietary protein and carbohydrate on honeybee survival to adulthood, time to eclosion, body mass/size and adult RMR. High carbohydrate larval diets increased survival to adulthood and time to eclosion compared with both low carbohydrate and high protein diets. Upon emergence, bees reared on the high protein diet were smaller and lighter than those reared on other diets, whilst those raised on the high carbohydrate diet varied more in body mass. Newly emerged adult bees reared on the high carbohydrate diet showed a significantly steeper increase in allometric scaling of RMR compared with those reared on other diets. This suggests that the nutritional composition of larval diets influences survival to adulthood, time to eclosion and the allometric scaling of RMR. Given that agricultural intensification and increasing urbanisation have led to a decrease in both forage availability and dietary diversity for bees, our results are critical to improving understanding of the impacts of poor developmental nutrition on bee growth/development and physiology.
MeSH term(s)	Animals ; Bees ; Body Size ; Diet ; Dietary Proteins ; Larva ; Nutritional Status
Chemical Substances	Dietary Proteins
Language	English
Publishing date	2021-07-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218085-6
ISSN	1477-9145 ; 0022-0949
ISSN (online)	1477-9145
ISSN	0022-0949
DOI	10.1242/jeb.242393
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Article: Coupled Adsorption and Biodegradation of Trichloroethylene on Biochar from Pine Wood Wastes: A Combined Approach for a Sustainable Bioremediation Strategy

Rossi, Marta M. / Matturro, Bruna / Amanat, Neda / Rossetti, Simona / Petrangeli Papini, Marco

Microorganisms. 2022 Jan. 04, v. 10, no. 1

2022

Abstract: Towards chlorinated solvents, the effectiveness of the remediation strategy can be improved by combining a biological approach (e.g., anaerobic reductive dechlorination) with chemical/physical treatments (e.g., adsorption). A coupled adsorption and ... ...

Abstract	Towards chlorinated solvents, the effectiveness of the remediation strategy can be improved by combining a biological approach (e.g., anaerobic reductive dechlorination) with chemical/physical treatments (e.g., adsorption). A coupled adsorption and biodegradation (CAB) process for trichloroethylene (TCE) removal is proposed in a biofilm–biochar reactor (BBR) to assess whether biochar from pine wood (PWB) can support a dechlorinating biofilm by combining the TCE (100 µM) adsorption. The BBR operated for eight months in parallel with a biofilm reactor (BR)—no PWB (biological process alone), and with an abiotic biochar reactor (ABR)—no dechlorinating biofilm (only an adsorption mechanism). Two flow rates were investigated. Compared to the BR, which resulted in a TCE removal of 86.9 ± 11.9% and 78.73 ± 19.79%, the BBR demonstrated that PWB effectively adsorbs TCE and slows down the release of its intermediates. The elimination of TCE was quantitative, with 99.61 ± 0.79% and 99.87 ± 0.51% TCE removal. Interestingly, the biomarker of the reductive dechlorination process, Dehalococcoides mccartyi, was found in the BRR (9.2 × 10⁵ 16S rRNA gene copies/g), together with the specific genes tceA, bvcA, and vcrA (8.16 × 10⁶, 1.28 × 10⁵, and 8.01 × 10³ gene copies/g, respectively). This study suggests the feasibility of biochar to support the reductive dechlorination of D. mccartyi, opening new frontiers for field-scale applications.
Keywords	Dehalococcoides mccartyi ; adsorption ; biochar ; biodegradation ; biofilm ; biomarkers ; bioremediation ; dechlorination ; genes ; trichloroethylene ; wood
Language	English
Dates of publication	2022-0104
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10010101
Database	NAL-Catalogue (AGRICOLA)

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Article: pH-Responsive Semi-Interpenetrated Polymer Networks of pHEMA/PAA for the Capture of Copper Ions and Corrosion Removal

Guaragnone, Teresa / Rossi, Marta / Chelazzi, David / Mastrangelo, Rosangela / Severi, Mirko / Fratini, Emiliano / Baglioni, Piero

ACS applied materials & interfaces. 2022 Jan. 28, v. 14, no. 5

2022

Abstract: Bronze artifacts constitute a fundamental portion of Cultural Heritage, but effective methodologies for the removal of corrosion layers, such as those produced by the “bronze disease”, are currently missing. We propose the formulation and application of ... ...

Abstract	Bronze artifacts constitute a fundamental portion of Cultural Heritage, but effective methodologies for the removal of corrosion layers, such as those produced by the “bronze disease”, are currently missing. We propose the formulation and application of novel poly(2-hydroxyethyl methacrylate) (pHEMA) networks semi-interpenetrated (SIPN) with poly(acrylic acid) (PAA) to achieve enhanced capture of copper ions and removal of corrosion products. The pHEMA/PAA SIPNs were designed to improve previous pHEMA/poly(vinylpyrrolidone) (PVP) networks, taking advantage of the chelating ability of pH-responsive carboxylic groups in PAA. Increasing the pH ionizes carboxyls, increases the porosity in pHEMA/PAA, and leads to the co-presence of enol and enolate forms of vinylpyrrolidone (VP), changing the macroporosity and decreasing the mesh size in pHEMA/PVP. The ion–matrix interaction is stronger in pHEMA/PAA, where the process occurs through an initial diffusion-limited step followed by diffusion in smaller pores or adsorption by less available sites. In pHEMA/PVP, the uptake is probably controlled by adsorption as expected, considering the porogen role of PVP in the network. Upon application of the SIPNs loaded with tetraethylenpentamine (TEPA) onto corroded bronze, copper oxychlorides dissolve and migrate inside the gels, where Cu(II) ions form ternary complexes with TEPA and carboxylates in PAA or carbonyls in PVP. The removal of oxychlorides is more effective and faster for pHEMA/PAA than its /PVP counterpart. The selective action of the gels preserved the cuprite layers that are needed to passivate bronze against corrosion, and the pH-responsive behavior of pHEMA/PAA allows full control of the uptake and release of the Cu(II)–TEPA complex, making these systems appealing in several fields even beyond Cultural Heritage conservation (e.g., drug delivery, wastewater treatment, agricultural industry, and food chemistry).
Keywords	adsorption ; agricultural industry ; corrosion ; cultural heritage ; drugs ; enols ; food chemistry ; pH ; polyhydroxyethyl methacrylates ; porosity ; wastewater treatment
Language	English
Dates of publication	2022-0128
Size	p. 7471-7485.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c22837
Database	NAL-Catalogue (AGRICOLA)

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Article: Diabetes risk reduction diet and the risk of pancreatic cancer

Turati, Federica / Rossi, Marta / Mattioli, Veronica / Bravi, Francesca / Negri, Eva / La Vecchia, Carlo

European journal of nutrition. 2022 Feb., v. 61, no. 1

2022

Abstract: PURPOSE: To evaluate the role of a diabetes risk reduction diet (DRRD) on pancreatic cancer risk. METHODS: We used data from a hospital-based case–control study conducted in Italy between 1991 and 2008; the study included 326 incident pancreatic cancer ... ...

Abstract	PURPOSE: To evaluate the role of a diabetes risk reduction diet (DRRD) on pancreatic cancer risk. METHODS: We used data from a hospital-based case–control study conducted in Italy between 1991 and 2008; the study included 326 incident pancreatic cancer cases and 652 controls matched by age, gender and study center. Subjects’ usual diet was collected through a valid and reproducible food frequency questionnaire. A DRRD score was derived from 8 dietary components: cereal fiber, total fruit, coffee, polyunsaturated to saturated fats ratio and nuts (higher score for higher intake), and dietary glycemic index, red/processed meat and sugar-sweetened beverages/fruit juices (higher score for lower intake). The score ranged 8–37, with higher values indicating greater DRRD adherence. Odds ratios (ORs) of pancreatic cancer according to the DRRD score were estimated using multiple conditional logistic regression models. RESULTS: After allowance for confounding factors, the DRRD score was inversely related to pancreatic cancer risk, with ORs of 0.55 (95% confidence interval, CI 0.38–0.80) for the highest versus the lowest score tertile (p for trend across tertiles = 0.002) and 0.84 (95% CI 0.75–0.95) for a 3-point score increment. The exclusion of diabetic subjects and additional adjustment for vegetable intake did not change the results. Inverse associations were observed in subgroups defined by age, gender, education, body mass index, smoking and total energy intake. CONCLUSION: Study findings suggest a protective role of high adherence to a DRRD on pancreatic cancer risk.
Keywords	body mass index ; bran ; case-control studies ; confidence interval ; diabetes ; education ; energy intake ; food frequency questionnaires ; fruits ; gender ; glycemic index ; pancreatic neoplasms ; processed meat ; protective effect ; regression analysis ; risk ; risk reduction ; vegetable consumption ; Italy
Language	English
Dates of publication	2022-02
Size	p. 309-316.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-021-02646-5
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Article ; Online: Malpighamoeba infection compromises fluid secretion and P-glycoprotein detoxification in Malpighian tubules.

Rossi, Marta / Ott, Swidbert R / Niven, Jeremy E

Scientific reports

2020 Volume 10, Issue 1, Page(s) 15953

Abstract: Malpighian tubules, analogous to vertebrate nephrons, play a key role in insect osmoregulation and detoxification. Tubules can become infected with a protozoan, Malpighamoeba, which damages their epithelial cells, potentially compromising their function. ...

Abstract	Malpighian tubules, analogous to vertebrate nephrons, play a key role in insect osmoregulation and detoxification. Tubules can become infected with a protozoan, Malpighamoeba, which damages their epithelial cells, potentially compromising their function. Here we used a modified Ramsay assay to quantify the impact of Malpighamoeba infection on fluid secretion and P-glycoprotein-dependent detoxification by desert locust Malpighian tubules. Infected tubules have a greater surface area and a higher fluid secretion rate than uninfected tubules. Infection also impairs P-glycoprotein-dependent detoxification by reducing the net rhodamine extrusion per surface area. However, due to the increased surface area and fluid secretion rate, infected tubules have similar total net extrusion per tubule to uninfected tubules. Increased fluid secretion rate of infected tubules likely exposes locusts to greater water stress and increased energy costs. Coupled with reduced efficiency of P-glycoprotein detoxification per surface area, Malpighamoeba infection is likely to reduce insect survival in natural environments.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Amebiasis/parasitology ; Amoebida/metabolism ; Amoebida/pathogenicity ; Animals ; Biological Transport/physiology ; Bodily Secretions/metabolism ; Epithelial Cells/metabolism ; Grasshoppers/metabolism ; Grasshoppers/parasitology ; Grasshoppers/physiology ; Infections/metabolism ; Malpighian Tubules/microbiology ; Malpighian Tubules/physiology ; Water-Electrolyte Balance
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 1
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-72598-z
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Article: Biochar from Pine Wood, Rice Husks and Iron-Eupatorium Shrubs for Remediation Applications: Surface Characterization and Experimental Tests for Trichloroethylene Removal.

Rossi, Marta M / Silvani, Ludovica / Amanat, Neda / Petrangeli Papini, Marco

Materials (Basel, Switzerland)

2021 Volume 14, Issue 7

Abstract: Nowadays porous materials from organic waste, i.e., Biochar (BC), are receiving increased attention for environmental applications. This study adds information on three BCs that have undergone a number of studies in recent years. A Biochar from pine wood, ...

Abstract	Nowadays porous materials from organic waste, i.e., Biochar (BC), are receiving increased attention for environmental applications. This study adds information on three BCs that have undergone a number of studies in recent years. A Biochar from pine wood, one from rice husk and one from
Language	English
Publishing date	2021-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14071776
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