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  1. Book ; Online: Design Tools

    Bruno, Carmen / Gramegna, Silvia Maria / Mattioli, Francesca / Monna, Vanessa / Rossi, Martina

    A reflection towards the definition of a taxonomy

    (Design International)

    2022  

    Series title Design International
    Keywords Product design ; design tools, taxonomy, design process, design system
    Language 0|e
    Size 1 electronic resource (94 pages)
    Publisher FrancoAngeli
    Publishing place Milan
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021616335
    ISBN 9788835141730 ; 8835141737
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Massive Codesign

    Selloni, Daniela / Meroni, Anna / Rossi, Martina

    2018  

    Abstract: This book focuses on massive codesign: the idea that multiple and/or numerous participants having different voices collaborate in a design process broken down into different steps and formats and resulting in a relevant and diversified amount of data. ... ...

    Abstract This book focuses on massive codesign: the idea that multiple and/or numerous participants having different voices collaborate in a design process broken down into different steps and formats and resulting in a relevant and diversified amount of data. Services, strategies and scenarios are presented as the main field of application: these are complex items that demand complex processes be tackled, processes in which it is necessary to involve a variety of players who are largely interdependent and therefore who must collaborate in order to achieve any goal.The book essentially makes two main contributions: a Collaborative Design Framework to identify and structure codesign activities, methods and tools within massive creative processes; a set of quick lessons learnt to provide guidance to the conception and organisation of other massive creative processes.The whole book is oriented at practice: it discusses codesign activities from the designers point of view, detailing issues such as process from beginning to end, activity flow, manipulability of tools, roles and rules for participants and many others. It is intended as a support for designers dealing in massive codesign processes and aims towards improved results
    Keywords Architecture ; Arts in general
    Size 1 electronic resource ( p.)
    Publisher FrancoAngeli
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020098488
    ISBN 9788891767912 ; 8891767913
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Multicellular Tumor Spheroids in Nanomedicine Research: A Perspective.

    Rossi, Martina / Blasi, Paolo

    Frontiers in medical technology

    2022  Volume 4, Page(s) 909943

    Abstract: Multicellular tumor spheroids are largely exploited in cancer research since they are more predictive than bi-dimensional cell cultures. Nanomedicine would benefit from the integration of this three- ... ...

    Abstract Multicellular tumor spheroids are largely exploited in cancer research since they are more predictive than bi-dimensional cell cultures. Nanomedicine would benefit from the integration of this three-dimensional
    Language English
    Publishing date 2022-06-15
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3129
    ISSN (online) 2673-3129
    DOI 10.3389/fmedt.2022.909943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The four subunits of rabbit skeletal muscle lactate dehydrogenase do not exert their catalytic action additively.

    Rossi, Martina / Tomaselli, Fabio / Hochkoeppler, Alejandro

    Biochemical and biophysical research communications

    2023  Volume 690, Page(s) 149294

    Abstract: Oligomeric enzymes containing multiple active sites are usually considered to perform their catalytic action at higher rates when compared with their monomeric counterparts. This implies, in turn, that the activity performed by different holoenzyme ... ...

    Abstract Oligomeric enzymes containing multiple active sites are usually considered to perform their catalytic action at higher rates when compared with their monomeric counterparts. This implies, in turn, that the activity performed by different holoenzyme subunits features additivity. Nevertheless, the extent of this additivity occurring in holoenzymes is far from being adequately understood. To tackle this point, we used tetrameric rabbit lactate dehydrogenase (rbLDH) as a model system to assay the reduction of pyruvate catalysed by this enzyme at the expense of β-NADH under pre-steady-state conditions. In particular, we observed the kinetics of reactions triggered by concentrations of β-NADH equimolar to 1, 2, 3, or all 4 subunits of the rbLDH holoenzyme, in the presence of an excess of pyruvate. Surprisingly, when the concentration of the limiting reactant exceeded that of a single holoenzyme subunit, we observed a sharp slowdown of the enzyme conformational rearrangements associated to the generation and the release of l-lactate. Furthermore, using a model to interpret the complex kinetics observed under the highest concentration of the limiting reactant, we estimated the diversity of the rates describing the action of the different rbLDH subunits.
    MeSH term(s) Animals ; Rabbits ; L-Lactate Dehydrogenase/metabolism ; NAD/metabolism ; Muscle, Skeletal/metabolism ; Pyruvic Acid ; Holoenzymes ; Kinetics
    Chemical Substances L-Lactate Dehydrogenase (EC 1.1.1.27) ; NAD (0U46U6E8UK) ; Pyruvic Acid (8558G7RUTR) ; Holoenzymes
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.149294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets.

    Rossi, Martina / Abdelmohsen, Kotb

    Cells

    2021  Volume 10, Issue 7

    Abstract: Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics. Senomorphics suppress the traits ... ...

    Abstract Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics. Senomorphics suppress the traits associated with senescence phenotypes, while senolytics aim to clear senescent cells by suppressing their survival and enhancing the apoptotic pathways. The main goal of these approaches is to suppress the proinflammatory senescence-associated secretory phenotype (SASP) and to promote the immune recognition and elimination of senescent cells. One increasingly attractive approach is the targeting of molecules or proteins specifically present on the surface of senescent cells. These proteins may play roles in the maintenance and survival of senescent cells and hence can be targeted for senolysis. In this review, we summarize the recent knowledge regarding senolysis with a focus on novel surface biomarkers of cellular senescence and discuss their emergence as senotherapeutic targets.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Cell Membrane/metabolism ; Cellular Senescence ; Humans ; Membrane Proteins/metabolism ; Molecular Targeted Therapy ; Signal Transduction
    Chemical Substances Biomarkers ; Membrane Proteins
    Language English
    Publishing date 2021-07-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10071740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Potential of Honeybee Products for Biomaterial Applications.

    Rossi, Martina / Marrazzo, Pasquale

    Biomimetics (Basel, Switzerland)

    2021  Volume 6, Issue 1

    Abstract: The development of biomaterials required continuous improvements in their properties for new tissue engineering applications. Implants based on biocompatible materials and biomaterial-based dressings are susceptible to infection threat; moreover, target ... ...

    Abstract The development of biomaterials required continuous improvements in their properties for new tissue engineering applications. Implants based on biocompatible materials and biomaterial-based dressings are susceptible to infection threat; moreover, target tissues can suffer injuring inflammation. The inclusion of nature-derived bioactive compounds usually offers a suitable strategy to expand or increase the functional properties of biomaterial scaffolds and can even promote tissue healing. Honey is traditionally known for its healing property and is a mixture of phytochemicals that have a proven reputation as antimicrobial, anti-inflammatory, and antioxidant agents. This review discusses on the potential of honey and other honeybee products for biomaterial improvements. Our study illustrates the available and most recent literature reporting the use of these natural products combined with different polymeric scaffolds, to provide original insights in wound healing and other tissue regenerative approaches.
    Language English
    Publishing date 2021-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics6010006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging.

    Rossi, Martina / Gorospe, Myriam

    Trends in molecular medicine

    2020  Volume 26, Issue 4, Page(s) 422–433

    Abstract: Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can eventually lead to pathology such as cardiovascular and neurodegenerative diseases, cancer, and ... ...

    Abstract Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can eventually lead to pathology such as cardiovascular and neurodegenerative diseases, cancer, and diabetes. A prominent molecular process underlying aging is the progressive shortening of telomeres, the structures that protect the ends of chromosomes, eventually triggering cellular senescence. Noncoding (nc)RNAs are emerging as major regulators of telomere length homeostasis. In this review, we describe the impact of ncRNAs on telomere function and discuss their implications in senescence and age-related diseases. We discuss emerging therapeutic strategies targeting telomere-regulatory ncRNAs in aging pathology.
    MeSH term(s) Aging/genetics ; Animals ; Cellular Senescence/genetics ; Homeostasis/genetics ; Humans ; RNA, Untranslated/genetics ; Telomere/genetics ; Telomere Homeostasis/genetics
    Chemical Substances RNA, Untranslated
    Language English
    Publishing date 2020-02-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2020.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4345: Show issues Location:
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  8. Article: Nanospermidine in Combination with Nanofenretinide Induces Cell Death in Neuroblastoma Cell Lines.

    Lodeserto, Pietro / Rossi, Martina / Blasi, Paolo / Farruggia, Giovanna / Orienti, Isabella

    Pharmaceutics

    2022  Volume 14, Issue 6

    Abstract: A new strategy to cause cell death in tumors might be the increase of intracellular polyamines at concentrations above their physiological values to trigger the production of oxidation metabolites at levels exceeding cell tolerance. To test this ... ...

    Abstract A new strategy to cause cell death in tumors might be the increase of intracellular polyamines at concentrations above their physiological values to trigger the production of oxidation metabolites at levels exceeding cell tolerance. To test this hypothesis, we prepared nanospermidine as a carrier for spermidine penetration into the cells, able to escape the polyamine transport system that strictly regulates intracellular polyamine levels. Nanospermidine was prepared by spermidine encapsulation in nanomicelles and was characterized by size, zeta potential, loading, dimensional stability to dilution, and stability to spermidine leakage. Antitumor activity, ROS production, and cell penetration ability were evaluated in vitro in two neuroblastoma cell lines (NLF and BR6). Nanospermidine was tested as a single agent and in combination with nanofenretinide. Free spermidine was also tested as a comparison. The results indicated that the nanomicelles successfully transported spermidine into the cells inducing cell death in a concentration range (150-200 μM) tenfold lower than that required to provide similar cytotoxicity with free spermidine (1500-2000 μM). Nanofenretinide provided a cytostatic effect in combination with the lowest nanospermidine concentrations evaluated and slightly improved nanospermidine cytotoxicity at the highest concentrations. These data suggest that nanospermidine has the potential to become a new approach in cancer treatment. At the cellular level, in fact, it exploits polyamine catabolism by means of biocompatible doses of spermidine and, in vivo settings, it can exploit the selective accumulation of nanomedicines at the tumor site. Nanofenretinide combination further improves its efficacy. Furthermore, the proven ability of spermidine to activate macrophages and lymphocytes suggests that nanospermidine could inhibit immunosuppression in the tumor environment.
    Language English
    Publishing date 2022-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14061215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Warning regarding hematological toxicity of tamoxifen activated CreERT2 in young Rosa26CreERT2 mice.

    Rossi, Martina / Salomon, Aude / Chaumontel, Nicolas / Molet, Jenny / Bailly, Sabine / Tillet, Emmanuelle / Bouvard, Claire

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5976

    Abstract: The Cre-lox system is a versatile and powerful tool used in mouse genetics. It allows spatial and/or temporal control of the deletion of a target gene. The Rosa26-CreERT2 (R26CreERT2) mouse model allows ubiquitous expression of CreERT2. Once activated by ...

    Abstract The Cre-lox system is a versatile and powerful tool used in mouse genetics. It allows spatial and/or temporal control of the deletion of a target gene. The Rosa26-CreERT2 (R26CreERT2) mouse model allows ubiquitous expression of CreERT2. Once activated by tamoxifen, CreERT2 will enter into the nuclei and delete floxed DNA sequences. Here, we show that intraperitoneal injection of tamoxifen in young R26CreERT2 mice leads to morbidity and mortality within 10 days after the first injection, in the absence of a floxed allele. Activation of CreERT2 by tamoxifen led to severe hematological defects, with anemia and a strong disorganization of the bone marrow vascular bed. Cell proliferation was significantly reduced in the bone marrow and the spleen resulting in the depletion of several hematopoietic cells. However, not all cell types or organs were affected to the same extent. We realized that many research groups are not aware of the potential toxicity of Cre recombinases, resulting in misinterpretation of the observed phenotype and in a waste of time and resources. We discuss the necessity to include tamoxifen injected CreERT2 controls lacking a floxed allele in experimental designs and to improve communication about the limitations of Cre-lox mouse models among the scientific community.
    MeSH term(s) Mice ; Animals ; Mice, Transgenic ; Tamoxifen/toxicity ; Disease Models, Animal ; Integrases/genetics ; Integrases/metabolism
    Chemical Substances Tamoxifen (094ZI81Y45) ; Integrases (EC 2.7.7.-)
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32633-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: School-Based Meditation and Interoceptive Awareness Program for Preventing Somatic Symptoms: The Role of Emotional Awareness.

    Rossi, Martina / Rossi, Stefano / Diari, Laura / Ciaramella, Antonella

    Advances in mind-body medicine

    2020  Volume 34, Issue 4, Page(s) 17–23

    Abstract: Although meditation has been used to alleviate somatic symptoms in adults, there is little literature on this issue in children. School-based meditation programs are mainly used to increase attention control and self-awareness in children. Here, however, ...

    Abstract Although meditation has been used to alleviate somatic symptoms in adults, there is little literature on this issue in children. School-based meditation programs are mainly used to increase attention control and self-awareness in children. Here, however, we evaluate the effects of a three-month school-based psychoeducational meditation and interoceptive awareness program (EETB) on somatic symptoms in 281 children (126 females and 155 males) aged 6-9 years. Outcome measures were scores on the Children's Somatisation Inventory (CSI) and KidScreen-10 for quality of life (QoL), administered at baseline and over the three-month program. ANOVA repeated measures showed a reduction in somatic symptoms (F = 46.43; P < .0001; η = .14; Cohen's d effect size: 0.538) while there was little effect on QoL (F = 4.63, P = .003; η = 0.016; Cohen's d effect size: 0.010). Emotional awareness (EA) influenced QoL, but not CSI outcome. The EETB program is effective at reducing somatic symptoms, even one month after baseline. As EA cognitive abilities increase after age 8, the application of this project in even younger children indicates that a state of general well-being requires enough emotional awareness to be perceived.
    MeSH term(s) Awareness ; Child ; Emotions ; Female ; Humans ; Interoception ; Male ; Medically Unexplained Symptoms ; Meditation ; Quality of Life/psychology ; Role ; Schools
    Language English
    Publishing date 2020-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1425573-x
    ISSN 1532-1843 ; 1470-3556 ; 0741-9783
    ISSN (online) 1532-1843
    ISSN 1470-3556 ; 0741-9783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2788: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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