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  1. AU="Rossi, Simone"
  2. AU="Bryan, Nathan S."
  3. AU="Sodhi, Sohail"
  4. AU="Sotiropoulos, Thodoris"
  5. AU="Osborne, Cameron"
  6. AU="Seira, Jordan"
  7. AU="Komiya, Ryota"
  8. AU="Yeonsoo Joe"
  9. AU="Christina Drake"
  10. AU="Rosenbloom, E Scott"
  11. AU="Clémentine Schilte"
  12. AU="Montanari, Andrea"
  13. AU="Salehi Karizmeh, Mojtaba"
  14. AU="Svanberg Frisinger, Frida"
  15. AU="Iyappan, Petchi"
  16. AU="Naomi Nakagata"
  17. AU="Marianne A. van der Sande"
  18. AU="Reno, Chiara"

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  1. Artikel ; Online: Student evaluation of an instructional video on how to use a national medicines information resource.

    Tait, Kirsty / Gandhi, Jimit / Ward, Michael / Calabretto, Jean-Pierre / Rossi, Simone

    The International journal of pharmacy practice

    2024  Band 32, Heft 3, Seite(n) 251–255

    Abstract: Objectives: The objective of this project was to obtain students' perception of an educational companion video designed to increase the understanding of a national medicines information resource.: Methods: An instructional video was developed to ... ...

    Abstract Objectives: The objective of this project was to obtain students' perception of an educational companion video designed to increase the understanding of a national medicines information resource.
    Methods: An instructional video was developed to guide students in utilizing the online version of the Australian Medicines Handbook (AMH). All students enrolled in the Bachelor of Pharmacy program during 2021 were given access to this video. A cross-sectional electronic survey was administered to evaluate the video's effectiveness and its impact on students' confidence. The survey results were analysed using both descriptive and inferential statistics, in addition to qualitative analysis to identify common themes. Ethics approval was obtained prior to conducting the study.
    Key findings: Most students (78%; n = 72/92) reported that watching the video increased their understanding. The most growth in confidence was seen by students in their first or second year of study. Fifty-four percent (n = 48/89) of students was very likely or extremely likely to recommend the video to others, and 37% (n = 33/89) of students were somewhat likely. Students found the instructional video to be useful and expressed a desire for similar content to be integrated into other facets of teaching. The audio-visual mode of delivery was regarded as effective for this context. Constructive feedback included suggestions of incorporating more advanced educational features such as how to interpret comparative medication charts and interaction checkers.
    Conclusions: The 'How to use the AMH' video is a good introductory resource for undergraduate Australian healthcare students. Our results indicate that this video would be best suited to complement the teaching of students early on in their studies.
    Mesh-Begriff(e) Humans ; Students, Pharmacy/psychology ; Cross-Sectional Studies ; Australia ; Education, Pharmacy/methods ; Female ; Male ; Surveys and Questionnaires ; Video Recording ; Young Adult ; Adult
    Sprache Englisch
    Erscheinungsdatum 2024-04-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1087040-4
    ISSN 2042-7174 ; 0961-7671
    ISSN (online) 2042-7174
    ISSN 0961-7671
    DOI 10.1093/ijpp/riae010
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  2. Buch ; Online: On permutation symmetries in Bayesian neural network posteriors

    Rossi, Simone / Singh, Ankit / Hannagan, Thomas

    a variational perspective

    2023  

    Abstract: The elusive nature of gradient-based optimization in neural networks is tied to their loss landscape geometry, which is poorly understood. However recent work has brought solid evidence that there is essentially no loss barrier between the local ... ...

    Abstract The elusive nature of gradient-based optimization in neural networks is tied to their loss landscape geometry, which is poorly understood. However recent work has brought solid evidence that there is essentially no loss barrier between the local solutions of gradient descent, once accounting for weight-permutations that leave the network's computation unchanged. This raises questions for approximate inference in Bayesian neural networks (BNNs), where we are interested in marginalizing over multiple points in the loss landscape. In this work, we first extend the formalism of marginalized loss barrier and solution interpolation to BNNs, before proposing a matching algorithm to search for linearly connected solutions. This is achieved by aligning the distributions of two independent approximate Bayesian solutions with respect to permutation matrices. We build on the results of Ainsworth et al. (2023), reframing the problem as a combinatorial optimization one, using an approximation to the sum of bilinear assignment problem. We then experiment on a variety of architectures and datasets, finding nearly zero marginalized loss barriers for linearly connected solutions.
    Schlagwörter Statistics - Machine Learning ; Computer Science - Machine Learning
    Thema/Rubrik (Code) 006
    Erscheinungsdatum 2023-10-16
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Buch ; Online: Class Balanced Dynamic Acquisition for Domain Adaptive Semantic Segmentation using Active Learning

    Schachtsiek, Marc / Rossi, Simone / Hannagan, Thomas

    2023  

    Abstract: Domain adaptive active learning is leading the charge in label-efficient training of neural networks. For semantic segmentation, state-of-the-art models jointly use two criteria of uncertainty and diversity to select training labels, combined with a ... ...

    Abstract Domain adaptive active learning is leading the charge in label-efficient training of neural networks. For semantic segmentation, state-of-the-art models jointly use two criteria of uncertainty and diversity to select training labels, combined with a pixel-wise acquisition strategy. However, we show that such methods currently suffer from a class imbalance issue which degrades their performance for larger active learning budgets. We then introduce Class Balanced Dynamic Acquisition (CBDA), a novel active learning method that mitigates this issue, especially in high-budget regimes. The more balanced labels increase minority class performance, which in turn allows the model to outperform the previous baseline by 0.6, 1.7, and 2.4 mIoU for budgets of 5%, 10%, and 20%, respectively. Additionally, the focus on minority classes leads to improvements of the minimum class performance of 0.5, 2.9, and 4.6 IoU respectively. The top-performing model even exceeds the fully supervised baseline, showing that a more balanced label than the entire ground truth can be beneficial.

    Comment: NeurIPS 2023 Workshop on Adaptive Experimental Design and Active Learning in the Real World
    Schlagwörter Computer Science - Computer Vision and Pattern Recognition ; Statistics - Machine Learning
    Thema/Rubrik (Code) 004
    Erscheinungsdatum 2023-11-23
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: How Much Is Enough? A Study on Diffusion Times in Score-Based Generative Models.

    Franzese, Giulio / Rossi, Simone / Yang, Lixuan / Finamore, Alessandro / Rossi, Dario / Filippone, Maurizio / Michiardi, Pietro

    Entropy (Basel, Switzerland)

    2023  Band 25, Heft 4

    Abstract: Score-based diffusion models are a class of generative models whose dynamics is described by stochastic differential equations that map noise into data. While recent works have started to lay down a theoretical foundation for these models, a detailed ... ...

    Abstract Score-based diffusion models are a class of generative models whose dynamics is described by stochastic differential equations that map noise into data. While recent works have started to lay down a theoretical foundation for these models, a detailed understanding of the role of the diffusion time
    Sprache Englisch
    Erscheinungsdatum 2023-04-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25040633
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  5. Artikel: Noninvasive brain stimulation and brain oscillations.

    Rossi, Simone / Santarnecchi, Emiliano / Feurra, Matteo

    Handbook of clinical neurology

    2021  Band 184, Seite(n) 239–247

    Abstract: Recent technological advances in the field of noninvasive brain stimulation (NIBS) have allowed to interact with endogenous brain oscillatory activity, the main neural communication code of our brain, opening new scenarios for transient modifications of ... ...

    Abstract Recent technological advances in the field of noninvasive brain stimulation (NIBS) have allowed to interact with endogenous brain oscillatory activity, the main neural communication code of our brain, opening new scenarios for transient modifications of cognitive and behavioral performances: such a possibility can be capitalized both for research purposes in healthy subjects, as well as in the context of therapeutic and rehabilitative settings. Among NiBS methodologies, transcranial magnetic stimulation (TMS) has been the first used to this purpose, and also thanks to the technical development of TMS-EEG co-registering systems, the mechanistic knowledge regarding the role of brain oscillations has been improved. Another approach to brain oscillations considers electric stimulation methods, such as transcranial direct current stimulation (tDCS), and especially transcranial alternating current stimulation (tACS), for which -however- some technical and conceptual caveats have emerged. In this chapter, we briefly review the uses of NiBS in this field up to now, by providing an update on the current status of research applications as well as of its attempts of exploitation in translational clinical applications, especially regarding motor disorders and for understanding and reducing some psychiatric symptoms.
    Mesh-Begriff(e) Brain ; Humans ; Mental Disorders ; Transcranial Direct Current Stimulation ; Transcranial Magnetic Stimulation
    Sprache Englisch
    Erscheinungsdatum 2021-06-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-12-819410-2.00013-8
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  6. Artikel: Modulation of Corticospinal Excitability during Action Observation in Patients with Disorders of Consciousness.

    Mancuso, Mauro / Mencarelli, Lucia / Abbruzzese, Laura / Basagni, Benedetta / Zoccolotti, Pierluigi / Scarselli, Cristiano / Capitani, Simone / Neri, Francesco / Santarnecchi, Emiliano / Rossi, Simone

    Brain sciences

    2024  Band 14, Heft 4

    Abstract: Brain imaging studies have recently provided some evidence in favor of covert cognitive processes that are ongoing in patients with disorders of consciousness (DoC) (e.g., a minimally conscious state and vegetative state/unresponsive wakefulness syndrome) ...

    Abstract Brain imaging studies have recently provided some evidence in favor of covert cognitive processes that are ongoing in patients with disorders of consciousness (DoC) (e.g., a minimally conscious state and vegetative state/unresponsive wakefulness syndrome) when engaged in passive sensory stimulation or active tasks such as motor imagery. In this exploratory study, we used transcranial magnetic stimulation (TMS) of the motor cortex to assess modulations of corticospinal excitability induced by action observation in eleven patients with DoC. Action observation is known to facilitate corticospinal excitability in healthy subjects, unveiling how the observer's motor system maps others' actions onto her/his motor repertoire. Additional stimuli were non-biological motion and acoustic startle stimuli, considering that sudden and loud acoustic stimulation is known to lower corticospinal excitability in healthy subjects. The results indicate that some form of motor resonance is spared in a subset of patients with DoC, with some significant difference between biological and non-biological motion stimuli. However, there was no covariation between corticospinal excitability and the type of DoC diagnosis (i.e., whether diagnosed with VS/UWS or MCS). Similarly, no covariation was detected with clinical changes between admission and discharge in clinical outcome measures. Both motor resonance and the difference between the resonance with biological/non-biological motion discrimination correlated with the amplitude of the N20 somatosensory evoked potentials, following the stimulation of the median nerve at the wrist (i.e., the temporal marker signaling the activation of the contralateral primary somatosensory cortex). Moreover, the startle-evoking stimulus produced an anomalous increase in corticospinal excitability, suggesting a functional dissociation between cortical and subcortical circuits in patients with DoC. Further work is needed to better comprehend the conditions in which corticospinal facilitation occurs and whether and how they may relate to individual clinical parameters.
    Sprache Englisch
    Erscheinungsdatum 2024-04-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14040371
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  7. Artikel ; Online: Life cycle assessment of biostimulant production from algal biomass grown on piggery wastewater.

    Rojo, Elena M / Rossi, Simone / Bolado, Silvia / Stampino, Paola Gallo / Ficara, Elena / Dotelli, Giovanni

    The Science of the total environment

    2023  Band 907, Seite(n) 168083

    Abstract: Piggery wastewater has become a large source of pollution with high concentrations of nutrients, that must be managed and properly treated to increase its environmental viability. Currently, the use of microalgae for treating this type of wastewater has ... ...

    Abstract Piggery wastewater has become a large source of pollution with high concentrations of nutrients, that must be managed and properly treated to increase its environmental viability. Currently, the use of microalgae for treating this type of wastewater has emerged as a sustainable process with several benefits, including nutrient recovery to produce valuable products such as biostimulants, and CO
    Mesh-Begriff(e) Humans ; Animals ; Wastewater ; Carbon Dioxide ; Biomass ; Ecosystem ; Gases ; Microalgae ; Life Cycle Stages ; Biofuels
    Chemische Substanzen Wastewater ; Carbon Dioxide (142M471B3J) ; Gases ; Biofuels
    Sprache Englisch
    Erscheinungsdatum 2023-10-24
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.168083
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  8. Artikel ; Online: Removal of pharmaceutical compounds from the liquid phase of anaerobic sludge in a pilot-scale high-rate algae-bacteria pond.

    Mantovani, Marco / Rossi, Simone / Ficara, Elena / Collina, Elena / Marazzi, Francesca / Lasagni, Marina / Mezzanotte, Valeria

    The Science of the total environment

    2023  Band 908, Seite(n) 167881

    Abstract: This study evaluates the effectiveness of a pilot-scale high-rate algae-bacteria pond (HRAP) to remove pharmaceutical compounds (PhACs) from municipal centrate. The studied PhACs belonged to different classes of synthetic active compounds: ... ...

    Abstract This study evaluates the effectiveness of a pilot-scale high-rate algae-bacteria pond (HRAP) to remove pharmaceutical compounds (PhACs) from municipal centrate. The studied PhACs belonged to different classes of synthetic active compounds: antihypertensives, antiepileptics, antidepressants, neuroprotectors, and anti-inflammatory drugs. The HRAP, growing a mixed microalgal consortium made of Chlorella spp. and Scenedesmus spp., was operated in continuous mode (6 days hydraulic retention time) from May to November 2021. Removal efficiencies were high (>85 %) for Sulfamethoxazole and Lamotrigine, promising (65-70 %) for Metoprolol, Fluoxetine, and Diclofenac but low (30-40 %) for Amisulpride, Ofloxacin, Carbamazepine, and Clarithromycin. Propyphenazone and Irbesartan were not removed, and their concentrations increased after the treatment. The combination of abiotic and biotic drivers (mostly global radiation and the synergy between microalgae and bacteria metabolisms) fostered photo and biodegradation processes. Overall, results suggest that microalgae-based systems can be a valuable solution to remove PhACs from wastewater.
    Mesh-Begriff(e) Sewage ; Waste Disposal, Fluid/methods ; Ponds/microbiology ; Chlorella ; Anaerobiosis ; Bacteria ; Pharmaceutical Preparations/metabolism ; Microalgae/metabolism ; Biomass
    Chemische Substanzen Sewage ; Pharmaceutical Preparations
    Sprache Englisch
    Erscheinungsdatum 2023-10-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.167881
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  9. Artikel ; Online: One century of healing currents into the brain from the scalp: From electroconvulsive therapy to repetitive transcranial magnetic stimulation for neuropsychiatric disorders.

    Di Iorio, Riccardo / Rossi, Simone / Rossini, Paolo M

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2021  Band 133, Seite(n) 145–151

    Abstract: Electroconvulsive therapy (ECT) was applied for the first time in humans in 1938: after 80 years, it remains conceptually similar today except for modifications of the original protocol aimed to reduce adverse effects (as persistent memory deficits) ... ...

    Abstract Electroconvulsive therapy (ECT) was applied for the first time in humans in 1938: after 80 years, it remains conceptually similar today except for modifications of the original protocol aimed to reduce adverse effects (as persistent memory deficits) without losing clinical efficacy. We illustrate the stages of development as well as ups and downs of ECT use in the last eighty years, and the impact that it still maintains for treatment of certain psychiatric conditions. Targeted, individualized and safe noninvasive neuromodulatory interventions are now possible for many neuropsychiatric disorders thanks to repetitive transcranial magnetic stimulation (rTMS) that injects currents in the brain through electromagnetic induction, powerful enough to depolarize cortical neurons and related networks. Although ECT and rTMS differ in basic concepts, mechanisms, tolerability, side effects and acceptability, and beyond their conceptual remoteness (ECT) or proximity (rTMS) to "precision medicine" approaches, the two brain stimulation techniques may be considered as complementary rather than competing in the current treatment of certain neuropsychiatric disorders.
    Mesh-Begriff(e) Depressive Disorder/therapy ; Electroconvulsive Therapy/history ; Electroconvulsive Therapy/methods ; History, 20th Century ; History, 21st Century ; Humans ; Transcranial Magnetic Stimulation/history ; Transcranial Magnetic Stimulation/methods
    Sprache Englisch
    Erscheinungsdatum 2021-11-11
    Erscheinungsland Netherlands
    Dokumenttyp Historical Article ; Journal Article ; Review
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2021.10.014
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  10. Artikel ; Online: Embedded Computational Heart Model for External Ventricular Assist Device Investigations.

    Kummer, Thomas / Rossi, Simone / Vandenberghe, Stijn / Demertzis, Stefanos / Jenny, Patrick

    Cardiovascular engineering and technology

    2022  Band 13, Heft 5, Seite(n) 764–782

    Abstract: Purpose: External cardiac assist devices are based on a promising and simple concept for treating heart failure, but they are surprisingly difficult to design. Thus, a structured approach combining experiments with computer-based optimization is ... ...

    Abstract Purpose: External cardiac assist devices are based on a promising and simple concept for treating heart failure, but they are surprisingly difficult to design. Thus, a structured approach combining experiments with computer-based optimization is essential. The latter provides the motivation for the work presented in this paper.
    Methods: We present a computational modeling framework for realistic representation of the heart's tissue structure, electrophysiology and actuation. The passive heart tissue is described by a nonlinear anisotropic material law, considering fiber and sheetlet directions. For muscle contraction, an orthotropic active-strain model is employed, initiated by a periodically propagating electrical potential. The model allows for boundary conditions at the epicardium accounting for external assist devices, and it is coupled to a circulation network providing appropriate pressure boundary conditions inside the ventricles.
    Results: Simulated results from an unsupported healthy and a pathological heart model are presented and reproduce accurate deformations compared to phenomenological measurements. Moreover, cardiac output and ventricular pressure signals are in good agreement too. By investigating the impact of applying an exemplary external actuation to the pathological heart model, it shows that cardiac patches can restore a healthy blood flow.
    Conclusion: We demonstrate that the devised computational modeling framework is capable of predicting characteristic trends (e.g. apex shortening, wall thickening and apex twisting) of a healthy heart, and that it can be used to study pathological hearts and external activation thereof.
    Mesh-Begriff(e) Humans ; Heart-Assist Devices ; Models, Cardiovascular ; Heart/physiology ; Heart Ventricles ; Heart Failure/therapy ; Computer Simulation
    Sprache Englisch
    Erscheinungsdatum 2022-03-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2543111-0
    ISSN 1869-4098 ; 1869-408X
    ISSN (online) 1869-4098
    ISSN 1869-408X
    DOI 10.1007/s13239-022-00610-w
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