Result 1 - 10 of total 484
Outre-Terre, N 57, 2, 2020-07-23, pp.21-22
2020
| Keywords | covid19 |
|---|---|
| Language | French |
| Publishing country | fr |
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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Chemistry (Weinheim an der Bergstrasse, Germany)
2023 Volume 29, Issue 45, Page(s) e202300755
Abstract: An increase in the click-to-release reaction rate between cleavable trans-cyclooctenes (TCO) and tetrazines would be beneficial for drug delivery applications. In this work, we have developed a short and stereoselective synthesis route towards highly ... ...
| Abstract | An increase in the click-to-release reaction rate between cleavable trans-cyclooctenes (TCO) and tetrazines would be beneficial for drug delivery applications. In this work, we have developed a short and stereoselective synthesis route towards highly reactive sTCOs that serve as cleavable linkers, affording quantitative tetrazine-triggered payload release. In addition, the fivefold more reactive sTCO exhibited the same in vivo stability as current TCO linkers when used as antibody linkers in circulation in mice. |
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| MeSH term(s) | Animals ; Mice ; Cyclooctanes/chemistry ; Drug Delivery Systems |
| Chemical Substances | Cyclooctanes |
| Language | English |
| Publishing date | 2023-07-14 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 1478547-X |
| ISSN | 1521-3765 ; 0947-6539 |
| ISSN (online) | 1521-3765 |
| ISSN | 0947-6539 |
| DOI | 10.1002/chem.202300755 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2022 Volume 19, Issue 11, Page(s) 4111–4122
Abstract: Small molecule imaging agents such as [ ...
| Abstract | Small molecule imaging agents such as [ |
|---|---|
| MeSH term(s) | Animals ; Mice ; Mannose ; Immunoconjugates/pharmacology ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Mice, Transgenic ; Amyloid/metabolism ; Antibodies/metabolism ; Disease Progression ; Neuroimaging ; Positron-Emission Tomography/methods |
| Chemical Substances | Mannose (PHA4727WTP) ; Immunoconjugates ; Amyloid beta-Peptides ; Amyloid ; Antibodies |
| Language | English |
| Publishing date | 2022-10-06 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2138405-8 |
| ISSN | 1543-8392 ; 1543-8384 |
| ISSN (online) | 1543-8392 |
| ISSN | 1543-8384 |
| DOI | 10.1021/acs.molpharmaceut.2c00536 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6250: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Current opinion in chemical biology
2014 Volume 21, Page(s) 161–169
Abstract: Following the successful application of in vivo chemistry in chemical biology there has been growing interest in extending the application scope to non-invasive molecular imaging and therapy in living animals and eventually humans. A typical example of ... ...
| Abstract | Following the successful application of in vivo chemistry in chemical biology there has been growing interest in extending the application scope to non-invasive molecular imaging and therapy in living animals and eventually humans. A typical example of such an application is pretargeted radioimmuno-imaging and -therapy: the tumor targeting of a tagged antibody followed by administration and binding of a small radiolabeled probe to the tag of the tumor-bound antibody. In this review, we describe the requirements to take the step to non-invasive applications in animals, summarize recent achievements in this field, and we offer a perspective on future developments. |
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| MeSH term(s) | Alkynes/chemistry ; Animals ; Azides/chemistry ; Biochemistry/methods ; Cycloaddition Reaction ; Electron Transport ; Humans ; Mice ; Molecular Imaging/methods |
| Chemical Substances | Alkynes ; Azides |
| Language | English |
| Publishing date | 2014-08 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 1439176-4 |
| ISSN | 1879-0402 ; 1367-5931 |
| ISSN (online) | 1879-0402 |
| ISSN | 1367-5931 |
| DOI | 10.1016/j.cbpa.2014.07.023 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4986: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 13, Issue 12, Page(s) 4004–4015
Abstract: One of the main challenges of PET imaging ... ...
| Abstract | One of the main challenges of PET imaging with |
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| MeSH term(s) | Animals ; Mice ; Trastuzumab ; Radioimmunodetection ; Antibodies, Monoclonal/chemistry ; Positron-Emission Tomography/methods ; Neoplasms ; Cyclooctanes/chemistry ; Cell Line, Tumor ; Zirconium/chemistry |
| Chemical Substances | Trastuzumab (P188ANX8CK) ; Antibodies, Monoclonal ; Cyclooctanes ; Zirconium (C6V6S92N3C) |
| Language | English |
| Publishing date | 2023-07-09 |
| Publishing country | Australia |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2592097-2 |
| ISSN | 1838-7640 ; 1838-7640 |
| ISSN (online) | 1838-7640 |
| ISSN | 1838-7640 |
| DOI | 10.7150/thno.84865 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2017 Volume 152, Page(s) 462–469
Abstract: Artisanal and small-scale gold mining (ASGM) is a crucial economic activity in Burkina Faso, however it is associated with significant mercury exposure and health concerns. The aim of the present study was to assess the level of mercury (Hg) vapour ... ...
| Abstract | Artisanal and small-scale gold mining (ASGM) is a crucial economic activity in Burkina Faso, however it is associated with significant mercury exposure and health concerns. The aim of the present study was to assess the level of mercury (Hg) vapour exposures and occupational behaviours at a representative site using Hg vapour monitor badges and questionnaires. To our knowledge this is the first time that personal exposure to Hg vapour during ASGM activities has been reported. The study population were ASGM workers who completed a questionnaire (n=100) or participated with an occupational exposure assessment using commercially available passive Hg vapour samplers (n=44). Occupational exposure to Hg was high during open-air burn events with a time weighted average (TWA) exposure of 7026±6857µg/m |
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| MeSH term(s) | Adult ; Air Pollutants/analysis ; Burkina Faso ; Environmental Exposure ; Environmental Monitoring/methods ; Female ; Gases/analysis ; Humans ; Male ; Mercury/analysis ; Middle Aged ; Miners ; Occupational Exposure ; Young Adult |
| Chemical Substances | Air Pollutants ; Gases ; Mercury (FXS1BY2PGL) |
| Language | English |
| Publishing date | 2017-01 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 205699-9 |
| ISSN | 1096-0953 ; 0013-9351 |
| ISSN (online) | 1096-0953 |
| ISSN | 0013-9351 |
| DOI | 10.1016/j.envres.2016.06.004 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 726: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Anti-cancer agents in medicinal chemistry
2012 Volume 12, Issue 5, Page(s) 462–475
Abstract: Radiolabeled peptides hold promise for diagnosis and therapy of cancer as well as for early monitoring of therapy outcomes, patient stratification, etc. This manuscript focuses on the development of peptides labeled with 18F, 64Cu, 68Ga and other ... ...
| Abstract | Radiolabeled peptides hold promise for diagnosis and therapy of cancer as well as for early monitoring of therapy outcomes, patient stratification, etc. This manuscript focuses on the development of peptides labeled with 18F, 64Cu, 68Ga and other positron-emitting radionuclides for PET imaging. The major techniques for radionuclide incorporation are briefly discussed. Then, examples of positron-emitting peptides targeting somatostatin receptors, integrins, gastrin-releasing peptide receptors, vasointestinal peptide receptors, melanocortin 1 receptors and others are reviewed. |
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| MeSH term(s) | Animals ; Humans ; Models, Molecular ; Molecular Imaging/methods ; Neoplasms/diagnosis ; Neoplasms/diagnostic imaging ; Neoplasms/metabolism ; Peptides/chemistry ; Peptides/metabolism ; Positron-Emission Tomography/methods ; Radioisotopes/chemistry ; Radioisotopes/metabolism |
| Chemical Substances | Peptides ; Radioisotopes |
| Language | English |
| Publishing date | 2012-01-18 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Review |
| ZDB-ID | 2217610-X |
| ISSN | 1875-5992 ; 1871-5206 |
| ISSN (online) | 1875-5992 |
| ISSN | 1871-5206 |
| DOI | 10.2174/187152012800617812 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5583: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Molecules (Basel, Switzerland)
2020 Volume 25, Issue 3
Abstract: The bioorthogonal reaction between a tetrazine and strained transcyclooctene (TCO) has garnered success in pretargeted imaging. This reaction was first validated in nuclear imaging using ... ...
| Abstract | The bioorthogonal reaction between a tetrazine and strained transcyclooctene (TCO) has garnered success in pretargeted imaging. This reaction was first validated in nuclear imaging using an |
|---|---|
| MeSH term(s) | Animals ; Cell Line, Tumor ; Female ; Gallium Radioisotopes/analysis ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Positron-Emission Tomography/methods ; Tomography, Emission-Computed, Single-Photon/methods |
| Chemical Substances | Gallium Radioisotopes ; Gallium-68 (98B30EPP5S) |
| Language | English |
| Publishing date | 2020-01-22 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 1413402-0 |
| ISSN | 1420-3049 ; 1431-5165 ; 1420-3049 |
| ISSN (online) | 1420-3049 |
| ISSN | 1431-5165 ; 1420-3049 |
| DOI | 10.3390/molecules25030463 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.MO 81: Show issues |
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2008 Volume 52, Issue 3, Page(s) 267–277
Abstract: Recent advances in the field of nanomedicine offer the promise of better diagnostic and therapeutic options. Synthetic chemists are making strides in developing nanoparticle constructs that can be used as platforms for attaching different functionalities ...
| Abstract | Recent advances in the field of nanomedicine offer the promise of better diagnostic and therapeutic options. Synthetic chemists are making strides in developing nanoparticle constructs that can be used as platforms for attaching different functionalities for the purposes of molecular imaging and targeted drug delivery. As new nanoparticles are developed, it is imperative to evaluate their biological effectiveness by in vitro and in vivo screening techniques. While the in vitro results give insight into the cellular structure and function at sub-cellular level, the in vivo and ex vivo data give vital information about the pharmacokinetics of these novel particles, along with their ability to reach the desired target. This three-way information is pertinent to developing effective drugs and imaging probes for targeting key cancer/inflammation biomarkers such as the alphavbeta3 integrin. Labeling nanoparticles with positron emitting radionuclides can speed up this evaluation. In fact, small animal Positron Emission Tomography (PET) scanners allow researchers to quantitatively image the uptake of candidate nanocarriers at the target site with high sensitivity. In addition to conventional ex vivo biodistribution techniques, the pharmacokinetic profile of new nanomaterials with potential medical application can be obtained with dynamic and/or longitudinal PET studies on a relatively small number of laboratory animals. This article will focus on some of the approaches to label nanoparticles with positron emitting radionuclides along with in vitro and in vivo protocols that have been optimized and are being used for evaluating nanoparticles. |
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| MeSH term(s) | Bromine Radioisotopes/chemistry ; Chromatography, Liquid/methods ; Chromatography, Thin Layer/methods ; Copper Radioisotopes/chemistry ; Drug Carriers ; Drug Delivery Systems ; Drug Design ; Drug Evaluation, Preclinical ; In Vitro Techniques ; Iodine Radioisotopes/chemistry ; Nanomedicine/methods ; Nanoparticles/chemistry ; Nanotechnology/methods ; Positron-Emission Tomography/instrumentation ; Positron-Emission Tomography/methods ; Time Factors |
| Chemical Substances | Bromine Radioisotopes ; Copper Radioisotopes ; Drug Carriers ; Iodine Radioisotopes |
| Language | English |
| Publishing date | 2008-09 |
| Publishing country | Italy |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review |
| ZDB-ID | 1281687-5 |
| ISSN | 1827-1936 ; 1824-4785 ; 0392-0208 ; 1125-0135 ; 1824-4661 |
| ISSN (online) | 1827-1936 |
| ISSN | 1824-4785 ; 0392-0208 ; 1125-0135 ; 1824-4661 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 18: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2019 Volume 30, Issue 3, Page(s) 547–551
Abstract: Multimodal imaging agents combine two or more imaging modalities into one probe. Self-assembling fluorescent nanoparticles are a promising class of modular multimodal imaging probes as they can allow easy blending of imaging and targeting modalities. Our ...
| Abstract | Multimodal imaging agents combine two or more imaging modalities into one probe. Self-assembling fluorescent nanoparticles are a promising class of modular multimodal imaging probes as they can allow easy blending of imaging and targeting modalities. Our group recently developed a class of self-assembling and intrinsically fluorescent small molecule-based nanoparticles (SMNPs) with excellent optical properties. In this article, we describe the efficient radiolabeling of these SMNPs via a two-step bioconjugation strategy involving the inverse-electron-demand Diels-Alder ligation between a tetrazine (Tz)-tagged radiolabel and a trans-cyclooctene (TCO)-tagged fluorescent small molecule building block of the SMNPs. Studies in mice revealed that the SMNPs are well tolerated and could be monitored by both radioactivity and fluorescence, thereby demonstrating the potential of SMNPs in optical and dual-mode imaging in vivo. The work also testifies to the utility of the Tz-TCO conjugation chemistry for the labeling of self-assembled nanoparticles. |
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| MeSH term(s) | Animals ; Cycloaddition Reaction ; Cyclooctanes/analogs & derivatives ; Cyclooctanes/pharmacokinetics ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/pharmacokinetics ; Heterocyclic Compounds, 1-Ring/chemistry ; Heterocyclic Compounds, 1-Ring/pharmacokinetics ; Mice ; Nanoparticles/chemistry ; Optical Imaging ; Radionuclide Imaging ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution |
| Chemical Substances | Cyclooctanes ; Fluorescent Dyes ; Heterocyclic Compounds, 1-Ring ; Radiopharmaceuticals |
| Language | English |
| Publishing date | 2019-02-12 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1024041-x |
| ISSN | 1520-4812 ; 1043-1802 |
| ISSN (online) | 1520-4812 |
| ISSN | 1043-1802 |
| DOI | 10.1021/acs.bioconjchem.9b00038 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3400: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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