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Article ; Online: Antimicrobial Resistance Patterns of Gram-negative Bacteria in an Iranian Referral Pediatric Hospital: A Present Danger of New Delhi Metallo-β- lactamase.

Mahmoudi, Shima / Pourakbari, Babak / Rostamyan, Maryam / Raji, Hojatollah / Sadeghi, Reihaneh Hosseinpour / Mamishi, Setareh

Infectious disorders drug targets

2023 Volume 23, Issue 6, Page(s) e180423215994

Abstract: Background: Antimicrobial resistance among gram-negative bacteria has been growing, particularly in developing countries, like Iran. The emergence and spread of carbapenem-resistance mechanisms is a major public health concern because no definite ... ...

Abstract	Background: Antimicrobial resistance among gram-negative bacteria has been growing, particularly in developing countries, like Iran. The emergence and spread of carbapenem-resistance mechanisms is a major public health concern because no definite treatments have yet been established for this problem. This study aimed to evaluate antibiotic susceptibility of gram-negative bacteria, metallo-β-lactamases (MBLs) and carbapenemase-producing genes, including bla Material and methods: In this cross-sectional study, a total of 944 gram-negative isolates were tested in the study, and antimicrobial susceptibility testing was performed. Moreover, MBL production of carbapenem-resistant isolates, as well as the presence of bla Results: The most common gram-negative isolated bacteria were Escherichia coli (489 samples, 52%), followed by Klebsiella pneumoniae (167 samples, 18%), Pseudomonas aeruginosa (101 samples, 11%), Enterobacter spp. (64 samples, 7%), Pseudomonas spp. (35 samples, 4%), Acinetobacter baumannii (18 samples, 2%), and Burkholderia cepacia (17 samples, 2%). Imipenemresistant was found in 75%, 61%, and 60% of Stenotrophomonas maltophilia, Enterobacter spp., and A. baumannii isolates, respectively. Moreover, the highest resistance to meropenem was observed in S. maltophilia, A. baumannii, P. aeruginosa, and B. cepacia (100%, 96%, 83%, and 61.5%, respectively). Double disk synergy test (DDST) results showed that 112 out of 255 carbapenem- resistant isolates (44%) were MBL-producing ones. The presence of the bla Conclusion: Our findings suggest the emergence of NDM-producing strains in our hospital, and bla NDM was the most frequently detected carbapenemase gene in MBL-producing P. aeruginosa, K. pneumoniae, and Klebsiella spp. Since such bacteria can easily spread among patients in the hospital, a strong infection control and prevention plan is highly recommended.
MeSH term(s)	Child ; Humans ; Anti-Bacterial Agents/pharmacology ; Iran/epidemiology ; Escherichia coli ; Cross-Sectional Studies ; Hospitals, Pediatric ; Drug Resistance, Bacterial ; beta-Lactamases/genetics ; Carbapenems/pharmacology ; Gram-Negative Bacteria ; Pseudomonas aeruginosa ; Klebsiella pneumoniae ; Referral and Consultation
Chemical Substances	Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; Carbapenems
Language	English
Publishing date	2023-04-27
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/1871526523666230418114213
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Article ; Online: SARS-CoV-2 RNAaemia in children: An Iranian referral hospital-based study.

Pourakbari, Babak / Mahmoudi, Shima / Mahmoudieh, Yasmine / Eshaghi, Hamid / Navaeian, Amene / Rostamyan, Maryam / Mamishi, Setareh

Journal of medical virology

2021 Volume 93, Issue 9, Page(s) 5452–5457

Abstract: Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is generally detected in nasopharyngeal swabs, viral RNA can be found in other samples including blood. Recently, associations between SARS-CoV-2 RNAaemia and disease severity and ... ...

Abstract	Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is generally detected in nasopharyngeal swabs, viral RNA can be found in other samples including blood. Recently, associations between SARS-CoV-2 RNAaemia and disease severity and mortality have been reported in adults, while no reports are available in pediatric patients with coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the mortality, severity, clinical, and laboratory findings of SARS-CoV-2 RNA detection in blood in 96 pediatric patients with confirmed COVID-19. Among all patients, 6 (6%) had SARS-CoV-2 RNAaemia. Out of the six patients with SARS-CoV-2 RNAaemia, four (67%) had a severe form of the disease, and two out of the 6 patients with SARS-CoV-2 RNAaemia passed away (33%). Our results show that the symptoms more commonly found in the cases of COVID-19 in the study (fever, cough, tachypnea, and vomiting), were found at a higher percentage in the patients with SARS-CoV-2 RNAaemia. Creatine phosphokinase and magnesium tests showed significant differences between the positive and negative SARS-CoV-2 RNAaemia groups. Among all laboratory tests, magnesium and creatine phosphokinase could better predict SARS-CoV-2 RNAemia with area under the curve levels of 0.808 and 0.748, respectively. In conclusion, 67% of individuals with SARS-CoV-2 RNAaemia showed a severe COVID-19 and one-third of the patients with SARS-CoV-2 RNAaemia passed away. Our findings suggest that magnesium and creatine phosphokinase might be considered as markers to estimate the SARS-CoV-2 RNAaemia.
MeSH term(s)	Adolescent ; Biomarkers/blood ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/pathology ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Child ; Child, Preschool ; Cough/diagnosis ; Cough/mortality ; Cough/pathology ; Cough/virology ; Creatine Kinase/blood ; Female ; Fever/diagnosis ; Fever/mortality ; Fever/pathology ; Fever/virology ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Iran ; Magnesium/blood ; Male ; RNA, Viral/blood ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Survival Analysis ; Tachypnea/diagnosis ; Tachypnea/mortality ; Tachypnea/pathology ; Tachypnea/virology ; Viremia/diagnosis ; Viremia/mortality ; Viremia/pathology ; Viremia/virology
Chemical Substances	Biomarkers ; RNA, Viral ; Creatine Kinase (EC 2.7.3.2) ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2021-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27065
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The First Confirmed Case of Coronavirus Disease 2019 (COVID-19) in an Adolescent with Abdominal Pain in Iran.

Mahmoudi, Shima / Rostamyan, Maryam / Aziz-Ahari, Alireza / Pourakbari, Babak / Ghaffari, Mohammad / Mamishi, Setareh

Tanaffos

2020 Volume 19, Issue 2, Page(s) 156–159

Abstract: Background: The outbreak of coronavirus disease 2019 (COVID-19) is evolving rapidly. However, there is limited information about this disease in children and adolescents. Only a few pediatric cases of COVID-19 have been reported so far. Since the immune ...

Abstract	Background: The outbreak of coronavirus disease 2019 (COVID-19) is evolving rapidly. However, there is limited information about this disease in children and adolescents. Only a few pediatric cases of COVID-19 have been reported so far. Since the immune responses of children are different from adults, their clinical findings and therapeutic responses may differ. To the best of our knowledge, this is the first confirmed case of COVID-19 in a 12-year-old girl with abdominal pain in Iran. Case presentation: A 12-year-old girl with a history of cold, dry cough, sore throat, fever, and left-sided abdominal pain was referred to the Children's Medical Center, Tehran, Iran, on March 7, 2020. The chest X-ray indicated air space opacification in the right lower lobe and faint ground-glass opacity in the left lower lung. A subsequent chest computed tomography (CT) scan indicated blialteral patchy lower lobe consolidations. The patient's oropharyngeal swab was positive for COVID-19, based on the result of real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay. The patient's clinical status was improved, and she was discharged five days after admission (March 11, 2020). Conclusion: Since the number of infected cases with COVID-19 is growing rapidly in Iran, early detection and management of infected cases are highly recommended for preventing the disease transmission and reducing the rate of infection.
Language	English
Publishing date	2020-07-10
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2233372-1
ISSN	1735-0344
ISSN	1735-0344
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Coronavirus Disease 2019 (COVID-19) in Children

Mahmoudi, Shima / Mehdizadeh, Mehrzad / Shervin Badv, Reza / Navaeian, Amene / Pourakbari, Babak / Rostamyan, Maryam / Sharifzadeh Ekbatani, Meisam / Eshaghi, Hamid / Abdolsalehi, Mohammad Reza / Alimadadi, Hosein / Movahedi, Zahra / Mamishi, Setareh

A Study in an Iranian Children’s Referral Hospital

2020

Abstract: Shima Mahmoudi,1 Mehrzad Mehdizadeh,2,3 Reza Shervin Badv,3 Amene Navaeian,4 Babak Pourakbari,1 Maryam Rostamyan,4 Meisam Sharifzadeh Ekbatani,3 Hamid Eshaghi,4 Mohammad Reza Abdolsalehi,4 Hosein Alimadadi,5 Zahra Movahedi,6 Setareh Mamishi1,4 1Tehran ... ...

Abstract	Shima Mahmoudi,1 Mehrzad Mehdizadeh,2,3 Reza Shervin Badv,3 Amene Navaeian,4 Babak Pourakbari,1 Maryam Rostamyan,4 Meisam Sharifzadeh Ekbatani,3 Hamid Eshaghi,4 Mohammad Reza Abdolsalehi,4 Hosein Alimadadi,5 Zahra Movahedi,6 Setareh Mamishi1,4 1Tehran University of Medical Sciences, Tehran, Iran; 2School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 3Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran; 4Department of Infectious Diseases, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran; 5Tehran University of Medical Sciences, Tehran, Iran; 6Department of Pediatric Infectious Disease, Faculty of Medicine, Qom University of Medical Sciences, Qom, IranCorrespondence: Setareh Mamishi Department of Infectious DiseasesPediatrics Center of Excellence, Children’s Medical Center Hospital, Keshavarz Boulevard, Tehran, IranTel/ Fax +98- 21- 6642- 8996Email smamishi@sina.tums.ac.irBackground: Despite the worldwide spread of the coronavirus disease 2019 (COVID-19), the epidemiological and clinical patterns of the COVID-19 infection remain largely unclear, particularly among children. In this study, we explored the epidemiological characteristics, clinical patterns, and laboratory and imaging findings of pediatric patients with COVID-19.Materials and Methods: From March 7 to March 30, 2020, there were a total of 35 patients who had confirmed COVID-19 infection by laboratory virus nucleic acid test (RT-PCR) assay with throat swab samples or typical chest CT manifestation compatible with COVID-19, in addition to a history of close contact with suspected or confirmed SARSâ€CoVâ€2 in family members. Information recorded included demographic data, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings and radiologic assessments, severity of disease, treatment, and mortality.Results: The median age of the patients was 7.5 years (IQR=4– 11; range=4 months to 15 years). A total of 63% were male. Cough was present in 80% of the patients, followed by fever (77%), nausea or vomiting (29%), diarrhea (26%), shortness of breath (29%), headache (20%), and myalgia (14%). Lymphopenia was present in 43% of the patients, thrombocytopenia in 9%, neutopenia in 8%, and leucopenia in 26%. We reported severe pneumonia in 40% of the hospitalized patients and 18 (51%) had underlying diseases. Of 35 patients, 11 had positive RT-PCR results (31%). The chest CT images of 24 patients (69%) suggested COVID-19, while their RT-PCR assays from throat swab samples were negative.Conclusion: This study demonstrates different clinical findings of pediatrics compared to the previous reports of children. Since a high rate of false negative RT-PCR test was observed, early detection of children with COVID-19 infection by CT is conducive to reasonable management and early treatment.Keywords: COVID-19, children, severe pneumonia, Iran
Keywords	Infection and Drug Resistance ; covid19
Subject code	610
Language	English
Publishing date	2020-07-31
Publisher	Dove Press
Publishing country	us
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Coronavirus Disease 2019 (COVID-19) in Children: A Study in an Iranian Children's Referral Hospital.

Infection and drug resistance

2020 Volume 13, Page(s) 2649–2655

Abstract: Background: Despite the worldwide spread of the coronavirus disease 2019 (COVID-19), the epidemiological and clinical patterns of the COVID-19 infection remain largely unclear, particularly among children. In this study, we explored the epidemiological ... ...

Abstract	Background: Despite the worldwide spread of the coronavirus disease 2019 (COVID-19), the epidemiological and clinical patterns of the COVID-19 infection remain largely unclear, particularly among children. In this study, we explored the epidemiological characteristics, clinical patterns, and laboratory and imaging findings of pediatric patients with COVID-19. Materials and methods: From March 7 to March 30, 2020, there were a total of 35 patients who had confirmed COVID-19 infection by laboratory virus nucleic acid test (RT-PCR) assay with throat swab samples or typical chest CT manifestation compatible with COVID-19, in addition to a history of close contact with suspected or confirmed SARS-CoV-2 in family members. Information recorded included demographic data, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings and radiologic assessments, severity of disease, treatment, and mortality. Results: The median age of the patients was 7.5 years (IQR=4-11; range=4 months to 15 years). A total of 63% were male. Cough was present in 80% of the patients, followed by fever (77%), nausea or vomiting (29%), diarrhea (26%), shortness of breath (29%), headache (20%), and myalgia (14%). Lymphopenia was present in 43% of the patients, thrombocytopenia in 9%, neutopenia in 8%, and leucopenia in 26%. We reported severe pneumonia in 40% of the hospitalized patients and 18 (51%) had underlying diseases. Of 35 patients, 11 had positive RT-PCR results (31%). The chest CT images of 24 patients (69%) suggested COVID-19, while their RT-PCR assays from throat swab samples were negative. Conclusion: This study demonstrates different clinical findings of pediatrics compared to the previous reports of children. Since a high rate of false negative RT-PCR test was observed, early detection of children with COVID-19 infection by CT is conducive to reasonable management and early treatment.
Keywords	covid19
Language	English
Publishing date	2020-07-31
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S259064
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Coronavirus Disease 2019 (COVID-19) in Children

Infection and Drug Resistance

A Study in an Iranian Children’s Referral Hospital

2020 Volume Volume 13, Page(s) 2649–2655

Keywords	Pharmacology (medical) ; Pharmacology ; Infectious Diseases ; covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/idr.s259064
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Coronavirus Disease 2019 (COVID-19) in Children: A Study in an Iranian Children's Referral Hospital

Infect Drug Resist

Abstract	Background: Despite the worldwide spread of the coronavirus disease 2019 (COVID-19), the epidemiological and clinical patterns of the COVID-19 infection remain largely unclear, particularly among children. In this study, we explored the epidemiological characteristics, clinical patterns, and laboratory and imaging findings of pediatric patients with COVID-19. Materials and Methods: From March 7 to March 30, 2020, there were a total of 35 patients who had confirmed COVID-19 infection by laboratory virus nucleic acid test (RT-PCR) assay with throat swab samples or typical chest CT manifestation compatible with COVID-19, in addition to a history of close contact with suspected or confirmed SARS-CoV-2 in family members. Information recorded included demographic data, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings and radiologic assessments, severity of disease, treatment, and mortality. Results: The median age of the patients was 7.5 years (IQR=4-11; range=4 months to 15 years). A total of 63% were male. Cough was present in 80% of the patients, followed by fever (77%), nausea or vomiting (29%), diarrhea (26%), shortness of breath (29%), headache (20%), and myalgia (14%). Lymphopenia was present in 43% of the patients, thrombocytopenia in 9%, neutopenia in 8%, and leucopenia in 26%. We reported severe pneumonia in 40% of the hospitalized patients and 18 (51%) had underlying diseases. Of 35 patients, 11 had positive RT-PCR results (31%). The chest CT images of 24 patients (69%) suggested COVID-19, while their RT-PCR assays from throat swab samples were negative. Conclusion: This study demonstrates different clinical findings of pediatrics compared to the previous reports of children. Since a high rate of false negative RT-PCR test was observed, early detection of children with COVID-19 infection by CT is conducive to reasonable management and early treatment.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #703758
Database	COVID19

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Article ; Online: Antimicrobial Resistance Patterns of Gram-negative Bacteria in an Iranian Referral Pediatric Hospital: A Present Danger of New Delhi Metallo-β- lactamase.

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Article ; Online: SARS-CoV-2 RNAaemia in children: An Iranian referral hospital-based study.

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Article: The First Confirmed Case of Coronavirus Disease 2019 (COVID-19) in an Adolescent with Abdominal Pain in Iran.

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Article ; Online: The Coronavirus Disease 2019 (COVID-19) in Children

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Article: The Coronavirus Disease 2019 (COVID-19) in Children: A Study in an Iranian Children's Referral Hospital.

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Article ; Online: The Coronavirus Disease 2019 (COVID-19) in Children

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Article: The Coronavirus Disease 2019 (COVID-19) in Children: A Study in an Iranian Children's Referral Hospital

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