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  1. Article ; Online: One step forward in health promotion.

    Rosu, M

    Journal of medicine and life

    2012  Volume 5, Issue 3, Page(s) 367–372

    Abstract: Thalassemias are inherited blood disorders. In 2011, there was no clear situation regarding the number of thalassemia or other hemoglobinopathy patients in Romania. The luck of information has led to an increased number of patients registered by Fundeni ... ...

    Abstract Thalassemias are inherited blood disorders. In 2011, there was no clear situation regarding the number of thalassemia or other hemoglobinopathy patients in Romania. The luck of information has led to an increased number of patients registered by Fundeni Hospital, Bucharest in the last years. The main goal of this article is to underline the importance of implementing a screening program in Romania for thalassemia and other hemoglobinopathies, parallel with an awareness program. The importance of this objective is strongly supported by the following example: in Sardinia, thalassemia major was present in one out of 250 births, and has declined to one out of 4000 births after they implemented the screening program. The article is written by Monica Rosu, a participant to the World Wide Opportunities for Woman course, held in Canada, in 1999 and states one of the first results of thalassemia awareness in Romania with a positive impact on the patient's life, registering the following results: 2000: A website in Romanian language regarding thalassemias and addressed to patients was created. 2005: The Association of People with thalassemia major was founded and become member of Thalassemia International Federation. 2011: Thalassemia major patients from Romania have access to free treatment and the latest medical oral chelator, Exjade. The association participated in various meetings addressed to patients and doctors as well, created their own website, held workshops, fought together for an improved quality of life for themselves, for healthy people (possible thalassemia carriers) and for all Romanian children.
    MeSH term(s) Female ; Health Promotion ; Humans ; Pregnancy ; Thalassemia/classification ; Thalassemia/diagnosis ; Thalassemia/prevention & control ; Thalassemia/therapy
    Language English
    Publishing date 2012-09-25
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2559353-5
    ISSN 1844-3117 ; 1844-3109 ; 1844-122X
    ISSN (online) 1844-3117 ; 1844-3109
    ISSN 1844-122X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Severe osteoporosis as atypical presentation of hereditary hemochromatosis.

    Taujan, Georgiana Cristina / Iconaru, Laura / Rosu, Mihaela / Kosmopoulou, Olga Ana / Papadopoulou, Ioana Blerta / Baleanu, Felicia

    Clinical case reports

    2022  Volume 10, Issue 10, Page(s) e6396

    Abstract: Besides important metabolic repercussions, iron overload is reported to be associated with deleterious effects on articulations and bones. We present the case of a male patient diagnosed with severe osteoporosis and vertebral fracture, in whom the ... ...

    Abstract Besides important metabolic repercussions, iron overload is reported to be associated with deleterious effects on articulations and bones. We present the case of a male patient diagnosed with severe osteoporosis and vertebral fracture, in whom the evaluation for secondary osteoporosis revealed hereditary hemochromatosis.
    Language English
    Publishing date 2022-10-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pentraxin-3 and Other Inflammatory Markers for an Infected Diabetic Foot Ulcer Diagnosis: A Prospective Study.

    Ardelean, Andrei / Balta, Diana-Federica / Neamtu, Carmen / Neamtu, Adriana Andreea / Rosu, Mihai / Pilat, Luminita / Moldovan, Silviu / Tarta, Cristi / Totolici, Bogdan

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 14

    Abstract: Strategies have been researched and implemented to reduce the number of people with diabetic foot ulcers (DFUs). One problem is the accurate assessment of DFU severity, which is the main factor in resource allocation and treatment choice. The primary ... ...

    Abstract Strategies have been researched and implemented to reduce the number of people with diabetic foot ulcers (DFUs). One problem is the accurate assessment of DFU severity, which is the main factor in resource allocation and treatment choice. The primary objective of this study was to assess pentraxin-3 as a biomarker of an infected DFU (IDFU), the limb amputation level prognosis, and patient survival. The secondary objectives were to evaluate and compare other markers, including white blood cells (WBCs), C-reactive protein (CRP), the erythrocyte sedimentation rate (ESR), and procalcitonin (PCT), for identifying IDFUs. Over a period of two years, 145 patients were followed; 131 of these were analyzed for this study. Pentraxin-3 was found to be a good predictor of death (
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13142366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Predictive Role of Serum Lipid Levels, p53 and ki-67, According to Molecular Subtypes in Breast Cancer: A Randomized Clinical Study.

    Faur, Ionut Flaviu / Dobrescu, Amadeus / Clim, Ioana Adelina / Pasca, Paul / Prodan-Barbulescu, Catalin / Tarta, Cristi / Neamtu, Andreea-Adriana / Brebu, Dan / Neamtu, Carmen / Rosu, Mihai / Duta, Ciprian / Clim, Andreea / Lazar, Gabriel / Totolici, Bogdan

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Dyslipidemia is a component of metabolic syndrome, having an important role in the carcinogenesis of different tumor types, such as prostate, ovarian, or renal cancer. The number of studies on the predictive potential of the different components of the ... ...

    Abstract Dyslipidemia is a component of metabolic syndrome, having an important role in the carcinogenesis of different tumor types, such as prostate, ovarian, or renal cancer. The number of studies on the predictive potential of the different components of the lipid profile with a predictive potential in breast cancer is quite low. The evaluation of the lipid profile was carried out for the 142 patients who benefited from neoadjuvant therapy (NAC) in order to identify a potential predictive biomarker. The serological sample collection was performed sequentially according to a standardized protocol, pre-NAC, post-NAC and 6 months post-NAC after a 6-h pre-collection fast. We also investigated in the general group the presence or absence of the p53 mutation (TP53) and of the mitotic index ki-67, respectively, in relation to the molecular subtypes. The menopausal status, tumor size, family history, grading, Ki-67, p53 and LN metastases have a predictive nature regarding overall survival (OS) (
    MeSH term(s) Male ; Humans ; Ki-67 Antigen/genetics ; Cholesterol, LDL ; Triple Negative Breast Neoplasms ; Tumor Suppressor Protein p53/genetics ; Kidney Neoplasms
    Chemical Substances Ki-67 Antigen ; Cholesterol, LDL ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2024-03-31
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Congenital hyperinsulinism-A case of mild hypoglycemia in an adult, detected by family testing.

    Baleanu, Felicia / Taujan, Georgiana / Rosu, Mihaela / Kosmopoulou, Olga / Papadopoulou, Blerta Ioanna / Boros, Emese / Iconaru, Laura

    Clinical case reports

    2022  Volume 10, Issue 12, Page(s) e6636

    Abstract: Symptoms of mild hypoglycemia are easily overlooked especially when there are no complaints from the patients, but it could be a warning sign of an underlying genetic disease. Genetic testing for the entire family is a key step in neonatal hypoglycemia ... ...

    Abstract Symptoms of mild hypoglycemia are easily overlooked especially when there are no complaints from the patients, but it could be a warning sign of an underlying genetic disease. Genetic testing for the entire family is a key step in neonatal hypoglycemia workup.
    Language English
    Publishing date 2022-12-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Rare cause of a resistant hypertension in a middle-aged man: A case report.

    Marecek, Renata / De Keyzer, Eva / Taujan, Georgiana / Baleanu, Felicia / Rosu, Mihaela / Papadopoulou, Ioanna / Kosmopoulou, Olga / Laura, Iconaru

    Clinical case reports

    2022  Volume 10, Issue 12, Page(s) e6606

    Abstract: Congenital adrenal hyperplasia associated to 11-beta-hydroxylase deficiency is a rare cause of secondary hypertension, usually discovered during childhood; however, a late diagnosis in adults has also been reported. Despite low cortisol levels, ... ...

    Abstract Congenital adrenal hyperplasia associated to 11-beta-hydroxylase deficiency is a rare cause of secondary hypertension, usually discovered during childhood; however, a late diagnosis in adults has also been reported. Despite low cortisol levels, accumulated adrenal steroid precursors can activate the glucocorticoid receptor and thus protect the patient against adrenal crisis.
    Language English
    Publishing date 2022-12-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells

    Hudita, A / Radu, I C / Galateanu, B / Ginghina, O / Herman, H / Balta, C / Rosu, M / Zaharia, C / Costache, M / Tanasa, E / Velonia, K / Tsatsakis, A / Hermenean, A

    Nanotoxicology

    2021  Volume 15, Issue 7, Page(s) 973–994

    Abstract: Colorectal cancer (CRC), is the second cause of cancer-related deaths worldwide is one of the most prevalent types of cancers. Conventional treatment continues to rely on surgery, chemotherapy, and radiotherapy, but for advanced cases, adjuvant ... ...

    Abstract Colorectal cancer (CRC), is the second cause of cancer-related deaths worldwide is one of the most prevalent types of cancers. Conventional treatment continues to rely on surgery, chemotherapy, and radiotherapy, but for advanced cases, adjuvant chemotherapy remains the main approach for improving surgical outcomes and lower the disease recurrence probability. Chemotherapy-induced gastrointestinal (GI) toxicity is the main dose-limiting factor for many chemotherapeutic regimens, including 5-FU, and one of the biggest oncological challenges. Up to 40% of the patients receiving 5-FU get mucositis, 10-15% of which develop severe symptoms. In this context, our study aimed to develop a bioinspired nanosized drug delivery system as a strategy to reduce 5-FU associated side effects, such as GI mucositis. To this end, SF-based nanoparticles were prepared and characterized in terms of size and morphology, as well as in terms of
    MeSH term(s) Colorectal Neoplasms/drug therapy ; Fibroins ; Fluorouracil/toxicity ; HT29 Cells ; Humans ; Mucositis
    Chemical Substances Fibroins (9007-76-5) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2021-07-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2237988-5
    ISSN 1743-5404 ; 1743-5390
    ISSN (online) 1743-5404
    ISSN 1743-5390
    DOI 10.1080/17435390.2021.1943032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Calcinosis in Rheumatic Disease Is Still an Unmet Need: A Retrospective Single-Center Study.

    Nita, Cristina / Groseanu, Laura / Opris, Daniela / Predeteanu, Denisa / Bojinca, Violeta / Berghea, Florian / Vlad, Violeta / Abobului, Mihai / Constantinescu, Cosmin / Negru, Magdalena / Saulescu, Ioana / Daia, Sanziana / Mazilu, Diana / Borangiu, Andreea / Cobilinschi, Claudia / Mardale, Denisse / Rosu, Madalina / Balanescu, Andra

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 6

    Abstract: Patients with immune-mediated rheumatic disease-related calcinosis comprise a subgroup at risk of encountering a more severe clinical outcome. Early assessment is pivotal for preventing overall disease progression, as calcinosis is commonly overlooked ... ...

    Abstract Patients with immune-mediated rheumatic disease-related calcinosis comprise a subgroup at risk of encountering a more severe clinical outcome. Early assessment is pivotal for preventing overall disease progression, as calcinosis is commonly overlooked until several years into the disease and is considered as a 'non-lethal' manifestation. This single-center retrospective study explored the prevalence, clinical associations, and impact on survival of subcutaneous calcinosis in 86 patients with immune-mediated rheumatic diseases (IMRD). Calcinosis predominantly appeared in individuals with longstanding disease, particularly systemic sclerosis (SSc), constituting 74% of cases. Smaller calcinosis lesions (≤1 cm) were associated with interstitial lung disease, musculoskeletal involvement, and digital ulcerations, while larger lesions (≥4 cm) were associated with malignancy, severe peripheral artery disease, and systemic arterial hypertension. The SSc calcinosis subgroup exhibited a higher mean adjusted European Scleroderma Study Group Activity Index score than those without. However, survival rates did not significantly differ between the two groups. Diltiazem was the most commonly used treatment, and while bisphosphonates reduced complications related to calcinosis, complete resolution was not achieved. The findings underscore current limitations in diagnosing, monitoring, and treating calcinosis, emphasizing the need for further research and improved therapeutic strategies to improve patient care and outcomes.
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14060637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Thesis: Einfluss der Benetzbarkeit suspendierter Katalysatoren auf den G/L-Stoffübergang in Rührkesseln

    Rosu, Marius

    2011  

    Author's details von Marius Rosu
    Keywords Trägerkatalysator ; Stoffübergang ; Hydrophobieren ; Trägersubstanz ; Mehrphasensystem ; Rührreaktor ; Suspension
    Language German
    Size XXI, 128 S., Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Sierke
    Publishing place Göttingen
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss.--Braunschweig, 2010
    ISBN 9783868443103 ; 386844310X
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article: Low-Cost and Reproductible Method to Obtain Mapping of Lymphatic Drainage in Patient with Early Endometrial Cancer.

    Faur, Flaviu Ionut / Clim, Ioana Adelina / Pasca, Paul / Prodan, Catalin / Nati, Ionel / Dobrescu, Amadeus / Florea, Sabrina / Rosu, Mihai / Totolici, Bogdan / Duta, Ciprian / Lazar, Gabriel

    Chirurgia (Bucharest, Romania : 1990)

    2023  Volume 118, Issue 2, Page(s) 153–160

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Female ; Humans ; Middle Aged ; Sentinel Lymph Node Biopsy/methods ; Coloring Agents ; Prospective Studies ; Methylene Blue ; Reproducibility of Results ; Treatment Outcome ; Endometrial Neoplasms/surgery ; Endometrial Neoplasms/pathology ; Lymph Node Excision/methods
    Chemical Substances Coloring Agents ; Methylene Blue (T42P99266K)
    Language English
    Publishing date 2023-05-05
    Publishing country Romania
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 419244-8
    ISSN 1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
    ISSN (online) 1842-368X
    ISSN 1221-9118 ; 0009-4730 ; 0377-5003
    DOI 10.21614/chirurgia.2837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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