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  1. AU="Rota, Sarah G"
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  1. Article ; Online: Diosmetin Induces Apoptosis of Acute Myeloid Leukemia Cells.

    Roma, Alessia / Rota, Sarah G / Spagnuolo, Paul A

    Molecular pharmaceutics

    2018  Volume 15, Issue 3, Page(s) 1353–1360

    Abstract: Acute myeloid leukemia is an aggressive disease with limited and nonselective therapeutic options. This study explored the bioactivity and cell death inducing mechanism of diosmetin, a novel compound identified in a nutraceutical screen to impart ... ...

    Abstract Acute myeloid leukemia is an aggressive disease with limited and nonselective therapeutic options. This study explored the bioactivity and cell death inducing mechanism of diosmetin, a novel compound identified in a nutraceutical screen to impart selective anti-AML activity. Diosmetin, a citrus flavone, induced apoptosis characterized by increases in caspases 8 and 3/7 and the death inducing cytokine TNFα. In fact, through protein and mRNA expression analysis, activity was shown to be dependent on expression of estrogen receptor (ER) β. Treatment with diosmetin also delayed tumor growth in AML mouse xenografts. In summary, these studies highlight diosmetin as a novel therapeutic that induces apoptosis through estrogen receptor β.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 7/metabolism ; Caspase 8/metabolism ; Cell Line, Tumor ; Estrogen Receptor beta/metabolism ; Flavonoids/pharmacology ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Tumor Necrosis Factor-alpha/metabolism ; Xenograft Model Antitumor Assays
    Chemical Substances ESR2 protein, human ; Estrogen Receptor beta ; Flavonoids ; TNF protein, human ; Tumor Necrosis Factor-alpha ; CASP3 protein, human (EC 3.4.22.-) ; CASP7 protein, human (EC 3.4.22.-) ; CASP8 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 7 (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) ; diosmetin (TWZ37241OT)
    Language English
    Publishing date 2018-02-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.7b01151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells.

    Angka, Leonard / Lee, Eric A / Rota, Sarah G / Hanlon, Thomas / Sukhai, Mahadeo / Minden, Mark / McMillan, Elliott M / Quadrilatero, Joe / Spagnuolo, Paul A

    Cancer letters

    2014  Volume 348, Issue 1-2, Page(s) 29–37

    Abstract: To identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively toxic toward AML cell lines and ... ...

    Abstract To identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively toxic toward AML cell lines and primary AML patient samples with no effect toward normal hematopoietic cells. It delayed tumor growth and reduced tumor weights in mouse xenograft models without imparting toxicity. Glucopsychosine increased cytosolic calcium and induced apoptosis through calpain enzymes. Extracellular calcium was functionally important for glucopsychosine-induced AML cell death and surface calcium channel expression is altered in AML cells highlighting a unique mechanism of glucopsychosine's selectivity.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Calcium/metabolism ; Calcium Channels/drug effects ; Calcium Channels/metabolism ; Calpain/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/enzymology ; Leukemia, Myeloid, Acute/pathology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Psychosine/analogs & derivatives ; Psychosine/pharmacology ; Signal Transduction/drug effects ; Time Factors ; Tumor Burden/drug effects ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
    Chemical Substances Antineoplastic Agents ; Calcium Channels ; Psychosine (2238-90-6) ; sphingosyl beta-glucoside (52050-17-6) ; Calpain (EC 3.4.22.-) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2014-06-28
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2014.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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